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  • Abstract Number: 819 • 2015 ACR/ARHP Annual Meeting

    Upregulation of Complement C3 and Alpha-2-Macroglobulin in Cerebrospinal Fluid of Neuropsychiatric Systemic Lupus Erythematosus

    Tomoyuki Asano1, Shuzo Sato1, Hiroko Kobayashi1, Yoshinobu Kariya2, Hiromi Ito2, Kyoka Hoshi2, Akioh Yoshihara3, Yoshikazu Ugawa3, Minoru Takahashi4, Hideharu Sekine4, Shunsei Hirohata5, Hiroshi Watanabe1, Hiromasa Ohira1 and Yasuhiro Hashimoto2, 1Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan, 2Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan, 3Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan, 4Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, 5Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan

    Background/Purpose: Various autoantibodies have been identified in cerebrospinal fluids (CSF) of neuropsychiatric systemic lupus erythematosus (NPSLE). They are supposed to form immune complex with complement…
  • Abstract Number: 820 • 2015 ACR/ARHP Annual Meeting

    Peripheral Blood and Disease Features Associated with Complement Components C3 and C4 in SLE

    Mikhail Olferiev, David Fernandez, Leila Khalili, Dina Greenman, Mary K. Crow and Kyriakos A. Kirou, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY

    Background/Purpose: Decreases in peripheral blood levels of complement components of C3 and C4 are associated with SLE and often indicate a lupus flare. The aim…
  • Abstract Number: 821 • 2015 ACR/ARHP Annual Meeting

    Elevated Serum Levels of Soluble CD146 in Patients with Systemic Sclerosis

    Kazunori Kato1, Tomoko Ito2, Naoto Tamura2, Sayuri Okuda1, Masakazu Matsushita2, Kurisu Tada2, Ken Yamaji2 and Yoshinari Takasaki2, 1Department of Biomedical Engineering, Toyo University, Saitama, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: CD146 is a transmembrane glycoprotein belonging to Ig-superfamily. Human endothelial cells, activated fibroblasts and Th17 cells express CD146 that involved in angiogenesis, fibrosis and…
  • Abstract Number: 822 • 2015 ACR/ARHP Annual Meeting

    Beneficial Effect of Botulinum Toxin-a on Raynaud’s Phenomenon in Japanese Patients with Systemic Sclerosis: A Prospective, Open-Label Trial

    Sei-ichiro Motegi1, Kazuya Yamada1, Sayaka Toki1, Akihiko Uchiyama1, Tetsuya Nakamura2 and Osamu Ishikawa1, 1Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, 2Clinical Investigation and Research Unit, Gunma University Graduate School of Medicine, Gunma, Japan

    Background/Purpose: Systemic scleroderma (SSc) is a generalized connective tissue disease characterized by fibrosis of the skin and internal organs, vascular dysfunction and immune disorder. Patients…
  • Abstract Number: 823 • 2015 ACR/ARHP Annual Meeting

    Anti-IFI16 Antibodies in Scleroderma Are Associated with Digital Gangrene

    Zsuzsanna McMahan1, Ami A. Shah2, Dhananjay Vaidya3, Fredrick M. Wigley4, Antony Rosen5 and Livia Casciola-Rosen6, 1Rheumatology, Johns Hopkins University, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Medicine, School of Medicine, Johns Hopkins, Baltimore, MD, 4Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, 5Mason Lord Bldg Ctr Tower, Johns Hopkins University, School of Medicine, Baltimore, MD, 6Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Our aim was to examine and confirm the association between anti-IFI16 antibodies and clinical features of scleroderma.   Methods: Sera from a discovery sample…
  • Abstract Number: 824 • 2015 ACR/ARHP Annual Meeting

    Familial Risk of Systemic Sclerosis and Co-Aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study

    Chang-Fu Kuo1, Matthew J. Grainge2, Ana Valdes3, Shue-Fen Luo4, Lai-Chu See5, Kuang-Hui Yu6, Weiya Zhang7 and Michael Doherty8, 1Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memorial Hospital, Tayuan, Taiwan, 2Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, 3Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, 4Rheumatology, Chang Gung Memorial Hosp, Taipei, Taiwan, 5Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, 6Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memoria Hospital, Tayuan, Taiwan, 7Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, 8Academic Rheumatology, City Hospital, Nottingham, United Kingdom

    Background/Purpose: To investigate familial aggregation of systemic sclerosis and the relative risks (RRs) of other autoimmune disease in relatives of affected patients. Methods: We identified…
  • Abstract Number: 825 • 2015 ACR/ARHP Annual Meeting

    Subclinical Atherosclerosis and Estimation of Cardiovascular Risk in Systemic Sclerosis

    Gulsen Ozen1, Fatmanur Korkmaz2, Murat Sunbul3, Rabia Deniz4, Kursat Tigen3, Pamir Atagunduz1, Nevsun Inanc1 and Haner Direskeneli1, 1Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Department of Internal Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey, 3Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey, 4Marmara University Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: During the last decade, it has been shown that cardiovascular disease (CVD) in systemic sclerosis (SSc) is increased and accounts for ~30% of the…
  • Abstract Number: 826 • 2015 ACR/ARHP Annual Meeting

    Systemic Sclerosis Inpatient Mortality Has Not Improved from 1995-2011. Results from a National Irish Audit of Scleroderma Co-Morbidities.

    Len Harty1, Deirdre Fitzgerald2, Michael Henry2, John Ryan3 and Sinead Harney3, 1Cork University Hospital, Cork, Ireland, 2Respiratory, Cork University Hospital, Cork, Ireland, 3Rheumatology, Cork University Hospital, Cork, Ireland

    Background/Purpose: Despite the advent of potent immunosuppressive and vasoactive therapies it is not clear that longevity of patients with systemic sclerosis (SSc) has improved. Therefore…
  • Abstract Number: 827 • 2015 ACR/ARHP Annual Meeting

    Reliability of the Quantitative Assessment of Peripheral Blood Perfusion By Laser Speckle Contrast Analysis in a Systemic Sclerosis Cohort

    Valérie Lambrecht1, Maurizio Cutolo2, Filip De Keyser3, Saskia Decuman4, Barbara Ruaro2, Alberto Sulli5, Ellen Deschepper6 and Vanessa Smith7, 1Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, 3Rheumatology, Ghent University Hospital, Ghent, Belgium, 4Department of Rheumatology, UGent, Ghent, Belgium, 5Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy, 6Biostatistics Unit, Biostatistics Unit, Ghent University, Ghent, Belgium, 7Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium

    Background/Purpose: Laser speckle contrast analysis (LASCA) is an innovative technique to quantify peripheral blood perfusion (PBP) over a given area. Quantification of blood flow might…
  • Abstract Number: 828 • 2015 ACR/ARHP Annual Meeting

    Development of a Disease Damage Index in Systemic Sclerosis Using Consensus and Data Driven Methods

    Nava Ferdowsi1, Molla Huq1, Jodie Burchell2, Sam Mancuso2, Tien Tay1,3, Wendy Stevens4, Candice Rabusa4, Marie Hudson5, Vijaya Sundararajan2, David Prior6, Susanna Proudman7, Murray Baron8 and Mandana Nikpour9,10, 1Rheumatology, The University of Melbourne at St Vincent’s Hospital, Melbourne, Australia, 2Medicine, The University of Melbourne at St Vincent’s Hospital, Melbourne, Australia, 341 Victoria Parade, Fitzroy, St Vincent's Hospital, Melbourne, Australia, 4Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, 5Medicine, McGill University, Montreal, QC, Canada, 6Cardiology, St Vincent's Hospital, Melbourne, Australia, 7Rheumatology Unit, Royal Adelaide Hospital North Terrace, Adelaide, Australia, 8Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, 9St Vincent's Hospital, Melbourne, Australia, 10Medicine, The University of Melbourne at St. Vincent’s Hospital, Melbourne, Australia

    Background/Purpose: As there is currently no existing index for quantifying organ damage in systemic sclerosis (SSc), we sought to develop a disease damage index in…
  • Abstract Number: 829 • 2015 ACR/ARHP Annual Meeting

    Fecal Incontinence and Association with Bowel Dysfunction in Systemic Sclerosis: A Canadian Multicenter Study

    Nicolas Richard1,2, Marie Hudson2, Genevieve Gyger2, Murray Baron3, Evelyn Sutton4, Nader A. Khalidi5, Janet E. Pope6, Nathalie Carrier1, Maggie J. Larche5, Alexandra Albert7, Paul R. Fortin7, Carter Thorne8, Ariel Masetto9 and Canadian Scleroderma Research Group, 1Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 2McGill University, Jewish General Hospital, Montreal, QC, Canada, 3Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, 4Rheumatology, Dalhousie University, Nova Scotia Rehabilitation Centre, Halifax, NS, Canada, 5McMaster University, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 6Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada, 7Université Laval, CHU de Québec, Québec, QC, Canada, 8Southlake Regional Health Centre, Newmarket, ON, Canada, 9Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada

    Background/Purpose: Gastrointestinal (GI) tract involvement is a common and serious complication of systemic sclerosis (SSc). However, the prevalence of fecal incontinence (FI) and its relationship…
  • Abstract Number: 830 • 2015 ACR/ARHP Annual Meeting

    Calcinosis Is Associated with Digital Ulcers and Osteoporosis in Patients with Systemic Sclerosis

    Antonia Valenzuela1, Murray Baron2, Ariane L. Herrick3, Susana Proudman4, Wendy Stevens5, Tatiana Sofia Rodriguez-Reyna6, Alessandra Vacca7, Thomas A. Medsger Jr.8, Monique Hinchcliff9, Vivien Hsu10, David Fiorentino11, Lorinda Chung12 and the Canadian Scleroderma Research Group, and the ASIG rubric, 1Stanford University School of Medicine, Stanford, CA, 2Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, 3Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Rheumatology Unit, Royal Adelaide Hospital North Terrace, Adelaide, Australia, 5Department of Rheumatology, St. Vincent’s Hospital Melbourne, Melbourne, Australia, 6Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 7University Hospital of Cagliari, Rheumatology Unit, Monserrato, Italy, 8Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, 9Rheumatology, Northwestern University, Chicago, IL, 10Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ, 11Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, 12Stanford University, Palo Alto, CA

    Background/Purpose: Calcinosis is a debilitating complication of systemic sclerosis (SSc). We sought to determine the clinical factors associated with calcinosis in an international multi-center collaborative…
  • Abstract Number: 831 • 2015 ACR/ARHP Annual Meeting

    Mycophenolate Decreases the Frequency of Endoscopic Therapy for Gastric Antral Vascular Ectasia in Patients with Systemic Sclerosis

    Tiffany Lin1, James Bena2, Shannon Morrison2 and Soumya Chatterjee3, 1Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, 2Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Gastric antral vascular ectasia (GAVE) is an increasingly recognized cause of upper gastrointestinal bleeding in patients with systemic sclerosis (SSc).  These patients may require…
  • Abstract Number: 832 • 2015 ACR/ARHP Annual Meeting

    The Validity and Reliability of Online Obituaries As a Source of Mortality Data

    Medha Soowamber1, John T. Granton2, Fatemeh Bavaghar-Zaeimi3 and Sindhu R. Johnson4,5, 1Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, 2Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, 3Rheumatology, Toronto Scleroderma Program, Toronto Western Hospital and Mount Sinai Hospital, Toronto, ON, Canada, 4Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, 5Institute of Health Policy, Management and Evaluation,, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Loss to follow-up is a major threat to the conduct of chronic disease cohort research. Tracking the survival status of patients who are lost…
  • Abstract Number: 833 • 2015 ACR/ARHP Annual Meeting

    Safety and Immunogenicity of Pneumococcal Vaccine in Patients with Systemic Sclerosis and Healthy Controls

    Johanna Nagel1, Tore Saxne2, Pierre Geborek3, Lillemor Scattum4, Roger Hesselstrand5 and Meliha C. Kapetanovic3, 1Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University and Skåne University Hospital, Lund, Sweden, Lund, Sweden, 2Dept of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden, 3Department of Clinical Sciences Lund, Section of Rheumatology Lund University and Skåne University Hospital, Lund, Sweden, 4Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, 5Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden

    Background/Purpose: Studies investigating the immunogenicity of pneumococcal vaccine in patients with systemic sclerosis (SSc) are scarce. We aim to investigate the impact of SSs disease and treatment…
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