Abstracts Archive - Page 1696 of 2607 - ACR Meeting Abstracts

Abstract Number: 1452 • 2016 ACR/ARHP Annual Meeting
18 F-FDG PET Imaging: An In Vivo quantitative Drug Screening Tool for Novel Antiinflammatory Therapies
Siba P. Raychaudhuri¹, Smriti K. Raychaudhuri², Anupam Mitra³ and Abhijit Chaudhari⁴, ¹Davis, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, ³Dermatology, UC Davis School of Medicine, Davis, CA, ⁴Radiology, UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Collagen induced arthritis (CIA) mouse model is used for screening of new drugs for autoimmune arthritis. The conventional read outs of this model are…
Abstract Number: 1453 • 2016 ACR/ARHP Annual Meeting
Treatment of BAFF Transgenic Mice with Anti-TNF: Monoclonals Are Associated with a Higher Risk of Lymphoma Than Etanercept
Gaetane Nocturne^1,2, Bineta Ly³, Saida Boudaoud⁴, raphaèle seror^5,6, Carole Nicco⁷, Christiane Chereau⁷, Niloufar Kavian^7,8, Frederic Batteux^7,8, Fabienne Mackay⁹, Fabien Vincent⁹, Thierry Lazure¹⁰, Sophie Ferlicot¹⁰, Lev Stimmer¹¹, Roman Krzysiek¹⁰, Salima Hacein-Bey¹⁰ and Xavier Mariette^12,13, ¹Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ²INSERM U1184, Université Paris Sud, Le Kremlin Bicêtre, France, ³INSERM U1184, Paris Sud University, Kremlin Bicetre, France, ⁴INSERM U1184, Paris Sud University, Le Kremlin Bicêtre, France, ⁵Assistance Publique-Hôpitaux de Paris (APHP), Hôpitaux universitaires Paris Sud, Université Paris Sud, kremlin bicetre, France, ⁶INSERM U1184, Paris Sud University, Le Kremlin Bicetre, France, ⁷Institut Cochin, Paris, France, ⁸Immunology, APHP Hopital Cochin, Paris, France, ⁹Monash university, Melbourne, Australia, ¹⁰APHP Hopitaux universitaires Paris sud, Le Kremlin Bicetre, France, ¹¹CEA - MIRCen, Fontenay aux Roses, France, ¹²Department of Rheumatology, APHP - Hopitaux universitaire Paris Sud, Le Kremlin Bicetre, France, ¹³INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) have an increased risk of lymphoma and disease activity is the main risk factor. The impact of treatment,…
Abstract Number: 1454 • 2016 ACR/ARHP Annual Meeting
Combination of the SYK Inhibitor, GS-9876, with a JAK Inhibitor Increases Efficacy in a Chronic Rat Model of Collagen-Induced Arthritis
Julie Di Paolo¹, David Alonzo², Christian Franci³, Terry Gentzler¹, Li Li⁴, Bernard Murray⁵ and Jim Zheng⁵, ¹Biology, Gilead Sciences, Foster City, CA, ²FPD, Gilead Sciences, Foster City, CA, ³Biology, Gilead Sciences, Foster, CA, ⁴Gilead Sciences, South San Francisco, CA, ⁵DMPK, Gilead Sciences, Foster City, CA
Background/Purpose: Here we demonstrate that 1) the single agent activity of GS-9876 is efficacious in a late stage rat model of collagen-induced arthritis (CIA);…
Abstract Number: 1455 • 2016 ACR/ARHP Annual Meeting
Collagen-Induced Arthritis and Uveitis in Mice Lacking TNF Receptors
Chiharu Iwahashi¹, Minoru Fujimoto², Tomoharu Ohkawara³, Hayato Urushima¹, Satoshi Serada¹ and Tetsuji Naka⁴, ¹Laboratory for Immune Signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, ²Laboratry of immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, ³Laboratory for immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan, ⁴Laboratory for immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan
Background/Purpose: Tumor necrosis factor (TNF) is a critical effector of the autoimmune inflammation in rheumatoid arthritis (RA) and uveitis. TNF inhibitors are preferably used in…
Abstract Number: 1456 • 2016 ACR/ARHP Annual Meeting
Identification of a Unique Population of B220hi B-Cells in Inflamed Lymph Nodes (Bin) As a Potential Biomarker of Arthritic Progression in the Tumor Necrosis Factor Transgenic Mouse Model of Rheumatoid Arthritis
Megan Forney¹, Richard Bell², Edward Schwarz³ and Homaira Rahimi⁴, ¹Orthopedics, University of Rochester, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Orthopedeatrics, University of Rochester, Rochester, NY, ⁴Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY
Background/Purpose: Using the tumor necrosis factor transgenic (TNF-Tg) mouse model of rheumatoid arthritis (RA), we have shown that during progression of knee synovitis, popliteal lymph…
Abstract Number: 1457 • 2016 ACR/ARHP Annual Meeting
Early Onset Morbidity and Mortality in Female Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis and Interstitial Lung Disease
Richard Bell¹, Emily Wu², Ronald Wood³, Joe Chakkalakal², Javier Rangel-Moreno⁴, Maria de la Luz Garcia-Hernandez², Christopher T. Ritchlin⁵, Edward Schwarz⁶ and Homaira Rahimi⁷, ¹Center for Musculoskelatal Research, University of Rochester, Rochester, NY, ²University of Rochaester, Rochester, NY, ³University of Rochester, Rochester, NY, ⁴Allergy, Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁶Orthopedeatrics, University of Rochester, Rochester, NY, ⁷Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY
Background/Purpose: Although exacerbated morbidity and mortality in rheumatoid arthritis (RA) is frequently seen in women, the etiology of this sexual dimorphism remains unclear. Previously, we…
Abstract Number: 1458 • 2016 ACR/ARHP Annual Meeting
Intraadrenal Dendritic Cells Inhibit Corticosterone Response during Collagen-Induced Arthritis – a Role for IL-1β and CXC Chemokines?
Hubert Stangl, Christine Wolff, Martin Lesiak and Rainer Straub, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis (RA) and collagen-induced arthritis (CIA) the phenomenon of a relative insufficiency of adrenal glands to produce an adequate amount of anti-inflammatory…
Abstract Number: 1459 • 2016 ACR/ARHP Annual Meeting
Enhanced Efficacy of Early Vs. Late IL-1β Antagonism in Murine Arthritis Mediated By Deficiency of the IL-1 Receptor Antagonist IL-1ra
Anais Levescot¹, Allyn Morris² and Peter Nigrovic³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: IL-1 blockade is highly effective for systemic juvenile idiopathic arthritis (sJIA), but clinical observations raise the possibility that initiation of treatment in a “window…
Abstract Number: 1460 • 2016 ACR/ARHP Annual Meeting
Suppression of Cholesterol Levels and Impairment in Cholesterol Efflux By HDL in K/BxN Mice Is Associated with a Specific Cytokine/Chemokine Profile
Christina Charles-Schoeman¹, Ani Shahbazian², Yuen Yin Lee³, Buzand Oganesian⁴, Victor Grijalva⁵, Anabel Garcia Heredia¹ and Srinivasa T. Reddy⁵, ¹University of California, Los Angeles, Los Angeles, CA, ²Medicine-Rheumatology, University of California, Los Angeles, Los Angeles, CA, ³Medicine- Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁴Medicine-Rheumatology, University of California, Los Angeles, Los ANgeles, CA, ⁵Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Better understanding of lipid metabolism in active rheumatoid arthritis (RA) is needed to understand the cholesterol changes associated with active disease, as well as…
Abstract Number: 1461 • 2016 ACR/ARHP Annual Meeting
Modification of Proteins with Malondialdehyde-Acetaldehyde and Citrulline Elicit Antibody Responses in DBA/1J Mice
Peter M. Maloley¹, Michael J. Duryee², Carlos D. Hunter², James R. O'Dell³, Daniel R. Anderson¹, Ted R Mikuls⁴, Geoffrey M. Thiele¹ and Lynell W. Klassen³, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Previous studies have shown that proteins modified with malondialdehyde-acetaldehyde (MAA) and/or citrulline (CIT) co-localize in rheumatoid arthritis (RA) synovial tissues, are pro-inflammatory, and promote…
Abstract Number: 1462 • 2016 ACR/ARHP Annual Meeting
Magnesium Is a New Mediator Arthritis Severity and Joint Damage
Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Given the effects of magnesium supplementation in suppressing components of the innate immunity in short-term studies, we examined the effect of dietary magnesium modifications…
Abstract Number: 1463 • 2016 ACR/ARHP Annual Meeting
Helminths Based Tuftsin-Phosphorylcholine Prevent Development of Mouse Collagen Induced Arthritis, While Maintaining Normal Gut Microbiota
Yehuda Shoenfeld¹, Hila Mizrahi², Tomer Bashi³, Hadar Mor², Miri Blank³ and Omry Koren⁴, ¹Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, ²Bar Ilan University, Sefat, Israel, ³Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ⁴Sefat medical school, Bar-Ilan university, Sefat, Israel
Background/Purpose: , Rheumatoid arthritis (RA) is a chronic auto inflammation of the joints, with a prevalence of about 1% in Western population. Treatment with lives…
Abstract Number: 1464 • 2016 ACR/ARHP Annual Meeting
Utility of Relative Cardiovascular Risk Score Scales and Vascular Age Predictors in Patients with Reumathoid Arthritis UNDER 50 YEARS of Age
Andrea Zacarias¹, Carmen Gomez Vaquero², Francisco Javier Narváez³, Joan Miquel Nolla⁴, Miguel Angel González-Gay⁵, Carlos González-Juanatey⁶ and Javier Llorca⁷, ¹Hospital Universitari de Bellvitge, Barcelona, Spain, ²Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ³Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain, ⁴Rheumatology, Bellvitge University Hospital, Barcelona, Spain, ⁵Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, ⁶Cardiology Division, Hospital Xeral-Calde, Lugo, Spain, ⁷Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain
Background/Purpose: Rheumatoid Arthritis (RA) is associated with a greater cardiovascular mortality than the general population of the same age and gender. Cardiovascular events prediction scales,…
Abstract Number: 1465 • 2016 ACR/ARHP Annual Meeting
Utility of Relative Cardiovascular Risk Score Scales in Patients UNDER the Age of 50 and Its Association with the Presence of Carotid Atherosclerosis in the Ultrasound
Andrea Zacarias¹, Carmen Gomez Vaquero², Francisco Javier Narváez³, Miguel Angel González-Gay⁴, Alfonso Corrales⁵, Carlos González-Juanatey⁶, Javier Llorca⁷ and Joan Miquel Nolla⁸, ¹Hospital Universitari de Bellvitge, Barcelona, Spain, ²Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ³Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, ⁵Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁶Cardiology Division, Hospital Xeral-Calde, Lugo, Spain, ⁷Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁸Rheumatology, Bellvitge University Hospital, Barcelona, Spain
Background/Purpose: Rheumatoid Arthritis (RA) is associated with a greater cardiovascular mortality than the general population of the same age and gender. Cardiovascular events prediction scales,…
Abstract Number: 1466 • 2016 ACR/ARHP Annual Meeting
Cardiovascular Risk Assessment in Persons with Rheumatoid Arthritis: A Correlative Study of Non-Invasive Arterial Health Testing with the Inflammatory Burden of Disease
Erin Scanlon¹, Rekha Mankad², Cynthia S. Crowson³, Iftikhar Kullo⁴, Sharon Mulvagh², Eric L. Matteson¹, Zoran Kvrgic¹ and John M. Davis III⁵, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Persons with rheumatoid arthritis (RA) have increased morbidity and mortality attributable to atherosclerotic cardiovascular disease (ASCVD) events. It is unknown how presence of subclinical…

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