Abstracts Archive - Page 1664 of 2425 - ACR Meeting Abstracts

Abstract Number: 2880 • 2015 ACR/ARHP Annual Meeting
Real-World Impact of Anti-TNF Medication Use on Patient Reported Outcomes in a Prospective Cohort of Patients with Ankylosing Spondylitis
Walter Maksymowych¹, Annelies Boonen², Helena Marzo-Ortega³, Marina N. Magrey⁴, Manish Mittal⁵, Michael Halpern⁶, Jeanette Renaud⁶, Yanjun Bao⁵ and Avani D. Joshi⁵, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Maastricht University Medical Center, Maastricht, Netherlands, ³LMBRU, Chapel Allerton Hospital, and University of Leeds, Leeds, United Kingdom, ⁴Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, ⁵AbbVie Inc., North Chicago, IL, ⁶RTI International, Washington, DC
Background/Purpose: Clinical trial results have demonstrated benefits of anti-TNF therapy in improving clinical outcomes, including overall health-related quality of life (HRQoL) in patients with ankylosing…
Abstract Number: 2881 • 2015 ACR/ARHP Annual Meeting
Infliximab in Spondyloarthritis Patients: Utility of Drug Level Monitoring
Claudia Deaconu¹, Diana Mazilu², Laura Grosanu², Ioana Saulescu², Andreea Borangiu², Cecilia Gainaru³, Cosmin Constantinescu², Violeta Bojinca², Violeta Vlad¹, Andra Balanescu², Denisa Predeteanu², Ruxandra Ionescu² and Daniela Opris², ¹Department of Internal Medicine and Rheumatology “Sf. Maria” Hospital, Bucharest, Romania, ²University of Medicine and Pharmacy “Carol Davila”, Department of Internal Medicine and Rheumatology “Sf. Maria” Hospital, Bucharest, Romania, ³"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Background/Purpose: Spondyloarthritides, a heterogeneous group of chronic, inflammatory disorders with overlapping organ and joint targeting, share the same therapeutic approach in regard to biological therapy.…
Abstract Number: 2882 • 2015 ACR/ARHP Annual Meeting
Baseline Extent of Damage at the Spine Predicts Radiographic Progression in Korean Patients Using Golimumab for Ankylosing Spondylitis
Jeong Seok Lee¹, Dae Young Yu², Stephen Xu³ and Eun Young Lee⁴, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University Hospital, Seoul, South Korea, ²Medical Affairs, Janssen Korea, Seoul, South Korea, ³Janssen Research & Development, LLC, Spring House, PA, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: Ankylosing spondylitis (AS) is a chronic rheumatic disease associated with radiographic damage of the spine. Golimumab had consistent efficacy in controlling disease activity through…
Abstract Number: 2883 • 2015 ACR/ARHP Annual Meeting
Relationship Between Improvements in Fatigue and Signs & Symptoms of Active Psoriatic: Arthritis a Sub-Analysis of a Phase 3 Study with Secukinumab
Laure Gossec¹, Tore K. Kvien², Philip G. Conaghan³, Mikkel Østergaard⁴, Juan D. Cañete⁵, C. Gaillez⁶, Shephard Mpofu⁶, Bintu Sherif⁷ and Steffen Jugl⁸, ¹Rheumatology Department, Paris 06 University,Hôpital Pitié Salpêtrière, Paris, France, ²Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, ⁵Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷RTI Health Solutions, Durham, NC, ⁸BF I&D GPA, Health Economics and Outcomes Research, Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Fatigue is highly important to patients (pts) with psoriatic arthritis (PsA). Secukinumab, an anti-interleukin-17A monoclonal antibody, significantly improved the signs and symptoms of active…
Abstract Number: 2884 • 2015 ACR/ARHP Annual Meeting
Epidemiological Parameters Affecting Therapeutic Response in Psoriatic Arthritis Patients
Michail P. Migkos¹, George Somarakis², Evripidis Kaltsonoudis³, Theodora E. Markatseli⁴, Paraskevi V. Voulgari^5,6 and Alexandros A. Drosos⁷, ¹Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Fellow in Rheumatology, Ioannina, Greece, ²Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, University of Ioannina, Rheumatology Clinic, Ioannina, Greece, ³Rheumatology Clinic, Department of Internal Medicine, Rheumatologist, Ioannina, Greece, ⁴Rheumatology Clinic, Department of Internal Medicine, Fellow in Rheumatology, Ioannina, Greece, ⁵Rheumatology Clinic, Department of Internal Medicine, Assistant Professor of Rheumatology, Ioannina, Greece, ⁶Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Assistant Professor of Rheumatology, Ioannina, Greece, ⁷Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Professor of Medicine/Rheumatology, Ioannina, Greece
Background/Purpose: Published data have shown that epidemiological parameters such as Body Mass Index (BMI), gender and disease duration may affect the therapeutic response in psoriatic…
Abstract Number: 2885 • 2015 ACR/ARHP Annual Meeting
Long-Term Effects of Etanercept on Patient-Reported Outcomes in Early Non-Radiographic Axial Spondyloarthritis: 104-Week Results of a Phase III Study
Filip van Den Bosch^1,2, Edit Drescher³, Jan Rosa⁴, Ronald Pedersen⁵, Randi Bonin⁶, Bonnie Vlahos⁷, Jack F Bukowski⁶ and Sameer Kotak⁸, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Csolnoky Ferenc Hospital, Veszprém, Hungary, ⁴Mediscan Group, Prague, Czech Republic, ⁵Department of Biostatistics, Pfizer, Collegeville, PA, ⁶Clinical Affairs, Pfizer, Collegeville, PA, ⁷GIPB - Clinical Sciences, Pfizer, Collegeville, PA, ⁸Global Health and Value, Pfizer, New York, NY
Background/Purpose: In patients with active, NSAID-resistant, non-radiographic axial spondyloarthritis (nr-axSpA) who participated in the multiphase, randomized, placebo (PBO)-controlled EMBARK study (ClinicalTrials.gov identifier: NCT01258738), health-related quality-of-life…
Abstract Number: 2886 • 2015 ACR/ARHP Annual Meeting
Secukinumab Safety and Tolerability in Patients with Active Psoriatic Arthritis and Psoriasis: Results from a Pooled Safety Analysis
Philip J. Mease¹, Iain B. McInnes², Alice B. Gottlieb³, Albert Widmer⁴, Luminita Pricop⁵ and Shephard Mpofu⁴, ¹Rheumatology Research, Swedish Medical Center, Seattle, WA, ²Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom, ³Dermatology, Tufts Medical Center, Boston, MA, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Integrated Hospital Care (IHC) Franchise, Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Secukinumab, a fully human anti–interleukin-17A monoclonal antibody, has been shown to improve the signs and symptoms of psoriasis and psoriatic arthritis (PsA).1–3 Here, we…
Abstract Number: 2887 • 2015 ACR/ARHP Annual Meeting
Safety and Tolerability of Secukinumab in Patients with Active Ankylosing Spondylitis: Pooled Safety Analysis of Two Phase 3, Randomized, Controlled Trials
Atul A. Deodhar¹, Dominique Baeten², Joachim Sieper³, Brian Porter⁴, Albert Widmer⁵ and Hanno Richards⁵, ¹Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ²Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³University Clinic Benjamin Franklin, Berlin, Germany, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁵Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab, an anti–interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) in 2 Phase 3, randomized, double-blind, placebo (PBO)-controlled studies, MEASURE…
Abstract Number: 2888 • 2015 ACR/ARHP Annual Meeting
Apremilast, an Oral Phosphodiesterase 4 Inhibitor, Is Associated with Long-Term (104-Week) Improvements in Enthesitis and Dactylitis in Patients with Psoriatic Arthritis: Pooled Results from Three Phase III, Randomized, Controlled Trials
Dafna D. Gladman¹, Arthur Kavanaugh², Adewale O. Adebajo³, Juan J. Gomez-Reino⁴, Jürgen Wollenhaupt⁵, Maurizio Cutolo⁶, Georg A. Schett⁷, Eric Lespessailles⁸, Melissa McIlraith⁹, ChiaChi Hu⁹, Christopher J. Edwards¹⁰, Charles A. Birbara¹¹ and Philip J. Mease¹², ¹Toronto Western Hospital, Toronto, ON, Canada, ²University of California, San Diego School of Medicine, LaJolla, CA, ³University of Sheffield, Sheffield, United Kingdom, ⁴Hospital Clinico Universitario, Santiago, Spain, ⁵Schön Klinik Hamburg Eilbek, Hamburg, Germany, ⁶University of Genova, Genova, Italy, ⁷University of Erlangen-Nuremberg, Erlangen, Germany, ⁸University of Orléans, Orléans, France, ⁹Celgene Corporation, Warren, NJ, ¹⁰University Hospital Southampton, Southampton, United Kingdom, ¹¹University of Massachusetts Medical School, Worcester, MA, ¹²Rheumatology Research, Swedish Medical Center, Seattle, WA
Background/Purpose: Apremilast (APR), a PDE4 inhibitor, helps regulate immune responses in psoriatic arthritis (PsA). PALACE 1, 2, and 3 compared apremilast (APR) efficacy/safety with placebo…
Abstract Number: 2889 • 2015 ACR/ARHP Annual Meeting
Apremilast, an Oral Phosphodiesterase 4 Inhibitor: Improvements in Nail and Scalp Psoriasis and Psoriasis Area and Severity Index in Patients with Moderate to Severe Plaque Psoriasis
Kim Papp¹, Jeffrey Crowley², Carle Paul³, Melinda Gooderham⁴, Kristian Reich⁵, ChiaChi Hu⁶, Robert M. Day⁶ and Christopher E.M Griffiths⁷, ¹Probity Medical Research, Waterloo, ON, Canada, ²Bakersfield Dermatology, Bakersfield, CA, ³Toulouse University, Hôpital Larrey, Toulouse, France, ⁴SKiN Centre for Dermatology and Probity Medical Research, Peterborough, ON, Canada, ⁵SCIderm Research Institute and Dermatologikum Hamburg, Hamburg, Germany, ⁶Celgene Corporation, Warren, NJ, ⁷Dermatology Centre, University of Manchester, Manchester, United Kingdom
Background/Purpose: Scalp and nail psoriasis are difficult-to-manage manifestations of psoriasis and psoriatic arthritis (PsA). Nail involvement occurs in ~80% of pts with PsA and can…
Abstract Number: 2890 • 2015 ACR/ARHP Annual Meeting
Secukinumab Provides Sustained Improvements in the Signs and Symptoms of Active Ankylosing Spondylitis in Anti-TNF-Naïve Patients and Those Previously Exposed to Anti-TNF Therapy: 52-Week Results from Two Randomized, Double-Blind, Placebo-Controlled Phase 3 Trials
Dominique Baeten¹, Ricardo Blanco², Piet Geusens³, Joachim Sieper⁴, Tseng Jui-Cheng⁵, Ruvie Martin⁶, Brian Porter⁶ and Hanno Richards⁷, ¹Academic Medical Center/ University of Amsterdam, Amsterdam, Netherlands, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Maastricht University, Maastricht, Netherlands, ⁴University Clinic Benjamin Franklin, Berlin, Germany, ⁵Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁷Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Anti‒TNFs are the only biologics currently approved for ankylosing spondylitis (AS). There is a significant unmet need in those patients (pts) with an inadequate…
Abstract Number: 2891 • 2015 ACR/ARHP Annual Meeting
Assessment of Disability Levels in a Cohort of 1,489 Patients with Active Psoriatic Arthritis, and the Effect of Apremilast Treatment: Pooled Data from Three Phase III, Randomized, Controlled Trials
Philip J. Mease¹, Jürgen Wollenhaupt², Stephen Hall³, Filip van Den Bosch⁴, Eric Lespessailles⁵, Melissa McIlraith⁶, Lichen Teng⁶ and Christopher J. Edwards⁷, ¹Rheumatology Research, Swedish Medical Center, Seattle, WA, ²Schön Klinik Hamburg Eilbek, Hamburg, Germany, ³Monash University, CabriniHealth, Melbourne, Australia, ⁴Rheumatology, Ghent University Hospital, VIB, Ghent, Belgium, ⁵University of Orléans, Orléans, France, ⁶Celgene Corporation, Warren, NJ, ⁷University Hospital Southampton, Southampton, United Kingdom
Background/Purpose: PsA, a chronic systemic inflammatory disease, reduces physical function and QOL. Treatment improves/maintains functionality. PALACE 1-3 compared apremilast (APR) efficacy/safety with placebo (PBO) in…
Abstract Number: 2892 • 2015 ACR/ARHP Annual Meeting
Statin Treatment in Patients with Ankylosing Spondylitis
Grunde Wibetoe¹, Eirik Ikdahl¹, Tore K. Kvien², Silvia Rollefstad¹ and Anne Grete Semb³, ¹Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Patients with ankylosing spondylitis (AS) have increased risk of cardiovascular disease (CVD). In the general population, CVD risk reduction can be achieved by lipid…
Abstract Number: 2893 • 2015 ACR/ARHP Annual Meeting
Quality of Life in Patients with Active Nonradiographic Axial Spondyloarthritis after 16 Weeks of Golimumab Treatment
Walter Maksymowych¹, Sean P. Curtis², Maxime Dougados³, Gina Bergman², Susan Huyck², Anjela Tzontcheva² and Joachim Sieper⁴, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Merck & Co., Inc., Kenilworth, NJ, ³Paris-Descartes University, Paris, France, ⁴University Clinic Benjamin Franklin, Berlin, Germany
Background/Purpose: Chronic inflammation, back pain, and progressive spinal stiffness associated with axial spondyloarthritis (axSpA) can decrease quality of life (QoL). The purpose of this study…
Abstract Number: 2894 • 2015 ACR/ARHP Annual Meeting
The Majority of Patients with Moderate to Severe Psoriatic Arthritis Had Existing Structural Damage, Predisposing Them to Further Progression, Which Was Markedly Inhibited By Adalimumab
Pranav Sheth¹, Philip J. Mease², Yihan Li³, Fabiana Ganz⁴ and Maja Hojnik⁵, ¹Group Health Associates, Trihealth, Cincinnati, OH, ²Seattle Rheumatology Associates, Seattle, WA, ³AbbVie Inc., North Chicago, IL, ⁴Neuhofstrasse 23, AbbVie AG, Baar, Switzerland, ⁵AbbVie, Ljubljana, Slovenia
Background/Purpose: Patients (pts) with psoriatic arthritis (PsA) may experience structural damage if not appropriately treated. The purpose was to determine 1) the frequency of radiographic…

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