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Abstract Number: 983

Objectively Assessed Sedentary Behaviour and Light Physical Activity Are Associated with Long-Term Cardiovascular Risk in People Living with Rheumatoid Arthritis Independently of Moderate-to-Vigorous Physical Activity

Sally Fenton1,2, Jet Veldhuijzen van Zanten2,3, George D. Kitas2,4, Joan Duda4, Peter Rouse5, Chen-an Yu1 and George Metsios2,6, 1School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom, 2Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, 3University of Birmingham, Birmingham, United Kingdom, 4School of Sport, Exercise and Rehabilitation, University of Birmingham, Birmingham, United Kingdom, 5Department for Health, University of Bath, Bath, United Kingdom, 6Department of Physical Activity Exercise and Health, University of Wolverhampton, Walsall, United Kingdom

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Cardiovascular disease, physical activity, rheumatoid arthritis (RA) and risk

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Session Information

Date: Sunday, November 13, 2016

Session Title: ARHP I: Exemplary Abstracts

Session Type: ARHP Concurrent Abstract Session

Session Time: 2:30PM-4:00PM

 

Background/Purpose: Rheumatoid Arthritis (RA) can result in functional disability and is associated with an increased risk of cardiovascular disease (CVD). In healthy adults and patient populations, light physical activity (LPA) engagement is reported to confer benefits to cardiovascular health and physical function, with time spent sedentary (i.e., activities ≤ 1.5 METS whilst sitting/lying) demonstrated to be adversely related to these health outcomes. Studies also indicate the manner in which sedentary time is accumulated (i.e., sedentary time, bouts, breaks) to hold implications for CVD profile and physical function. However, it is not known whether sedentary behaviour patterns and LPA are relevant to CVD risk and functional ability in RA. The aims of this study were therefore to investigate relationships between objectively assessed sedentary behaviour patterns and LPA with (1) 10-year risk of CVD, and (2) individual CVD risk factors and functional disability in RA. A secondary aim was to determine if associations were independent of moderate-to-vigorous physical activity (MVPA) engagement.

Methods: Patients with RA (N = 61) provided a fasted blood sample and underwent physical assessments to evaluate factors associated with their cardiovascular health. Ten-year CVD risk was computed via the Q-risk-score. Individual CVD risk factors were determined from fasted blood samples (Table 1), and functional disability assessed via the Stanford Health Assessment Questionnaire (HAQ). Sedentary behaviour patterns, LPA and MVPA were measured via 7-days of accelerometry. Sedentary time, LPA and MVPA (min/day) were defined as <100, 100 – 2019, and ≥2020 counts per minute, respectively. Sedentary breaks (number/day) were calculated as interruptions in sedentary time for ≥1 minute. Sedentary bout variables (number/day, average length) were derived by determining the number and length of consecutive zeros recorded above a ≥20 zero-count threshold.

Results: Regressions analyses were conducted to answer study aims. Models were adjusted as appropriate for age, gender and accelerometer-wear time (Model 1).  Where significant associations were observed, models were further adjusted for daily MVPA engagement (Model 2). Results revealed significant positive associations between sedentary time and the number of sedentary bouts per day ≥20 minutes with 10-year CVD risk, with the reverse true for LPA participation (model 1; sedentary time, β = .38, p <.01, sedentary bouts, β = .37, p <.01, LPA, β = −.45, p <.01). Associations were independent of MVPA engagement (model 2; β change = .01 to .03). Sedentary behaviour patterns and LPA were not related to individual CVD risk factors or functional disability.

Conclusion: Promoting LPA participation and restricting sedentary time to bouts <20 minutes may attenuate long-term CVD risk in RA, independent of MVPA engagement.

Table 1. Descriptive statistics

 

 

 Male

 (N = 20)

 

 

  Female

  (N = 41)

 

Total

(N = 61)

Age (years)                                           58.85 ± 9.44

          53.00 ± 13.28

  54.92 ± 12.39

Height (m)                         1.73 ± .10                 1.63 ± .06      1.66  ± .09
Weight (kg)

    78.13 ± 10.33

      76.81 ± 19.42

  77.23 ± 16.94

RA duration (years from diagnosis)

    5.05 ± 5.44

                                   

                      7.97 ± 10.34

                                           6.96  ± 9.01
 

 

 

 

Accelerometer data

 

 

 

Average valid wear time (hours/day)                                           12.99 ± .74      13.12 ± .77    13.08 ± .76
Sedentary time (min/day)           505.40 ± 71.45    493.52 ± 67.24

497.42 ± 68.28

LPA (min/day)           251.14 ± 71.79             278.23 ± 67.22

269.35 ± 69.35

MVPA (min/day)                                22.65 ± 22.53                                  15.70 ± 13.77

  17.98 ± 17.26

 

 

 

 

Sedentary behaviour patterns

 

 

 

Number of Sedentary breaks/day)

      79.59 ± 16.89

      86.52 ± 11.94

  84.32 ± 14.02

Number of Sedentary bouts ≥ 20 minutes/day                         6.37 ± 2.41

          5.45 ± 1.91

  5.75 ± 2.11

Average time per Sbouts ≥ 20 (min)             31.08 ± 2.07      30.64 ± 2.75

30.78 ± 2.54

 

 

 

 

10 year risk of CVD

 

 

 

Qrisk (% risk of 10 year CVD)

   24.14 ± 14.82

     12.54 ± 11.05

  16.33 ± 13.45

   

 

 

Individual CVD risk factors  

 

 

C-reactive protein (mg/l)       6.72 ± 8.12

      7.66 ± 9.58

  7.35 ± 9.09

Erythrocyte sedimentation rate (mg/l)     10.00 ± 8.12

      16.55 ± 16.50

  14.37 ± 14.52

Fibrinogen (mg/l)

   4.64 ± 0.90

      4.60 ± 1.20

  4.62 ± 1.10

Total cholesterol (mg/l)       4.77 ± .70

      5.01 ± 1.09

            4.93 ± .98
HDL-cholesterol (mg/l)       1.26 ± .32         1.54 ± .36             1.45 ± .37
LDL- cholesterol  (mg/l)       2.88 ± .80         2.99 ± .93          2.95 ± .88
Triglycerides (mg/l)       1.39 ± .83         1.05 ± .52

1.16 ± .65

Systolic-blood pressure (mm HG)   138.07 ± 19.45    132.32 ± 16.98

134.08 ± 17.77

Diastolic-blood pressure (mm HG)     83.13 ± 9.96              79.18 ± 8.58

80.39 ± 9.11

Plasma insulin (mg/l)     57.35 ± 26.68

          59.32 ± 55.82

  58.67 ± 47.99

Plasma glucose (mg/l)       4.65 ± .38

      4.80 ± 1.21

  4.75 ± 1.01

HOMA status       1.70 ± .82

      2.11 ± 3.34

  1.97 ± 2.77

 

 

 

 

Functional Disability

 

 

 

¶HAQ       1.74 ± .63        1.64 ± .56

1.67 ± .58

 


Disclosure: S. Fenton, None; J. Veldhuijzen van Zanten, None; G. D. Kitas, None; J. Duda, None; P. Rouse, None; C. A. Yu, None; G. Metsios, None.

To cite this abstract in AMA style:

Fenton S, Veldhuijzen van Zanten J, Kitas GD, Duda J, Rouse P, Yu CA, Metsios G. Objectively Assessed Sedentary Behaviour and Light Physical Activity Are Associated with Long-Term Cardiovascular Risk in People Living with Rheumatoid Arthritis Independently of Moderate-to-Vigorous Physical Activity [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/objectively-assessed-sedentary-behaviour-and-light-physical-activity-are-associated-with-long-term-cardiovascular-risk-in-people-living-with-rheumatoid-arthritis-independently-of-moderate-to-vigorous/. Accessed April 16, 2021.
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