Session Type: ARHP Concurrent Abstract Session
Session Time: 2:30PM-4:00PM
Background/Purpose: To describe the clinical presentation and associations of patients with IM associated with cancer in a large group of inflamatory myopathy (IM) from the multicentric REMICAM registry
Methods: A multicenter retrospective study from the REMICAM registry was performed. Patients older than 40 years at diagnosis were selected. All patients were diagnosed with IM according to Bohan and Peter criteria, followed between Jan 1980 and Dec 2014 and classified into 7 different clinical subgroups: primary dermatomyositis (DM), primary polymyositis (PM), cancer associated myositis (CAM), overlap myositis (OM), inclusion body myositis (IBM) and necrotizing myositis (NM). Only cancers diagnosed within 3 years of IM diagnosis were considered as CAM. Descriptive statistics, univariate and multivariate analysis were performed. Kaplan Meyer curves with long-rank analysis were used for survival.
Results: From 283 patients (72% w, 60±11 y at diagnosis, 9±7 y of follow-up, 39% DM, 61% PM), 64 (23%) presented any type of cancer: 11 lung, 8 hematological, 8 skin, 7 breast, 4 colon, 4 stomach, 4 ovary, 4 bladder, 3 endometrium, 3 prostate and 8 others. Median time between IM and cancer was 5 months. In multivariate analysis, patients with cancer were more frequently men (p<.0001), with DM (p=.005) and presented more ischemic lesions (p<.0001). No other clinical findings were different between patients with or without cancer. Mortality was higher in patients with cancer, with a median survival of 10±3 years, compared to 22±3 years for patients without cancer (p<.0001). From the CAM group, 41 (64%) patients died, mainly as a consequence of cancer.
Conclusion: In our registry, over 20% of patients older than 40 years presented IM associated with cancer. This type of IM is more common in men and present as dermatomyositis with ischemic lesions. As expected, mortality is highly increased in IM patients with cancer.
To cite this abstract in AMA style:de la Cámara Fernández I, Carreira P, Joven BE, López Longo FJ, Cobo-Ibáñez T, Lojo L, Larena C, Barbadillo C, Martínez-Barrio J, Lopez-Robledillo JC, Garcia De La Peña P, Tomero E, Llorente I, Moruno Cruz H, Pérez Gómez A, Nuño L, Almodóvar González R, MALDONADO V, Ruiz Gutiérrez L, GARCIA DE YEBENES Y PROUS MJ. Clinical Characteristics of Inflammatory Myopathies Associated with Cancer: A Report from the Remicam Registry [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/clinical-characteristics-of-inflammatory-myopathies-associated-with-cancer-a-report-from-the-remicam-registry/. Accessed October 28, 2020.
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