Abstracts Archive - Page 1656 of 2425 - ACR Meeting Abstracts

Abstract Number: 2759 • 2015 ACR/ARHP Annual Meeting
Long-Term Survival of Biological Therapy in Rheumatoid Arthritis Elderly Patients in Clinical Practice
Cristina Lajas¹, Alejandro Gomez-Gomez¹, Luis Rodriguez-Rodriguez², Leticia Leon², Cristina Vadillo¹, Dalifer Freites Núñez¹, Pilar Macarrón¹, José María Leal Pozuelo², Juan A Jover¹ and Lydia Abasolo², ¹Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ²Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain
Background/Purpose: With the increasingly widespread use of biological agents (BA), a thorough knowledge of their long-term behavior in clinical practice is fundamental. The purpose of…
Abstract Number: 2760 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Sarilumab Plus MTX in Subgroups of Patients with Rheumatoid Arthritis in a Phase 3 Study
Arthur Kavanaugh¹, Alan J. Kivitz², P Miranda³, Stefano Fiore⁴, Jonathan Fay⁵, Chunpeng Fan⁶, Janet van Adelsberg⁷ and T. W. J. Huizinga⁸, ¹University of California San Diego, La Jolla, CA, ²Altoona Center for Clinical Research, Duncansville, PA, ³Centro De Estudios Reumatológicos, Santiago, Chile, ⁴Sanofi, Bridgewater, NJ, ⁵Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁶Biostatistics, Sanofi, Bridgewater, NJ, ⁷Clinical Science, Regeneron Pharmaceutials, Inc., Tarrytown, NY, ⁸Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The investigational drug sarilumab is a human mAb directed against the IL-6 receptor.1 The phase 3 part of MOBILITY (NCT01061736) examined sarilumab + MTX…
Abstract Number: 2761 • 2015 ACR/ARHP Annual Meeting
IL-6R Blockade with Sarilumab Plus Methotrexate Results in Changes in Clinical and Laboratory Parameters Associated with Chronic Inflammation in Patients with Moderate-to-Severe RA in a Phase 3 Study
Maxime Dougados¹, Ernest H. Choy², Hideto Kameda³, Janet van Adelsberg⁴, Jonathan Fay⁵, Stefano Fiore⁶, Chunpeng Fan⁷ and Georg Schett⁸, ¹Paris-Descartes University, Paris, France, ²Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, ³Dep of Rheumatol/Clin Immun, Saitama Medical Ctr, Kawagoe, Japan, ⁴Clinical Science, Regeneron Pharmaceutials, Inc., Tarrytown, NY, ⁵Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁶Sanofi, Bridgewater, NJ, ⁷Biostatistics, Sanofi, Bridgewater, NJ, ⁸Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Chronic inflammation in RA is characterized by biochemical changes, including decreased hemoglobin, elevated CRP, changes in lipid metabolism, and hypoalbuminemia.1 Some parameters, including CRP,…
Abstract Number: 2762 • 2015 ACR/ARHP Annual Meeting
Sarilumab Dose Reduction to Manage Laboratory Abnormalities in an Open-Label Extension Study in RA Patients
Gerd Burmester¹, Anju Garg², Hubert van Hoogstraten², Neil Graham³, Alex Boddy², Janie Parrino⁴ and Mark C. Genovese⁵, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Sanofi, Bridgewater, NJ, ³Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁴Merck & Co., Inc., Whitehouse Station, NJ, ⁵Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: The investigational agent sarilumab is a human mAb directed against the IL-6 receptor. In the phase 3 MOBILITY study (NCT01061736), sarilumab (150 or 200…
Abstract Number: 2763 • 2015 ACR/ARHP Annual Meeting
Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, Shows Similar Pharmacokinetics and Pharmacodynamics Profiles in Japanese and Caucasian Healthy Volunteers
Namour Florence¹, Béatrice Vayssière¹, René Galien², Liesbeth Fagard³, Annegret Van der Aa³, Sandy Goss⁴, Pille Harrison³ and Chantal Tasset³, ¹Galapagos SASU, Romainville, France, ²102 Avenue Gaston Roussel, Galapagos SASU, Romainville, France, ³Galapagos NV, Mechelen, Belgium, ⁴Abbvie, Chicago, IL
Background/Purpose: Filgotinib is an oral, selective Janus kinase 1 (JAK1) inhibitor combining clinical efficacy and a rapid onset of action with a good safety profile…
Abstract Number: 2764 • 2015 ACR/ARHP Annual Meeting
Head-to-Head Comparison of the Retention Rate of First Biologics in Elderly Patients with Rheumatoid Arthritis in Japanese Clinical Practice: Results from the Multicenter Biologic Registry
Masatoshi Hayashi¹, Toshihisa Kanamono², Hiroyuki Matsubara³, Toshihisa Kojima⁴, Koji Funahashi⁵, Nobunori Takahashi⁴ and Naoki Ishiguro⁶, ¹Departments of Orthopedic surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, ²Reumatology, Nagano Red Cross Hospital, Nagano, Japan, ³Department of Orthopedic Surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, ⁴Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, ⁵Nagoya University, Nagoya, Japan, ⁶Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan
Background/Purpose: The objective of this report was to clarify and compare the retention rate of first biologics used to treat elderly Japanese patients with rheumatoid…
Abstract Number: 2765 • 2015 ACR/ARHP Annual Meeting
Long-Term Retention Rate of First Biologics in Patients of Age over 75 Years with Rheumatoid Arthritis in Japanese Clinical Practice: Results from the Multicenter Biologic Registry
Masatoshi Hayashi¹, Toshihisa Kanamono², Hiroyuki Matsubara³, Toshihisa Kojima⁴, Koji Funahashi⁵, Nobunori Takahashi⁴ and Naoki Ishiguro⁶, ¹Department of Orhtopedic Surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, ²Reumatology, Nagano Red Cross Hospital, Nagano, Japan, ³Department of Orthopedic Surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, ⁴Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, ⁵Nagoya University, Nagoya, Japan, ⁶Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan
Background/Purpose: The objective of this report was to clarify and compare the retention rate of first biologics used to treat elderly Japanese patients with rheumatoid…
Abstract Number: 2766 • 2015 ACR/ARHP Annual Meeting
Glucocorticoid-Sparing Effects of Abatacept in Real Life Practice: Data from a Paneuropean Analysis of RA Registries
Jacques Gottenberg¹, Xavier Mariette², Maria Victoria Hernandez³, Florenzo Iannone⁴, Elisabeth Lie⁵, Helena Canhão⁶, Karel Pavelka⁷, Carl Turesson⁸, Merete Lund Hetland⁹ and Axel Finckh¹⁰, ¹Hautepierre, Strasbourg, France, ²Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ³Biobadaser, Barcelona, Spain, ⁴Bari University, Rheumatology, Bari, Italy, ⁵Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Rheumatology, Lisbonne, Portugal, ⁷Charles University, Prague, Czech Republic, ⁸Lund University, Rheumatology, Dept. of Clinical Sciences,, Malmö, Sweden, ⁹DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ¹⁰Rheumatology Division, University Hospital of Geneva, Geneva, Switzerland
Background/Purpose: Despite disease modifying anti-rheumatic drugs (bDMARDs), glucocorticoids (GCs) are still widely prescribed in rheumatoid arthritis (RA). GCs are associated with numerous potential side effects,…
Abstract Number: 2767 • 2015 ACR/ARHP Annual Meeting
Comparative Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated By Serum Amyloid a
Katja Lakota¹, Dolores Hrušovar², Katjusa Mrak-Poljšak³, Polona Žigon¹, SaÂša Čučnik^1,2, Borut BoÂžiÄ�^2,3, Matija Tomšič¹ and Snezna Sodin Semrl^1,4, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ³University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁴Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia
Background/Purpose: In certain chronic diseases, such as rheumatoid arthritis (RA), atherosclerosis is more prevalent. RA patients have a higher incidence of cardiovascular disease and at…
Abstract Number: 2768 • 2015 ACR/ARHP Annual Meeting
Trend and Factors Associated with Switching Treatment after Initial Anti-TNF Therapy Among Patients with Rheumatoid Arthritis
Wenhui Wei¹, Emma Sullivan², Chieh-I Chen³, James Piercy² and Stuart Blackburn², ¹Sanofi-Aventis, Bridgewater, NJ, ²Adelphi Real World, Manchester, United Kingdom, ³Regeneron Pharmaceuticals, Inc., Tarrytown, NY
Background/Purpose: Among rheumatoid arthritis (RA) patients who progress beyond their first biologic disease-modifying antirheumatic drug (bDMARD), in-class cycling between different tumor necrosis factor inhibitors (TNFi)…
Abstract Number: 2769 • 2015 ACR/ARHP Annual Meeting
Factors Associated with TNF Switching: a Retrospective Real-World Study of Patients with Rheumatoid Arthritis
Wenhui Wei¹, Keith Knapp², Li Wang³, Chieh-I Chen⁴, Gary Craig², Karen Ferguson² and Sergio Schwartzman⁵, ¹Sanofi-Aventis, Bridgewater, NJ, ²Discus Analytics, Inc., Spokane, WA, ³Director, Analytic Research, STATinMED Research, Plano, TX, ⁴Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁵Hospital for Special Surgery, New York, NY
Background/Purpose: Switching of disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) patient treatment is common in real-world clinical practice. The context for why patients switch…
Abstract Number: 2770 • 2015 ACR/ARHP Annual Meeting
Efficacy of Sarilumab Plus Methotrexate in Achieving Clinical Remission, Using 4 Different Definitions, in Patients with Active, Moderate-to-Severe Rheumatoid Arthritis in a Phase 3 Study
Mark C. Genovese¹, Marina Stanislav², Hubert van Hoogstraten³, Renata Martincova⁴, Chunpeng Fan⁵ and Janet van Adelsberg⁶, ¹Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA, ²Research Institute of Rhumato, Moscow, Russia, ³Sanofi, Bridgewater, NJ, ⁴Sanofi Czech Republic, Prague, Czech Republic, ⁵Biostatistics, Sanofi, Bridgewater, NJ, ⁶Clinical Science, Regeneron Pharmaceutials, Inc., Tarrytown, NY
Background/Purpose: Remission is an important clinical outcome in RA1 and is associated with improved physical function and health-related quality of life.2 Several definitions of remission…
Abstract Number: 2771 • 2015 ACR/ARHP Annual Meeting
Impact of Tocilizumab Monotherapy in Patients with Moderate to High Disease Activity: Real-World Analyses from the US Corrona Registry
Leslie Harrold^1,2, Ani John³, George W. Reed^1,4, Chitra Karki¹, YouFu Li⁴, Joel Kremer⁵, Tmirah Haselkorn⁶ and Jeffrey D. Greenberg^1,7, ¹Corrona, LLC, Southborough, MA, ²Department of Orthopedics and Medicine, University of Massachusetts Medical School, Worcester, MA, ³Genentech, Inc., South San Francisco, CA, ⁴University of Massachusetts Medical School, Worcester, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Genentech, Inc, South San Francisco, CA, ⁷NYU School of Medicine, New York, NY
Background/Purpose: Little is known regarding the real-world use and effectiveness of the interleukin-6 receptor α inhibitor tocilizumab (TCZ) as monotherapy. The effectiveness of TCZ monotherapy…
Abstract Number: 2772 • 2015 ACR/ARHP Annual Meeting
Activated Memory B Cells in Rheumatoid Arthritis and Relationship to Anti-TNF Treatment
Jennifer Barnard¹, Nida Meednu², Kelly Callahan¹, Andreea Coca¹, Bethany A. Marston¹, Ralf G. Thiele¹, Darren Tabechian¹, Marcy Bolster³, Jeffrey R. Curtis⁴, Meggan C. Mackay⁵, Jonathan D. Graf⁶, Richard Keating⁷, Edwin Smith⁸, Karen Boyle⁹, Lynette Keyes-Elstein⁹, Beverly Welch¹⁰, Ellen Goldmuntz¹¹ and Jennifer H. Anolik¹, ¹University of Rochester Medical Center, Rochester, NY, ²Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³MUSC, Charleston, SC, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Autoimmune & Musculoskeletal Disorders, The Feinstein Institute for Medical Research, Manhasset, NY, ⁶Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁷University of Chicago, Chicago, IL, ⁸Dept of Med Div of Rheum, MUSC, Charleston, SC, ⁹Rho Federal Systems, Inc., Chapel Hill, NC, ¹⁰6610 Rockledge Dr., NIAID/NIH, Bethesda, MD, ¹¹DAIT, NIAID/NIH, Bethesda, MD
Background/Purpose: TNF blockade is a mainstay of treatment for rheumatoid arthritis (RA), but a significant proportion of patients fail to respond to treatment or lose…
Abstract Number: 2773 • 2015 ACR/ARHP Annual Meeting
Novel Mechanisms of Action for Methotrexate and Doxycycline: Prevention of Protein Adduct Formation and Free Radical Scavenging
Daniel Anderson¹, Michael J. Duryee², Matthew Zimmerman³, Jun Tian³, Cleofes Sarmiento³, Lynell W. Klassen⁴, James R. O'Dell¹, Geoffrey M. Thiele⁵ and Ted R. Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁴Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Oxidative stress and free radical formation play an important pathogenic role in rheumatoid arthritis (RA) and a number of other inflammatory diseases. Oxidative stress…

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