Abstract Number: 456 • 2016 ACR/ARHP Annual Meeting
Patient Engagement in Research: Understanding Patient Interest and Needs
Background/Purpose: The goal of clinical and health-related research is to benefit the end-consumer—the patient. Since patients are the experts on their unique experiences living with…Abstract Number: 457 • 2016 ACR/ARHP Annual Meeting
Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis
Background/Purpose: Checkpoints and mechanisms regulating the onset of rheumatoid arthritis (RA) remain largely elusive. Apart from B cells and auto-antibodies, Th17 cells were shown to…Abstract Number: 458 • 2016 ACR/ARHP Annual Meeting
The TAM Receptors Axl and Mer Play a Protective Role in a Temporal and Spatial Manner in Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in selective, anatomically distinct synovial joints. The innate immune system…Abstract Number: 459 • 2016 ACR/ARHP Annual Meeting
Resident Non-Classical Monocytes Are Critically Important for Tissue Destruction in Arthritis
Background/Purpose: Bone destruction in rheumatoid arthritis is mediated by osteoclasts, which are derived from precursor cells of the myeloid lineage. Although there is much known…Abstract Number: 460 • 2016 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Demonstrates Anti-Inflammatory Effect in Autoimmune Disease Models
Background/Purpose: Bruton’s Tyrosine Kinase (BTK), a non-receptor tyrosine kinase is involved in intracellular signaling pathways downstream of several receptors, including the B cell receptor (BCR),…Abstract Number: 461 • 2016 ACR/ARHP Annual Meeting
Involvement of CD163-Positive Macrophages in the Pathogenesis of Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Synovium of a Murine Model
Background/Purpose: Synovial-lining macrophages play a crucial role in the onset and maintenance of joint inflammation in arthritis. CD68 and CD163 are commonly used markers of…Abstract Number: 462 • 2016 ACR/ARHP Annual Meeting
Selective Inhibition of MMP9 Using a Monoclonal Antibody As a Therapeutic Strategy for Rheumatoid Arthritis
Background/Purpose: Matrix metalloproteinase-9 (MMP9), highly expressed by infiltrating inflammatory cells, pannus tissue, and multinucleated cells in the synovium and subchondral bone tissue, including osteoclasts, participates…Abstract Number: 463 • 2016 ACR/ARHP Annual Meeting
Deficiency of Transmembrane Protein VISTA (V-domain Immunoglobulin Suppressor of T-cell Activation) Ameliorates Murine Collagen-II Antibody-Induced Arthritis
Background/Purpose: The transmembrane protein VISTA, is a member of the B7/CD28 family of immune modulator proteins and can function as a negative immune checkpoint regulator…Abstract Number: 464 • 2016 ACR/ARHP Annual Meeting
an Anti-Fima Antibody Attenuates Porphyromonas Gingivalis-Associated Experimental Arthritis
Background/Purpose: Evidence suggests that periodontal infection by Porphyromonas gingivalis(Pg) exacerbates rheumatoid arthritis (RA); however, the underlying mechanisms remain unknown. Here, we examined the pathogenic and therapeutic…Abstract Number: 465 • 2016 ACR/ARHP Annual Meeting
Genetic and Metabolic Signatures of Purified Synovial Macrophage Subsets during an Acute Murine Model of Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Macrophages have been implicated in…Abstract Number: 466 • 2016 ACR/ARHP Annual Meeting
Sexually Dimorphic Dysbiosis of Gut Microbiota in Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis
Background/Purpose: Recent studies identify gut microbiota dysbiosis as a possible contributor to rheumatoid arthritis (RA) pathogenesis. RA patients have significantly different microbiomes than healthy controls.…Abstract Number: 467 • 2016 ACR/ARHP Annual Meeting
Interleukin-21-Signaling in B Cells, but Not in T Cells, Is Indispensable for Development of Collagen-Induced Arthritis in Mice
Background/Purpose: IL-21 is a T cell-derived cytokine whose receptor is expressed on variety of cells in immune system. IL-21was reported to be involved in the…Abstract Number: 468 • 2016 ACR/ARHP Annual Meeting
Angiotensin II Exacerbates Bone Destruction in TNF-Transgenic Arthritis Mice
Background/Purpose: Angiotensin II (Ang II) is known to function on various organs including kidneys, adrenal glands as well as the nervous and cardiovascular systems. In…Abstract Number: 469 • 2016 ACR/ARHP Annual Meeting
Role of Microbiota in Development of Autoimmune Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with an unknown cause. Observations of dysbiosis and mucosal inflammation in patients with RA has raised interest…Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting
Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis
Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
ACR Meeting Abstracts