Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Synovial-lining macrophages play a crucial role in the onset and maintenance of joint inflammation in arthritis. CD68 and CD163 are commonly used markers of synovial macrophages in the RA synovium. CD163 is a cell-surface glycoprotein of the group B cysteine-rich scavenger receptor family that binds to and internalizes hemoglobin-haptoglobin complexes, thereby releasing IL-10 and carbon oxide with strong anti-inflammatory effects. Serum-soluble CD163 levels are significantly elevated in long-standing RA patients. The restrictive expression of CD163 by monocytes-macrophages was confirmed in the affected joint tissues of RA patients; however, the pathogenic roles of CD163-positive macrophages in inflammatory arthritis remain unclear. We investigated the roles of CD163-positive macrophages in arthritis development in mice.
To cite this abstract in AMA style:Kaieda S, Ida H, Hoshino T. Involvement of CD163-Positive Macrophages in the Pathogenesis of Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Synovium of a Murine Model [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/involvement-of-cd163-positive-macrophages-in-the-pathogenesis-of-arthritis-via-modulation-of-inflammatory-cytokine-and-chemokine-expression-in-the-synovium-of-a-murine-model/. Accessed December 5, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/involvement-of-cd163-positive-macrophages-in-the-pathogenesis-of-arthritis-via-modulation-of-inflammatory-cytokine-and-chemokine-expression-in-the-synovium-of-a-murine-model/