ACR Meeting Abstracts

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  • Abstract Number: 3000 • 2016 ACR/ARHP Annual Meeting

    Safety of the Knee Needle Arthroscopy: A Review of 1136 Procedures in 919 Patients

    Alla ISHCHENKO1, Jean-cyr YOMBI2 and Adrien Nzeusseu Toukap3, 1Rheumatology, Cliniques universitaires Saint-Luc, Brussels, Belgium, 2Internal Medicine, IREC/Cliniques universitaires St-Luc/Faculté de médecine/Université Catholique de Louvain, Brussels, Belgium, 3Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

    Background/Purpose: Knee needle arthroscopy (KNA) is a minimally invasive procedure consisting in insertion of a thin fiber-optic needle system in the joint cavity, followed by…
  • Abstract Number: 3001 • 2016 ACR/ARHP Annual Meeting

    Lumbar CT-Guided Steroid Infiltration on the Refractory Low Back Pain. Study of 258 Procedures in the Same Center

    Eva Galindez Agirregoikoa1, Olaia Fernandez Berrizbeitia1, M. Luz García Vivar2, Esther Ruíz Lucea2, Jose Francisco Garcia Llorente2, Ignacio Torre Salaberri3, Catalina Gómez Arango2, Juan Maria Blanco Madrigal2, Edurne Guerrero Basterretxea1, Itziar Calvo Zorrilla1, Natalia Garcia Rivera1 and Maria Jesus Allande Lopez Linares1, 1Rheumatology Department, Basurto University Hospital, Bilbao, Spain, 2Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, 3Rheumaytology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain

    Background/Purpose: Low back pain of mechanical origin is a major cause of disability and surgical intervention. The lumbar computed tomography (CT)-guided steroid infiltration can accelerate…
  • Abstract Number: 3002 • 2016 ACR/ARHP Annual Meeting

    Does Morbid Obesity Negatively Affect Patient Reported Outcomes Following Total Knee Arthroplasty?

    Jamie E. Collins1, Heidi Y. Yang2, Ilana M. Usiskin3, Jeffrey N. Katz4 and Elena Losina5, 1Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, 2Orthopaedic and Arthritis Center for Outcomes Research, Brigham & Women's Hospital, Boston, MA, 3Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 4Orthopaedics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Orthopaedics, Brigham & Women's Hospital, Boston, MA

    Background/Purpose: Utilization of total knee arthroplasty (TKA) continues to grow. Recent literature has questioned the appropriateness of TKA for patients that are morbidly obese, citing…
  • Abstract Number: 3003 • 2016 ACR/ARHP Annual Meeting

    Impact of Preoperative Opioid Use on Total Knee Arthroplasty Outcomes

    Savannah R. Smith1, Heidi Y. Yang2, Jamie E. Collins3, Jeffrey N. Katz4 and Elena Losina5, 1Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 2Orthopaedic and Arthritis Center for Outcomes Research, Brigham & Women's Hospital, Boston, MA, 3Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, 4Orthopaedics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Orthopaedics, Brigham & Women's Hospital, Boston, MA

    Background/Purpose: Total knee arthroplasty (TKA) is an effective treatment for patients with end-stage knee osteoarthritis (OA); however, a growing body of evidence suggests that patients…
  • Abstract Number: 3004 • 2016 ACR/ARHP Annual Meeting

    The Choosing Wisely Initiative: Is It Complete?

    Navya Kuchipudi and Cathie-Ann Mancuso, Internal Medicine, Saint Peters University Hospital, New Brunswick, NJ

    Background/Purpose: Low back pain is a highly prevalent problem affecting approximately 70-85% of Americans in their lifetime (1). American College of Physicians (ACP) has recommended…
  • Abstract Number: 3005 • 2016 ACR/ARHP Annual Meeting

    Development and Initial Validation of the “MH Score”, a New Diagnostic Tool That Differentiates Primary Hemophagocytic  Lymphohistiocytosis from Macrophage Activation Syndrome

    Francesca Minoia1, AnnaCarin Horne2, Francesca Bovis1, Sergio Davì1, Laura Pagani1, Graciela Espada3, Gao Yi-Jin4, Antonella Insalaco5, Kai Lehmberg6, Helga Sanner7, Susan Shenoi8, Sheila Weitzman9, Nicolino Ruperto10, Alberto Martini1, Randy Q. Cron11 and Angelo Ravelli1, 1Istituto Giannina Gaslini, Genoa, Italy, 2Karolinska University Hospital Solna, Stockholm, Sweden, 3Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina, 4Children's Hospital of Fudan, Shanghai, China, 5Ospedale Pediatrico Bambino Gesù, Rome, Italy, 6University Medical Center, Hamburg, Germany, 7Norwegian National Advisory Unit on Rheumatic Diseases in Children and Adolescents, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 8Seattle Children's Hospital, Seattle, WA, 9The Hospital for Sick Children, Toronto, ON, Canada, 10Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, 11University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: It is common view that macrophage activation syndrome (MAS) bears close similarities with primary hemophagocytic lymphohistiocytosis (pHLH). The resemblance of their clinical and laboratory…
  • Abstract Number: 3006 • 2016 ACR/ARHP Annual Meeting

    IFN-Gamma (IFNγ), IFNγ-Induced Chemokines and Other Biomarkers in Macrophage Activation Syndrome (MAS)

    Claudia Bracaglia1, Denise Pires Marafon2, Ivan Caiello2, Kathy de Graaf3, Florence Guilhot3, Walter Ferlin3, Sergio Davì4, Grant Schulert5, Angelo Ravelli4, Alexei Grom6, Robert Nelson3, Cristina de Min3 and Fabrizio De Benedetti1, 1Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Italy, 2Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy, 3NovImmune S.A., Geneva, Switzerland, 4Istituto Giannina Gaslini, Genoa, Italy, 5Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose:  Evidence in animals and humans points to a pivotal role of IFNγ in primary HLH. We have recently generated data in an animal model…
  • Abstract Number: 3007 • 2016 ACR/ARHP Annual Meeting

    Long-Term Efficacy and Safety of Canakinumab in Patients with Active Systemic Juvenile Idiopathic Arthritis (SJIA): Results from a PHASE III Extension Study

    Hermine I. Brunner1, Nicolino Ruperto2, Pierre Quartier3, Tamás Constantin4, Ekaterina Alexeeva5, Isabelle Koné-Paut6, Katherine Marzan7, Nico Wulffraat5, Rayfel Schneider7, Shai Padeh5, Vyacheslav Chasnyk8, Carine Wouters5, Jasmin B. Kuemmerle-Deschner5, Tilmann Kallinich5, Bernard Lauwerys9, Elie Haddad7, Evgeny L Nasonov5, Maria Trachana5, Olga Vougiouka5, Karolynn Leon10, Eleni Vritzali11, Karine Lheritier12, Alberto Martini5 and Daniel J Lovell13, 1Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, 3Hôpital Necker-Enfants Malades, Paris, France, 4Paediatric Rheumatology International Trials Organization (PRINTO), Genova, Italy, 5PRINTO-Istituto Gaslini, Genova, Italy, 6Pediatric Rheumatology, Department of Paediatric Rheumatology, AP-HP Bicêtre Hospital, Le Kremlin Bicêtre, France, 7PRCSG, Cincinnati, OH, 8PRINTO-Istituto Gaslini, Genoa, Italy, 9Cliniques Universitaires Saint-Luc and Université Catholique de Louvain, Brussels, Belgium, 10Novartis Pharmaceuticals Corporation, East Hanover, NJ, 11Immunology and Dermatology Franchise, Novartis Pharma AG, Basel, Switzerland, 12Novartis Pharma AG, Basel, Switzerland, 13Rheumatology, PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH

    Background/Purpose:   The management of SJIA with biological therapies is aimed to achieve and maintain clinical remission (CR), and accordingly taper corticosteroids (CS). Canakinumab (CAN)…
  • Abstract Number: 3008 • 2016 ACR/ARHP Annual Meeting

    Clinical Factors Associated with Non-Response to Methotrexate in Children with Juvenile Idiopathic Arthritis: Results from the Childhood Arthritis Response to Treatment Consortium

    Sunil Sampath1,2, Jamie C Sergeant1,3, Sebastien Viatte2, Roberto Carrasco1, Joanna Cobb2, Samantha Smith4, Anne Hinks2, Lucy R Wedderburn5,6, Michael W. Beresford7,8, Kimme L. Hyrich1, Wendy Thomson2 and Childhood Arthritis Response to Medication Study,Childhood Arthritis Prospective Study, British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study, Biologics for Children with Rheumatic Diseases Study, 1Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, 3NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, 4Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Mancherster, United Kingdom, 5Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 6Infection, Inflammation and Rheumatology Section, UCL Institute of Child Health, London, United Kingdom, 7Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, United Kingdom, 8Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Although the recommended first line treatment for JIA, up to 50% of children will not respond to MTX. Currently, it is not possibly to…
  • Abstract Number: 3009 • 2016 ACR/ARHP Annual Meeting

    Safety and Effectiveness of Adalimumab±Methotrexate for the Treatment of Polyarticular Juvenile Idiopathic Arthritis

    Daniel J Lovell1, Nicola Ruperto2, Carol Wallace1, Mary Toth1, Ivan Foeldvari2, John Bohnsack1, Diana Milojevic1, C. Egla Rabinovich1, Daniel Kingsbury1, Katherine Marzan1, Pierre Quartier3, Kirsten Minden2, Elizabeth Chalom1, Gerd Horneff2, Rolf M. Kuester2, Jason Dare1, Miriam Heinrich4, Hartmut Kupper4, Jasmina Kalabic4, Hermine I. Brunner1, Alberto Martini2 and on behalf of PRINTO and PRCSG, 1PRCSG, Cincinnati, OH, 2PRINTO-IRCCS, Genova, Italy, 3Hopital Necker-Enfants Malades, Paris, France, 4AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany

    Background/Purpose:  Juvenile Idiopathic Arthritis (JIA) is the most common chronic inflammatory rheumatic diseases of childhood. Due to their long-term safety and efficacy, biologic disease modifying…
  • Abstract Number: 3010 • 2016 ACR/ARHP Annual Meeting

    Improvement of Spinal Inflammation Induced By Etanercept in Enthesitis Related Arthritis JIA-Patients. Data of the Reminder-Study

    Gerd Horneff1, Ivan Foeldvari2, Kirsten Minden3,4, Hans-Iko Huppertz5 and Ariane Klein6, 1Department of Pediatrics, Centre of Pediatric Rheumatology, Sankt Augustin, Germany, 2Kinder- und Jugenrheumatologie, Hamburger Zentrum Kinder-und Jugendrheumatologie, Hamburg, Germany, 3Epidemiology, Charite, DRFZ, Berlin, Germany, 4Children’s University Hospital Charite/German Rheumatism Research Centre Berlin, Berlin, Germany, 5Klinikum Bremen-Mitte, Prof.-Hess-Kinderklinik, Bremen, Germany, 6Center of Pediatrics and Neonatology, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany

    Background/Purpose: The data of the REMINDER study, a two-part, 48-week, randomized, placebo-controlled, double-blind withdrawal study on efficacy of etanercept (ETA) compared to placebo (PLC) in…
  • Abstract Number: 3011 • 2016 ACR/ARHP Annual Meeting

    Long-Term Outcomes after Disease Activity Guided Tapering of Tumor Necrosis Factor Inhibition in Rheumatoid Arthritis: 3 Year Data of a Randomised Controlled Pragmatic Non Inferiority Strategy Study

    Alfons A. den Broeder1, Chantal A.M. Bouman1, Frank H.J. van den Hoogen1,2, Jaap Fransen2, Ronald F. van Vollenhoven3, Johannes W.J. Bijlsma4, Aatke van der Maas1 and Noortje van Herwaarden1, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Long-term Outcomes After Disease Activity Guided Tapering of TNF Inhibitors in Rheumatoid Arthritis: 3 Year Data of a Randomized Controlled Pragmatic Non Inferiority Strategy Study…
  • Abstract Number: 3012 • 2016 ACR/ARHP Annual Meeting

    Clinical Predictors of TNF-Inhibitor Free Disease Control in Patients with Rheumatoid Arthritis after Stopping TNFi Treatment: Results from a Dutch Multicentre Pragmatic Open-Label Randomized Controlled Trial.

    Marjan Ghiti Moghadam1, Harald E. Vonkeman2, Peter M. ten Klooster3,4, Femke Lamers-Karnebeek5, Janneke Tekstra6, Barbara van Schaeybroeck7, Ruth Klaasen8, Marieke van Onna9, Hein J. Bernelot Moens10, H. Visser11, Annemarie Schilder12, Mark R. Kok13, Robert Landewé14, Piet L.C.M. van Riel15, Mart A.F.J. van de Laar16 and Tim Jansen17, 1rheumatology, Arthritis Centre Twente, University of Twente and Medisch Spectrum Twente, Enschede, The Netherlands, Enschede, Netherlands, 2Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, 3Psychology, Health & Technology, University of Twente, Enschede, Netherlands, 4Arthritis Centre Twente, University of Twente and Medisch Spectrum Twente, Enschede, The Netherlands, Enschede, Netherlands, 5rheumatology, RadboudUMC, Nijmegen, Netherlands, 6Dept. Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 7Rheumatology, Albert Schweitzer MC, Dordrecht, Netherlands, 8Rheumatology, Meander MC, Amersfoort, Netherlands, 9Huispostnummer F4-105, PO Box, AMC medical centre, Amsterdam, Netherlands, 10rheumatology, Ziekenhuisgroep Twente, Almelo, Netherlands, 11Department of Rheumatolgy, Rijnstate Hospital Arnhem, Arnhem, Netherlands, 12Rheumatology, Medisch Centrum Leeuwarden, Leeuwarden, Netherlands, 13Rheumatology, Maaststadziekenhuis, Rotterdam, Netherlands, 14University of Amsterdam, Amsterdam, Netherlands, 15IQ Health Care, radboudUMC, Nijmegen, Netherlands, 16Rheymatology, Arthritis Centre Twente, University of Twente and Medisch Spectrum Twente, Enschede, Netherlands, 17VieCuri Medical Center, Venlo, Netherlands

    Background/Purpose:   Tumor Necrosis Factor inhibitor (TNFi) free prolonged acceptable disease control in patients with rheumatoid arthritis (RA), in stable remission or low disease activity…
  • Abstract Number: 3013 • 2016 ACR/ARHP Annual Meeting

    Dose Reduction or Discontinuation of Biological Therapy in Patients with Rheumatoid Arthritis in Remission –  1-Year Results of a Guideline-Directed Longitudinal Cohort Study

    Cecilie Heegaard Brahe1, Simon Krabbe2, Mikkel Østergaard3, Henrik Rogind4, Hanne Slott Jensen3, Annette Hansen5, Jesper Nørregaard6, Søren Jacobsen7, Lene Terslev8, Tuan K. Huynh9, Dorte Vendelbo Jensen5, Natalia Manilo10, Karsten Heller Asmussen11, Per Brown-Frandsen7, Mikael Boesen12, Zoreh Rastiemadabadi13, Daniel Glinatsi14, Lone Morsel-Carlsen15, Jakob M. Møller16, Niels Steen Krogh17 and Merete Lund Hetland3,18, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Glostrup, Denmark, 2Center for Rheumatology and Spine diseases, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Glostrup, Denmark, 3Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 4Center for Rheumatology and Spine Diseases, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 5DANBIO, On behalf of Depts of Rheumatology, North, South, Central, Zealand and Capital Region, Copenhagen, Denmark, 6Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 7Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 8Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, 9Department of Rheumatology, Copenhagen University Hospital at Nordsjælland, Denmark, Hillerød, Denmark, 10The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 11Department of Rheumatology, Copenhagen University Hospital at Frederiksberg-Bispebjerg, Denmark, Frederiksberg, Denmark, 12Frederiksberg Hospital, Parker Institute, Frederiksberg, Denmark, 13Department of Radiology, Frederiksberg Hospital, Frederiksberg, Denmark, 14Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Glostrup, Denmark, 15Department of Radiology, Rigshospitalet, Copenhagen, Denmark, 16Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark, 17Zitelab, Frederiksberg, Denmark, 18Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark

    Background/Purpose: Dose tapering in patients in remission has previously proven promising in randomized controlled trials. However, systematic implementation in clinical practice is lacking. A new…
  • Abstract Number: 3014 • 2016 ACR/ARHP Annual Meeting

    Tapering of Adalimumab Based on Therapeutic Drug Monitoring in Rheumatoid Arthritis

    Merel J. l'Ami1, Anneke F. Marsman1, Charlotte LM Krieckaert1, Mike T. Nurmohamed2,3, Jill Ruwaard1, Ingrid M. Visman1, Eva L. Kneepkens1 and Gertjan Wolbink1,4, 1Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, 2Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, 3Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, Amsterdam, Netherlands, 4Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Center, Amsterdam, Netherlands

    Background/Purpose: Treatment with biologicals is based on the principle of ‘one size fits all’ without taking differences into account for dosing schemes, patients’ characteristics and…
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