Abstracts Archive - Page 1611 of 2425 - ACR Meeting Abstracts

Abstract Number: 2910 • 2016 ACR/ARHP Annual Meeting
Work Productivity in Systemic Sclerosis and Association with Health Related Quality of Life
Kathleen Morrisroe¹, Molla Huq², Wendy Stevens³, Joanne Sahhar⁴, Susanna Proudman^5,6, Mandana Nikpour⁷ and Australian Scleroderma Interest Group, ¹Rheumatology, St Vincent's Hospital, Melbourne, Melbourne, Australia, ²Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ³Department of Rheumatology, St. Vincent’s Hospital Melbourne, Melbourne, Australia, ⁴Department of Rheumatology, Monash Medical Centre, Melbourne, Australia, ⁵Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁶Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁷Melbourne University, Melbourne, Australia
Background/Purpose: We sought to assess work productivity, factors associated with reduced productivity, and the relationship between work productivity and health-related quality of life (HRQoL) in…
Abstract Number: 2911 • 2016 ACR/ARHP Annual Meeting
A Comparison of Gastrointestinal Disease Severity in African American and Caucasian Scleroderma Patients
Carolyn Fridley¹ and Virginia D. Steen², ¹Rheumatology, Georgetown University, Washington, DC, ²Rheumatology, Georgetown University Medical Center, Washington, DC
A Comparison of Gastrointestinal Disease Severity in African American and Caucasian Scleroderma Patients Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease. After skin involvement…
Abstract Number: 2912 • 2016 ACR/ARHP Annual Meeting
Performance of the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 in Systemic Sclerosis -Associated Interstitial Lung Disease (SSc-ILD)
Caitlyn Fisher^1,2, Rajaie Namas³, Amber Young², Holly Wilhalme⁴ and Dinesh Khanna⁵, ¹Cognitive Science / Creative Writing, Beloit College, Beloit, WI, ²Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, ⁴University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: PROMIS-29 is a generic health-related quality of life (HRQoL) instrument that was developed as part of the NIH Patient Reported Outcomes (PROs) Roadmap. Our…
Abstract Number: 2913 • 2016 ACR/ARHP Annual Meeting
Four Year Effects of Combined Bosentan and Iloprost Treatment on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion and Clinical Status, in Systemic Sclerosis Patients
Amelia Chiara Trombetta¹, Carmen Pizzorni², Barbara Ruaro³, Sabrina Paolino³, Alberto Sulli², Vanessa Smith⁴ and Maurizio Cutolo³, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genova, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genoa, Italy, ⁴Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: In systemic sclerosis (SSc), microvascular damage progresses from capillary dilation to capillary loss and reactive angiogenesis, as detectable by nailfold videocapillaroscopy (NVC) [1]. The…
Abstract Number: 2914 • 2016 ACR/ARHP Annual Meeting
Association of Radiographic Findings in Hand X-Ray with Autoantibodies in Patients with Systemic Sclerosis
Komei Sakata¹, Yuko Kaneko¹, Hidekata Yasuoka², Kunihiro Yamaoka² and Tsutomu Takeuchi³, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ³Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Musculoskeletal involvement is a major complication for patients with systemic sclerosis (SSc). Various radiographic abnormalities are observed, especially in hands, however, the detailed prevalence…
Abstract Number: 2915 • 2016 ACR/ARHP Annual Meeting
An Increased Circulating Level of Periostin in Patients with Systemic Sclerosis: Associations with Functional Impairment in Various Affected Organs
Yukie Yamaguchi¹, Yuichiro Shirai², Junya Ono^3,4, Yasushi Kawaguchi⁵, Kenji Izuhara³, Masataka Kuwana² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, ⁴Shino-Test Corporation, Sagamihara, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Periostin is one of the matricellular proteins, a class of ECM-related molecules defined by their ability to modulate cell–matrix interactions. Several lines of evidences…
Abstract Number: 2916 • 2016 ACR/ARHP Annual Meeting
The Number of Micro-Haemorrhages and Micro-Thrombosis Detected By Nailfold Videocapillaroscopy Is a Good Predictor of Disease Activity in Systemic Sclerosis: The Validation Study of NEMO Score
Nicoletta Del Papa¹, Romina Andracco¹, Rosaria Irace², Serena Vettori³, Francesca Pignataro¹, Wanda Maglione¹, Eleonora Zaccara⁴, Domenico Sambataro⁵, Gabriele Valentini⁶ and Claudio Vitali⁷, ¹Dept. Rheumatology, G. Pini Hospital, Milano, Italy, ²Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ³Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁴Gaetano Pini, Savona, Italy, ⁵Rheumatology Unit, Istituto G.Pini, Milan, Italy, ⁶Rheumatology Unit, Dept Internal Experimental Medicine, II University Naples, Napoli, Italy, ⁷Rheumatology Section, Istituto San Giuseppe, Como, Italy
Background/Purpose: In a previous study it was demonstrated that, in patients with systemic sclerosis (SSc) the cumulative number of micro-haemorrhages (MH) and micro-thrombosis (MT) (the…
Abstract Number: 2917 • 2016 ACR/ARHP Annual Meeting
Nailfold Capillaroscopy and Mortality in Systemic Sclerosis
Thais Rohde Pavan, Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Porto Alegre, Brazil
Background/Purpose: To test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). Methods: One hundred and seventy SSc…
Abstract Number: 2918 • 2016 ACR/ARHP Annual Meeting
The Clinical Relevance of Common ANA Patterns in Systemic Sclerosis
Ashraf Raslan¹, Clifford Stermer² and Vivien Hsu³, ¹Medicine, Rutgers-RWJ Medical School, Jersey City, NJ, ²Medicine, Rutgers-RWJMS, New York, NY, ³Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Background/Purpose: Antinuclear antibody (ANA) test is positive in nearly 95% of patients with systemic sclerosis (SSc) [1]. We aim to identify the clinical relevance of…
Abstract Number: 2919 • 2016 ACR/ARHP Annual Meeting
Prevalence of Antiphospholipid Antibodies and Their Clinical Associations in Systemic Sclerosis: Data from a French Cohort
Angélique Lemaire^1,2, Vincent Sobanski^2,3,4,5, Jonathan Giovannelli⁶, Eric Hachulla^1,2,4,5, Sylvain Dubucquoi^4,7, Marc Lambert^1,2,4,5, Pierre-Yves Hatron^1,2,6 and David Launay^1,2,4,5, ¹CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, ²CHU Lille, Centre national de référence maladies systémiques et auto-immunes rares (sclérodermie systémique), F-59000 Lille, France, Lille, France, ³CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, ⁴Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France, Lille, France, ⁵Inserm, U995, F-59000 Lille, France, Lille, France, ⁶Univ Lille, CHU Lille, F-59000 Lille, France, Lille, France, ⁷CHU Lille, Laboratoire d’Immunologie, F-59000 Lille, France, Lille, France
Background/Purpose: Antiphospholipid antibodies (aPL) have been found in patients with various autoimmune and rheumatic diseases, including systemic sclerosis (SSc). However, in the absence of clinical…
Abstract Number: 2920 • 2016 ACR/ARHP Annual Meeting
The Effect of Rituximab on B Cells in Skin and Peripheral Blood in Systemic Sclerosis
Maaike Boonstra¹, Annemarie L. Dorjée¹, Koen D. Quint², Tom W.J. Huizinga¹, Hans U. Scherer³ and Jeska K. de Vries-Bouwstra¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Dermatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Open-label studies provided evidence for possible efficacy of rituximab (RTX) in systemic sclerosis (SSc). Previously, we reported on a randomized placebo-controlled clinical trial in…
Abstract Number: 2921 • 2016 ACR/ARHP Annual Meeting
Patient Participation in Patient Reported Outcome Instrument Development in Systemic Sclerosis
John Pauling^1,2, Tracy M. Frech^3,4, Robyn T. Domsic⁵ and Marie Hudson^6,7, ¹Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ²Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, ⁴Internal Medicine-Division of Rheumatology, University of Utah School of Medicine, SLC, UT, ⁵Medicine - Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ⁶Medicine, McGill University, Montreal, QC, Canada, ⁷Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada
Background/Purpose: The patient perspective captured using Patient-Reported Outcome (PRO) instruments provide valuable insight into the patient condition not always captured by physician-derived assessment tools. Target…
Abstract Number: 2922 • 2016 ACR/ARHP Annual Meeting
Disability, Fatigue, and Their Associates in Early Diffuse Cutaneous Systemic Sclerosis
Ariane L. Herrick¹, Sébastien Peytrignet², Xiaoyan Pan³, Roger Hesselstrand⁴, Luc Mouthon⁵, László Czirják⁶, Madelon C. Vonk⁷, Oliver Distler⁸, Joerg H.W Distler⁹, Edith Brown³, Kim Fligelstone³, Rachel Ochiel¹⁰, William Gregory¹¹, Alan Silman¹², Mark Lunt¹³ and Christopher Denton¹⁴, ¹Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ²Manchester Academic Health Sciences Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³Manchester Academic Health Science Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ⁴Department of Rheumatology, Lund University, Lund, Sweden, ⁵Internal Medicine, Hopital Cochin, Paris, France, ⁶Department of Rheumatology and Immunology, University of Pécs, Faculty of Medicine, Pécs, Hungary, ⁷Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁸Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁹Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Royal Free London NHS Foundation Trust, London, United Kingdom, ¹¹Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ¹²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ¹³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ¹⁴Centre for Rheumatology, Royal Free Hospital, London, Great Britain
Background/Purpose: ESOS (European Scleroderma Observational Study) was a prospective observational study of 326 patients with early diffuse cutaneous systemic sclerosis (dcSSc) from 50 centres. Here…
Abstract Number: 2923 • 2016 ACR/ARHP Annual Meeting
T-Cell Receptor Signaling Inhibition By CC-90005, a Selective Protein Kinase C Theta Antagonist, Reduces Antigen Mediated T-Cell Activation and Arthritis Pathology in the Mouse CIA Model
Garth Ringheim¹, Jolanta Kosek¹, Lori Capone², Eun Mi Hur¹ and Peter H. Schafer³, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: PKC-θ is a member of the Ca2+-independent novel PKC subfamily, most abundantly expressed in T-cells, and mediates early antigen recognition signal transduction and cell…
Abstract Number: 2924 • 2016 ACR/ARHP Annual Meeting
Terminally Differentiated CD8 T Cell Subset Has Distinct Signiture in RA
Masaru Takeshita¹, Katsuya Suzuki², Yoshiaki Kassai³, Maiko Takiguchi³, Yusuke Nakayama⁴, Keiko Koga³, Rimpei Morita⁵, Takahiro Miyazaki³, Akihiko Yoshimura⁵ and Tsutomu Takeuchi², ¹Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁴Takeda Pharmaceutical Company Limited, Fujisawa-shi, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Previous reports showed that both CD4 and CD8 T cells were related to the RA disease activity, such as Th17, follicular helper 2, and…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].