Abstract Number: 2700 • 2016 ACR/ARHP Annual Meeting
The Lymphatic System: A Gatekeeper for Migration of Pathogenic T-Cells Towards Synovial Joints and Entheses in Psoriasis
Background/Purpose: Psoriasis (PsO) is a common inflammatory skin disease that is characterized by acanthosis, impaired immune cell migration, and remodeling of the vascular and lymphatic…Abstract Number: 2701 • 2016 ACR/ARHP Annual Meeting
Increased Frequency of Regulatory CD19+CD24high Cd38high B Cells in Patients with Ankylosing Spondylitis (AS)
Background/Purpose: CD19+CD24highCD38high B cells have been described to have a regulatory capacity and their frequency is altered in the peripheral blood of patients with various…Abstract Number: 2702 • 2016 ACR/ARHP Annual Meeting
Taking Fly for Understanding the Molecular Role of HLA-B27/hB2m in Spondyloarthritis
Background/Purpose: After more than 40 years of researches, the mechanisms underlying the association of HLA-B27 with spondyloarthritis (SpA) remain poorly understood. The Drosophila has been…Abstract Number: 2703 • 2016 ACR/ARHP Annual Meeting
Apremilast May Improve Atherosclerosis By Promoting Cholesterol Efflux and Inhibiting Foam Cell Formation in Atherosclerotic Plaques
Background/Purpose: Atherosclerosis is characterized by the accumulation of lipid-laden macrophages in the arterial walls. Patients with inflammatory arthritis and psoriasis are at greater risk of…Abstract Number: 2704 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Psoriasis
Background/Purpose: Psoriasis is an auto-immune disease of the skin, characterized by inflammation and fibrosis producing patches of red, itchy and scaly skin. Wnt signaling plays…Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…Abstract Number: 2706 • 2016 ACR/ARHP Annual Meeting
Elevated Levels of Serum Myeloid Related Protein 8/14 in Ankylosing Spondylitis: Associated with Peripheral Arthritis and Active Disease
Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) show Toll-like receptor 4 (TLR4) over-expression. Myeloid-related proteins (MRP) 8/14 protein complexes are calcium-binding proteins, which act…Abstract Number: 2707 • 2016 ACR/ARHP Annual Meeting
Autoantibodies Against CD74 – a New Diagnostic Marker for Spondyloarthritis (SpA)
Background/Purpose: Spondyloarthritis (SpA) is a common debilitating inflammatory disorder. Pathogenesis of axial SpA (axSpA) including ankylosing spondylitis (AS) is still largely unclear. Diagnosis is difficult,…Abstract Number: 2708 • 2016 ACR/ARHP Annual Meeting
Type 17 Immunity in Spondyloarthritis Is Expanded Across Multiple Lymphocyte Subsets
Background/Purpose: The spondyloarthritides (SpA) are a group of chronic inflammatory disorders involving the axial spine and the peripheral joints. Genetic, functional and clinical trial evidences…Abstract Number: 2709 • 2016 ACR/ARHP Annual Meeting
Which Cells Correspond to the Typical Signals for Fatty and Inflammatory Lesions Seen in Magnetic Resonance Imaging in Ankylosing Spondylitis ? -a Prospective Study Using Biopsy Material Obtained during Spinal Surgery-
Background/Purpose: The occurrence of bone marrow edema (BME) and fat metaplasia detected by magnetic resonance imaging (MRI) were shown to be significantly associated with syndesmophyte…Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting
Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis
Background/Purpose: The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…Abstract Number: 2711 • 2016 ACR/ARHP Annual Meeting
Tissue-Resident IL-23 Responsive Innate T Cells in Mice Comprise Tcrαβ+ and TCRγδ+ Subsets with Overlapping Function
Background/Purpose: Multiple lines of evidence suggest a critical role for the IL-23/IL-17A axis in spondyloarthritis. In susceptible inbred strains, hydrodynamic injection of IL-23 minicircles into…Abstract Number: 2712 • 2016 ACR/ARHP Annual Meeting
Inverse Correlation Between IL-10-Producing Bregs and IFN-Gamma-Producing NK Cells in Psoriatic Arthritis and Psoriasis
Background/Purpose: A recent study from our group has shown functional impairment and numerical decrease of transitional and memory IL-10-producing regulatory B cells (Bregs) in patients…Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting
Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis
Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…Abstract Number: 2714 • 2016 ACR/ARHP Annual Meeting
Association of Polymorphisms of Activation-Induced Cytidine Deaminase with Ankylosing Spondylitis
Background/Purpose: There was a biased repertoire of the immunoglobulin (Ig) heavy chain variable (VH) segment gene in B cells in patients with ankylosing spondylitis (AS).…
ACR Meeting Abstracts