ACR Meeting Abstracts

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  • Abstract Number: 2670 • 2016 ACR/ARHP Annual Meeting

    Work Disability in Newly Diagnosed Patients with Primary SjöGren’s Syndrome – a Population-Based Cohort Study

    Thomas Mandl1, Tanja Schjødt Jørgensen2, Marie Skougaard Nielsen2, Peter Olsson1 and Lars Erik Kristensen3, 1Dept of Rheumatology, Skane University Hospital Malmö, Lund University, Malmo, Sweden, 2The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, 3The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark

    Background/Purpose:   To study long-term work disability (WD) and possible predictors in newly diagnosed patients with primary Sjögren’s syndrome (pSS). Methods:   51 pSS patients…
  • Abstract Number: 2671 • 2016 ACR/ARHP Annual Meeting

    Impaired Bone Health in Patients with Primary Sjogren’s Syndrome

    Zaiying Hu1, Shanglin Zhu2, Zetao Liao3 and Baiyu Zhang2, 1Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 3Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China

    Background/Purpose:  Patients were all Chinese from the outpatient and inpatient clinic of our hospital (Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China). Primary SS…
  • Abstract Number: 2672 • 2016 ACR/ARHP Annual Meeting

    Elderly Patients Risk a False Positive Diagnosis of Primary Sjogren’s Syndrome If a Positive Labial Gland Biopsy Is Solely Based on Focus Score

    Erlin A. Haacke1,2, Jolien F. van Nimwegen1, Martha S. van Ginkel1, Suzanne Arends1, Fred K.L. Spijkervet3, Gwenny M. Verstappen1, Nicole Sillevis Smitt-Kamminga4, Arjan Vissink5, Frans G.M. Kroese1, Bert van der Vegt6 and Hendrika Bootsma7, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Opthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 6Pathology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 7Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands

    Background/Purpose:  Primary Sjögren’s syndrome (pSS) is a systemic auto-immune disease affecting the exocrine glands leading to sicca complaints. For the diagnosis of pSS, a positive…
  • Abstract Number: 2673 • 2016 ACR/ARHP Annual Meeting

    Glandular Ultrasonography in Primary SjöGren Syndrome: Clinical and Laboratory Correlation

    Tania Fidelix1, Virginia Trevisani2, Adagmar Andriolo3 and Adriano Czapkowski4, 1Evidence Based Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil, 2Health Evidence Based, Escola Paulista de Medicina, São Paulo, Brazil, 3Clinical Laboratories, Escola Paulista de Medicina, Sao Paulo, Brazil, 4Radiology, Radiology Department- Escola Paulista de Medicina, Sao Paulo, Brazil

    Background/Purpose: Primary SjogrenÕs syndrome (pSS) is a chronic autoimmune disorder that is characterized clinically by dryness of the eyes (xerophthalmia) and mouth (xerostomia). The assayÕs…
  • Abstract Number: 2674 • 2016 ACR/ARHP Annual Meeting

    Primary Sjögren’s Syndrome: Extraglandular Manifestations and Hydroxychloroquine Therapy

    Julia Demarchi1, Silvia Beatriz Papasidero2, María Alejandra Medina3, Diana Klajn4, Rafael Chaparro del Moral2, Oscar Luis Rillo5, María Victoria Martire6, Gloria Crespo7, Anastasia Secco8, Antonio Catalan Pellet6, Cristina Amitrano9, Catherine Crow10, Cecilia Asnal9, Paula Pucci9, Francisco Caeiro11, Nadia Benzaquén11, Juan Pablo Pirola11, Marcela Colazo11, M. Mayer12, F. Zazzetti12, S. Velez12, J. C. Barreira13, Natalia Tamborenea14, M. L. Santiago14 and Laura Raiti15, 1Rheumatology Deparment, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 2Rheumatology Department, Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 3Rheumatology Department, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 4Research Committee, Research Committee, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 5Rheumatology Department, Hospital General de Agudos “Dr. Ignacio Pirovano”, Buenos Aires, Argentina, Buenos Aires, Argentina, 6Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 7Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, 8Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 9Rheumatology, Hospital Alemán, Buenos Aires, Argentina, 10Rheumatology, Hospital Alemán, Buenos aires, Argentina, 11Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 12Hospital Británico, Buenos Aires, Argentina, 13Rheumatology Service, Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 14Rheumatology, OMI, Buenos Aires, Argentina, 15Clínica Bessone, San Miguel, Argentina

    Background/Purpose: The use of Hydroxychloroquine (HCQ) in Primary Sjögren's Syndrome (PSS) has been assessed in different studies over the last years, with conflicting results regarding…
  • Abstract Number: 2675 • 2016 ACR/ARHP Annual Meeting

    Essdai, Clinessdai and DAS Scoring at Diagnosis of Primary Sjogren Syndrome: Association with the Development of Hematologic and Solid Neoplasias in 1301 Patients

    Soledad Retamozo1,2, Belchin Kostov3, Guadalupe Fraile4, Daniel Caravia-Durán5, Brenda Maure6, Francisco Javier Rascón7, Mónica Zamora8, Arnau Casanovas9, Miguel Lopez-Dupla10, Mar Ripoll11, Blanca Pinilla12, Eva Fonseca13, Miriam Akasbi14, Gloria De la Red15, Miguel-Angel Duarte-Millán16, Patricia Fanlo Mateo17, Pablo Guisado18, Roberto Pérez-Alvarez19, Sandra Rodríguez-Rodríguez20, César Morcillo21, Iratxe Jiménez-Heredia22, Alberto Gato23, Jordi Gratacós1, Isabel Sánchez-Berná1, Manuel Ramos-Casals24,25, Pilar Brito-Zerón1,26 and SS Registry GEAS-SEMI, 1Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 2Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, 3Primary Care Research Group, IDIBAPS, ABS Les Corts, CAPSE, Barcelona, Barcelona, Spain, 4Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, 5Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain, 6Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo, Vigo, Spain, 7Department of Internal Medicine, Hospital Son Espases, Palma de Mallorca, Palma de Mallorca, Spain, 8Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Granada, Spain, 9Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Sadabell, Spain, 10Department of Internal Medicine, Hospital Joan XXIII, Tarragona, Tarragona, Spain, 11Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Madrid, Spain, 12Department of Internal Medicine, Hospital Gregorio Marañón, Madrid, Madrid, Spain, 13Department of Internal Medicine, Hospital de Cabueñes, Gijón, Gijón, Spain, 14Department of Internal Medicine, Hospital Infanta Leonor, Madrid, Madrid, Spain, 15Department of Internal Medicine, Hospital Esperit Sant, Badalona, Badalona, Spain, 16Department of Internal Medicine, Hospital de Fuenlabrada, Fuenlabrada, Spain, 17Department of Internal Medicine, Hospital Virgen del Camino, Pamplona, Spain, 18Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid, Madrid, Spain, 19Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, 20Department of Internal Medicine, Hospital de Salamanca, Salamanca, Salamanca, Spain, 21Department of Medicine, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, 22Department of Internal Medicine, Hospital de Sagunto, Valencia, Valencia, Spain, 23Department of Internal Medicine, Complejo Hospitalario Albacete, Albacete, Albacete, Spain, 24Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 25Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain, 26Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain

    Background/Purpose: To score systemic activity at diagnosis of primary Sjogren syndrome (pSS) using the European systemic activity indexes ESSDAI, clinESSDAI and DAS in order to…
  • Abstract Number: 2676 • 2016 ACR/ARHP Annual Meeting

    Changes in Salivary Gland Echostructure in Patients with Primary SjöGren’s Syndrome over the Time: A Four-Year Longitudinal Study

    Chiara Baldini1, Nicoletta Luciano2, Francesco Ferro3, Elena Elefante3, Stefano Bombardieri3 and Marta Mosca4, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Pisa, Pisa, Italy, 4Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy

    Background/Purpose: Salivary gland ultrasonography (SGUS) has recently appeared as a promising tool for a non-invasive diagnosis of primary Sjögren’s syndrome (pSS). However, it is still…
  • Abstract Number: 2677 • 2016 ACR/ARHP Annual Meeting

    Clinical Features of Primary Sjogren’s Syndrome Associated Lung Involvement with Extro-Glandular Manifestations at Onset

    Hui Gao1, Xuewu Zhang1,2 and Zhan-Guo Li1,3, 1Peking University International Hospital, Beijing, China, 2Rheumatology, Peking University People's Hospital, Beijing, China, 3Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China

    Background/Purpose:  To investigate the common initial clinical presentations of primary Sjogren’s syndrome with pulmonary complications, and to explore the differences between patients with extro-glandular manifestations…
  • Abstract Number: 2678 • 2016 ACR/ARHP Annual Meeting

    EULAR Primary SjöGren’s Syndrome Disease Activity Index (ESSDAI), Results from the National Registry of the Spanish Society of Rheumatology (SJÖGRENSER)

    José Rosas1, Carlos Sánchez-Piedra2, Monica Fernandez Castro3, Jose Luis Andreu4, Víctor Martínez Taboada5, Alejandro Olivé6,7, Enrique Judez8, Clara Moriano9, Vicente Torrente-Segarra10, Hector Corominas11, Blanca García Magallon12, Cristina Bohórquez Heras13, Javier Loricera14, Joaquin Maria Belzunegui Otano15, Carlos Guillén-Astete16, Ivan Castellvi17, José Miguel Senabre-Gallego1, Ana Pons1 and on behalf of SJOGRENSER project (GEEAS-SER), 1Rheumatology, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 2Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 3Rheumatology, Hospital Infanta Sofía, Madrid, Spain, 4Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 5Rheumatology, Hospital Marqués de Valdecilla, Santander, Spain, 6Rheumatology, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, 7Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain, 8Rheumatology Department. Hospital de Albacete, Albacete, Spain, 9Rheumatology, Hospital de León, Leon, Spain, 10Hospital de L'Hospitalet, L'Hospitalet de Llobregat, Spain, 11Hospital Sant Joan Despí Moisès Broggi, Barcelona, Spain, 12Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, 13University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, 14Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 15Rheumatology, Donostia University Hospital, Donostia, Spain, 16Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 17Rheumatology, Hospital Santa Creu i San Pau, Barcelona, Spain

    Background/Purpose:  Primary Sjögren’s syndrome (PSS) is a systemic disease primarily characterized by lymphocytic infiltration of exocrine glands, but lymphocytic infiltration, can also can affect extraglandular…
  • Abstract Number: 2679 • 2016 ACR/ARHP Annual Meeting

    Clinically Meaningful Improvement of Essdai and Esspri in Patients with Primary SjöGren’s Syndrome in Real Life: A 12-Month Longitudinal Study

    Chiara Baldini1, Francesco Ferro2, Nicoletta Luciano2, Elena Elefante2, Alessandra Tripoli2 and Marta Mosca3, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2Rheumatology Unit, University of Pisa, Pisa, Italy, 3Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy

    Background/Purpose: The increasing use of ESSDAI and patient reported outcomes (PROs) in primary Sjögren’s syndrome (pSS) clinical trials has pointed out that the performance of…
  • Abstract Number: 2680 • 2016 ACR/ARHP Annual Meeting

    Determinants of Fatigue in Patients with Primary SjöGren’s Syndrome and Impact of Fatigue on Patients’ Treatments: A Cohort Study

    Chiara Baldini1, Luca Quartuccio2, Elena Bartoloni-Bocci3, Roberta Priori4, Alessia Alunno3, Francesco Carubbi5 and GRIS group, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 3Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 4Rheumatology Unit, Sapienza University of Rome, Rome, Italy, 5Rheumatology Clinic, University of L'Aquila, L'Aquila, Italy

    Background/Purpose: Fatigue is a common clinical feature in patients with primary Sjögren’s syndrome (pSS). Objectives of this study were to assess major determinants contributing to…
  • Abstract Number: 2681 • 2016 ACR/ARHP Annual Meeting

    Clinical and Immunological Characteristics of Primary Sjogren´s Syndrome in Men

    Rebeca Belmonte1, Carlos Sánchez-Piedra2, Monica Fernandez Castro3, Jose Luis Andreu4, Victor Martinez Taboada5, Alejandro Olivé6, José Rosas7, Jorge González Martín8, Esther Ruiz Lucea9, Antonio Naranjo10, Oscar Illera11, Lurdes Romani12, Sheila Melchor13, Begoña Moreira14, Enrique Raya15, Marina Rodriguez16, Natalia Cid17 and on behalf of SJOGRENSER project (GEEAS-SER), 1Rheumatoloy, Hospital Virgen de la Salud, Toledo, Spain, 2Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 3Rheumatology, Hospital Infanta Sofía, Madrid, Spain, 4Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 5Hospital Marqués de Valdecilla., Santander, Spain, 6Rheumatology, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, 7Rheumatology, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 8Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, 9Rheumatology, Hospital de Basurto, Bilbao, Spain, 10Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, 11Rheumatology, Hospital Universitario Infanta Sofía, Madrid, Spain, 12Hospital Virgen de las Nieves., Granada, Spain, 13Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 14Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, 15Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, 16Rheumatology, University Hospital Complex of Vigo, Vigo, Spain, 17Rheumatology, Hospital de Valme, Sevilla, Spain

    Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease involving primarily the exocrine glandular system. pSS in men is uncommon. Data of pSS in…
  • Abstract Number: 2682 • 2016 ACR/ARHP Annual Meeting

    How Does Primary Sjogren Syndrome Present in Biopsy-Proven Patients without Circulating Ro/La Autoantibodies? Characteristics at Diagnosis of 2073 Patients from the SjöGren Big Data Project

    Pilar Brito-Zerón1,2,3, Nihan Acar-Denizli4, Margit Zeher5, Astrid Rasmussen6, Raphaele Seror7, Elke Theander8, Xiaomei Li9, Chiara Baldini10, Jacques-Eric Gottenberg11, Debashish Danda12, Luca Quartuccio13, Roberta Priori14,15, Gabriela Hernandez-Molina16, Aike A. Kruize17, Valeria Valim18, Marika Kvarnström19, Damien Sene20, Roberto Gerli21, Sonja Praprotnik22, David A. Isenberg23, Roser Solans24, Maureen Rischmueller25, Seung-Ki Kwok26, Gunnel Nordmark27, Yasunori Suzuki28, Roberto Giacomelli29, Valerie Devauchelle-Pensec30, Michele Bombardieri31, Benedikt Hofauer32, Hendrika Bootsma33, Johan G. Brun34, Guadalupe Fraile35, Steven E. Carsons36, Tamer Gheita37, Jacques Morel38, Cristina F. Vollenweider39, Fabiola Atzeni40, Soledad Retamozo41, Ildike-Fanny Horvath5, Kathy Sivils6, Thomas Mandl42,43, Pulukool Sandhya12, Salvatore De Vita44, Jorge Sánchez-Guerrero45, Eefje van der Heijden17, Virginia Moça Trevisano46, Marie Wahren-Herlenius19, Xavier Mariette7, Manuel Ramos-Casals3,47,48 and EULAR-SS Task Force Big Data Consortium (ASSES, GEAS-SEMI, EULAR), 1Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 4Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Turkey, Istabul, Turkey, 5Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, 7Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, 8Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Malmö, Sweden, 9Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, China, Hefei, Anhui, China, 10Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 11Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France, Strasbourg, France, 12Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, 13Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, 14Rheumatology Unit, Sapienza University of Rome, Rome, Italy, 15Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, 16Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 17Department of Rheumatology & Clinical Immunology, Medical Center Utrecht, The Netherlands, Utrecht, Netherlands, 18Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, 19Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 20Service de Médecine Interne 2, Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, 2, Paris, France, Paris, France, 21Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Italy, Perugia, Italy, 22Department of Rheumatology, University Medical Centre Ljubljana, Slovenia, Ljubljana, Slovenia, 23Centre for Rheumatology Research, University College Hospital London, UK, London, United Kingdom, 24Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, 25Department of Rheumatology, School of Medicine, The University of Western Australia, Crawley, Australia, Crawley, Australia, 26[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 27Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 28Division of Rheumatology , Kanazawa University Hospital , Kanazawa , Ishikawa , Japan, Ishikawa, Japan, 29Clinical Unit of Rheumatology, University of l'Aquila, School of Medicine, L'Aquila, Italy, L'Aquila, Italy, 30Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, 31Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, QMUL, UK, London, United Kingdom, 32Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, München, Germany, München, Germany, 33Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands, 34Department of Clinical Science, University of Bergen. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, Bergen, Norway, 35Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, 36Division of Rheumatology, Allergy and Immunology Winthrop-University Hospital, Stony Brook University School of Medicine, NY, USA, Mineola, NY, 37Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, 38Department of Rheumatology, Teaching hospital and University of Montpellier, France, Montpellier, France, 39Rheumatology, German Hospital, Buenos Aires, Argentina, Buenos Aires, Argentina, 40IRCCS Galeazzi Orthopedic Institute, Milan, Italy, Milan, Italy, 41Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, 42Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Rheumatology, Malmö, Sweden, Malmö, Sweden, 43Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Lund, Sweden, 44Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital "Santa Maria della Misericordia", Udine, Italy, Udine, Italy, 45Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico, 46Federal University of São Paulo, Sao Paulo, Brazil, San Paulo, Brazil, 47Sjögren Syndrome Research Group (AGAUR), Barcelona, Spain, 48Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain

    Background/Purpose: To analyse the main characteristics of patients with primary Sjögren syndrome (SjS) with focal lymphocytic sialadenitis (FLS) unrelated to the presence of circulating anti-Ro/La…
  • Abstract Number: 2683 • 2016 ACR/ARHP Annual Meeting

    Isolated Anti-La/SS-B Positivity in Patients Diagnosed with Primary Sjogren Syndrome: Analysis of 222 Patients from the Sjogren Big Data Cohort

    Pilar Brito-Zerón1,2,3, Nihan Acar-Denizli4, Margit Zeher5, Astrid Rasmussen6, Raphaele Seror7, Elke Theander8, Xiaomei Li9, Chiara Baldini10, Jacques-Eric Gottenberg11, Debashish Danda12, Luca Quartuccio13, Roberta Priori14,15, Gabriela Hernandez-Molina16, Aike A. Kruize17, Valeria Valim18, Marika Kvarnström19, Damien Sene20, Roberto Gerli21, Sonja Praprotnik22, David A. Isenberg23, Roser Solans24, Maureen Rischmueller25, Seung-Ki Kwok26, Gunnel Nordmark27, Yasunori Suzuki28, Roberto Giacomelli29, Valerie Devauchelle-Pensec30, Michele Bombardieri31, Benedikt Hofauer32, Hendrika Bootsma33, Johan G. Brun34, Guadalupe Fraile35, Steven E. Carsons36, Tamer Gheita37, Jacques Morel38, Cristina F. Vollenweider39, Fabiola Atzeni40, Soledad Retamozo41, Ildike-Fanny Horvath5, Kathy Sivils6, Thomas Mandl42, Pulukool Sandhya12, Salvatore De Vita43, Jorge Sánchez-Guerrero44, Eefje van der Heijden17, Virginia Moça Trevisano45, Marie Wahren-Herlenius19, Manuel Ramos-Casals3,46,47 and EULAR-SS Task Force Big Bata Consortium (ASSES, GEAS-SEMI EULAR), 1Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 4Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Istambul, Turkey, 5Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, 7Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, 8Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Malmö, Sweden, 9Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, China, Hefei, Anhui, China, 10University of Pisa, Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 11Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France, Strasbourg, France, 12Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, 13Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, 14Rheumatology Unit, Sapienza University of Rome, Rome, Italy, 15Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, 16Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 17Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Utrecht, Netherlands, 18Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, 19Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 20Service de Médecine Interne 2, Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, 2, Paris, France, Paris, France, 21Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Italy, Perugia, Italy, 22Department of Rheumatology, University Medical Centre Ljubljana, Slovenia, Ljubljana, Slovenia, 23Centre for Rheumatology Research, University College Hospital London, UK, London, United Kingdom, 24Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, 25Department of Rheumatology, School of Medicine, The University of Western Australia, Crawley, Australia, Crawley, Australia, 26Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea, 27Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 28Division of Rheumatology , Kanazawa University Hospital , Kanazawa , Ishikawa , Japan, Ishikawa, Japan, 29Clinical Unit of Rheumatology, University of l'Aquila, School of Medicine, L'Aquila, Italy, L'Aquila, Italy, 30Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, 31Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, QMUL, UK, London, United Kingdom, 32Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, München, Germany, München, Germany, 33Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands, 34Department of Clinical Science, University of Bergen. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, Bergen, Norway, 35Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, 36Division of Rheumatology, Allergy and Immunology Winthrop-University Hospital, Stony Brook University School of Medicine, NY, USA, Mineola, NY, 37Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, 38Department of Rheumatology, Teaching hospital and University of Montpellier, France, Montpellier, France, 39Rheumatology, German Hospital, Buenos Aires, Argentina, Buenos Aires, Argentina, 40IRCCS Galeazzi Orthopedic Institute, Milan, Italy, Milan, Italy, 41Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, 42Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Lund, Sweden, 43Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital "Santa Maria della Misericordia", Udine, Italy, Udine, Italy, 44Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico, 45Federal University of São Paulo, Sao Paulo, Brazil, San Paulo, Brazil, 46Sjögren Syndrome Research Group (AGAUR), Barcelona, Spain, 47Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain

    Background/Purpose: To describe the clinical, immunological and histopathological profile of patients with primary Sjögren syndrome (SjS) presenting with isolated circulating anti-La/SS-B antibodies in the absence…
  • Abstract Number: 2684 • 2016 ACR/ARHP Annual Meeting

    Diagnosis of Systemic Diseases in Patients Presenting with Sicca Syndrome Using a Minimally-Invasive Minor Salivary Gland Biopsy: Analysis of 901 Patients

    Soledad Retamozo1,2,3, Pilar Brito-Zerón1,4,5, Alejandro Alvarellos3, Veronica Saurit3, Ana C. Alvarez3, Maria Soledad Fiorentino3, Nadia Benzaquén3, Juan Pablo Pirola3, Diego Baenas3, Maria Jezabel Haye Salinas3, Albert Bove6, Isabel Sánchez-Berná7, César Morcillo8, Francisco Caeiro3 and Manuel Ramos-Casals2,5,9, 1Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 2Sjögren Syndrome Research Group (AGAUR), Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Postgraduate Career of Rheumatology Catholic University of Córdoba, Fundación para las Ciencias Biomédicas de Córdoba (FUCIBICO), Cordoba, Argentina, 4Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, 5Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 6Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 7Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institutd’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Department of Autoimmune Diseases, ICMiD, Barcelona, Spain, 8Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Spain, Barcelona, Spain, 9Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain

    Background/Purpose: Sicca syndrome is a clinical presentation that is common for several systemic diseases that may infiltrate the exocrine glands. The most frequent disease is…
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