ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 96

Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index and Skindex-29 with Cutaneous Childhood Lupus Erythematous

Pinar Ozge Avar Aydin1, Ashwaq AleEd2, Nora AlMutairi3, Sulaiman Al-Mayouf4, Hafize Emine Sonmez5, Seza Ozen6,7, Jennifer L. Huggins8 and Hermine Brunner9, 1Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Rheumatology, Department of Pediatrics, College of Medicine , Qassim University , Qassim , Saudi Arabia, Qassim, Saudi Arabia, 3Pedaitric Rheumatology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, 4Department of Pediatrics Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, Riyadh, Saudi Arabia, 5Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 6Department of Pediatric Rheumatology Hacettepe University Faculty of Medicine Ankara, Turkey, Ankara, Turkey, 7Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 8Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH, 9Rheumatology, PRCSG, Cincinnati, OH

Meeting: 2017 Pediatric Rheumatology Symposium

Keywords:

Session Information

Date: Thursday, May 18, 2017

Session Title: Clinical and Therapeutic Poster Session

Session Type: Abstract Submissions

Session Time: 5:30PM-7:00PM

Background/Purpose:

Characteristic inflammatory cutaneous lesions are common manifestations of children with systemic lupus erythematosus (cSLE); however they are among understudied areas of cSLE. The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) allows for measuring active inflammation and chronic damage and, it has been validated to determine the impact of therapy on the activity of the cutaneous manifestations in adults. The Skindex-29 is a skin-specific Quality of Life Score (QoL). Their validation in cSLE has not been shown.

Methods:

Patients with cSLE from different three centers were enrolled in a prospective longitudinal cohort study. Inclusion criteria were (1) being diagnosed with SLE according to the American College of Rheumatology criteria for SLE, (2) being diagnosed before 18th birthday, (3) being under 18 years of age at the enrollment, (4) having active or chronic mucocutaneous involvement of lupus. In this ongoing study; CLASI, the PedsQL Generic Core scale and the Rheumatology Module, the Skindex-29, physicians-rated cSLE activity (SLEDAI) and completed the SLICC/ACR damage index (SDI) were achieved besides the clinical and laboratory data obtained from two routine visits 6 months apart.

Results:

The study cohort consisted of 48 patients (90% females) with a mean age at the first visit 14.5 years (ranges: 3-18). 62.5 % of patients completed their second visits. Patients had moderately active cSLE (total SLEDAI scores: 8.7±7.3) and 40 % had a SDI score >0. The mean mucocutaneous domain (MC) scores were 2.2±1.7 for SLEDAI-MC and 0.1±0.1 for SDI-MC at their baseline visits.

The average scores of patients were 6.7±7.6 for SLEDAI, 1.6±1.7 for SLEDAI-MC and 0.1±0.1 for SLICC-MC; 53 % had a SDI score >0 at their second visits. We found that SLEDAI, SLEDAI-MC, SDI-MC, the Skindex, CLASI activity and damage scores are strongly correlated with each other (p<0.01). In addition, cSLE activity (SLEDAI, SLEDAI-MC), damage (SDI, SDI-MC) and QoL are moderately associated with CLASI and the Skindex scores.

Conclusion:

We conclude that CLASI and the Skindex demonstrate a high validity and reliability when used in cSLE showing mucocutaneous involvement.

Disclosure: P. O. Avar Aydin, None; A. AleEd, None; N. AlMutairi, None; S. Al-Mayouf, None; H. E. Sonmez, None; S. Ozen, None; J. L. Huggins, None; H. Brunner, None.

To cite this abstract in AMA style:

Avar Aydin PO, AleEd A, AlMutairi N, Al-Mayouf S, Sonmez HE, Ozen S, Huggins JL, Brunner H. Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index and Skindex-29 with Cutaneous Childhood Lupus Erythematous [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 4). https://acrabstracts.org/abstract/correlation-and-responsiveness-of-cutaneous-lupus-disease-area-and-severity-index-and-skindex-29-with-cutaneous-childhood-lupus-erythematous/. Accessed February 4, 2023.

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