Abstracts Archive - Page 1589 of 2607 - ACR Meeting Abstracts

Abstract Number: 55 • 2017 Pediatric Rheumatology Symposium
Celiac Disease in Children Diagnosed with Juvenile Idiopathic Arthritis
Alexandra Smith¹, Nicole Johnson², Nadia Luca³, Dwaraka Veeramreddy⁴ and Heinrike Schmeling⁵, ¹Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, ²Pediatrics, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ³Pediatric Rheumatology, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ⁴Department of Pediatrics/Alberta Children's Hospital, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, ⁵University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada
Background/Purpose: Celiac disease (CD) is a systemic autoimmune disease triggered by gluten. A higher incidence of CD in rheumatology conditions is reported. Joint pain and…
Abstract Number: 52 • 2017 Pediatric Rheumatology Symposium
How Young People with Juvenile Idiopathic Arthritis and Their Caregivers Weigh the Risks of the Disease and its Treatment: A Mixed-Methods Study
Daniel B. Horton^1,2, Jomaira Salas³, Aleksandra Wec⁴, Timothy Beukelman^5,6, Alexis Boneparth¹, Ky Haverkamp⁷, Melanie Kohlheim⁸, Melissa Mannion⁵, Nandini Moorthy¹, Sarah Ringold⁹ and Marsha Rosenthal², ¹Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, ³Department of Sociology, Rutgers, the State University of New Jersey, New Brunswick, NJ, ⁴Rutgers, the State University of New Jersey, New Brunswick, NJ, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Family Medicine, University of Washington School of Medicine, Seattle, WA, ⁸Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, OH, ⁹Seattle Children's Hospital, Seattle, WA
Background/Purpose: Prior research has examined factors important to clinicians in deciding whether to withdraw therapy for inactive JIA, but little is known about the perspectives…
Abstract Number: 140 • 2017 Pediatric Rheumatology Symposium
Modular Gene Expression Discrimination of Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Subphenotypes in Peripheral Blood
Urko Marigota¹, Angela Mo¹, Jarod Prince², Lai Hin Kimi Chan³, Subramaniam Kugathasan², Greg Gibson¹ and Sampath Prahalad⁴, ¹Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, ²Emory University School of Medicine, Atlanta, GA, ³Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁴Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases which have in common inflammatory arthritis, but distinct clinical and genetic associations. Using biological…
Abstract Number: 81 • 2017 Pediatric Rheumatology Symposium
Preliminary Consensus Treatment Plans for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis: The Foundation for Capturing Treatment Responses in PFAPA from the CARRA PFAPA Subcommittee
Gil Amarilyo¹, Deborah Rothman², Kalpana Manthiram³, Suzanne Li⁴, Liora Harel⁵, Kathryn Edwards⁶, Gary Marshall⁷, Simona Nativ⁸, Kathleen Haines⁹, Geraldina Lionetti¹⁰, Julie Cherian¹¹, Yongdong Zhao¹², Patricia DeLaMora¹³, Grant Syverson¹⁴, Ian Michelow¹⁵, Yuriy Stepanovskiy¹⁶, Akaluck Thatayatikom¹⁷, Cagri Yildirim-Toruner¹⁸, Shoghik Akoghlanian¹⁹, Lori Tucker²⁰, Katalin Koranyi¹⁹, Hemaltha Srinivasalu²¹, Fatma Dedeoglu²² and Sivia Lapidus⁸, ¹Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel, ²Albany Medical Center, Albany, NY, ³National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁴Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ⁵Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁶Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, ⁷Norton Children's Hospital, University of Louisville, Louisville, KY, ⁸Pediatric Rheumatology, Goryeb Children's Hospital, Morristown, NJ, ⁹Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ¹⁰Pediatric Rheumatology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, ¹¹Department of Pediatrics, Stony Brook University Hospital, Stony Brook, NY, ¹²Seattle Children's Hospital, Department of Pediatric Rheumatology, University of Washington, Seattle, WA, ¹³Weill Cornell Medical College, New York, NY, ¹⁴Pediatric Rheumatology, Medical College of Wisconsin, Wauwatosa, WI, ¹⁵Center for International Health Research, Alpert Medical School of Brown University, Providence, RI, ¹⁶Shupyk National Academy of Postgraduate Education, Kyiv, Ukraine, ¹⁷UF Health Shands Hospital, Gainesville, FL, ¹⁸Rheumatology, Nationwide Children's Hospital, Columbus, OH, ¹⁹Nationwide Children's Hospital, Columbus, OH, ²⁰Pediatric Rheum/Rm K4-120, BC Childrens Hospital, Vancouver, BC, Canada, ²¹Children's National Medical Center, Washington, DC, ²²Division of Immunology, Rheumatology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: PFAPA is the most common recurrent fever condition in children. A recent survey showed heterogeneity in physicians’ management strategies. In order to evaluate the…
Abstract Number: 138 • 2017 Pediatric Rheumatology Symposium
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James Jarvis⁴, ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
Abstract Number: 137 • 2017 Pediatric Rheumatology Symposium
Chromatin Landscapes and Genetic Risk For Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Lai Ping Wong³, Tao Liu⁴, Kaiyu Jiang³ and Yanmin Chen³, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Department of Biochemistry, University at Buffalo, Buffalo, NY
Background/Purpose: The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) show distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To…
Abstract Number: 74 • 2017 Pediatric Rheumatology Symposium
Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis
Esraa M. A. Eloseily^1,2, Peter Weiser¹, Hilary Haines³, Melissa Mannion⁴, Matthew L. Stoll¹, Timothy Beukelman¹, Prescott Atkinson⁵ and Randy Q. Cron¹, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pediatrics, Assiut University, Assiut, Egypt, ³Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, ⁴Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatric Allergy and Immunology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Familial, or primary, hemophagocytic lymphohistiocytosis (pHLH), is a rare but highly fatal condition due to mutations in lymphocyte cytolytic pathway genes. Secondary HLH (sHLH),…
Abstract Number: 34 • 2017 Pediatric Rheumatology Symposium
The SLCO1B1 *14 Allele is Associated with Poor Response to Subcutaneous Methotrexate in Patients with Juvenile Idiopathic Arthritis
Halima Moncrieffe¹, Laura B Ramsey², Marc Sudman³, Beth Gottlieb⁴, Carl D Langefeld⁵, Daniel Lovell⁶, Susan D Thompson⁷ and JIA Gene Expression Study Consortium, ¹Center for Autoimmune Genomics and Etiology and Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cohen Children's Medical Center of New York, New Hyde Park, NY, ⁵Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, ⁶Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Disease Genomics and Etiology and Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Variants in the SLCO1B1 gene, encoding a hepatic methotrexate (MTX) transporter, affect clearance of high-dose MTX in leukemia patients. We aimed to assess the…
Abstract Number: 29 • 2017 Pediatric Rheumatology Symposium
Spinal Cord Inflammation in Children with Small Vessel Primary CNS Vasculitis
Anastasia Dropol¹, Navpreet Dhillon², Marinka Twilt¹, Fareha Nishat², Shehla Sheikh³, Helen Branson² and Susanne Benseler¹, ¹Pediatric Rheumatology, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Small vessel childhood primary angiitis of CNS (SVcPACNS) is an increasingly recognized inflammatory brain disease requiring rapid targeted investigation and initiation of tailored therapies…
Abstract Number: 152 • 2017 Pediatric Rheumatology Symposium
Characteristics of Patients With Juvenile Idiopathic Arthritis in a US Healthcare Claims Database
TA Simon¹, A Baheti², N Ray², S Kelly¹ and Z Guo¹, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India
Background/Purpose: Abatacept, the first selective co-stimulation modulator approved and used for the treatment of juvenile idiopathic arthritis (JIA), has a mechanism of action that is…
Abstract Number: 99 • 2017 Pediatric Rheumatology Symposium
PILOT STUDY MEASURING HEPCIDIN AND ARTERIAL STIFFNESS IN CHILDREN WITH SLE AND LUPUS NEPHRITIS
Sangeeta Sule¹, Sarah Joo² and Meredith Atkinson², ¹Pediatrics, Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD
Background/Purpose: Cardiovascular disease (CV dz) is common in SLE and lupus nephritis (LN), but premature atherosclerosis risk does not appear to be linked to classic…
Abstract Number: 16 • 2017 Pediatric Rheumatology Symposium
Novel Serum Broad-Based Proteomic Discovery Analysis Identifies Proteins and Pathways Dysregulated in Juvenile Dermatomyositis (JDM) Myositis Autoantibody Groups
Hanna Kim¹, Angélique Biancotto², Foo Cheung³, Terrance P. O'Hanlon⁴, Ira N. Targoff⁵, Yan Huang⁶, Frederick Miller⁴, Raphaela Goldbach-Mansky⁶ and Lisa G. Rider⁴, ¹Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, MD, ²Center for Human Immunology, Autoimmunity and Inflammation (CHI), NHLBI, NIH, Bethesda, MD, ³Center for Human Immunology Autoimmunity and Inflammation (CHI), NHLBI, NIH, Bethesda, MD, ⁴Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁵VA Medical Center, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Translational Autoinflammatory Disease Studies (TADS), NIAID, NIH, Bethesda, MD
Background/Purpose: Juvenile dermatomyositis (JDM) is a complex heterogeneous autoimmune disease. Myositis-specific autoantibodies (MSAs), present in up to 80% of JDM patients, help define distinct phenotypes…
Abstract Number: 139 • 2017 Pediatric Rheumatology Symposium
Dysregulation of miRNA in mononuclear cells of patients with enthesitis related arthritis
Amita Aggarwal¹ and Sushma Singh², ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in Asia. Identifying dysregulated microRNA may help in understanding the pathogenesis of ERA.…
Abstract Number: 17 • 2017 Pediatric Rheumatology Symposium
Anti-endothelial cell antibodies in juvenile dermatomyositis
Rie Karasawa¹, Mayumi Tamaki¹, Toshiko Sato¹, Megumi Tanaka¹, Kazuo Yudoh² and James Jarvis³, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ³Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: Juvenile dermatomyositis (JDM) is the most common form of inflammatory myopathy in children. Although classified as a myopathy, involved tissues in JDM are characterized…
Abstract Number: 38 • 2017 Pediatric Rheumatology Symposium
Knowledge Translation in Juvenile Idiopathic Arthritis Research in Canada: A Focus on Pediatric Rheumatologists and Allied Health Professionals
Benjamin Rose-Davis¹, Janet Curran², Tania Cellucci³, Ciarán M. Duffy⁴, Lori Tucker^5,6, Michelle Batthish⁷, Adam Huber⁸, Bianca Lang^9,10, Deborah M. Levy¹¹, Dax Rumsey¹², Karen N Watanabe Duffy¹³ and Elizabeth Stringer¹⁴, ¹Division of Pediatric Rheumatology, IWK Health Centre, Halifax, NS, Canada, ²Department of Pediatrics, IWK Health Centre, Halifax, NS, Canada, ³Pediatrics/Rheumatology, McMaster Children's Hospital, Hamilton, ON, Canada, ⁴Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁵Rheumatology, BC Childrens Hospital, Vancouver, BC, Canada, ⁶Pediatric Rheum/Rm K4-120, BC Childrens Hospital, Vancouver, BC, Canada, ⁷Division of Pediatric Rheumatology, McMaster Children's Hospital, Hamilton, ON, Canada, ⁸IWK Health Centre, Halifax, NS, Canada, ⁹Pediatrics, IWK Health Centre, Halifax, NS, Canada, ¹⁰Rheumatology, IWK Health Centre, Halifax, NS, Canada, ¹¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹²Stollery Children's Hospital, Edmonton, AB, Canada, ¹³Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹⁴Department of Rheumatology, IWK Health Centre, Halifax, NS, Canada
Background/Purpose: Knowledge Translation (KT) is an iterative process that includes synthesis, dissemination, and application of knowledge to improve health. The aim of this study is…

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