Abstracts Archive - Page 1569 of 2425 - ACR Meeting Abstracts

Abstract Number: 2277 • 2016 ACR/ARHP Annual Meeting
Exon Sequencing Reveals a Significant Burden of Non-Synonymous Variants in Both SLC22A11 (OAT4) and SLC22A12 (URAT1) in European Hyperuricemic Individuals
Tanya Flynn¹, James Boocock¹, Murray Cadzow¹, Ruth Topless¹, Amanda Phipps-Green¹, Nicola Dalbeth², Lisa K. Stamp³, David B. Mount⁴, Asim Mandal⁴, Hyon K. Choi⁵, Eli A. Stahl⁶ and Tony R. Merriman⁷, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Common variants within the uric acid transporter genes SLC22A11 (OAT4) and SLC22A12 (URAT1) have been associated with hyperuricaemia and gout in multiple populations, but…
Abstract Number: 2278 • 2016 ACR/ARHP Annual Meeting
Precision of Gout Definitions for Population-Based Genetic Studies: Analysis of the UK Biobank
Murray Cadzow¹, Tony R. Merriman² and Nicola Dalbeth³, ¹University of Otago, Dunedin, New Zealand, ²Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ³University of Auckland, Auckland, New Zealand
Background/Purpose : Accurate case-definition is important for epidemiological studies of gout. However, in multipurpose cohort studies frequently used for genome wide association studies, limited information…
Abstract Number: 2279 • 2016 ACR/ARHP Annual Meeting
Soluble Urate: A Direct Mediator of Bone Turnover?
Nicola Dalbeth¹, Bregina Pool², Ashika Chhana³, Jian-Ming Lin¹, Mei-Lin Tay¹, Paul Tan¹, Karen E. Callon¹, Dorit Naot³ and Jillian Cornish², ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Observational studies have reported that hyperuricemia may be protective in the development of osteoporosis. Serum urate concentrations positively correlate with bone density, and higher…
Abstract Number: 2280 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Crystal-Induced Inflammation Promotes Osteocyte Expression of Pro-Resorptive and Inflammatory Mediators: Implications for Erosive Gout
Ashika Chhana¹, Mei-Lin Tay², Bregina Pool³, Karen E. Callon², David Musson², Dorit Naot¹, Gregory Gamble³, Jillian Cornish³ and Nicola Dalbeth², ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Bone erosion in gout is strongly associated with tophi; lesions comprising of inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are…
Abstract Number: 2281 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate (MSU) Crystals Induces Cartilage Degeneration By Accelerating Hypertrophy and Mineralization.
Nicole Yang¹, Anthony M. Reginato² and Changqi Sun³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ²Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Previous studies have shown that abnormal loads induce meniscus cell damage and matrix degradation both in-vivo and in-vitro1,2. Monosodium urate (MSU) crystal is considered…
Abstract Number: 2282 • 2016 ACR/ARHP Annual Meeting
Ferritin Levels Are Associated with Urate and Gout – a Role for Iron Metabolism in Gout ?
Tahzeeb Fatima¹, Tony R. Merriman², Lisa K. Stamp³, Nicola Dalbeth⁴, Cory Iverson⁵ and Jeffrey N. Miner⁶, ¹University of Otago, Dunedin, New Zealand, ²Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶Discovery Biology, Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: Transferrin and its cell-surface receptor regulate iron uptake and ferritin sequesters free iron and acts as a store for excess iron. Ferritin has been…
Abstract Number: 2283 • 2016 ACR/ARHP Annual Meeting
Suppression of Monosodium Urate (MSU) Crystals-Induced Inflammatory Response By Inhibiting TGF-β Activated Kinase 1 (TAK1)
Anil Singh¹, Kayla O’Sullivan², Mukesh Chourasia³, Sadiq Umar⁴, Mahamudul Haque², Bhanupriya Madarampalli² and Salahuddin Ahmed², ¹Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Department of Pharmaceutical Science, Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: Methods: Results: Conclusion:
Abstract Number: 2284 • 2016 ACR/ARHP Annual Meeting
Differential Effect of MSU-Crystal Induced Inflammation on Macrophage Polarization
Rashid Ahmed¹, Nicole Yang², Changqi Sun³ and Anthony M. Reginato³, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ³Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI
Background/Purpose: Gouty arthritis is a common inflammatory joint disease that arises in response to the deposition of monosodium urate (MSU) crystals in soft joints, periarticular…
Abstract Number: 2285 • 2016 ACR/ARHP Annual Meeting
12/15-Lipoxygenase Inhibition By ML351 Protects Against Uric Acid Crystal-Induced Acute Arthritis in Mice
Roxana Coras¹, Alex Stubelius², Oswald Quehenberger³ and Monica Guma¹, ¹Medicine, UCSD, La Jolla, CA, ²Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA, ³Pharmacology, UCSD, La Jolla, CA
Background/Purpose: Treatment of acute gout involves the use of NSAIDs, colchicine or corticosteroids. Unfortunately, co-morbid conditions such as chronic kidney disease, peptic ulcer disease and…
Abstract Number: 2286 • 2016 ACR/ARHP Annual Meeting
Bioresponsive Glucocorticoid-Loaded Microparticles to Prevent Acute Gout Flares
Alex Stubelius¹, Wangzhong Sheng², Sangeun Lee¹, Adah Almutairi³ and Monica Guma⁴, ¹Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA, ²1Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA, ³Skaggs School of Pharmacy and Pharmaceutical Sciences., UCSD, La Jolla, CA, ⁴Medicine, UCSD, La Jolla, CA
Background/Purpose: Gout is a common and very painful form of arthritis triggered by deposits of monosodium urate (MSU) crystals in the joints. Lifestyle factors such…
Abstract Number: 2287 • 2016 ACR/ARHP Annual Meeting
Serum Urate and Its Association with Endothelial Dysfunction in Young Adults
Michael B. Saddekni¹, Kenneth G. Saag¹, Tanja Dudenbostel², Suzanne Oparil², David A. Calhoun², Daniel I. Feig³, Paul M. Muntner⁴, David T. Redden⁵, Phillip J. Foster¹, Elizabeth J. Rahn¹, Stephanie R. Biggers¹, Peng Li⁵ and Angelo L. Gaffo¹, ¹Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, ³Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Both serum urate (sUA) and endothelial dysfunction have been associated with hypertension and cardiovascular disease. Increasing sUA level has been associated with endothelial dysfunction…
Abstract Number: 2288 • 2016 ACR/ARHP Annual Meeting
Inflammatory Status and Serum Uric Acid Determine High-Density Lipoprotein Cholesterol Levels in a Non-Rheumatic Population
Mariano Andrés¹, María Amparo Quintanilla², Eliseo Pascual³, Pedro Morillas² and FAPRES study group, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Servicio de Cardiología, Hospital General Universitario de Elche, Elche, Spain, ³Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: In inflammatory disorders, highest incidence of cardiovascular (CV) events paradoxically occurs at lower lipid levels [ARD.70:482], especially for high-density lipoprotein cholesterol (HDLc). Current data…
Abstract Number: 2289 • 2016 ACR/ARHP Annual Meeting
Obesity and Echocardiographic Changes in the Different Stages of Gout
Rada Gancheva¹, Atanas Kundurdjiev², Mariana Ivanova¹, Todor Kundurzhiev³ and Zlatimir Kolarov¹, ¹Medical Faculty, Medical University, University Hospital "St. Iv. Rilski", Clinic of Rheumatology, Sofia, Bulgaria, ²Medical Faculty, Medical University, University Hospital "St. Iv. Rilski", Clinic of Nephrology, Sofia, Bulgaria, ³Medical University, Faculty of Public Health, Sofia, Bulgaria
Background/Purpose: Studies on gout and its stages as a cardiovascular (CV) risk factor are few and with contradictory results. We compared echocardiographic parameters, known as…
Abstract Number: 2290 • 2016 ACR/ARHP Annual Meeting
Crystal-Proven Gout and Disease Severity Factors Influencing the Prevalence of Cardiovascular Diseases
I.J.M. Disveld^1,2, J. Fransen³, L.B.E. Kienhorst⁴, H.J.E.M. Janssens⁵, S. Zoakman¹, A.J.W. Branten¹, C.M.A. de Gendt¹, A.J.L. de Jong⁶, H. Visser⁷ and M. Janssen¹, ¹Department of Rheumatology, Rijnstate Hospital Arnhem, Arnhem, Netherlands, ²Radboudumc Nijmegen, Nijmegen, Netherlands, ³Department of Rheumatolgy, Radboudumc Nijmegen, Nijmegen, Netherlands, ⁴UMC Utrecht, Utrecht, Netherlands, ⁵Rijnstate Hospital Arnhem, Arnhem, Netherlands, ⁶Department of Rheumatology, Rijnstate Arnhem, Arnhem, Netherlands, ⁷Department of Rheumatolgy, Rijnstate Hospital Arnhem, Arnhem, Netherlands
Background/Purpose: Gout is a health disorder affecting many patients worldwide. Clinical gout studies showed a high prevalence of cardiovascular diseases (CVD), raising the question whether…
Abstract Number: 2291 • 2016 ACR/ARHP Annual Meeting
Impact of Plasma Urate and Tophaceous Burden on Inflammatory Biomarkers of Cardiovascular Disease
John FitzGerald¹, Benjamin D. Levine², Jennifer Raymond³ and Maureen A. McMahon¹, ¹Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Gout and hyperuricemia have been associated with cardiovascular disease. Studies have documented the impact of serum urate levels on hypertension and that increased urate…

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