Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting
Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation
Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…Abstract Number: 2067 • 2016 ACR/ARHP Annual Meeting
Dermal Fibroblasts from Patients with Lupus Nephritis Express an Anti-Fibrotic Transcriptome
Background/Purpose: The premise of this study is that the impact of renal injury in lupus nephritis is widespread with consequences to resident cells in other…Abstract Number: 2068 • 2016 ACR/ARHP Annual Meeting
Type 2 Innate Lymphoid Cells – Cellular Source of Profibrotic Mediators Rapidly and Persistently Recruited in Experimental Fibrosis and Systemic Sclerosis
Background/Purpose: We aimed to profile ILC2s in fibrotic tissues and to evaluate the functional impact of IC2s in the pathogenesis of systemic sclerosis (SSc). Methods:…Abstract Number: 2069 • 2016 ACR/ARHP Annual Meeting
Dipeptidyl-Peptidase-4 (DPP4) Positive Fibroblast Subpopulation Promotes Fibrosis and Are a Molecular Target for Treatment of Fibrosis
Background/Purpose: Dipeptidyl-peptidase-4 (DPP4) has been recently shown to identify a distinct dermal lineage with intrinsic fibrogenic potential and its targeted inhibition leads to reduced scar…Abstract Number: 2070 • 2016 ACR/ARHP Annual Meeting
Long Noncoding RNA H19X Is a Master Regulator of Extracellular Matrix Production in Systemic Sclerosis and Other Fibrotic Disease
Background/Purpose: Long noncoding RNAs (lncRNAs) are an emerging class of large noncoding transcripts involved in the regulation of gene expression in health and disease. We…Abstract Number: 2071 • 2016 ACR/ARHP Annual Meeting
Expression of Neuraminidase 1 (NEU1) Is Upregulated in the Lungs of Scleroderma Patients with Pulmonary Fibrosis, and Gene Delivery of NEU1 to Mouse Lungs Elicits Accumulation of CD8+ Lymphocytes and Collagen
Background/Purpose: We and others have previously reported that pulmonary fibrosis in patients with scleroderma is accompanied by pulmonary accumulation of predominantly CD8+ T lymphocytes. Earlier…Abstract Number: 2072 • 2016 ACR/ARHP Annual Meeting
Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity/inflammation, vasculopathy, and tissue fibrosis. Fli1 is a member of Ets family transcription…Abstract Number: 2073 • 2016 ACR/ARHP Annual Meeting
Jumonji Domain Containing Protein 3 (JMJD3) As a Novel Epigenetic Mechanism of Fibroblast Activation By Regulation of Fra-2
Background/Purpose: Prolonged endogenous activation of fibroblasts is a major hallmark of fibrosing disorders such as Systemic Sclerosis (SSc). It results in tissue fibrosis, organ failure…Abstract Number: 2074 • 2016 ACR/ARHP Annual Meeting
Herpes Zoster and the Risk of Incident Giant Cell Arteritis
Background/Purpose: Antigenic triggers initiating granulomatous inflammation in giant cell arteritis (GCA) have yet to be elucidated. Recently, histopathological studies of temporal arteries from GCA patients…Abstract Number: 2075 • 2016 ACR/ARHP Annual Meeting
No Detection of Varicella-Zoster Virus in Temporal Arteries of Patients with Giant Cell Arteritis
Background/Purpose: Recent studies found an high prevalence of varicella-zoster virus (VZV) infection in temporal arteries (TAs) from both temporal artery biopsy (TAB)-positive and TAB-negative giant…Abstract Number: 2076 • 2016 ACR/ARHP Annual Meeting
Impact of Vasculitis on Employment and Income: An Online Survey of Participants in the Rare Diseases Clinical Research Network – Vasculitis Clinical Research Consortium Patient Contact Registry
Background/Purpose: Work disability associated with rheumatic diseases accounts for an important part of the costs of these conditions. Few studies have investigated disability among patients…Abstract Number: 2077 • 2016 ACR/ARHP Annual Meeting
Impact of Diabetes, Angiotensin Converting Enzyme Inhibitor or Angiotensin II Receptor Blocker Use, and Statin Use on Presentation and Outcomes in Patients with Giant Cell Arteritis
Background/Purpose: Few retrospective studies in giant cell arteritis (GCA) previously reported, separately, that 1) patients with diabetes had less positive temporal artery biopsies (TAB), 2)…Abstract Number: 2078 • 2016 ACR/ARHP Annual Meeting
Global Ethnic and Geographic Differences in the Clinical Features of ANCA-Associated Vasculitis
Background/Purpose: There are few data on clinical profiles of ANCA-associated vasculitis (AAV) and or ANCA specificity in different ethnic populations. This study examined differences in…Abstract Number: 2079 • 2016 ACR/ARHP Annual Meeting
Incidence and Risk of Pneumocystis Jirovecii Pneumonia Following Rituximab Treatment in Granulomatosis with Polyangiitis in the United States: An Analysis from a National Database
Background/Purpose: Pneumocystis Jirovecii pneumonia (PJP) is a life-threatening complication in granulomatosis with polyangiitis (GPA). Guidelines from EULAR for ANCA-associated vasculitis (AAV) recommend institution of PJP…Abstract Number: 2080 • 2016 ACR/ARHP Annual Meeting
Three Simple Tests to Raise the Index of Suspicion for Fibromyalgia in Primary Care
Background/Purpose: 356 patients were studied (mean age 50 ± 16.3 years, 70% female). Chart review revealed that 53 (15%) of these patients carried a…
ACR Meeting Abstracts