Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: The trabecular bone score (TBS) is a novel tool used to evaluate bone microarchitecture. It is a textural index that evaluates pixel gray-level variations in the lumbar spine DXA image, thereby providing an indirect index of trabecular microarchitecture. To date, no studies have compared TBS between patients with axSpA and matched controls. Therefore, the present study was conducted to assess TBS in these two groups and to identify the risk factors related to a low TBS in patients with axSpA.
Methods: TBS and bone mineral density (BMD) were assessed in the two groups (axSpA and control) using dual-energy X-ray absorptiometry (DXA). Osteoporosis risk factors and inflammatory markers were also assessed. Disease activity and radiographic progression in the sacroiliac joint and spine were evaluated in the axSpA group. Multivariate linear regression analysis was performed to identify risk factors associated with TBS.
Results: In the axSpA group, 248 subjects were enrolled; an equal number of age- and sex-matched subjects comprised the control group. The mean TBS was 1.43±0.08 and 1.38±0.12 in the control and axSpA groups, respectively (p<0.001); BMD at the lumbar spine did not differ between the two groups. The TBS was negatively correlated with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels in the axSpA group only (p<0.001 and p=0.007, respectively). Syndesmophytes in the axSpA group was associated with lower TBS (p<0.001) but higher lumbar BMD (p=0.021) versus controls. In the multivariate analyses, ESR, CRP, and spinal radiographic progression were significantly associated with TBS.
Conclusion: TBS assessments revealed poor bone quality in patients with axSpA compared with the matched controls. In axSpA, systemic inflammatory markers were negatively correlated with TBS and spinal radiographic progression and inflammatory markers were independently correlated with low TBS. TBS may, therefore, be a useful clinical tool to identify the risk of osteoporosis in patients with axSpA.
To cite this abstract in AMA style:Kang KY. Trabecular Bone Score As an Assessment Tool to Identify the Risk of Osteoporosis in Axial Spondyloarthritis: A Case-Control Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/trabecular-bone-score-as-an-assessment-tool-to-identify-the-risk-of-osteoporosis-in-axial-spondyloarthritis-a-case-control-study/. Accessed February 16, 2019.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/trabecular-bone-score-as-an-assessment-tool-to-identify-the-risk-of-osteoporosis-in-axial-spondyloarthritis-a-case-control-study/