Abstracts Archive - Page 1532 of 2607 - ACR Meeting Abstracts

Abstract Number: 2171 • 2017 ACR/ARHP Annual Meeting
Functional Measures and Patient Home Self-Assessments in the Idiopathic Inflammatory Myopathies
Amanda Kocoloski¹, Courtney Ward², Diane Koontz², Chester V. Oddis³ and Rohit Aggarwal⁴, ¹Internal Medicine, Division of Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Internal Medicine Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Rheumatology/Clinical Immunology, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Medicine / Rheumatology, University of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: Myositis leads to significant morbidity and loss of function. Currently, simple objective measures of patient functional outcomes are lacking. Our aims were to a)…
Abstract Number: 2172 • 2017 ACR/ARHP Annual Meeting
Clinical Significance of Serum Levels of Anti-Transcriptional Intermediary Factor 1-γ Antibody in Patients with Dermatomyositis
Nobuaki Ikeda, Yukie Yamaguchi, Miwa Kanaoka, Yasushi Ototake, Eriko Takebayashi and Michiko Aihara, Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Dermatomyositis (DM) is an autoimmune inflammatory disease characterized by skin eruptions and myositis, which is occasionally complicated by interstitial lung disease (ILD) or concomitant…
Abstract Number: 2173 • 2017 ACR/ARHP Annual Meeting
Characteristics Unique to MDA5 and Anti-Ro/SSA-52 Kda Dual Antibody Positive Patients with Inflammatory Myopathies
Juan J Maya, Olga Pinkston, Florentina Berianu, Benjamin Wang and Andy Abril, Rheumatology, Mayo Clinic Florida, Jacksonville, FL
Background/Purpose: The anti-melanoma differentiation-associated gene 5 antibody (MDA5) was recently classified as a myositis-specific antibody (MSA), and has been associated with rapidly progressive interstitial lung…
Abstract Number: 2174 • 2017 ACR/ARHP Annual Meeting
Investigating Exercise- and Crossfit-Induced Rhabdomyolysis: Data from a Community Healthcare System
Sneha Sundaram¹, Michelle Meyer², Richard Shaw³ and Ingeborg Schafhalter-Zoppoth¹, ¹Internal Medicine, California Pacific Medical Center, San Francisco, CA, ²Pediatrics, UCSF Benioff Children's Hospital Oakland, Oakland, CA, ³California Pacific Medical Center, San Francisco, CA
Background/Purpose: The work-up of elevated muscle enzymes is a common reason for rheumatology consults. The differential diagnosis of rhabdomyolysis includes trauma, exertion, hereditary myopathies, drugs,…
Abstract Number: 2175 • 2017 ACR/ARHP Annual Meeting
Novel Assessment of Interstitial Lung Disease Using the “Computer-Aided Lung Informatics for Pathology Evaluation and Rating” Software System in Idiopathic Inflammatory Myopathies
Patompong Ungprasert¹, Katelynn Wilton², Floranne C. Ernste³, Sanjay Kalra⁴, Cynthia S. Crowson⁵, Srinivasan Rajagopalan⁶ and Brian Bartholmai⁷, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Immunology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁴Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, ⁵Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁶Mayo Clinic, Rochester, MN, ⁷Thoracic Radiology, Mayo Clinic, Rochester, MN
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are often associated with interstitial lung diseases (ILD). Yet, pulmonary function testing (PFT) results can be confounded by patient…
Abstract Number: 2176 • 2017 ACR/ARHP Annual Meeting
Clusterin Is Upregulated in Muscle Tissue and Serum in Idiopathic Inflammatory Myopathies and Is Associated with Clinical Disease Activity
Tereza Lennerova^1,2, Lucia Vernerova¹, Martin Klein¹, Veronika Hruskova^1,3, Lucie Andres Cerezo¹, Barbora Sumova^1,2, Michal Tomcik^1,2, Sabina Oreska^1,2, Herman F Mann^1,2, Josef Zamecnik⁴, Karel Pavelka^1,2, Jiri Vencovsky^1,2 and Ladislav Senolt^1,2, ¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ²Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Department of Pathology and Molecular Medicine, 2nd Medical School and University Hospital Motol, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Clusterin (also known as apolipoprotein J) is a molecular chaperone that participates in a number of biological processes, such as inflammation and apoptosis. Recent…
Abstract Number: 2177 • 2017 ACR/ARHP Annual Meeting
The Medial Shift of the Tibial Articular Surface Is One Factor of Medial Osteoarthritis of the Knee
Ryuji Nagamine, Artificial joint and rheumatism, Fukuoka Tokushukai Medical Center, Kasuga, Japan
Background/Purpose: Varus alignment is one factor of medial osteoarthritis (OA) of the knee. According to the concept of the constitutional varus, the bone growth disturbance…
Abstract Number: 2178 • 2017 ACR/ARHP Annual Meeting
Metabolic Osteoarthritis: Relation of Cardiovascular Disease and Diabetes to Knee Osteoarthritis
Laura Kuusalo¹, David T. Felson², Carrie Brown³, Cora E. Lewis⁴, James Torner⁵ and Tuhina Neogi², ¹University of Turku and Turku University Hospital, Turku, Finland, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Boston University School of Public Health, Boston, MA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA
Background/Purpose: Metabolic changes or low-grade inflammation related to cardiovascular disease (CVD) and diabetes have been hypothesized to contribute to the development of OA. Prior studies…
Abstract Number: 2179 • 2017 ACR/ARHP Annual Meeting
Comparing Observed with Expected Assessments of Osteoarthritic Pain over Time: Application of Successive Prediction to Data from the Osteoarthritis Initiative
Steven Mongin¹, Naoko Onizuka², Lisa Langsetmo³ and Anna Shmagel⁴, ¹Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³University of Minnesota School of Public Health, Minneapolis, MN, ⁴Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: High variability in patient-reported outcome scores presents a major challenge in the design and interpretation of clinical studies in osteoarthritis (OA). We present a…
Abstract Number: 2180 • 2017 ACR/ARHP Annual Meeting
Metabolic Syndrome Does Not Modify the Association between Obesity and Hip Osteoarthritis
Karen Cheng¹, Scott Ball¹, Simon Schenk¹, Elsa Strotmeyer², John Schousboe³, Marcia Stefanick⁴, Elizabeth Barrett-Connor⁵, Deborah Kado⁵, Michael Nevitt⁶, Nancy E. Lane⁷, Eric Orwoll⁸ and Jan M. Hughes-Austin⁹, ¹Orthopaedic Surgery, University of California, San Diego, San Diego, CA, ²Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³University of Minnesota, Minneapolis, MN, ⁴Stanford University, Stanford, CA, ⁵University of California, San Diego, San Diego, CA, ⁶Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, ⁷Center for Musculoskeletal Health, University of California at Davis, Hillsborough, CA, ⁸OHSU, Portland, OR, ⁹Orthopaedic Surgery, University of California, San Diego, La Jolla, CA
Background/Purpose: Obesity and metabolic syndrome (MetS) are the strongest modifiable risk factors of knee OA, and frequently affect the same individual. The reported associations in…
Abstract Number: 2181 • 2017 ACR/ARHP Annual Meeting
Is a Decrease in MRI-Defined Inflammation Associated with a Decrease in Pain in Patients with Hand Osteoarthritis? a Two-Year Follow-up Study
S. van Beest¹, W. Damman¹, R. Liu¹ and M. Kloppenburg², ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Joint pain in hand osteoarthritis (OA) is associated with synovitis in cross-sectional studies. Therefore we hypothesized that synovitis could be a target for treatment.…
Abstract Number: 2182 • 2017 ACR/ARHP Annual Meeting
Cardiovascular Events in Patients with Diffuse Idiopathic Skeletal Hyperostosis. a 10 Years Follow-up Study
Karina Glick¹, Irina Novofastovski², Naama Schwartz³ and Reuven Mader², ¹Medicine C, Emek Medical Center, Afula, Israel, Afula, Israel, ²Rheumatology, Emek Medical Center, Afula, Israel, Afula, Israel, ³Biostatistics, Emek Medical Center, Afula, Israel, Afula, Israel
Background/Purpose: DISH has been reported to be associated with constitutional and metabolic derangement. In particular, patients with DISH were reported to bear a higher cardiovascular…
Abstract Number: 2183 • 2017 ACR/ARHP Annual Meeting
Two-Year Changes in Knee Osteoarthritis Symptoms: Comparing Clinical Relevance of Patient-Reported Outcomes By Anchoring to Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Erin Ashbeck³, Michael J Hannon⁴ and Aida Aydemir⁵, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³The University of Arizona Arthritis Center, Tucson, AZ, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA, ⁵EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Randomized controlled trials (RCTs) of interventions for knee OA (KOA) may include a patient-reported outcome (PRO) measure as a primary endpoint. Several measures of…
Abstract Number: 2184 • 2017 ACR/ARHP Annual Meeting
Relation of Gait Speed to Incident Knee Replacement: The Multicenter Osteoarthritis Study
Joshua Stefanik¹, Jodie McClelland², Carrie Brown³, Michael P. LaValley³, James Torner⁴, Michael Nevitt⁵, Cora E. Lewis⁶ and Tuhina Neogi¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Latrobe University, Melbourne, Australia, ³Boston University School of Public Health, Boston, MA, ⁴University of Iowa, Iowa City, IA, ⁵Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, ⁶University of Alabama Birmingham, Birmingham, AL
Background/Purpose: For some individuals with knee osteoarthritis (OA), the failure of conservative management can often lead to knee replacement (KR). Identifying who will progress to…
Abstract Number: 2185 • 2017 ACR/ARHP Annual Meeting
Relation of Foot Pronation to Medial Knee Load in Persons with Medial Knee Osteoarthritis
K. Douglas Gross¹, Richard Jones², David T. Felson³, Salinda Chong⁴ and Howard J. Hillstrom⁵, ¹Physical Therapy, MGH Institute of Health Professions, Boston, MA, ²School of Health Sciences, University of Salford, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴MGH Institute of Health Professions, Boston, MA, ⁵Rehabilitation, Hospital Special Surgery (HSS), New York, NY
Background/Purpose: The knee adduction moment (KAM) estimates medial knee load during gait, with high KAM fueling worsening OA. Understanding how foot mechanics contribute to KAM…

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