Abstracts Archive - Page 1516 of 2607 - ACR Meeting Abstracts

Abstract Number: 1931 • 2017 ACR/ARHP Annual Meeting
Targeting Cartilage Aging As Osteoarthritis Therapeutics By Drug Repurposing
Beatriz Carames¹, Uxia Nogueira-Recalde², Maria I. Loza³, Francisco J Blanco² and Eduardo Dominguez⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–CHUAC, A Coruña, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Background: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause…
Abstract Number: 1932 • 2017 ACR/ARHP Annual Meeting
A2A Adenosine Receptor (A2AR) Stimulation Modulates NR4A2 Orphan Receptor Expression during Osteoclast Differentiation
Carmen Corciulo¹, Tuere Wilder¹ and Bruce Cronstein², ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Orphan receptors comprise a large number of evolutionarily conserved molecules that have unknown ligands but may have potent biologic effects. Among these receptors are…
Abstract Number: 1933 • 2017 ACR/ARHP Annual Meeting
Mitochondrial ROS Activate the p38-MAPK/AP1 Pathway to Induce the Expression of Matrix Metalloproteases and IL-6 in Human Chondrocytes
Mohammad Y. Ansari¹ and Tariq M Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Mitochondria not only ‘power’ the cell, but are also essential for maintaining physiological levels of prooxidants (ROS) which is critical for homeostasis. Damaged and…
Abstract Number: 1934 • 2017 ACR/ARHP Annual Meeting
Chondrocytes Derived from Mesenchymal Stem Cells Differentiated in the Presence of Plasma-Derived Extracellular Vesicles from Osteoarthritic Patients Express Disease-Related Genes
Bartijn C.H. Pieters¹, Onno J. Arntz¹, Arjen B. Blom², Peter M. van der Kraan² and Fons A.J. van de Loo², ¹Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is an age-related musculoskeletal disease and the most common form of arthritis characterized by low grade synovial inflammation and articular cartilage degeneration.…
Abstract Number: 1935 • 2017 ACR/ARHP Annual Meeting
Influence of Adipokines on the Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients
Lali Tsiklauri¹, Janina Werner², Klaus W. Frommer¹, Rosel Engel³, Stefan Rehart⁴, Sabine Wenisch², Ulf Müller-Ladner⁵ and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Institute of Veterinary-Anatomy, -Histology and –Embryology, Clinic of Small Animals, Giessen Germany, Giessen, Germany, ³Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Osteoporosis predominantly affects elderly people and is characterized by bone loss, increased fracture risk and reduced regeneration ability. An inverse relationship between bone marrow…
Abstract Number: 1936 • 2017 ACR/ARHP Annual Meeting
Bimekizumab Blocks T Cell-Mediated Osteogenic Differentiation of Periosteal Stem Cells: Coupling Pathological Bone Formation to IL-17A and IL-17F Signaling
Mittal Shah^1,2, Ash Maroof¹, Rawiya Al-Hosni², Panagiotis Gikas³, Neil Gozzard¹, Stevan Shaw¹ and Scott Roberts^1,2, ¹UCB Pharma, Slough, United Kingdom, ²University College London, London, United Kingdom, ³The Royal National Orthopaedic Hospital, London, United Kingdom
Background/Purpose: Structural tissue damage, as a result of pathological bone formation, is a major cause of disability in spondyloarthritis (SpA). A paucity of in vitro…
Abstract Number: 1937 • 2017 ACR/ARHP Annual Meeting
Abaloparatide, an Osteoanabolic PTHrP Analog, Increased Bone Mineral Density in Rabbits with Glucocorticoid Induced Osteopenia
Heidi Chandler¹, Allen Pierce², Jeffery Brown², Michael Ominsky² and Gary Hattersley³, ¹Research, Radius Health Inc, Waltham, MA, ²Radius Health Inc, Waltham, MA, ³Radius Health, Inc., Waltham, MA
Background/Purpose: Estrogen deficiency and glucocorticoid (GC) therapy are the main causes of postmenopausal and secondary osteoporosis, respectively. Bone loss in both states relate to a…
Abstract Number: 1938 • 2017 ACR/ARHP Annual Meeting
TGFB1 Governs Osteoblast Differentiation in Ankylosing Spondylitis Via Modulating BMP2
Sungsin Jo¹, Seung Hyun Choi², Il-Hoon Sung³, Ye-Soo Park⁴ and Tae-Hwan Kim¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Choate Rosemary Hall, Wallingford, CT, ³Orthopaedic, Hanyang University Seoul Hospital, Seoul, Korea, Republic of (South), ⁴Orthopaedic, Hanyang University Guri Hospital, Guri, Korea, Republic of (South)
Background/Purpose: Ankylosing spondylitis (AS) is characterized by inflammation, high osteoblastic activity, leading to ankyloses. Transforming growth factor beta 1 (TGFB1) has been known to be…
Abstract Number: 1939 • 2017 ACR/ARHP Annual Meeting
Dipyridamole, an Ent-1 Adenosine Transporter Inhibitor, Reverts De Osteoclastic Phenotype Induced By Tenofovir
Francisco Miguel Conesa-Buendia¹, Patricia Llamas², Tuere Wilder³, Patricia Atencio⁴, Alfonso Cabello⁵, Miguel Gorgolas⁴, Bruce Cronstein⁶, Raquel Largo⁷, Gabriel Herrero-Beaumont⁷ and Aranzazu Mediero⁸, ¹Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, ²Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, ³Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ⁴Internal Medicine Department, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain, ⁵Internal MEdicine Department, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain, ⁶Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, ⁷Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, ⁸Bone and Joint Research Unit, Fundación Jiménez Díaz-UAM, Madrid, Spain
Background/Purpose: Adenosine, generated from the catabolism of adenine nucleotides, modulates cell function by interacting with specific cell-surface receptors (A1R, A2AR, A2BR, A3R). Inhibition of osteoclast…
Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting
Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis
Aurélie Najm^1,2, Benoît Le Goff MD PhD^2,3, Frédéric Blanchard¹, Jérome Amiaud⁴, Céline Charrier⁵ and Veit Krenn⁶, ¹INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁴UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁵UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁶Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany
Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
Abstract Number: 1941 • 2017 ACR/ARHP Annual Meeting
Microenvironmental and Systematic Evaluation of the Immunome in Osteoarthritis
Bhairav Paleja¹, Ying Ying Leung², Pavanish Kumar¹, Suzan Saidin¹, Ahmad Lajam², Liyun Lai¹ and Salvatore Albani¹, ¹SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²Singapore General Hospital, Singapore, Singapore
Background/Purpose: Osteoarthritis is the most common joint disease and involves whole joint, including degeneration of articular cartilage and surrounding tissues. Although widely prevalent, the exact…
Abstract Number: 1942 • 2017 ACR/ARHP Annual Meeting
CTLA4-Ig Directly Inhibits Osteoclast Generation from Human Peripheral Monocytes and Tumor Necrosis Factor α-Treated Inflammatory Monocytes
Katsuhiro Oi¹, Tadahiro Tokunaga¹, Tatsuomi Kuranobu¹, Yusuke Yoshida², Shintaro Hirata¹, Takaki Nojima³ and Eiji Sugiyama², ¹Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ²Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ³Clinical Immunology and Rheumatolog, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: CTLA-4 is a surface protein on T lymphocytes, which negatively regulates the co-stimulation process between antigen-presenting cells and T cells. CTLA-4 binds to monocytes…
Abstract Number: 1943 • 2017 ACR/ARHP Annual Meeting
Adipocytokines in an Osteoarthritis Mouse Model
Marie-Lisa Hülser¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Elena Neumann⁴ and Ulf Müller-Ladner⁵, ¹Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁴Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: In the Western society adiposity and metabolic syndrome are an increasing field of medical research. Both entities influence the expression of adipokines such as…
Abstract Number: 1944 • 2017 ACR/ARHP Annual Meeting
A Dual Role for IL-23 Receptor Signaling in Normal Bone Remodeling Versus Inflammation-Mediated Bone Damage during Arthritis
Wida Razawy¹, Marijke Koedam², Patrick Asmawidjaja³, Anne-Marie Otten-Mus⁴, Bram van der Eerden² and Erik Lubberts³, ¹Rheumatology and Immunology, Erasmus MC, Rotterdam, Netherlands, ²Internal Medicine, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: The interleukin (IL)-23/IL-17A immune pathway is critical for the development of autoimmune arthritis. Systemic exposure of IL-23 induced chronic arthritis, increased osteoclast differentiation and…
Abstract Number: 1945 • 2017 ACR/ARHP Annual Meeting
Repositioning Suramin As a Cartilage-Protective Drug
Laura-An Guns¹, Silvia Monteagudo¹, Maryna Kvasnytsia¹, Greet Kerckhofs¹, Jennifer Vandooren², Ghislain Opdenakker², Frederic Cailotto^1,3 and Rik Lories⁴, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rega Institute, KU Leuven, Leuven, Belgium, ³University of Lorraine, Nancy, France, ⁴Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Drug repositioning is a recent pharmaceutical strategy to discover new uses for market-approved drugs with known safety profiles that can provide quick transition from…

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