Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Methods: A total of 369 patients with RA and 160 healthy controls were followed up for 5 years or until deaths in a prospective KARRA cohort study (412 patients and 221 controls at baseline). To detect the presence and progression of carotid atherosclerosis, we performed carotid ultrasound at baseline and 5-year. We analyzed the incidence of CVD, conventional CV risk factors, RA disease activity and severity markers, medication histories, mortality rate, and causes of death.
Results: During 5-year follow-up period, the mortality rate was 5.8% (24/412) in RA patients and 0% in healthy controls (p<0.001), while the incidence of CVD were 6.1% (25/412) in RA patients and 0.5% (1/221) in healthy controls (p<0.001). Among CVD in RA patients, cerebrovascular accident (CVA) and cardiovascular event (CVE) were 8 (32%) and 17 (68%) events, respectively. Major causes of death included infection (11/24, 45.8%), CVD (6/24, 25%), and others (7/24, 29.2%). The mean age, presence and number of carotid plaques, functional class, modified Korean version of the HAQ (mKHAQ), tender joint count (TJC), swollen joint count (SJC), ESR and CRP, and conventional CV risk factors at baseline were significantly associated with mortality among RA patients. Multivariate logistic regression analysis showed that the presence of carotid plaque (OR 5.32 [95% CI 1.09-25.99; P = 0.039]), mKHAQ (OR 1.07 [95% CI 1.02-1.13; P = 0.007]), and ESR (OR 1.04 [95% CI 1.02-1.06; P < 0.001]) at baseline were independent risk factor for mortality of RA patients. In contrast, factors associated with new-onset CVD included the mean age, presence and number of carotid plaques, peak CRP, and conventional CV risk factors at baseline. Carotid plaque (OR 7.86 [95% CI 2.14-28.83; P = 0.002]) and two or more CV risk factors (OR 4.77 [95% CI 1.07-21.23; P = 0.040]) at baseline were independent predictive factors for new-onset CVD of RA patients in a multivariate logistic regression analysis.
To cite this abstract in AMA style:Eun JS, Lee ES, Kang JW, Kim NR, Kim JH, Kang JY, Nam EJ, Kang YM. Cardiovascular Diseases and Mortality Are Independently Influenced By Carotid Plaque Presence in Rheumatoid Arthritis: The 5-Year Prospective Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/cardiovascular-diseases-and-mortality-are-independently-influenced-by-carotid-plaque-presence-in-rheumatoid-arthritis-the-5-year-prospective-study/. Accessed April 2, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/cardiovascular-diseases-and-mortality-are-independently-influenced-by-carotid-plaque-presence-in-rheumatoid-arthritis-the-5-year-prospective-study/