Abstract Number: 844 • 2016 ACR/ARHP Annual Meeting
Bardoxolone Methyl Produces Durable Benefits in Participants with Pulmonary Arterial Hypertension: Data from an Open-Label Extension Study
Background/Purpose: Bardoxolone methyl (BARD), an activator of the transcription factor Nrf2, and inhibitor of NF-kB, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. In an initial…Abstract Number: 845 • 2016 ACR/ARHP Annual Meeting
Current Use of Off-Label Therapies in Systemic Sclerosis-Associated Interstitial Lung Disease
Background/Purpose: Systemic Sclerosis (SSc) is a connective tissue disease that is often complicated by secondary interstitial lung disease (SSc-ILD). Due to its high morbidity and…Abstract Number: 846 • 2016 ACR/ARHP Annual Meeting
Progression of Left Ventricular Myocardial Dysfunction in Systemic Sclerosis: Using Speckle Tracking Strain Echocardiography to Identify Patients at Risk
Background/Purpose: Cardiac involvement is a main cause of mortality in systemic sclerosis, although reported prevalence of cardiac involvement is low and detection of cardiac involvement…Abstract Number: 847 • 2016 ACR/ARHP Annual Meeting
Forced Vital Capacity Predicts Lung Fibrosis Progression and Mortality in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) carries high risk for progressive interstitial lung disease (ILD), but there are no valid methods for early detection of SSc-ILD or…Abstract Number: 848 • 2016 ACR/ARHP Annual Meeting
Efficacy of Prucalopride in the Treatment of Systemic Sclerosis-Related Intestinal Involvement: Results from an Open Label Cross-over Study
Background/Purpose: The gastrointestinal tract (GIT) is frequently affected in SSc patients as a consequence of a reduction in enteric propulsive forces. Due to intestinal involvement,…Abstract Number: 849 • 2016 ACR/ARHP Annual Meeting
Collagen Formation/Degradation Neoepitopes Are Promising Biomarkers for Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease with extensive fibrosis of the skin and internal organs in which extracellular matrix (ECM) remodeling is…Abstract Number: 850 • 2016 ACR/ARHP Annual Meeting
A Multicentre Reliability Study of Laser Speckle Contrast Imaging and Thermography in Patients with Raynaud’s Phenomenon Secondary to Systemic Sclerosis
Background/Purpose: Effective treatments for systemic sclerosis (SSc) related Raynaud’s phenomenon (RP) are badly needed but clinical trials have been hampered by the lack of objective…Abstract Number: 851 • 2016 ACR/ARHP Annual Meeting
Perioral Autologous FAT Transplantation Is More Effective THAN Hyaluronic Acid Filler on Scleroderma Skin Fibrosis: Results from a LONG TERM Controlled Study
Background/Purpose: Autologous fat tissue grafting (AFTG) has been successfully used in the treatment of different sclerotic conditions, including scleroderma. We evaluated in patients with SSc…Abstract Number: 852 • 2016 ACR/ARHP Annual Meeting
Targeting Fibroblastoid-like Cells By Drug Loaded Engineered Gold Nanoparticles As a Novel Approach for ILD-SSc Treatment
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune fibrotic disorder characterised by collagen and extracellular matrix deposition in the skin and internal organs, such as the…Abstract Number: 853 • 2016 ACR/ARHP Annual Meeting
Clinical Associations of Anti-Eukaryotic Initiation Factor 2B (anti-eIF2B) Antibodies in a Large Cohort of Patients with Anti-Nuclear Antibody Negative Systemic Sclerosis
Background/Purpose: Autoantibodies can be characterized in up to 95% of patients with systemic sclerosis (SSc) and provide enormous diagnostic and prognostic value in the clinical…Abstract Number: 854 • 2016 ACR/ARHP Annual Meeting
The Ducas: Proposal for a Digital Ulcer Assessment Score in Scleroderma
Background/Purpose: No objective measure is presently available to assess digital ulcer (DU) in SSc patients apart from “healed/non healed” and experience-based clinical judgment. The aim…Abstract Number: 855 • 2016 ACR/ARHP Annual Meeting
The Relationship Between Systemic Sclerosis and Breast Cancer and the Effects on Treatment Outcome
Background/Purpose: Breast cancer has been shown to be more prevalent in patients with systemic sclerosis (SSc) compared to that in the general population. A close…Abstract Number: 856 • 2016 ACR/ARHP Annual Meeting
Rho Kinase Ezpression in Giant Cell Arteritis: Validating Perm Intensity Score As a Method of Increasing Sensitivity of Temporal Artery Biopsy
Background/Purpose: Aberrant rho-kinase (ROCK) activity is implicated in pathogenesis of several vascular and immunologic disorders. We previously demonstrated evidence of increased ROCK activity in histopathologically…Abstract Number: 857 • 2016 ACR/ARHP Annual Meeting
Ultrasound Cut-Off Values for Intima-Media Thickness of Temporal, Facial and Axillary Arteries in Giant Cell Arteritis
Abstract Background/Purpose: Ultrasound (US) is increasingly used in the diagnosis of giant cell arteritis (GCA). US findings mainly rely on morphology (“halo-sign” and “compression sign”).…Abstract Number: 858 • 2016 ACR/ARHP Annual Meeting
Is There a Place for Repetitive 18f-Fluorodeoxyglucose Positron Emission Tomography in Giant-Cell Arteritis with Large-Vessel Involvement?
Background/Purpose: Positron emission tomography combined with computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) can be used to assess large-vessel inflammation in giant-cell arteritis (GCA) and has demonstrated…
ACR Meeting Abstracts