Abstracts Archive - Page 1469 of 2425 - ACR Meeting Abstracts

Abstract Number: 769 • 2016 ACR/ARHP Annual Meeting
Response to Belimumab in SLE Patients with High Disease Activity: Data from a Multicentric Clinical-Practice Based Study Cohort
Luca Iaccarino¹, Silvano Bettio², Rossella Reggia³, Giacomo Emmi⁴, Fulvia Ceccarelli⁵, Chiara Tani⁶, Maria Gerosa⁷, Marcello Govoni⁸, Alesandra Bortoluzzi⁹, Salvatore De Vita¹⁰, Ginevra De Marchi¹¹, Rossella De Angelis¹², Andrea Di Matteo¹², Carlo Salvarani¹³, Giulia Pazzola¹³, Elena Bartoloni-Bocci¹⁴, Laura Andreoli¹⁵, Margherita Zen¹⁶, Fabrizio Conti¹⁷, Marta Mosca⁶, Pier Luigi Meroni¹⁸, Roberto Gerli¹⁴, Angela Tincani¹⁹, Andrea Doria²⁰ and Lorenzo Emmi²¹, ¹Department of Medicine-DIMED, University of Padova, Padova, Italy, ²Rheumatology Unit, Univeristy of Padova, Padova, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁴Medical Pathology, Careggi University Hospital, Firenze, Italy, ⁵Sapienza University of Rome, Rome, Italy, ⁶Rheumatology Unit, University of Pisa, Pisa, Italy, ⁷University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ⁸Medical Sciences, UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, ⁹UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, ¹⁰Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital "Santa Maria della Misericordia", Udine, Italy, Udine, Italy, ¹¹Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, ¹²Polytechnic university of Marche, Rheumatologic Clinic, Iesi, Italy, ¹³Rheumatology Unit, Internal Medicine Department, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ¹⁴Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ¹⁵University of Brescia, Spedali Civili, Brescia, Italy, ¹⁶Division of Rheumatology, University of Padova, Padova, Italy, ¹⁷Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, ¹⁸Rheumatology Department, University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ¹⁹Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Italy, ²⁰Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, ²¹Internal Interdisciplinary Medicine Center for Autoimmune Systemic Diseases, Lupus Clinic,, Internal Interdisciplinary Medicine Center for Autoimmune Systemic Diseases, Lupus Clinic, AOU Careggi, Florence, Italy
Background/Purpose: To investigate effectiveness and identify predictors of response to belimumab in patients with active SLE in clinical practice setting. Methods: One hundred eighty eight…
Abstract Number: 770 • 2016 ACR/ARHP Annual Meeting
Introducing a Novel SLE-Specific IFN-I Inhibitor CNTO 6358: Laying the Groundwork for Precision Medicine in Lupus
Jarrat Jordan¹, Matteo Cesaroni¹, Jessica Schreiter¹, Chichi Huang², Tanesha Cash-Mason³, Marc Chevrier¹ and Jacqueline Benson¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Biologics Research, Janssen Research and Development, LLC., Spring House, PA, ³Cardiovascular and Metabolism Research, Janssen Research and Development, LLC., Spring House, PA
Background/Purpose: The type I interferon (IFN-I) family of cytokines signal through a ubiquitously expressed heterodimeric receptor (IFNAR) composed of IFNAR1 and the high-affinity binding chain…
Abstract Number: 771 • 2016 ACR/ARHP Annual Meeting
Preventive Effects of Glucocorticoids on Progression of Atherosclerosis in Japanese Patients with SLE
Hisaji Oshima¹, Masaki Iwasaki¹, Ikuko Tanaka², Misako Higashida³, Mari Ushikubo⁴, Eriko Takei⁵, Kumiko Akiya³ and Keisuke Izumi⁶, ¹Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ²NAGOYA Rheumatology Clinic, Nagoya, Japan, ³Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ⁴Department of Connective Tissue Disease, National Tokyo Medical Center, Tokyo, Japan, ⁵Connective tissue disease, National Tokyo Medical Center, Tokyo, Japan, ⁶Connective Tissue Dseases, National Tokyo Medical Center, Tokyo, Japan
Background/Purpose: Several cross-sectional studies have shown a progression of atherosclerosis in SLE was associated with activities of SLE but not with glucocorticoid therapy. However, a…
Abstract Number: 772 • 2016 ACR/ARHP Annual Meeting
Effect of HMG-CoA Reductase Inhibitor Drugs (Statins) on Systemic Lupus Erythematosus Disease Activity: A Systematic Review and Meta-Analysis
Givenchy Maree Garcia, Annalyn Urbano and Evelyn Salido, Section of Rheumatology, University of the Philippines - Philippine General Hospital, Manila, Philippines
Background/Purpose: Statins have been shown to have anti-inflammatory and immunomodulatory effects. In vitro studies show that these drugs inhibit inflammatory cells, decrease the expression of…
Abstract Number: 773 • 2016 ACR/ARHP Annual Meeting
Risk Factors for Severe Infections in Rituximab Treated Patients: Comparison of Systemic Lupus Erythematosus and Inflammatory Myositis
Cristiane Medeiros¹, Luciana Seguro², Fernando Henrique Carlos de Souza², Nadia E Aikawa³ and Eloisa Bonfa⁴, ¹Rheumatology, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ²Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Pediatric Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
Background/Purpose: The use of Rituximab (RTX) in patients with autoimmune diseases has been associated with an increased incidence of infection and risk factors for this…
Abstract Number: 774 • 2016 ACR/ARHP Annual Meeting
BIIB059, an Anti-BDCA2 Monoclonal Antibody, Demonstrates Acceptable Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamic (PD) Effects in a Phase 1 Study with Single Ascending Doses (SAD) in Healthy Volunteers
David Martin, Lauren Stevenson, Pratapa Prasad, Karen Smirnakis, Amy Kao, Dania Rabah, Wenting Wang and Nathalie Franchimont, Biogen, Cambridge, MA
Background/Purpose: Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes stimulate plasmacytoid dendritic cells (pDCs) to…
Abstract Number: 775 • 2016 ACR/ARHP Annual Meeting
Evaluation of Use of Belimumab in Clinical Practice Settings: Results in Argentina
Alejandra Babini¹, Mercedes Argentina García², Juan Carlos Barreira³, Bernado Pons-Estel⁴, Melitza Iglesias⁵ and Gabriela Streger⁶, ¹Hospital Italiano de Cordoba, Cordoba, Argentina, ²Rheumatology Unit, HIGA San Martín La Plata, La Plata, Argentina, ³Hospital Britanico, Buenos Aires, Argentina, ⁴Sanatorio Parque, Rosario, Argentina, ⁵Medical Affairs, GlaxoSimthKline, Philadelphia, PA, ⁶Direccion Medica, GlaxoSmithKline, Buenos Aires, Argentina
Background/Purpose: Studying clinical effectiveness of belimumab treatment in real world clinical practice of Systemic Lupus Erythematosus (SLE) is relevant in assessing external validity of randomized…
Abstract Number: 776 • 2016 ACR/ARHP Annual Meeting
Eurolupus and Low Steroid Regimen in Proliferative Lupus Nephritis: Retrospective Evaluation of 38 Patients in the Black Population of Martinique
Charles Cartou¹, Katlyne Polomat², Florence MOINET², Serge ARFI³, Lauren Brunier-Agot⁴, Marie Blattery⁵, Aymeric Couturier⁶, Georges JEAN BAPTISTE⁷, Michel De Bandt⁸ and Christophe Deligny⁹, ¹nephrology, Pierre Zobda Quitman Hospital, Fort de France, Martinique, ²Rheumatology and Internal Medicine, Zobda Quitman Hospital, Fort de France, Martinique, ³University Hospital, CHU Fort de France, Fort de France, Martinique, ⁴Internal medicine and rheumatology, Zobda Quitman Hospital, Fort de France, Martinique, ⁵rheumatology, Pierre Zobda Quitman hospital, Fort de France, Martinique, ⁶nephrology, Pierre Zobda Quitman hospital, Fort de France, Martinique, ⁷RHEUMATOLOGY, CHU MARTINIQUE, FWI, Fort-de-France, Martinique, ⁸CHU Fort de France, Fort de France, France, ⁹Zobda Quitman Hospital, Rheumatology and Internal Medicine, Fort de France, Martinique
Background/Purpose: There is no data on the efficacy of the EUROLUPUS regimen associated with initial low steroids daily dose in African descent patients with proliferative…
Abstract Number: 777 • 2016 ACR/ARHP Annual Meeting
a Singlecenter Experience of Rituximab Treatment in 86 Patients with Systemic Lupus Erythematosus
Bahar Artim-Esen¹, Bahtiyar Toz¹, Burak Erer¹, Sevil Kamali¹, Ahmet Gul¹, Lale Ocal² and Murat Inanc³, ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Istanbul Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey, ³Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, İstanbul, Turkey
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical and serological manifestations. B-cell-targeted therapies have been promising new treatments for SLE.…
Abstract Number: 778 • 2016 ACR/ARHP Annual Meeting
WITHDRAWN
Abstract Number: 779 • 2016 ACR/ARHP Annual Meeting
Factors Determining Hydroxychloroquine Serum Levels in a Cohort of Chinese Patients with Systemic Lupus Erythematosus
Chi Chiu Mok¹, Ling Yin Ho² and Paul Jannetto³, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong, ³Director, Toxicology and Drug Monitoring Laboratory, Mayo Clinic, Rochester, MN
Background/Purpose: To study the factors determining the hydroxychloroquine (HCQ) serum concentration in a cohort of Chinese patients with systemic lupus erythematosus (SLE). Methods: Consecutive patients…
Abstract Number: 780 • 2016 ACR/ARHP Annual Meeting
Belimumab Use in African-American Patients in an U.S. Academic Medical Center
Paloma Alejandro¹, Anjani Pillarisetty² and Christopher E. Collins³, ¹Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ²Internal Medicine, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ³MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC
Background/Purpose: Belimumab is an anti-BAFF monoclonal antibody approved for the treatment of auto-antibody positive patients with SLE. In two large phase 3 clinical trials, belimumab…
Abstract Number: 781 • 2016 ACR/ARHP Annual Meeting
The Use of Rituximab in Newly Diagnosed Systemic Lupus Erythematosus Patients: Long Term Steroid Saving Capacity and Clinical Effectiveness
Borja del Carmelo Gracia Tello Sr.¹, David A. Isenberg² and Amara Ezeonyeji³, ¹Internal Medicina, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Zaragoza, Spain, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ³Rheumatology, University College of London Hospital, London, London, United Kingdom
Background/Purpose: To assess the long term steroid saving capacity and clinical effectiveness of B-cell depletion therapy (BCDT) in newly diagnosed SLE patients. Methods: Sixteen female…
Abstract Number: 782 • 2016 ACR/ARHP Annual Meeting
Can We Identify Who Benefits from Mycophenolate Mofetil in Systemic Lupus Erythematosus? a Systematic Review
Claudia Mendoza Pinto^1,2, Carmelo Pirone³, Ben Parker⁴ and Ian N. Bruce⁵, ¹Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR, IMSS, Puebla, Mexico, ²Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ³Rheumatology Unit, Sapienza University of Rome, Department of Internal Medicine and Medical Specialties,, Rome, Italy, ⁴Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁵Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Background/Purpose: Mycophenolate mofetil (MMF) is widely used in the treatment of SLE however little is known about factors that may predict response or other outcomes…
Abstract Number: 783 • 2016 ACR/ARHP Annual Meeting
Review of SLE Cohort to Identify Predictors of Response to B Cell Depletion in Patients with Active SLE
Pedro Mota¹, Ashleigh Hennessey², Ada Ferenkeh-Koroma² and David A. Isenberg², ¹Internal Medicine, Hospital da Luz, Lisbon, Portugal, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: The use of Rituximab (RTX) has been documented via published cohort data from over 20 sites worldwide (1,2) demonstrating its useful role in the…

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