Session Information
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose:
Some studies point to a differential clinical expression between men and women with PsA, but the information on gender differences is very scarce in the earliest stages of the disease. We aimed to describe the baseline characteristics and impact of disease among men and women included in the REAPSER (Recent-Onset PsA Registry of the Spanish Society of Rheumatology) cohort.
.
Methods:
REAPSER is an observational, multicenter study, with consecutive recruitment, that included adults of both sexes aged 18 yr or older that met CASPAR criteria for PsA, and had duration of less than two years since the appearance of symptoms attributed to PsA (recent-onset PsA). Annual follow-up visits will be carried out for 5 years. Measurements include socio-demographic data, employment status and impact of the disease, family history of PsA and other inflammatory diseases, comorbidities, lifestyle, use of health services, clinical status at disease presentation, anthropometric data, clinical evaluation of PsA manifestations, radiographic progression, analytical determinations, and treatment of the disease. The study has been approved by the ethical committees of the participating centers.
We have analyzed these aspects among men and women, with special emphasis on the perceived impact of the disease between both sexes. Descriptive statistic included central measures with dispersion values. Qualitative variables were compared by Chi-square and Fisher´s exact test. The normal quantitative variables were compared by a Student’s T test and the non-normal quantitative ones by non-parametric tests.
Results:
|
Parameter |
Men. N: 142 |
Women. N: 68 |
p-values |
|
Age (years) University studies Active worker BMI Waist-hip index Smoker Alcohol consumption Psoriasis family history PsA family history Charlson´s CI (> 3) Depression Common Psoriasis Pustular Psoriasis No psoriasis Onicopathy PASI Peripheral pattern Axial pattern Mixed Pattern TJC68 SJC66 BASDAI (0-10) BASFI (0-10) Dactylitis ESR (mm/h) |
50.2 (13.8) 18.3% 65% 27.3 (4.8) 0.94 (0.1) 29.6% 45.1% 40.1% 8.5% 18.3% 7.7% 81% 2.1% 8.5% 59% 1.5 (0.6-4.4) 80.3% 7% 12.7% 4 (2-7.2) 2 (1-4) 4.1 (2.2-6) 1.8 (0.4-4.5) 31.4% 12 (5-20) |
49.6 (14.1) 16.2% 49.3% 28.5 (6) 0.87 (0.1) 32.4% 16.2% 45.6% 10.3% 17.6% 19.4% 61.8% 11.8% 19.1% 49% 1.2 (0.6-3) 83.8% 1.5% 14.7% 4 (2-8) 2 (0-5) 4.8 (2.4-7.3) 2.9 (1.4-4.7) 47.1% 21 (10-29.5) |
NS NS <0.001 NS <0.001 NS <0.001 NS NS NS 0.014 0.003 0.006 0.027 NS NS NS NS NS NS NS 0.008 0.065 0.028 0.001 |
CI: comorbidity index. PASI: Psoriasis Area and Severity Index. Data are expressed in percentages, mean with SD (Standard Deviation), median and IQR (Interquartile Range)
|
PROs |
Men N: 142 |
Women N: 68 |
p-values |
|
Pain VAS Pat. global disease activity PsAID HAQ |
4 (2-7) 5 (3-7) 3.1 (1.5-6.1) 0.4 (0-1) |
6 (4-7) 6 (3-8) 4.2 (2.3-6) 0.8 (0.4-1) |
0.025 0.042 0.063 0.010 |
Values are expressed as median (IQR). PROs: Patient Reported Outcomes. Pat: patient. PsAID: Psoriatic Arthritis Impact of Disease. HAQ: Health Assessment Questionnaire.
Conclusion:
Female scored higher in several PROs compared to male. Thus the perception of having a severe disease is higher in female. This information could be of help for improving medical care for women with PsA.
To cite this abstract in AMA style:
Queiro R, Laiz A, Montilla-Morales CA, Galindez-Agirregoikoa E, Bethencourt JJ, Seoane D. The Perceived Impact of Recent-Onset Psoriatic Arthritis Is Different between Genders: A Spanish Multicenter Experience [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/the-perceived-impact-of-recent-onset-psoriatic-arthritis-is-different-between-genders-a-spanish-multicenter-experience/. Accessed .« Back to 2017 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-perceived-impact-of-recent-onset-psoriatic-arthritis-is-different-between-genders-a-spanish-multicenter-experience/