Abstract Number: 664 • 2016 ACR/ARHP Annual Meeting
Regulation of Interferon Signaling By a Calcium-Induced miRNA in Primary Human Salivary Gland Epithelial Cells
Background/Purpose: Sjögren's syndrome (SS), an autoimmune disease that targets the salivary and lacrimal glands which causes dry eyes (xerophthalmia) and dry mouth (xerostomia) phenotypes. In…Abstract Number: 665 • 2016 ACR/ARHP Annual Meeting
Salivary Gland Secretome: A Novel Tool to Identify Biomarkers of Dryness and Immunopathology in Primary Sjogren’s Syndrome and Non-Autoimmune Sicca Patients
Background/Purpose: Salivary gland biopsy is essential in primary Sjögren’s syndrome (pSS) diagnostics. However, tissue analysis using the traditional method has several limitations including inaccuracy of quantification of lymphocytic infiltration and poor correlation with dryness.…Abstract Number: 666 • 2016 ACR/ARHP Annual Meeting
Immunoglobulin N-Glycosylation Acquired By Somatic Hypermutation As a Potential Mechanism for Non-Specific B Cell Activation in Sjogren’s Syndrome
Background/Purpose: Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands resulting in tissue destruction, pathological dry…Abstract Number: 667 • 2016 ACR/ARHP Annual Meeting
Cytokine and Chemokine Levels in Serum and Saliva As Disease Activity Biomarkers in Patients with Primary Sjögren’s Syndrome
Background/Purpose: Background Evidence suggests that levels of different cytokines in primary Sjögren's syndrome (pSS) are associated with cell infiltration degree within salivary and lacrimal glands…Abstract Number: 668 • 2016 ACR/ARHP Annual Meeting
The TNFAIP3 F127C Coding Variation in Sjogren’s Syndrome: Results from a Greek Cohort
Background/Purpose: TNFAIP3 gene encodes the A20 protein which is an important negative feedback regulator of the NF-κB pathway. A coding TNFAIP3 polymorphism, namely rs2230926, has…Abstract Number: 669 • 2016 ACR/ARHP Annual Meeting
RNA-Sequencing Reveals Sjogren’s Syndrome Anti-Ro Negative Patients Share Similar Pathways to Multiple Sclerosis Patients
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by autoantibodies to Ro and/or La proteins and lymphocytic infiltration into exocrine glands. Multiple sclerosis (MS)…Abstract Number: 670 • 2016 ACR/ARHP Annual Meeting
Identification and Characterization of Sjogren’s Syndrome-Associated Genetic Variants in the IL12A and DDX6-CXCR5 Loci
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune-mediated disease with hallmark features of dry eyes/mouth and autoantibodies. Genetic susceptibility to SS involves many loci, including the…Abstract Number: 671 • 2016 ACR/ARHP Annual Meeting
Steered Screening for Sjögren Syndrome in Patients with Sicca Syndrome. Role of Salival Beta-2 Microglogulin
Background/Purpose: Sicca Syndrome patients represent a diagnostic challenge for the wide variety of etiologies that can afford it. Beta-2 Microglogulin (B2MG) is a non-glycosylated protein,…Abstract Number: 672 • 2016 ACR/ARHP Annual Meeting
Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)
Background/Purpose: To analyse the influence of geolocation (North-to-South gradient) on the clinical presentation of primary Sjögren syndrome (SjS) at diagnosis. Methods: The Big Data Sjögren…Abstract Number: 673 • 2016 ACR/ARHP Annual Meeting
Sjögren’s Syndrome (SS): The Role of Traditional (SS-A/SS-B) and Novel Antibodies in Diagnosis
Background/Purpose: Diagnosing SS is often challenging, particularly distinguishing patients with primary SS from xerostomia and xerophthalmia (sicca). Recently, an IL-14 transgenic murine model led to…Abstract Number: 674 • 2016 ACR/ARHP Annual Meeting
Targeting Glandular IL-21-Production in Primary Sjogren′s Syndrome Patients By Immunomodulatory Treatment
Background/Purpose: Interleukin-21 plays a central role in plasma cell differentiation and germinal center (GC) formation and is likely involved in the pathogenesis of primary Sjögren’s…Abstract Number: 675 • 2016 ACR/ARHP Annual Meeting
Association Between Structural Lesions in the Sacroiliac Joints and Spinal Inflammatory Lesions in Patients with Non-Radiographic Axial Spondyloarthritis
Background/Purpose: The relevance of structural lesions in non-radiographic axial SpA (nr-axSpA) is unclear, particularly without signs of MRI inflammation. In a post hoc analysis we…Abstract Number: 676 • 2016 ACR/ARHP Annual Meeting
Syndesmophytes in the Thoracic Spine in Ankylosing Spondylitis As Detected By Computed Tomography and Association with Lumbar Radiographic Involvement
Background/Purpose: Because the thoracic spine has traditionally been excluded from radiographic examinations of spinal damage in ankylosing spondylitis (AS) due to poor visualization, little is…Abstract Number: 677 • 2016 ACR/ARHP Annual Meeting
Low Functional Relevance of Radiographic Spinal Progression in Patients with Early Axial Spondyloarthritis
Background/Purpose: It has been shown in the past that radiographic spinal progression is an important determinant of the functional outcome in patients with advanced axial…Abstract Number: 678 • 2016 ACR/ARHP Annual Meeting
Additional Information from CT or MRI Imaging Can Increase Rheumatologists’ Consensus on Grading Sacroiliitis By Radiography: Results of the Trimage Project
Background/Purpose: The diagnosis of ankylosing spondylitis (AS) is anchored on definitive changes of sacroiliits by radiography. This is relevant not only to clinical diagnosis, but…
ACR Meeting Abstracts