Abstract Number: 451 • 2016 ACR/ARHP Annual Meeting
Cross-Sectional and Longitudinal Construct Validity for the Improved Health Assessment Questionnaire Among Adults with Knee Osteoarthritis
Background/Purpose: The improved Health Assessment Questionnaire (iHAQ) is a novel version of the HAQ (ACR-recommended metric of physical function for RA) based on Item…Abstract Number: 452 • 2016 ACR/ARHP Annual Meeting
The Efficacy of Motivational Counselling and SMS-Reminders on Daily Sitting Time in Patients with Rheumatoid Arthritis: A Randomised Controlled Trial
Background/Purpose: Patients with rheumatoid arthritis (RA) are more sedentary than the general population, which can have serious health consequences. Reducing sedentary behaviour (SB) and increasing…Abstract Number: 453 • 2016 ACR/ARHP Annual Meeting
Adaptation and Validation the Systemic Sclerosis Quality of Life Questionnaire into Spanish Using Rasch Analysis
Background/Purpose: Systemic Sclerosis (SSc) represents a group of heterogeneous autoimmune disorders of connective tissue characterized by progressive fibrosis of the skin and internal organs [1].…Abstract Number: 455 • 2016 ACR/ARHP Annual Meeting
Validity, Reliability and Sensitivity to Change of Four Different Patient-Reported Outcomes (PROs) to Measure the Domains Pain, Fatigue, Experienced Disease Activity and General Well-Being in Patients with Rheumatoid Arthritis
Background/Purpose: With Patient-Reported Outcomes (PROs), the patient's perspective can be assessed. Several forms can be used; Verbal Rating Scale (VRS), Numerical Rating Scale (NRS), Visual…Abstract Number: 456 • 2016 ACR/ARHP Annual Meeting
Patient Engagement in Research: Understanding Patient Interest and Needs
Background/Purpose: The goal of clinical and health-related research is to benefit the end-consumer—the patient. Since patients are the experts on their unique experiences living with…Abstract Number: 457 • 2016 ACR/ARHP Annual Meeting
Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis
Background/Purpose: Checkpoints and mechanisms regulating the onset of rheumatoid arthritis (RA) remain largely elusive. Apart from B cells and auto-antibodies, Th17 cells were shown to…Abstract Number: 458 • 2016 ACR/ARHP Annual Meeting
The TAM Receptors Axl and Mer Play a Protective Role in a Temporal and Spatial Manner in Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in selective, anatomically distinct synovial joints. The innate immune system…Abstract Number: 459 • 2016 ACR/ARHP Annual Meeting
Resident Non-Classical Monocytes Are Critically Important for Tissue Destruction in Arthritis
Background/Purpose: Bone destruction in rheumatoid arthritis is mediated by osteoclasts, which are derived from precursor cells of the myeloid lineage. Although there is much known…Abstract Number: 460 • 2016 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Demonstrates Anti-Inflammatory Effect in Autoimmune Disease Models
Background/Purpose: Bruton’s Tyrosine Kinase (BTK), a non-receptor tyrosine kinase is involved in intracellular signaling pathways downstream of several receptors, including the B cell receptor (BCR),…Abstract Number: 461 • 2016 ACR/ARHP Annual Meeting
Involvement of CD163-Positive Macrophages in the Pathogenesis of Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Synovium of a Murine Model
Background/Purpose: Synovial-lining macrophages play a crucial role in the onset and maintenance of joint inflammation in arthritis. CD68 and CD163 are commonly used markers of…Abstract Number: 462 • 2016 ACR/ARHP Annual Meeting
Selective Inhibition of MMP9 Using a Monoclonal Antibody As a Therapeutic Strategy for Rheumatoid Arthritis
Background/Purpose: Matrix metalloproteinase-9 (MMP9), highly expressed by infiltrating inflammatory cells, pannus tissue, and multinucleated cells in the synovium and subchondral bone tissue, including osteoclasts, participates…Abstract Number: 463 • 2016 ACR/ARHP Annual Meeting
Deficiency of Transmembrane Protein VISTA (V-domain Immunoglobulin Suppressor of T-cell Activation) Ameliorates Murine Collagen-II Antibody-Induced Arthritis
Background/Purpose: The transmembrane protein VISTA, is a member of the B7/CD28 family of immune modulator proteins and can function as a negative immune checkpoint regulator…Abstract Number: 464 • 2016 ACR/ARHP Annual Meeting
an Anti-Fima Antibody Attenuates Porphyromonas Gingivalis-Associated Experimental Arthritis
Background/Purpose: Evidence suggests that periodontal infection by Porphyromonas gingivalis(Pg) exacerbates rheumatoid arthritis (RA); however, the underlying mechanisms remain unknown. Here, we examined the pathogenic and therapeutic…Abstract Number: 465 • 2016 ACR/ARHP Annual Meeting
Genetic and Metabolic Signatures of Purified Synovial Macrophage Subsets during an Acute Murine Model of Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Macrophages have been implicated in…Abstract Number: 466 • 2016 ACR/ARHP Annual Meeting
Sexually Dimorphic Dysbiosis of Gut Microbiota in Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis
Background/Purpose: Recent studies identify gut microbiota dysbiosis as a possible contributor to rheumatoid arthritis (RA) pathogenesis. RA patients have significantly different microbiomes than healthy controls.…
ACR Meeting Abstracts