Abstracts Archive - Page 1399 of 2607 - ACR Meeting Abstracts

Abstract Number: 175 • 2017 ACR/ARHP Annual Meeting
Precisely Controlled Differential Gene Expression System to Investigate the Effect of eQTL
Xiaoming Lu, PhD^1,2, Xiaoting Chen¹, Carmy Forney¹, Connor Schroeder¹, John B. Harley¹, Matthew Weirauch³ and Leah C. Kottyan⁴, ¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Immunobiology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Genome-wide association studies and large-scale sequencing studies identify many non-coding genetic variants that increase disease risk. At least 60% of these loci have been…
Abstract Number: 176 • 2017 ACR/ARHP Annual Meeting
SEC16A and Antigen Presentation Abnormalities in the Pathogenesis of Axial Spondyloarthritis
Fanxing Zeng¹, Vidya Ranganathan², Proton Rahman³, Darren O’Rielly⁴ and Nigil Haroon⁵, ¹University Health Network, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ⁴Memorial University, St John's, NF, Canada, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory rheumatic disease of axial skeleton. Our group recently identified a novel rare mutation of the SEC16A gene…
Abstract Number: 177 • 2017 ACR/ARHP Annual Meeting
Intronic Variants of the B-Cell Proliferator RASGRP3 Affect Its Expression, and Might Contribute to Lupus Risk
Bhupinder Singh¹, Philip Borden², Julio Molineros³, Celi Sun³, Loren Looger² and Swapan Nath¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, OKlahoma City, OK, ²Howard Hughes Medical Institute, Ashburn, VA, ³Oklahoma Medical Research Foundation, OKlahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease with complex genetic underpinnings. Variants from RASGRP3 (RAS Guanyl Releasing Protein 3) is one of…
Abstract Number: 178 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population
Maria Teruel¹, Patrick Coit², Mikhail Dozmorov³, Mario Cardiel⁴, Ignacio Garcia-De La Torre⁵, Marco A Maradiaga-Ceceña Sr.⁶, José Francisco Moctezuma⁷, Maria Teresa Tusié-Luna⁸, Marta Alarcón-Riquelme^9,10 and Amr H Sawalha², ¹GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁶Hospital General de Culiacán, Culiacán, Mexico, ⁷Servicio de Reumatología, Hospital General de Mexico, Ciudad de Mexico, Mexico, ⁸Medicina Genómica y Toxicología Ambiental, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico, ⁹Uppsala University, Uppsala, Sweden, ¹⁰Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose: Our knowledge about the pivotal role DNA methylation plays in the pathogenesis of SLE has significantly increased in the last few years. However, we…
Abstract Number: 179 • 2017 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging of Synovium: A Novel Approach to Classify the Rheumatoid and Psoriatic Arthritis Patients
Beatriz Rocha^1,2, Berta Cillero-Pastor³, Gert Eijkel³, Lennart R. Huizing³, Cristina Ruiz-Romero^1,4, Andrea Cuervo^5,6, Ron M A Heeren³, Juan D. Cañete^5,6 and Francisco J Blanco^1,6, ¹Rheumatology Division, ProteoRed/ISCIII Proteomics Group, INIBIC - Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Spain, ²The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Masstricht, Netherlands, ³The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Maastricht, Netherlands, ⁴CIBER-BBN Instituto de Salud Carlos III, INIBIC-CHUAC, A Coruña, Spain., A Coruña, Spain, ⁵Arthritis Unit, Rheumatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁶RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain
Background/Purpose: Psoriatic arthritis (PsA) and Rheumatoid arthritis (RA) are immune-mediated chronic inflammatory diseases. Synovial membrane is the initial site of inflammation in PsA and RA…
Abstract Number: 180 • 2017 ACR/ARHP Annual Meeting
Identification of a Functional Susceptible Variant in Distal Enhancer of Mir-146a By CRISPR-Cas9
Guojun Hou¹, Jing Zeng², Yuanjia Tang³ and Nan Shen^4,5, ¹Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) &Shanghai Jiao Tong University School of Medicine (SJTUSM), ShangHai, China, ²Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ⁵The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose: The majority of trait-associated SNPs occur in noncoding regions and are enriched in enhancers. GWAS have identified numerous genetic variants associated with Systemic Lupus…
Abstract Number: 181 • 2017 ACR/ARHP Annual Meeting
Identification of Disease-Susceptible Lncrna Contributed to Abnormal Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus
Nan Shen^1,2, Yuanjia Tang³, Zhixin Xue³ and Chaojie Cui⁴, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH, ³Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Dysregulation or dysfunction of some key moleculars in signaling pathway is involved in disease pathogenesis. Long non-coding RNA (lncRNA), as a regulator of gene…
Abstract Number: 182 • 2017 ACR/ARHP Annual Meeting
Genetic Determinants of Fatigue in Primary Sjögren`s Syndrome – a Genome Wide Association Study
Katrine Norheim¹, Andrei Alexsson², Juliana Imgenberg-Kreuz³, Johan Gorgas Brun^4,5, Roland Jonsson⁶, Wan-Fai Ng^7,8, Elke Theander⁹, Thomas Mandl¹⁰, Kathy L. Sivils¹¹, Lars Rönnblom¹², Gunnel Nordmark¹³ and Roald Omdal^5,14, ¹Clinical Immunology Department, Stavanger University Hospital, Stavanger, Norway, ²Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ³Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁴Section for Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, ⁵Department of Clinical Science, University of Bergen, Bergen, Norway, ⁶Department of Clinical Science, Broegelmann Research Laboratory, University of Bergen, Bergen, Norway, ⁷Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ⁸Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ⁹Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, ¹⁰Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, ¹¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ¹³Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ¹⁴Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Fatigue is common in primary Sjögren`s syndrome (pSS), but the mechanisms that lead to fatigue are not fully understood. We hypothesized that there is…
Abstract Number: 183 • 2017 ACR/ARHP Annual Meeting
Allele-Dependent Binding of a Viral Protein to Autoimmune Disease-Associated Genetic Variants
Matthew Weirauch¹, Daniel Miller², Leah C. Kottyan³, Ignacio Ibarra⁴, Arthur Lynch², Sayeed Syed⁵, Xiaoting Chen², Erin Zoller², Connor Schroeder², Josh Lee², Albert Magnusen⁶, Ally Yang⁷, Timothy R. Hughes⁷, Joo-Seop Park⁸, Charles Vinson⁵ and John B. Harley^2,9, ¹Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, ⁵NCI, Bethesda, MD, ⁶Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷University of Toronto, Toronto, ON, Canada, ⁸Divisions of Urology and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Risk factors are known for many diseases, but the etiologies of most autoimmune diseases remain unknown and are idiopathic. Pathogenesis of disease likely involves…
Abstract Number: 184 • 2017 ACR/ARHP Annual Meeting
An Epigenome-Guided Approach to Causal Variant Discovery in Autoimmune Disease
Richard C. Pelikan¹, Jennifer A. Kelly², Yao Fu², Caleb Lareau³, Graham B. Wiley¹, Stuart Glenn¹, Martin Aryee^3,4, Courtney Montgomery⁵ and Patrick Gaffney², ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Biostatistics, Harvard T.H. Chan School of Public Health, Charlestown, MA, ⁴Department of Pathology, Harvard Medical School, Boston, MA, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Genome-wide association studies have identified thousands of genetic associations with complex human diseases and traits. However, establishing the truly causal regions of risk haplotypes…
Abstract Number: 185 • 2017 ACR/ARHP Annual Meeting
Effect of Pre-Appointment Consult Triage on Patient Selection and Revenue Generation in a University Rheumatology Practice
Sterling West¹, Duane Pearson¹, Christopher C. Striebich², Ryan Goecker¹ and Jason Kolfenbach¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rhuematology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Academic hospital leadership puts a priority on all patients (pts) having access to subspecialists. Often the demand for rheumatology consultation exceeds the ability to…
Abstract Number: 186 • 2017 ACR/ARHP Annual Meeting
Paediatric Musculoskeletal (MSK) Triage in the Community – Rightpath – a Pilot Study
Nicola Smith¹, Sharmila Jandial², Jill Firth³, Helen Light³, Katharine Kinsey³, Neil Snowden³, Judith McNaught⁴, Tim Rapley⁵, Alan Nye³ and Helen E. Foster⁶, ¹Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, ²Paediatric Rheumatology, Great North Children’s Hospital, Newcastle Upon Tyne, United Kingdom, ³Pennine MSK Partnership Ltd, Oldham, United Kingdom, ⁴Physiotherapy, South Tyneside NHS Foundation Trust, South Shields, United Kingdom, ⁵Institute of Health and Society, Newcastle University, Newcastle Upon Tyne, United Kingdom, ⁶Institute of Cellular Medicine and Paediatric Rheumatology, Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom
Background/Purpose: We are piloting a children and young people (CYP) community-based triage (called Rightpath) based on a validated adult MSK triage model developed by Pennine…
Abstract Number: 187 • 2017 ACR/ARHP Annual Meeting
Improved Identification of Pseudogout in Electronic Medical Records By Adding Text String Searching to a Billing Code Algorithm
Sara K. Tedeschi, Kazuki Yoshida and Daniel H. Solomon, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) has a spectrum of manifestations, of which pseudogout is the most acute inflammatory phenotype. To facilitate clinical research on…
Abstract Number: 188 • 2017 ACR/ARHP Annual Meeting
Lupus Low Disease Activity State Is Associated with Reduced Direct Medical Costs in Patients with Systemic Lupus Erythematosus
Ai Li Yeo¹, Rachel Koelmeyer², Rangi Kandane-Rathnayake¹, Vera Golder², Alberta Y. Hoi², Edward R. Hammond³, Henk Nab⁴, Molla Huq⁵, Mandana Nikpour⁶ and Eric F Morand⁷, ¹Rheumatology, Monash University, Melbourne, Australia, ²Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ³AstraZeneca, Gaithersburg, MD, ⁴AstraZeneca, Cambridge, United Kingdom, ⁵Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ⁶Melbourne University, Melbourne, Australia, ⁷Monash University, Melbourne, Australia
Background/Purpose: High health care utilization and direct costs have been documented in multiple studies of SLE. The recently described lupus low disease activity state (LLDAS)…
Abstract Number: 189 • 2017 ACR/ARHP Annual Meeting
Challenges and Opportunities of Implementing a Patient-Reported Measure of Physical Function through an Online Electronic Health Record Patient Portal in Routine Rheumatology Practice
Jing Li¹, Jinoos Yazdany², Laura Trupin², Zara Izadi³, Milena Gianfrancesco¹, Sarah Goglin¹ and Gabriela Schmajuk⁴, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA
Background/Purpose: Despite significant interest in the collection of patient-reported outcomes (PROs) to make care more patient-centered, few studies have evaluated implementation efforts to collect PROs…

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