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  • Abstract Number: 2907 • 2018 ACR/ARHP Annual Meeting

    Comparison of the Joints Ultrasonography in the Patients with Rheumatoid Arthritis Treated By Biological Agents and the Corresponding Synovial Histological Findings

    Asami Abe1, Hajime Ishikawa2 and Kunihiko Wakaki3, 1Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 2Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 3Pathology, Niigata Prefectural Shibata Hospital, Shibata, Japan

    Comparison of the joints ultrasonography in the patients with rheumatoid arthritis treated by biological agents and the corresponding synovial histological findings Background/Purpose: In the treatment…
  • Abstract Number: 2908 • 2018 ACR/ARHP Annual Meeting

    Agreement between Ultrasound and Whole Body Magnetic Resonance Imaging Assessment of Joint Inflammation and Enthesitis in Rheumatoid Arthritis Patients

    Sin Ngai Ng1, Mette Bjørndal Axelsen2, Mikkel Østergaard3, Iris Eshed4, Merete Lund Hetland2, Jakob M. Møller5, Susanne J Pedersen6,7 and Lene Terslev8, 1Medicine, Queen Elizabeth Hospital , Hong Kong, Hong Kong, Hong Kong, 2Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 3Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 4Department of Radiology, Sheba Medical Center, Israel, Tel Hashomer, Israel, 5Dept. of Radiology, Copenhagen University Hospitals, Herlev and Gentofte, Copenhagen, Denmark, 6Depart of Rheumatology VRR, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, 7Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 8Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark

    Background/Purpose: To evaluate the agreement between ultrasound (US), whole body magnetic resonance imaging (WBMRI) and clinical assessment of joint inflammation and enthesitis in rheumatoid arthritis…
  • Abstract Number: 2909 • 2018 ACR/ARHP Annual Meeting

    Diagnostic and Prognostic Value of Ultrasound Compared with Plain Radiography in Knee Osteoarthritis

    Annie Yang1, Fernando Bomfim2, Kristen Lee2, Mukundan Attur3, Steven B. Abramson4 and Jonathan Samuels5, 1Department of Medicine, NYU Langone Health, New York, NY, 2NYU Langone Health, New York, NY, 3Rheumatology, NYU Langone Health, New York, NY, 4Dept of Medicine, NYU Langone Health, New York, NY, 5Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY

    Background/Purpose: Plain radiography of knee osteoarthritis (OA) has inherent diagnostic and prognostic limitations, especially in early disease.  Ultrasound (US) examination sheds light on disease activity…
  • Abstract Number: 2910 • 2018 ACR/ARHP Annual Meeting

    Development of a Rheumatoid Arthritis Global Outcome Measure to Enable Comparisons of Patient Experiences across Treatment Arms in Randomized Clinical Trials

    Liana Fraenkel1, W. Benjamin Nowell2, Carole Wiedmeyer2, Zhenglin Wei3, Kaleb Michaud4, Tuhina Neogi5, Christine Ramsey1 and David Broniatowski3, 1Yale University School of Medicine, New Haven, CT, 2Global Healthy Living Foundation, Upper Nyack, NY, 3George Washington University, Washington, DC, 4Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Randomized controlled trials currently report benefits and adverse events (AEs) separately, and therefore do not permit comparisons of patients’ overall experiences on one treatment…
  • Abstract Number: 2911 • 2018 ACR/ARHP Annual Meeting

    Patient-Reported Outcomes Measurement Information System (PROMIS®) Global Health Short Form Is Responsive to Patient Reported Changes in SLE Health Status

    Shanthini Kasturi1, Jackie Szymonifka2, Jessica R. Berman3, Kyriakos A. Kirou3, Alana B. Levine3, Lisa R Sammaritano4 and Lisa A. Mandl4, 1Medicine/Rheumatology, Tufts Medical Center, Boston, MA, 2Hospital for Special Surgery, New York, NY, 3Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 4Hospital for Special Surgery/Weill Cornell Medicine, New York, NY

    Background/Purpose: The accurate and efficient serial measurement of patient centered outcomes is a priority in the clinical care of SLE. Patient-Reported Outcomes Measurement Information Systems…
  • Abstract Number: 2912 • 2018 ACR/ARHP Annual Meeting

    Lupus Flare Activity from the Patient Perspective

    Winnie Nelson1, Patricia Katz2, R. Paola Daly3, Lauren Topf3, Erin Connolly-Strong4 and Michael Reed5, 1Health Economics and Outcomes Research, Mallinckrodt Pharmaceuticals, Bedminster, NJ, 2University of California San Francisco, San Francisco, CA, 3Lupus Foundation of America, Washington, DC, 4Mallinckrodt ARD, Inc., Bedminster, NJ, 5Vedanta Research, Chapel Hill, NC

    Background/Purpose: Lupus patients may experience flares in disease activity that require rapid management. This study describes the experience, identification, and management of a flare from…
  • Abstract Number: 2913 • 2018 ACR/ARHP Annual Meeting

    A Draft Modified Core Domain Set for Patient-Reported Outcomes (PRO) in Patients with Idiopathic Inflammatory Myopathies (IIM): An Omeract Report

    Malin Regardt1,2, Christopher A. Mecoli3,4,5, Jin Kyun Park6,7,8,9,10,11,12,13,14, Merrilee Needham15, Ingrid De Groot16, Catherine Sarver17, Ingrid E. Lundberg18, Beverly Shea19, Marianne De Visser20, Yeong Wook Song13, Clifton O. Bingham III21, Lisa Christopher-Stine22,23,24 and Helene Alexanderson25, 1Learning, Informatics,Management and Ethics, Karolinska institutet, Stockholm, Sweden, 2Function Area Occupational Therapy and Physical Therapy, Karolinska University Hospital, Stockholm, Sweden, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Internal Medicine/Rheumatology, Johns Hopkins University, Baltimore, MD, 5Rheumatology, Johns Hopkins University, Baltimore, MD, 6Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Republic of (South), 7Division of Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South), 8Department of Molecular medicine and biopharmaceutical science, Seoul National University, seoul, Korea, Republic of (South), 9Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), 10[email protected], Division of Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South), 11Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 12Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, Korea, Republic of (South), 13Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), 14Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Korea, Republic of (South), 15Murdoch University, Perth, Australia, 16patient research partner, Rotterdam, Netherlands, 17patient research partner, maryland, MD, 18Department of Medicine, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden, 19Bruyere Research Institute, Ottawa, ON, Canada, 20Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands, 21Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 22Ste 4100 Rm 409, Johns Hopkins University School of Medicine, Baltimore, MD, 23Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 24Medicine and Neurology, Johns Hopkins University, Baltimore, MD, 25Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, Sweden

    A Draft Modified Core Domain Set for Patient-Reported Outcomes (PRO) in Patients with Idiopathic Inflammatory Myopathies (IIM): An OMERACT ReportBackground/Purpose: The OMERACT Myositis special interest…
  • Abstract Number: 2914 • 2018 ACR/ARHP Annual Meeting

    Examination of Psychometric Properties of the Patient-Reported Outcomes Measurement Information System Fatigue 4-Item Short Form in Psoriatic Arthritis

    Patricia Katz1,2, Alexis Ogdie3, Evo Alemao4, Jayanti Mukherjee4 and Kaleb Michaud2,5, 1Forward/National Data Bank for Rheumatic Diseases, Wichita, KS, 2University of California San Francisco, San Francisco, CA, 3Hospital of the University of Pennsylvania, Philadelphia, PA, 4Bristol-Myers Squibb, Princeton, NJ, 5Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: PROMIS (Patient-Reported Outcomes Measurement Information System) measures have not been tested in psoriatic arthritis (PsA). We examined the reliability, validity and responsiveness of the…
  • Abstract Number: 2915 • 2018 ACR/ARHP Annual Meeting

    Can Passively-Collected Phone Behavior Determine Rheumatic Disease Activity?

    Kaleb Michaud, Sofia Pedro and Rebecca Schumacher, FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS

    Background/Purpose: Advances in reality mining combined with the pervasive use of smart phones have shown measurable changes in phone behavior due to changes in health.…
  • Abstract Number: 2916 • 2018 ACR/ARHP Annual Meeting

    New JADAS10- and cJADAS10-Based Cutoffs for Juvenile Idiopathic Arthritis Disease Activity States: Validation in a Multinational Dataset of 4830 Patients

    Alessandro Consolaro1,2, Chiara Trincianti1, Pieter van Dijkhuizen3, Giedre Januskeviciute4, Gabriella Giancane5, Alessandra Alongi1, Joost Swart3, Nicola Ruperto6,7 and Angelo Ravelli2,8, 1University of Genova, Genova, Italy, 2Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genova, Italy, 3UMC Utrecht, Wilhelmina Children’s Hospital, Utrecht, Netherlands, 4Istituto Giannina Gaslini, Genova, Italy, 5Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, 6Universita di Genova Pediatria II, Genova, Italy, 7Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, 8University of Genova, Genoa, Italy

    Background/Purpose: The Juvenile Arthritis Disease Activity Score (JADAS) and its clinical version excluding the acute phase reactant (cJADAS) were developed for measuring disease activity in…
  • Abstract Number: 2917 • 2018 ACR/ARHP Annual Meeting

    Multiplex Serum Biomarker Analysis before and during Therapy with Canakinumab in Patients with Systemic Juvenile Idiopathic Arthritis

    Tanja Hinze1, Christoph Kessel1, Claas Hinze1, Julia Seibert2, Hermann Gram2 and Dirk Foell3, 1Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, 2Novartis, Basel, Switzerland, 3Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany

    Background/Purpose: Canakinumab (CAN), a monoclonal anti-interleukin (IL)-1β antibody, is approved for the treatment of systemic juvenile idiopathic arthritis (SJIA). CAN-treated patients with SJIA showed a…
  • Abstract Number: 2918 • 2018 ACR/ARHP Annual Meeting

    Physical Activity in Canadian Children with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children with Arthritis)

    Lori Tucker1, Jaime Guzman1, Kristin Houghton2, Dax G. Rumsey3, Elizabeth Stringer4, Shirley M.L. Tse5, Rosie Scuccimarri6, Claire LeBlanc7, Roberta Berard8, Bianca Lang9, Karen N Watanabe Duffy10 and Ciarán M. Duffy11, 1BC Children's Hospital, Vancouver, BC, Canada, 2Rheumatology/Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada, 3Stollery Children's Hospital, Edmonton, AB, Canada, 4Department of Rheumatology, IWK Health Centre, Halifax, NS, Canada, 5The Hospital for Sick Children, Toronto, ON, Canada, 6Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada, 7Pediatrics, Montreal Children's Hospital, Montreal, QC, Canada, 8Pediatrics, Children's Hospital, London Health Sciences Centre, London, ON, Canada, 9Pediatrics, IWK Health Centre, Halifax, NS, Canada, 10Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, 11Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada

    Background/Purpose: Physical activity (PA) is an important component of health, and is essential for optimal growth and development. Children with juvenile idiopathic arthritis (JIA) are…
  • Abstract Number: 2919 • 2018 ACR/ARHP Annual Meeting

    An Epidemic: Severe Lung Disease in Patients with Systemic Juvenile Idiopathic Arthritis, Risk Factors and Predictors

    Shima Yasin1, Christopher Towe2,3, Ndate Fall4, Alexei Grom3,4 and Grant Schulert1,5, 1Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Pulmonology, Division of Pulmonology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 4Division of Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5Pediatrics, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: There is growing awareness of severe and often fatal chronic lung disease in patients with systemic juvenile idiopathic arthritis (sJIA). However, clinical features and…
  • Abstract Number: 2920 • 2018 ACR/ARHP Annual Meeting

    Correlations of Type I Interferon Score and Interferon Induced Chemokines CXCL10 and CXCL9 with Cutaneous and Muscular Disease Activity in Juvenile Dermatomyositis

    Gian Marco Moneta1, Ivan Caiello1, Lucilla Rava'2, Silvia Rosina3, Luisa Bracci Laudiero1,4, Angelo Ravelli3,5, Fabrizio De Benedetti6 and Rebecca Nicolai7, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 2Epidemiology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 3University of Genova, Genova, Italy, 4Institute of Translational Pharmacology, CNR, Roma, Italy, 5Rheumatology, Giannina Gaslini Institute, Genova, Italy, 6IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 7Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

    Background/Purpose: Interferons (IFNs) seem to play an important role in the pathogenesis of juvenile dermatomyositis (JDM). We previously reported that expression of both type I…
  • Abstract Number: 2921 • 2018 ACR/ARHP Annual Meeting

    The Performance of the Newly Proposed EULAR/Acr Classification Criteria in Juvenile-Onset Systemic Lupus Erythematosus

    Sezgin Sahin1, Sule Bektas1, Amra Adrovic1, Oya Koker2, Kenan Barut1 and Ozgur Kasapcopur3, 1Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, 2Istanbul University, Istanbul Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, 3Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey

    Background/Purpose: To avoid misclassifications, a new set of classification criteria have been developed by the collaboration of the EULAR/ACR and the draft was presented at…
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