ACR Meeting Abstracts

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  • Abstract Number: 2212 • 2017 ACR/ARHP Annual Meeting

    A Metabolite of C-Reactive Protein, a Marker of Disease Actvity, Is Prognostic of Radiographic Knee OA

    Anne C. Bay-Jensen1, Asger R. Bihlet2, Inger Byrjalsen3, Jeppe Andersen4, Yi He5, Anne Sofie Siebuhr1, Christian S. Thudium6, Bente J. Riis2, Claus Christiansen2 and Morten Asser Karsdal1, 1Rheumatology, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Clinical Development, Herlev, Denmark, 3Nordic Bioscience, Herlev, Denmark, 4Clinical Development, Nordic Bioscience, Herlev, Denmark, 5Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 6Biomarkers and Research, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: There are two major needs in clinical DMOAD development: Identifying a population with an active and progressive disease to demonstrate significant improvements by an…
  • Abstract Number: 2213 • 2017 ACR/ARHP Annual Meeting

    “Generalized Osteoarthritis”: Update to a Systematic Review

    Terese R. Gullo1,2 and Amanda Nelson3, 1Thurston Arthritis Research Center, Chapel Hill, NC, 2Ohio State University College of Medicine, Columbus, OH, 3Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: To perform a systematic review of the definitions of generalized osteoarthritis (GOA). An initial systematic review of the literature for GOA was published in…
  • Abstract Number: 2214 • 2017 ACR/ARHP Annual Meeting

    Contrary to Current Understanding of Osteoarthritis Pathogenesis, Only Gender and Radiographic Status Predict Progression: A Machine Learning Study of 9,254 Knees from the Osteoarthritis Initiative

    Michael A Bowes1, Oras Alabas2, Gwenael Guillard1, Graham R. Vincent1, Alan Brett3 and Philip G. Conaghan4, 1Imorphics Ltd, Manchester, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, United Kingdom, Leeds, United Kingdom, 3Imorphics Ltd, MANCHESTER, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Currently there are a large number of postulated predictors for OA progression, proposed on the basis of relatively small studies (100’s), and measurement approaches…
  • Abstract Number: 2215 • 2017 ACR/ARHP Annual Meeting

    Effect of Single 6 Ml Intraarticular Injection of Hylan G-F 20 in Patients with Knee Osteoarthritis: Results of a Single Centre Study

    SUNIL KUMAR PANDEY1 and SAT PAL SINGH2, 1ORTHOPEDIC DEPARTMENT, SAFDARJUNG HOSPITAL, VMMC, NEW DELHI, NEW DELHI, India, 2DEPARTMENT OF MEDICINE, SAFDARJUNG HOSPITAL,VMMC, NEW DELHI, NEW DELHI, India

    Background/Purpose: To evaluate the effect of single 6ml intraarticular injection of hylan G-F 20 in patients with knee osteoarthritis. Author: Dr. Pandey Sunil Kumar*, Dr.…
  • Abstract Number: 2216 • 2017 ACR/ARHP Annual Meeting

    Are Adults with Arthritis Advised to Exercise By Their Health Care Providers? National Health Interview Survey, 2002 and 2014

    Jennifer M. Hootman1, Louise Murphy2, Michael Boring3 and Teresa J. Brady3, 1Centers for Disease Control and Prevention, Kennesaw, GA, 2Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA, 3Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: Most published clinical practice guidelines for the management of osteoarthritis recommend exercise as a primary self-management strategy. Despite this, less than one-third of primary…
  • Abstract Number: 2217 • 2017 ACR/ARHP Annual Meeting

    Combined Impacts of Lifestyle Factors on Knee Osteoarthritis in the Osteoarthritis Initiative

    Zhaoli (Joy) Dai1, Carrie Brown2, Yuqing Zhang3 and David T. Felson4, 1Boston University School of Medicine, Boston, MA, 2Boston University School of Public Health, Boston, MA, 3School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Body mass index (BMI), healthy diet or components, physical activity, and tobacco smoking have been examined independently with risk of knee osteoarthritis (OA). Sleep…
  • Abstract Number: 2218 • 2017 ACR/ARHP Annual Meeting

    Concurrent Change in Quadriceps Strength and  Physical Function over 5 Years in the Multicenter Osteoarthritis Study

    Kathryn Bacon1, Neil Segal2, BE Øiestad3, Cora E. Lewis4, Michael C. Nevitt5, Carrie Brown6 and David T. Felson7, 1Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, 2University of Kansas, Shawnee, KS, 3Oslo and Akershus University College of Applied Sciences, Oslo, Norway, 4University of Alabama Birmingham, Birmingham, AL, 5Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 6Boston University School of Public Health, Boston, MA, 7Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Quadriceps weakness is associated with functional limitations and a target in the treatment of knee osteoarthritis (OA). There are limited data on the effect…
  • Abstract Number: 2219 • 2017 ACR/ARHP Annual Meeting

    Remaining Pain in DMARD-Naive Rheumatoid Arthritis Patients Treated with Baricitinib and Methotrexate

    Yvonne C. Lee1, Paul Emery2, John D. Bradley3, Baojin Zhu3, Carol L Gaich3, Zhihong Cai4, Amanda Quebe3, Anabela Cardoso3, Yun-Fei Chen3 and Roy Fleischmann5, 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Leeds Musculoskeletal Biomedical Research Unit, LTHT Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds, Leeds, United Kingdom, 3Eli Lilly and Company, Indianapolis, IN, 4Eli Lilly Japan K.K., Kobe, Japan, 5University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Patient (pt)-reported pain is common in rheumatoid arthritis (RA), even in pts with good disease control1.  This analysis evaluated pain control achieved by methotrexate…
  • Abstract Number: 2220 • 2017 ACR/ARHP Annual Meeting

    Neuropathic-like Pain Affects the Tender Joint Count and Health-Related Quality of Life in Patients with Rheumatoid Arthritis

    Kentaro Noda1, Miku Tajima2, Yosuke Oto3, Kazuhiro Otani3, Yoshiga Masayuki3, Haruyasu Ito1, Ken Yoshida1 and Daitaro Kurosaka1, 1Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medecine, Jikei University School of Medicine, Tokyo, Japan, 3Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose: Pain in rheumatoid arthritis (RA) has been thought to be due to nociceptive pain, but it was reported recently to include a mechanism associated…
  • Abstract Number: 2221 • 2017 ACR/ARHP Annual Meeting

    Eradication of Hepatitis C Among US Veterans: Examination of Changes in Pain Severity and Prescription Opioid Use Following Treatment

    Anand Kumthekar1, Sarah Shull2, Benjamin Morasco3,4, Travis Lovejoy3,4, Michael Chang2 and Jennifer Barton3, 1Rheumatology, Oregon Health & Science University, Portland, OR, 2Gastroenterology, VA Portland Health Care System, Portland, OR, 3VA Portland Health Care System, Portland, OR, 4Oregon Health & Science University, Portland, OR

    Background/Purpose: Hepatitis C virus (HCV) is associated with chronic wide spread pain, fatigue, myalgia, arthritis, sicca symptoms and vasculitis. Data regarding prior interferon-based treatment of…
  • Abstract Number: 2222 • 2017 ACR/ARHP Annual Meeting

    Comparative Risk of Respiratory Depression in Patients Treated with Opioids for Non-Malignant Pain

    Meghna Jani, Kamilla Kopec-Harding, Mark Lunt and William G Dixon, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Opioid use for non-cancer pain has increased considerably over the last 30 years. The U.S. Food and Drug Administration announced several boxed warnings in…
  • Abstract Number: 2223 • 2017 ACR/ARHP Annual Meeting

    Reallocating Time Spent in Sleep, Sedentary Behavior and Physical Activity and Its Association with Pain and Depression

    Jing Song1, Dorothy D. Dunlop1, Pamela Semanik2, Alison H. Chang3, Rebecca D. Jackson4, Rowland W. Chang5 and Julia (Jungwha) Lee6, 1Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, 2College of Nursing, Rush University, Chicago, IL, 3PT & Human Movement Sciences, Northwestern University, Chicago, IL, 4Ohio State University, Columbus, OH, 5Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose:  Osteoarthritis (OA) is a common cause of pain and is associated with depression in older adults. Pain and depression are major burdens to people…
  • Abstract Number: 2224 • 2017 ACR/ARHP Annual Meeting

    Analgesic Potential of NEO6860, a Modality Selective TRPV1 Antagonist, in Osteoarthritis Knee Pain:  Results of a Randomized, Controlled, Proof-of-Concept Trial

    Pierre Arsenault1, Richard Leff2, Nathaniel Katz3, Philippe Walker4 and Dan Chiche4, 1Diex Recherche Sherbrooke, Sherbrooke, QC, Canada, 2Richard L Leff LLC, Chadds Ford, PA, 3Analgesic Solutions, Natick, MA, 4NEOMED Institute, Montreal, QC, Canada

    Background/Purpose: Current treatments of osteoarthritis (OA) of the knee, such as NSAIDs, have significant limitations in both efficacy and safety. NEO6860 is a modality selective…
  • Abstract Number: 2225 • 2017 ACR/ARHP Annual Meeting

    Cntx-4975 (Trans-Capsaicin) Injection Provides Clinically Meaningful Pain Reduction in Subjects with Painful Intermetatarsal Neuroma (Morton’s Neuroma): An Open-Label, Ascending-Dose Study

    Peter Hanson1, Ira Gottlieb2, Margaret Kelly3, James Campbell1, Robert Allen4 and Randall Stevens1, 1Centrexion Therapeutics, Boston, MA, 2Chesapeake Research Group, Pasadena, MD, 3Edirutop, Christiansburg, VA, 4Allen Medical LLC, Malvern, PA

    Background/Purpose: Morton’s neuroma (MN) is a painful condition of the third intermetatarsal space caused by distal common digital nerve compression. CNTX-4975, a highly purified, synthetic…
  • Abstract Number: 2226 • 2017 ACR/ARHP Annual Meeting

    Cntx-4975 (Trans-Capsaicin) Injection Provides Clinically Meaningful Pain Reduction in Subjects with Painful Intermetatarsal Neuroma (Morton’s Neuroma): A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study

    James Campbell1, Randall Stevens1, Ira Gottlieb2, Kimberly Guedes1, Robin Burges1, Margaret Kelly3 and Peter Hanson1, 1Centrexion Therapeutics, Boston, MA, 2Chesapeake Research Group, Pasadena, MD, 3Edirutop, Christiansburg, VA

    Background/Purpose: Morton’s neuroma (MN) is a painful condition of the third intermetatarsal space caused by distal common digital nerve compression. CNTX-4975 is a highly purified,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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