Abstracts Archive - Page 1296 of 2425 - ACR Meeting Abstracts

Abstract Number: 1357 • 2017 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibody Positive Rheumatoid Arthritis Patients with Comorbid Post-Traumatic Stress Disorder Have Higher Serum Cytokine Expression
Bryant R. England¹, Harlan Sayles², Geoffrey M. Thiele², Kaleb Michaud², Jeremy Sokolove³, Grant Cannon⁴, Andreas Reimold⁵, Gail S. Kerr⁶, Liron Caplan⁷, Joshua Baker⁸ and Ted R. Mikuls⁹, ¹Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Division of Immunology and Rheumatology, Stanford University Medical Center, Mountain View, CA, ⁴Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ⁵Hospital of Southern Norway, Kristiansand, Norway, ⁶VAMC, Georgetown University, Washington, DC, ⁷Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁸Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: We have previously shown that rheumatoid arthritis (RA) patients with Post-Traumatic Stress Disorder (PTSD) have higher disease activity measures, due primarily to patient reported…
Abstract Number: 1358 • 2017 ACR/ARHP Annual Meeting
Relationship between Serum Protein Pattern and High Disease Activity in Patients with Rheumatoid Arthritis
Pavel Horak¹, Anna Petráčková², Martina Skácelová³, Eva Kriegová⁴, Petra Schneiderová⁵ and František Mrázek⁵, ¹III. Department of internal medicine, III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic, ²Department of Immunology, Department of Immunology, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic, ³III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic, ⁴Department of Immunology,, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic, ⁵Department of Immunology, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects joints. There is still limited information of serum biomarkers suitable for effective monitoring…
Abstract Number: 1359 • 2017 ACR/ARHP Annual Meeting
M-DAS28, M-SDAI and M-CDAI Performance in a Cohort of RA Patients with and without Concomitant Fibromyalgia
Julia Sosa¹, Silvana Karina Pérez¹, Maria Julia Santa Cruz¹, María Alejandra Medina¹, Silvia Beatriz Papasidero¹, Diana Klajn², Jose Angel Caracciolo¹, María de los Angeles Correa³, Roger Rolón⁴, Gustavo Citera⁴, Maria Constanza Bertolaccini⁵, LL Gonzalez⁶, L Vargas⁷ and Oscar Rillo⁷, ¹Rheumatology Department, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ²Research Committee, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ³Section Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Buenos Aires, Argentina, ⁴Rheumatology Department, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁵Rheumatology, Hospital Angel Cruz Padilla, Tucumán, Argentina, ⁶Hospital Angel Cruz Padilla, Tucumán, Argentina, ⁷Rheumatology Department, Hospital General de Agudos Dr. Ignacio Pirovano, Buenos Aires, Argentina
Background/Purpose: Fibromyalgia has been reported in approximately 20% of Rheumatoid Arthritis (RA) patients. Several studies have shown that the presence of Fibromyalgia (FM) is associated…
Abstract Number: 1360 • 2017 ACR/ARHP Annual Meeting
Validation of the Health Assessment Questionnaire-Upper Extremity (HAQUP) in Patients with Rheumatoid Arthritis
Juan Manuel Bande¹, José Ángel Caracciolo¹, Silvia Beatriz Papasidero¹, María Julia Santa Cruz², María Alejandra Medina¹, Diana Klajn³, María Gabriela Battaglia⁴, Julieta Giantinoto⁴ and Florencia Pelagagge⁴, ¹Rheumatology Department, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ²Section of Rheumatology, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ³Research Committee, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ⁴Occupational Therapy Department, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina
Background/Purpose: HAQ is considered the gold standard for the evaluation of functional capacity in patients with RA, even though it doesn´t focus in any particular…
Abstract Number: 1361 • 2017 ACR/ARHP Annual Meeting
How Often Do Rheumatologists Use Valid Prognostic Factors of Rheumatoid Arthritis? the Progresar Project
Teresa Oton-Sanchez¹, Loreto Carmona², Sara Luján³, Ana Royo³, Jose Luis Baquero⁴ and Santiago Muñoz-Fernandez⁵, ¹InMusc. Instituto de Salud Músculo-Esquelética, Madrid, Spain, ²Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, ³Medical Department Bristol-Myers Squibb, Madrid, Spain, ⁴Scientific Department Scientia Salus, Madrid, Spain, ⁵Rheumatology, Hospital Universitario Infanta Sofia. Universidad Europea, Madrid, Spain
Background/Purpose: Prognostic factors facilitate decisions on treatment and follow-up of patients with rheumatoid arthritis (RA). Rheumatologists might use factors with poor link to evidence in…
Abstract Number: 1362 • 2017 ACR/ARHP Annual Meeting
Assessing the Quality, Reliability and Readability of Online Health Information Regarding Rheumatoid Arthritis
Mathew Reynolds¹, David Ta¹ and Russell Buchanan², ¹Department of Rheumatology, Austin Health, Heidelberg, Australia, ²Department of Rheumatology, Austin Health, Melbourne, Australia
Background/Purpose: Rheumatoid arthritis is a common autoimmune disease with complex pathophysiology and varied treatment options, which accounts for many visits to health care professionals. With…
Abstract Number: 1363 • 2017 ACR/ARHP Annual Meeting
Disease Duration and Shared Epitope, but Not Smoking History, Are Associated with Peptidylarginine Deiminase 4-Antibody Development in Rheumatoid Arthritis
Laura Cappelli¹, Maximilian Konig¹, Pooja Naik², Arvin Saleh³, Allan C. Gelber³, Clifton O. Bingham III⁴ and Erika Darrah⁵, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Clinical characteristics and biomarkers help clinicians predict disease features in rheumatoid arthritis (RA). Both peptidylarginine deiminase 4 (PAD4) antibodies and smoking have been associated…
Abstract Number: 1364 • 2017 ACR/ARHP Annual Meeting
Incidence of Rheumatoid Arthritis in a Cohort of First Degree Relatives from the Studies of the Etiology of Rheumatoid Arthritis
Diraj R. Karnani¹, Lindsy J. Forbess², Michael Weisman³, Kevin D. Deane⁴, V. Michael Holers⁵ and Jill M. Norris⁶, ¹Department of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, ²Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ⁴Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁵Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁶Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: First-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) are at increased risk for developing RA compared to the general population. The purpose of…
Abstract Number: 1365 • 2017 ACR/ARHP Annual Meeting
Correlation of the Multi-Biomarker Disease Activity Score with Composite Rheumatoid Arthritis Disease Activity Measures: A Systematic Review and Meta-Analysis
Tate Johnson¹, Kyle A. Register², Cynthia Schmidt³, James R. O'Dell⁴, Ted R. Mikuls⁵, Kaleb Michaud¹ and Bryant R. England⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ³McGoogan Library of Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁶Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The regular assessment of disease activity is necessary to implement a treat-to-target management approach in RA. The Multi-Biomarker Disease Activity (MBDA) Score is a…
Abstract Number: 1366 • 2017 ACR/ARHP Annual Meeting
Evaluation of Synovial Fluid 14-3-3η Protein As a Marker of Joint Damage in Rheumatoid Arthritis Patients
Nevin Hammam^1,2, Shaimaa Salah³, Anthony Marotta⁴ and Emad F. Kholef⁵, ¹Rheumatology and Rehabilitation Department, University of Assiut, Assiut, Egypt, ²University of Alberta, Edmonton, AB, Canada, ³Rheumatology, Rehabilitation and Physical Medicine department, Faculty of Medicine, Assiut, Assiut, Egypt, ⁴Augurex Life Sciences Corp., Vancouver, BC, Canada, ⁵Clinical Pathology Department, Aswan University Hospital, Aswan, Egypt
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that results in severe joint damage and physical disability, therefore, the discovery of new marker(s) for…
Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting
Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Shilin Zhao², Ryan Allen², Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Marisol Ramirez², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
Abstract Number: 1368 • 2017 ACR/ARHP Annual Meeting
Small RNA Sequencing Identifies Plasma microRNA Panel for Rheumatoid Arthritis Diagnosis
Michelle J. Ormseth¹, Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Ryan Allen², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), are regulators of biological processes and serve as important biomarkers of disease. Most previous plasma sRNA…
Abstract Number: 1369 • 2017 ACR/ARHP Annual Meeting
Interferon Gamma Signature Genes and CXCL10 As New Biomarkers in Early Stage of Rheumatoid Arthritis
Kijun Lee¹, Jennifer Lee², Hong-Ki Min¹, Hae-Rim Kim³, Sang-Heon Lee⁴, Sung-Hwan Park⁵, Ji Hyeon Ju⁶ and Hoyoun Kim¹, ¹The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³Konkuk University Medical Center, Seoul, Korea, Republic of (South), ⁴Konkuk University School of Medicine, Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁶Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: The purpose of this study is to explore new biomarkers for early diagnosis of rheumatoid arthritis (RA). For better discrimination power, we especially investigated…
Abstract Number: 1370 • 2017 ACR/ARHP Annual Meeting
Higher Disease Activity in Current Smokers with Established RA: Is It Disease, Damage or Disability?
Emily Keeler¹, Danielle Feger², Nancy J. Olsen¹ and Rayford R. June³, ¹Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ²Medicine/Rheumatology, Penn State College of Medicine, Hershey, PA, ³Rheumatology, Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Smoking is an important environmental risk factor for development of rheumatoid arthritis (RA). Smoking has been linked to lower rates of disease remission, incomplete…
Abstract Number: 1371 • 2017 ACR/ARHP Annual Meeting
Development of an Adjusted Multi-Biomarker Disease Activity (MBDA) Score for Rheumatoid Arthritis (RA) That Accounts for Age, Sex and Adiposity, with Subsequent Evaluation of Ability to Predict Risk for Radiographic Damage
Jeffrey R. Curtis¹, Darl D. Flake II², Michael Weinblatt³, Nancy A. Shadick⁴, Mikkel Østergaard⁵, Merete Lund Hetland⁶, Cecilie Heegaard Brahe⁶, Yong Gil Hwang⁷, Daniel E. Furst⁸, Vibeke Strand⁹, Carol J. Etzel¹⁰, Dimitrios A. Pappas¹¹, Xingbin Wang¹², Ching Chang Hwang¹³, Eric H. Sasso¹², Alexander Gutin², Elena Hitraya¹² and Jerry S. Lanchbury², ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Myriad Genetics Inc., Salt Lake City, UT, ³Brigham and Women’s Hospital, Boston, MA, ⁴Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ⁶Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁷Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁹Stanford University, Palo Alto, CA, ¹⁰Departments of Epidemiology and Biostatistics, University of Texas School of Public Health, Houston, TX, ¹¹Columbia University, New York, NY, ¹²Crescendo Bioscience Inc., South San Francisco, CA, ¹³Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose: The MBDA score, based on 12 serum proteins, is a validated tool for assessing disease activity in RA patients. MBDA biomarkers may be influenced…

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