ACR Meeting Abstracts

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  • Abstract Number: 1192 • 2017 ACR/ARHP Annual Meeting

    Patient Characteristics That Predict the Effect of Laparoscopic Adjustable Gastric Band Weight Loss Surgery on Knee Osteoarthritis Pain

    Shannon Chen1, Fernando Bomfim2, Heekoung Youn3, Christine Ren-Fielding4 and Jonathan Samuels5, 1Medicine, NYU Langone Medical Center, New York, NY, 2NYU Langone Medical Center, New York, NY, 3Surgery, NYU Langone Medical Center, New York, NY, 4Department of Surgery, New York University School of Medicine, New York, NY, 5Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY

    Background/Purpose: Obesity is a modifiable risk factor for knee osteoarthritis (OA), yet diet and exercise often fail to achieve sustained weight loss or knee improvement.…
  • Abstract Number: 1193 • 2017 ACR/ARHP Annual Meeting

    A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial of the First-in-Class Imidazoline-2 Receptor Ligand CR4056 in Pain from Knee Osteoarthritis and Disease Phenotypes

    Lucio C. Rovati1, Nadia Brambilla1, Tomasz Blicharski2, Nicholas J Probert3, Cristina Vitalini1, Giampaolo Giacovelli1, Federica Girolami1 and Massimo D'Amato1, 1Clinical Research Department, Rottapharm Biotech, Monza, Italy, 2Lubelskie Centrum Diagnostyczne, Świdnik, Poland, 3MAC Clinical Research, Manchester, United Kingdom

    Background/Purpose: CR4056 is a novel imidazoline-2 receptor (I2R) ligand endowed with potent analgesic activities in several and diverse animal models of nociceptive and neuropathic pain,…
  • Abstract Number: 1194 • 2017 ACR/ARHP Annual Meeting

    Are Bisphosphonates Efficacious in Knee Osteoarthritis? A Meta-Analysis of Randomized Controlled Trials

    Mikala C. Osani1, Elizaveta Vaysbrot1, Raveendhara R. Bannuru2, Mia-Cara Musetti1 and Timothy E. McAlindon1, 1Division of Rheumatology, Tufts Medical Center, Boston, MA, 2Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA

    Background/Purpose: One of the key aspects of osteoarthritis (OA) pathogenesis is subchondral bone remodeling.  Bisphosphonates have been touted as disease-modifying agents for OA due to…
  • Abstract Number: 1195 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Subcutaneous Tanezumab in Patients with Knee or Hip Osteoarthritis (NCT01089725)

    Charles A. Birbara1, Eugene J. Dabezies2, Aimee M. Burr3, Robert J. Fountaine4, Michael D. Smith3, Mark T. Brown3, Christine R. West3, Rosalinda H. Arends3 and Kenneth M. Verburg3, 1University of Massachusetts Medical School, Worcester, MA, 2Pensacola Research Consultants, Pensacola, FL, 3Pfizer, Inc., Groton, CT, 4Pfizer, Inc., Grotoon, CT

    Background/Purpose : Tanezumab (TNZ) is a monoclonal antibody that inhibits nerve growth factor and reduces hip or knee osteoarthritis (OA) pain. A placebo-controlled phase 3…
  • Abstract Number: 1196 • 2017 ACR/ARHP Annual Meeting

    Safety and Efficacy of ABT-981, an Anti–Interleukin-1α/β Dual Variable Domain (DVD) Immunoglobulin, in Subjects with Knee Osteoarthritis: Results from the Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2 Trial

    Roy Fleischmann1, Henning Bliddal2, Francisco J Blanco3, Thomas J. Schnitzer4, Charles Peterfy5, Su Chen6, Li Wang6, Philip G. Conaghan7, Francis Berenbaum8, Jean-Pierre Pelletier9, Johanne Martel-Pelletier9, Ole Vaeterlein10, Wei Liu6, Gwen Levy6, Lanju Zhang6, Jeroen K. Medema6 and Marc C. Levesque6, 1University of Texas Southwestern Medical Center at Dallas, Metroplex Clinical Research Center, Dallas, TX, 2Parker Institute, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark, 3INIBIC-Instituto de Investigaciones Biomédicas de A Coruña-Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain, 4Northwestern Medicine, Feinberg School of Medicine, Chicago, IL, 5Spire Sciences, Inc., Boca Raton, FL, 6AbbVie Inc., North Chicago, IL, 7Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 8University Pierre & Marie Curie and Inserm, DHU i2B, APHP, Hospital Saint-Antoine, Paris, France, 9Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, 10Bioclinica, Hamburg, Germany

    Background/Purpose: Animal studies suggested that inhibiting IL-1α/β with ABT-981 may reduce pain and slow structural progression in OA. This study (NCT02087904; ILLUSTRATE-K) assessed the safety…
  • Abstract Number: 1197 • 2017 ACR/ARHP Annual Meeting

    Exploring Determinants Predicting Response to Intra-Articular Hyaluronic Acid Treatment in Symptomatic Knee Osteoarthritis

    Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, François Abram2, Marc Dorais3, Philippe Delorme4 and Johanne Martel-Pelletier1, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, 3StatSciences Inc., Notre-Dame-de-l’Île-Perrot, QC, Canada, 4ArthroLab Inc., Montreal, QC, Canada

    Background/Purpose: A major challenge regarding intraarticular hyaluronic acid (IAHA) treatment in knee osteoarthritis (OA) is identifying patients who will benefit most. This study aimed to…
  • Abstract Number: 1198 • 2017 ACR/ARHP Annual Meeting

    Intra-Articular Hyaluronic Acid Delay to Total Knee Arthroplasty By Number of Injection Courses Received: Analysis of an Administrative Database

    Andrew Concoff1, Faizan Niazi2, Peter Shaw2 and Jeffrey Rosen3, 1Rheumatology, St. Jude Medical Center, Fullerton, CA, 2Ferring Pharmaceuticals Inc., Parsippany, NJ, 3Department of Orthopaedics & Rehabilitation, New York Presbyterian Queens; Department of Clinical Orthopaedic Surgery, Weill Medical College of Cornell University, New York, NY, New York, NY

    Background/Purpose: Total knee arthroplasty (TKA) is the standard surgical treatment for patients with osteoarthritis (OA) that no longer experience symptom relief from conservative or pharmacologic…
  • Abstract Number: 1199 • 2017 ACR/ARHP Annual Meeting

    Costs Associated with Osteoarthritis Care Using Intra-Articular Hyaluronic Acid: Analysis of an Administrative Database

    Andrew Concoff1, Faizan Niazi2, Peter Shaw2 and Jeffrey Rosen3, 1Rheumatology, St. Jude Medical Center, Fullerton, CA, 2Ferring Pharmaceuticals Inc., Parsippany, NJ, 3Department of Orthopaedics & Rehabilitation, New York Presbyterian Queens; Department of Clinical Orthopaedic Surgery, Weill Medical College of Cornell University, New York, NY, New York, NY

    Background/Purpose: Many treatment options are available for the management of knee osteoarthritis (OA). The need for non-operative management is motivated by the large costs associated…
  • Abstract Number: 1200 • 2017 ACR/ARHP Annual Meeting

    Updating the Knee Osteoarthritis Intra-Articular Corticosteroid Meta-Analysis with Two Large Trials of Extended-Release Triamcinolone Acetonide (FX006) Versus Placebo

    Philip G. Conaghan1, Francis Berenbaum2, Virginia B. Kraus3, James Johnson4 and Scott Kelley5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Pierre & Marie Curie University, Saint-Antoine Hospital, Paris, France, 3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 4Summit Analytical, Denver, CO, 5Flexion Therapeutics, Inc., Burlington, MA

    Background/Purpose: A recent meta-analysis concluded that intra-articular corticosteroids (IACS) for knee osteoarthritis (OA) may be associated with moderate improvement in pain compared with control treatment.1,2…
  • Abstract Number: 1201 • 2017 ACR/ARHP Annual Meeting

    Reducing Heterogeneity in OA Clinical Trials: Data from a Phase 2 Study of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor in Knee Osteoarthritis

    Philip G. Conaghan1, Anita DiFrancesco2, Christopher J. Swearingen2, Sarah Kennedy2, Ismail Simsek2, Jeymi Tambiah2 and Yusuf Yazici2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Samumed, LLC, San Diego, CA

    Background/Purpose: Kellgren-Lawrence [KL] radiographic grading is used to classify knee osteoarthritis (OA), but may not accurately reflect disease progression. Classifying subjects by baseline medial joint…
  • Abstract Number: 1202 • 2017 ACR/ARHP Annual Meeting

    A Phase 2A, Placebo-Controlled, Randomized Study of ABT-981, an Anti-Interleukin-1Alpha and -1Beta Dual Variable Domain Immunoglobulin, to Treat Erosive Hand Osteoarthritis

    Margreet Kloppenburg1, Charles Peterfy2, Ida K. Haugen3, Féline Kroon4, Su Chen5, Li Wang5, Wei Liu5, Gwen Levy5, Roy Fleischmann6, Francis Berenbaum7, Désirée van der Heijde4, Jeroen K. Medema5 and Marc C. Levesque5, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Spire Sciences, Inc., Boca Raton, FL, 3Diakonhjemmet Hospital, Oslo, Norway, 4Leiden University Medical Center, Leiden, Netherlands, 5AbbVie Inc., North Chicago, IL, 6University of Texas Southwestern Medical Center at Dallas, Metroplex Clinical Research Center, Dallas, TX, 7University Pierre & Marie Curie and Inserm, DHU i2B, APHP, Hospital Saint-Antoine, Paris, France

    Background/Purpose: No approved OA therapies reduce pain and slow joint damage. Mouse data suggested that inhibiting IL-1α and -1β with ABT-981 would reduce pain and…
  • Abstract Number: 1203 • 2017 ACR/ARHP Annual Meeting

    Differences in Serum Protein Biomarkers between Combined Glucosamine and Chondroitin Versus Celecoxib Treatment in a Randomized, Double-Blind Trial in Osteoarthritis Patients

    Sandi L Navarro1, Marta Herrero2, Helena Martinez2, Jon Ladd1, Yuzheng Zhang1, Edward Lo1, David Shelley1, Timothy W Randolph1, Yvonne Schwarz1, Johanna W Lampe1 and Paul D Lampe1, 1Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 2Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain

    Background/Purpose: Non-steroidal anti-inflammatory drugs, e.g., celecoxib, are commonly used for inflammatory conditions, including osteoarthritis (OA), but are associated with adverse effects. Combined glucosamine hydrochloride plus…
  • Abstract Number: 1204 • 2017 ACR/ARHP Annual Meeting

    Radiographic Outcomes Were Associated with Pain and Function Responses: Post-Hoc Analysis of Results from a Phase 2 Study of a Small Molecule Wnt Pathway Inhibitor, SM04690, for Knee Osteoarthritis Treatment

    Yusuf Yazici1, Timothy E. McAlindon2, Allan Gibofsky3, Nancy E. Lane4, Nebojsa Skrepnik5, Eddie Armas6, Christopher J. Swearingen1, Anita DiFrancesco1, Jeymi Tambiah1 and Marc Hochberg7, 1Samumed, LLC, San Diego, CA, 2Division of Rheumatology, Tufts Medical Center, Boston, MA, 3Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, 4Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, 5Tuscon Orthopedics Institute, Tuscon, AZ, 6Well Pharma Medical Research, Miami, FL, 7Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to articular cartilage degradation and bone remodeling. Wnt signaling is involved in…
  • Abstract Number: 1205 • 2017 ACR/ARHP Annual Meeting

    Effectiveness of Low-Dose Radiation Therapy on Symptoms in Knee Osteoarthritis: First Results of a Triple Blinded, Randomized Controlled Trial

    E.A.M. Mahler1, M.J.M Minten1, M.M. Leseman-Hoogenboom2, P.M.P. Poortmans2, S.S. Boks3, J.W.J. Bijlsma4, F.H.J. van den Hoogen1,5, A.A. Den Broeder1,5 and C.H.M. van den Ende1,5, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Radiation Therapy, Radboud university medical centre, Nijmegen, Netherlands, 3Radiology, Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, 5Rheumatology, Radboud university medical centre, Nijmegen, Netherlands

    Background/Purpose: Previous research in animal osteoarthritis (OA) has shown that low-dose radiation therapy (LD-RT) exerts anti-inflammatory effects, but a systematic review concluded that the evidence…
  • Abstract Number: 1206 • 2017 ACR/ARHP Annual Meeting

    Chondroitin Sulfate Reduces Pain and Improves Function in Knee Osteoarthritis Significantly Better Than Placebo, Independently of the Definition of Responders

    J-Y Reginster, Bone Cartilage Unit, University of Liege, Liege, Belgium

    Background/Purpose: In addition to the assessment of the two co-primary endpoints – pain and function – regulatory agencies recommend the use of responder rates in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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