Abstracts Archive - Page 1276 of 2607 - ACR Meeting Abstracts

Abstract Number: 1345 • 2018 ACR/ARHP Annual Meeting
Association of HLA-DRB1*0301 with Antisynthetase Syndrome in Spanish Patients
Raquel Lopez-Mejías¹, Sara Remuzgo-Martínez¹, Fernanda Genre¹, Verónica Pulito-Cueto¹, Norberto Ortego Centeno², Eva Perez Pampín³, Antonio Mera³, Julia Martínez-Barrio⁴, Francisco Javier López Longo⁴, Verónica Mijares¹, Leticia Lera-Gomez¹, Sonia Fernández Rozas¹, Victor Mora Cuesta⁵, David Iturbe Fernández¹, Jose Manuel Cifrian Martinez¹, Fredeswinda Romero Bueno⁶, Olga Sanchez-Pernaute⁶, Ricardo Blanco¹, Laura Riesco-Dávila⁷, Laura Nuño⁸, María Gema Bonilla Hernán⁹, Alejandro Balsa⁹, Ernesto Trallero-Araguás¹⁰, Albert Selva O'Callaghan¹⁰, Javier Martin¹¹, Javier Llorca¹², Santos Castañeda¹³, Javier Gonzalo Ocejo⁷, Lorenzo Cavagna¹⁴ and Miguel Angel González-Gay^1,15,16, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ³Rheumatology Division. Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, ⁴Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santender, Spain, ⁶Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ⁷Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, ⁸Rheumatology, Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ⁹Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ¹⁰Rheumatology Department. Hospital Universitario Vall d´Hebron, Barcelona, Spain, ¹¹Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain., Granada, Spain, ¹²Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ¹³Rheumatology, Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ¹⁴Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ¹⁵School of Medicine, University of Cantabria, Santander, Spain, ¹⁶Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Antisynthetase syndrome (ASSD) is an inflammatory connective tissue disease characterized by the classic triad: arthritis, myositis, and interstitial lung disease (ILD) [1-3]. Raynaud’s phenomenon,…
Abstract Number: 1346 • 2018 ACR/ARHP Annual Meeting
Anti-NT5c1A Autoantibodies As Biomarkers in Inclusion Body Myositis
Adam Amlani¹, Mark Tarnopolsky², Lauren Brady², Ignacio Garcia de la Torre³, Michael Mahler⁴, May Choi⁵ and Marvin J. Fritzler⁵, ¹Medicine, University of Calgary, Calgary, AB, Canada, ²Department of Pediatrics and Medicine, McMaster University Medical Center, Hamilton, ON, Canada, ³University of Guadalajara, Guadalajara, Mexico, ⁴Research and Development, Inova Diagnostics, San Diego, CA, ⁵Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Sporadic Inclusion Body Myositis (sIBM) is an insidious onset, idiopathic inflammatory myopathy (IIM) with high morbidity. There has not been a reliable biomarker to…
Abstract Number: 1347 • 2018 ACR/ARHP Annual Meeting
A Semi-Quantitative Whole Body Magnetic Resonance Imaging Assessment Tool to Define Musculoskeletal Abnormalities in Patients with Idiopathic Inflammatory Myopathies
Sara Faghihi-Kashani¹, Lisa G. Rider², David Bluemke³, Ashkan Malayeri⁴, Evrim Turkbey⁴, Joseph Shrader⁵, John McGrath⁶, Elizabeth Jones⁷, Jamie Marco⁸, Frederick W. Miller⁹ and Adam Schiffenbauer¹⁰, ¹Environmental Autoimmunity Group, National Institute of Environmental Health, Bethesda, MD, ²Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁴Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, ⁵Rehabilitation Medicine, National Institutes of Health, Bethesda, MD, ⁶Social and Scientific Systems, Inc., Durham, NC, ⁷Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, ⁸Radiology and Imaging Sciences National Institutes of Health, Bethesda, MD, ⁹Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ¹⁰NIEHS, NIH, Bethesda, MD
Background/Purpose: There is a lack of standardized methodology for assessing whole body MRI (WBMRI) in idiopathic inflammatory myopathy (IIM) patients. This leads to difficulty in…
Abstract Number: 1348 • 2018 ACR/ARHP Annual Meeting
Quantitative High Throughput Screening of Small Molecules to Inhibit Interferon-Stimulated Major Histocompatibility Complex Class I in Myositis Muscle
Travis Kinder, Patricia Dranchak and James Inglese, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD
Background/Purpose: Common molecular and histological features of idiopathic inflammatory myopathies (myositis) include activation of the type 1 interferon (IFN) response and aberrant expression of major…
Abstract Number: 1349 • 2018 ACR/ARHP Annual Meeting
Rnaseq of Peripheral Blood Mononuclear Cells from Juvenile Dermatomyositis, Necrotizing Myopathy and Controls Are an Aid in Diagnosis
Chiang-Ching Huang¹, Elisha D.O. Roberson², Gabrielle A. Morgan³, Hua Huang⁴, Victoria Hans³ and Lauren M. Pachman^5,6, ¹Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI, ²Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, ³Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI, ⁵Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁶Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: The HMG-Cr form of Necrotizing Myopathy (NM) is a relatively newly recognized entity within the constellation of pediatric inflammatory myopathies. The purpose of this…
Abstract Number: 1350 • 2018 ACR/ARHP Annual Meeting
Elevated Serum Levels of Soluble CD146 and CD146 Autoantibody in Patients with Polymyositis/Dermatomyositis
Eri Watanabe¹, Takahisa Gono^1,2, Hiroki Yabe¹, Masataka Kuwana², Kazunori Kato³ and Chihiro Terai¹, ¹Department of Rheumatology, Saitama Medical Center, Jichi Medical University, Saitama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Biomedical Engineering, Faculty of Science and Engineering, Toyo University, Saitama, Japan
Background/Purpose: CD146 is a transmembrane glycoprotein belong to immunoglobulin superfamily, acts as adhesion molecule for the maintenance of cell monolayer. Human endothelial cells constitutively express…
Abstract Number: 1351 • 2018 ACR/ARHP Annual Meeting
In Situ Dendritic Cell Characterization in Idiopathic Inflammatory Myopathies
Iazsmin Bauer Ventura¹, Daniel Reilly², Peter Pytel³ and Vladimir Liarski², ¹Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, ²Medicine, Section of Rheumatology, University of Chicago, chicago, IL, ³Medicine, Section of Pathology, University of Chicago, chicago, IL
Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) are the largest number of acquired and potentially treatable muscle disorders. Nevertheless, there are currently no FDA or EMA-approved…
Abstract Number: 1352 • 2018 ACR/ARHP Annual Meeting
Low Density Granulocytes in Idiopathic Inflammatory Myopathy
David Fernandez¹, Linjia Jia², Mikhail Olferiev³, Annel M. Fernandez⁴, JoAnn Vega⁵, Kerri Merritt⁶, Michael Lockshin⁷ and Peggy Crow¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ³Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, ⁴Medicine- Rheumatology/ Research, Hospital for Special Surgery, New York, NY, ⁵Medicine - Rheumatology / Research, Hospital for Special Surgery, New York, NY, ⁶Hospital for Special Surgery, New York, NY, ⁷Barbara Volcker Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Idiopathic Inflammatory Myopathy (IIM) is a group of autoimmune diseases characterized by immune-mediated injury to skeletal muscle, including polymyositis (PM) and dermatomyositis (DM). Recent…
Abstract Number: 1353 • 2018 ACR/ARHP Annual Meeting
Autophagy Marker LC3 Accumulates in Immune-Mediated Necrotizing Myopathy Muscle Fibres
Margherita Giannini¹, Francesco Girolamo², Anna Lia², Angela Amati², Luigi Serlenga², Dario D'Abbicco³, Marilina Tampoia⁴, Maria Trojano² and Florenzo Iannone¹, ¹D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²Department of Basic Medical Sciences, Neuroscience and Sense Organs, Unit of Neurophysiopathology, Policlinico Hospital, University of Bari, BARI, Italy, ³Institute of General Surgery ‘G Marinaccio’ (DETO), Policlinico Hospital, University of Bari, BARI, Italy, ⁴Laboratory of Clinical Pathology, University Hospital of Bari, BARI, Italy
Background/Purpose: To investigate the expression of autophagy marker LC3, localization of macrophages and accumulation of misfolded proteins in myofibres of immune-mediated necrotizing myopathy (IMNM) muscle…
Abstract Number: 1354 • 2018 ACR/ARHP Annual Meeting
Correlates of Neuropathic Pain in Knee Osteoarthritis: The Modified Paindetect Questionnaire and the Osteoarthritis Initiative
Joshua Bernick¹, Wilma M. Hopman^2,3, Marc C. Hochberg⁴ and Jacqueline Hochman⁵, ¹Queen's University, Kingston, ON, Canada, ²Research Methodologist, Kingston General Health Research Institute, Queen's University, Kingston, ON, Canada, ³Adjunct Faculty, Department of Public Health Sciences, Faculty of Medicine, Queen's University, Kingston, ON, Canada, ⁴Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁵Women's College Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Cumulative evidence suggests central sensitization contributes to a neuropathic-like phenotype in a subset of patients with knee osteoarthritis (OA). Using a variety of validated…
Abstract Number: 1355 • 2018 ACR/ARHP Annual Meeting
Asymptomatic Hyperuricemia Is Associated with Increased Prevalence of Symptomatic Knee Osteoarthritis: Data from Third National Health and Nutrition Examination Survey
Shudan Wang^1,2, Michael Pillinger³, Svetlana Krasnokutsky Samuels⁴ and Kamil E. Barbour⁵, ¹Department of Medicine, Division of Rheumatology, NYU School Medicine, New York City, NY, ²Medicine/Rheumatology, VA Medical Center- Manhattan, New York, NY, ³Medicine/Rheumatology, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, New York, NY, ⁵Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Inflammation plays a pathogenetic role in OA, and catabolic cytokines including IL-1β potentiate joint space narrowing. Elevated serum urate (sUA) levels promote crystal-induced stimulation…
Abstract Number: 1356 • 2018 ACR/ARHP Annual Meeting
Increasing Oral Doses of GLPG1972 Administered Daily for 29 Days Show a Strong Target Engagement in Patients with Knee and/or Hip OA
Henri Deckx¹, Simon Hatch², Martine Robberechts¹, Sonia Dupont³, Julie Desrivot³, Hugh Coleman⁴, Staffan Larsson⁵, André Struglics⁵, Ellen van der Aar¹ and Ann Fieuw¹, ¹Galapagos NV, Mechelen, Belgium, ²Galapagos NV, Boston, MA, ³Galapagos SASU, Romainville, France, ⁴CRU, Covance, Daytona Beach, FL, ⁵Clinical Sciences, Lund University, Lund, Sweden
Background/Purpose: Osteoarthritis (OA) is characterized by structural changes of the joint, of which degradation of articular cartilage is one of the major signs1. The main…
Abstract Number: 1357 • 2018 ACR/ARHP Annual Meeting
Flexion Contractures Are Associated with Worse Pain, Stiffness, and Function in Patients with Knee Osteoarthritis
T Mark Campbell¹, Marc Monsour² and Guy Trudel³, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) causes pain, disability, and affects ~20% of the population in the United States [Wallace 2017]. Knee flexion contractures (FCs) are limitations…
Abstract Number: 1358 • 2018 ACR/ARHP Annual Meeting
The Association of Microbial Translocation and WOMAC Function in Patients with Knee Osteoarthritis
Sunghye Kim¹, Richard Loeser², Dennis Ang³ and Stephen P. Messier⁴, ¹Medicine, Wake Forest School of Medicine, Winston Salem, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Wake Forest University School of Medicine, Winston-Salem, NC, ⁴Department of Health and Exerc, Wake Forest University, Winston-Salem, NC
Background/Purpose: Osteoarthritis (OA) affects 33.6% of population ≥65. Knee OA (KOA) is the most prevalent OA and it is one of five leading causes of…
Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Matthew Fuller², Becki Cleveland³, Todd Schwartz⁴, Joanne M. Jordan¹, Leigh F. Callahan¹, J.S. Marron² and Richard Loeser¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…

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