Abstracts Archive - Page 1260 of 2607 - ACR Meeting Abstracts

Abstract Number: 1105 • 2018 ACR/ARHP Annual Meeting
Abatacept Is Effective in Experimental Digestive and Lung Tissue Fibrosis
Gonçalo Boleto¹, Christophe Guignabert², Sonia Pezet³, Anne Cauvet³, Jérémy Sadoine⁴, Ly Tu², Carole Nicco³, Camille Gobeaux⁵, Frederic Batteux³, Yannick Allanore³ and Jérôme Avouac¹, ¹Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France, Paris, France, ²INSERM UMR_S 999, Le Plessis-Robinson, France, Le Plessis-Robinson, France, ³Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France, Paris, France, ⁴EA 2496 Pathologie, Imagerie et Biothérapies Orofaciales, UFR Odontologie, Université Paris Descartes and PIDV, PRES Sorbonne Paris Cité, Montrouge, France, Montrouge, France, ⁵Clinical Chemistry Laboratory, Cochin and Hôtel-Dieu Hospitals, Paris, France, Paris, France
Background/Purpose: A previous report showed that abatacept (IgG-CTLA-4) prevented and induced regression of inflammation-driven dermal fibrosis in two different mouse models of systemic sclerosis (SSc)…
Abstract Number: 1106 • 2018 ACR/ARHP Annual Meeting
Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Peripheral Blood Mononuclear Cells of Systemic Sclerosis Patients: Correlation with Disease Specific Manifestations
Fabio Cacciapaglia¹, Simone Perniola^2,3, Livio Urso¹, Emanuela Praino⁴, Rita Bizzoca², Dorotea Natuzzi², Nunzia Lacarpia² and Florenzo Iannone⁵, ¹Department of Emergency and Organs Transplantation (DETO); University of Bari (Italy), Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ³Department of Verona - University of Verona (ITALY), Verona, Italy, ⁴DIM, Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ⁵D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy
Background/Purpose: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor regulated by phosphorylation of key tyrosine residues that regulates pivotal cell processes…
Abstract Number: 1107 • 2018 ACR/ARHP Annual Meeting
Expression Quantitative Trait Loci -eQTL- Analysis in Systemic Sclerosis
Martin Kerick¹, David Gonzalez Serna¹, Maria Teruel², Sepideh Babaei³, Marialbert Acosta-Herrera¹, Elena Carnero-Montoro², Zuzanna Makowska³, Anne Buttgereit⁴, Guillermo Barturen², Sikander Hayat⁴, Jorge Kageyama⁴, Manuel Martínez-Bueno², PRECISESADS Clinical Consortium⁵, Ralf Lesche³, Marta Alarcón-Riquelme² and Javier Martin¹, ¹Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ²Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain, ³Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁴Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁵Spain
Background/Purpose: Systemic Sclerosis (SSc) is a complex systemic autoimmune disorder characterized by fibrosis of the skin and internal organs. Genetics and environmental factors contribute both…
Abstract Number: 1108 • 2018 ACR/ARHP Annual Meeting
Antibody Repertoire Dynamics in Systemic Sclerosis after Myeloablative Autologous Hematopoietic Stem-Cell Transplantation or Cyclophosphamide Treatment
Julia Z. Adamska^1,2, Leslie Crofford³, Daniel E. Furst^4,5, Ellen Goldmuntz⁶, Lynette Keyes-Elstein⁷, Maureen D. Mayes⁸, Peter McSweeney⁹, Richard Nash⁹, Ashley Pinckney¹⁰, Beverly Welch¹¹, Keith Sullivan¹² and William H. Robinson^1,2, ¹Stanford University, Stanford, CA, ²VA Palo Alto Health Care System, Palo Alto, CA, ³Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ⁴University of California Los Angeles, Los Angeles, CA, ⁵University of Washington, Seattle, WA, ⁶NIAID, NIH, Bethesda, MD, ⁷Clinical Statistics, Rho Federal Systems, Inc., Chapel Hill, NC, ⁸Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁹Colorado Blood Cancer Institute, Denver, CO, ¹⁰Rho Federal Systems, Inc., Chapel Hill, NC, ¹¹National Institutes of Health, Bethesda, MD, ¹²Duke University Medical Center, Durham, NC
Background/Purpose: Myeloablative autologous hematopoietic stem-cell transplantation (HSCT) was recently demonstrated to provide benefit over monthly cyclophosphamide (CYC) in the treatment of diffuse cutaneous systemic sclerosis…
Abstract Number: 1109 • 2018 ACR/ARHP Annual Meeting
Gene Expressions of TMEM176A and TMEM176B Were Prominent at the Stage of Subclinical Pulmonary Vascular Disease in Systemic Sclerosis
Yoshinobu Koyama¹, Soichiro Fuke², Takashi Ohno³, Yoshiharu Sato⁴ and Toshie Higuchi¹, ¹Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, ²Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, ³Management of medical safety, Okayama University Hospital, Okayama, Japan, ⁴DNA Chip Research Inc, Tokyo, Japan
Background/Purpose: Pulmonary arterial hypertension (PAH) is prominent as a vascular involvement of systemic sclerosis (SSc), which remains a leading cause of death in spite of…
Abstract Number: 1110 • 2018 ACR/ARHP Annual Meeting
Characterization of CD20+ T Cells in Patients with Systemic Sclerosis
Monica D'Orazio¹, Elisabeth Fliesser², Florentine Moazedi-Fürst³, Martin Stradner⁴, Sonja Kielhauser³, Johannes Fessler⁵ and Hans-Peter Brezinschek¹, ¹Internal Medicine/Division of Rheumatoloy and Immunology, Rheumatology and Immunology, Medical University Graz, Austria, Graz, Austria, ²Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³Rheumatology and Immunology, Medical University Graz, Austria, Graz, Austria, ⁴Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ⁵Department of Neurology, Harvard Medical School, Boston, MA
Background/Purpose: Recently, it has been demonstrated that a subset of T cells expresses the B-cell marker CD20. It has been postulated that in rheumatoid arthritis…
Abstract Number: 1111 • 2018 ACR/ARHP Annual Meeting
CBS004, a Novel Monoclonal Antibody Against Bdca-2 Inhibits TLR-Induced Activation of Human pDC in Vitro and In Vivo. a Novel Therapeutic Target for Systemic Sclerosis
Clarissa Corinaldesi¹, Yasser M El-Sherbiny², Gemma Migneco³, Rebecca Ross¹, Steve Holmes⁴, Clive McKimmie⁵ and Francesco Del Galdo¹, ¹Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, ³Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom, ⁴Capella Biosciences, LTD, London, United Kingdom, ⁵Virus Host Interactions Team, Section of Infection and Immunity, University of Leeds, Leeds, United Kingdom
Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
Abstract Number: 1112 • 2018 ACR/ARHP Annual Meeting
Downregulated Expression of Interferon Regulatory Factor 8 in Circulating Monocytes Exhibits Pro-Fibrotic Phenotype in Patients with Systemic Sclerosis
Yasushi Ototake¹, Yukie Yamaguchi¹, Miho Asami¹, Noriko Ikeda¹, Daisuke Kurotaki², Tomohiko Tamura² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity, vasculopathy, and excessive organ fibrosis. Although the etiology of the disease is…
Abstract Number: 1113 • 2018 ACR/ARHP Annual Meeting
Distinct Pathways in Anti-RNP-Associated Pulmonary Hypertension and Anti-RNP-Associated Raynaud’s Phenomenon
Lisa Harlow¹, Ying Wang², YunJuan Zang², Vineet Gupta³, Karen Young⁴, Jian Huang⁴, Bethly Aubourg² and Eric Greidinger⁵, ¹Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ²Rheumatology, University of Miami, Miami, FL, ³Rush University, Chicago, IL, ⁴Pediatrics, University of Miami, Miami, FL, ⁵Miami VA Medical Center, Miami, FL
Background/Purpose: Anti-RNP Autoimmunity is associated with multiple manifestations of vasculopathy, including Raynaud’s Phenomenon (RP) and Pulmonary Hypertension (PH). We have previously linked anti-K10 antibodies to…
Abstract Number: 1114 • 2018 ACR/ARHP Annual Meeting
Proteomic Aptamer Analysis Reveals a Distinct Profile of Very Early Systemic Sclerosis (SSc) Patients at Risk for Progression Toward Definite SSc
Chiara Bellocchi¹, Shervin Assassi², Jun Ying³, Chandra Mohan⁴, Alessandro Santaniello¹ and Lorenzo Beretta¹, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²University of Texas McGovern Medical School, Houston, TX, ³Department of Internal Medicine - Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Department of Biomedical Engineering, University of Houston, Houston, Texas, USA, Houston, TX
Background/Purpose: To determine via SOMAscan aptamer proteomic analysis (>1200 proteins analyzed) the factors associated with disease transition from very early systemic sclerosis (EaSSc) to definite…
Abstract Number: 1115 • 2018 ACR/ARHP Annual Meeting
In Vivo Assessment of Prevention of Lung Fibrosis Using the Pan-PPAR Agonist Lanifibranor in the Tβriiδk-Fib Mouse Model of Systemic Sclerosis
Emma C. Derrett-Smith^1,2, Shiwen Xu¹, David Abraham³, Olivier Lacombe⁴, Pierre Broqua⁴, Jean-Louis Junien⁴, Irena Konstantinova⁵ and Christopher P. Denton⁶, ¹Division of Medicine, University College London, London, United Kingdom, ²Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Inventiva, DAIX, France, ⁵Inventiva, Daix, France, ⁶University College London, London, United Kingdom
Background/Purpose: The TbRIIDk-fib transgenic (TG) mouse model of scleroderma carries a fibroblast-specific transforming growth factor β (TGFβ) receptor II mutation resulting in balanced up-regulation of…
Abstract Number: 1116 • 2018 ACR/ARHP Annual Meeting
Risk of Systemic Sclerosis According to Charge of the HLA-DRβ1 Third Hypervariable Region
Oyku Sensoy¹, Sami B. Kanaan² and J. Lee Nelson³, ¹Clinical Research Division, Fred Hutchinson Cancer Research Center, seattle, WA, ²Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ³Fred Hutchinson Cancer Research Center, Seattle, WA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs and has a predilection for women. The strongest genetic…
Abstract Number: 1117 • 2018 ACR/ARHP Annual Meeting
Characterization of the Esophageal Microbiome in Patients with Systemic Sclerosis (SSc)
Monica Espinoza¹, Bhaven K. Mehta¹, Yue Wang¹, Aileen Hoffmann², Mary A. Carns³, Noelle Kosarek¹, Tammara A. Wood⁴, Monique Hinchcliff⁵ and Michael L. Whitfield⁶, ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Rheumatology, Northwestern University, Chicago, IL, ⁶Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and inflammation. Multiple organ systems are affected including the skin, gastrointestinal tract, vasculature, and…
Abstract Number: 1118 • 2018 ACR/ARHP Annual Meeting
Identification of Transcriptional Regulatory Networks in Systemic Sclerosis
Yue Wang¹, Jennifer Franks² and Michael L. Whitfield³, ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Geisel School of Medicine at Dartmouth, Hanover, NH, ³Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder with poor outcomes and no FDA-approved therapies. Prior work has shown gene expression patterns associated with…
Abstract Number: 1119 • 2018 ACR/ARHP Annual Meeting
Genetic Signatures from RNA Sequencing of Pediatric Localized Scleroderma (LS) Skin
Emily Mirizio¹, Roosha Mandal², Qi Yan³, William Horne⁴, Kaila Schollaert-Fitch³ and Kathryn S. Torok⁵, ¹Peds Rheum, University of Pittsburgh Med Ctr, Pittsburgh, PA, ²Carnegie Mellon University, Pittsburgh, PA, ³University of Pittsburgh Med Ctr, Pittsburgh, PA, ⁴Health Sciences Sequencing Core at Children's Hospital of Pittsburgh, Pittsburgh, PA, ⁵Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA
Background/Purpose: Localized scleroderma (LS) is a progressive disease of the skin and underlying tissue that causes significant functional disability and disfigurement, especially in developing children.…

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