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  • Abstract Number: 562 • 2017 ACR/ARHP Annual Meeting

    Anti-Muscarinic Receptor 3 Antibodies – a Cross Reactive Result of Ro60 Immunization

    Syed M.S. Quadri1, Biji T Kurien2, Kristi A. Koelsch3 and R. Hal Scofield4, 1Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjogren’s syndrome (SS) is a chronic autoimmune inflammatory disease characterized by impaired function of salivary and lacrimal glands leading to dry mouth and dry…
  • Abstract Number: 563 • 2017 ACR/ARHP Annual Meeting

    The Effect of Non-Invasive Vagus Nerve Stimulation on Fatigue and Immune Responses in Patients with Primary Sjögren’s Syndrome

    Jessica Tarn1, Sarah Legg2, Sheryl Mitchell2, Bruce Simon3 and Wan-Fai Ng4, 1Institute of Cellular Medicine, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 2Freeman Hospital, Newcastle upon Tyne, United Kingdom, 3electroCore Medical LLC, Basking Ridge, NJ, 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Primary Sjšgren's syndrome (pSS) sufferers have rated chronic fatigue as the most important symptom needing improvement and the main contributing factor to the loss…
  • Abstract Number: 564 • 2017 ACR/ARHP Annual Meeting

    Molecular Identification of a Ro-Specific Salivary IgA Repertoire with Unique Clonal Signatures in Primary Sjogren’s Syndrome

    Jing Jing Wang1, Alexander Colella1, Tim Chataway2, R. Hal Scofield3 and Tom Gordon1,4, 1Immunology, Flinders University, Adelaide, Australia, 2Proteomic Facility, Flinders University, Adelaide, Australia, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Immunology, SA Pathology, Adelaide, Australia

    Background/Purpose: Autoantibodies against 60-kD Ro (Ro60)/SSA have been detected in the saliva and serum of patients with primary Sjögren's syndrome (SS) by routine methods that…
  • Abstract Number: 565 • 2017 ACR/ARHP Annual Meeting

    Fatigue in Primary Sjögren’s Syndrome (pSS) Is Associated with Lower Levels of Proinflammatory Cytokines: A Validation Study

    Kristen Davies1, Kamran Mirza1, Jessica Tarn2, Nadia Howard Tripp3, Robert J. Moots4, Nagui Gendi5, Michele Bombardieri6, Costantino Pitzalis6, Nurhan Sutcliffe6, Simon Bowman7, Neil J. McHugh8, John McLaren9, Devesh Mewar10, David Coady11, Kirsten MacKay12, Susan Knight13, Monica Gupta14, Marian Regan15, Cathy Lawson16, Jacqueline Andrews17, Peter Lanyon18, Mohammed Akil19, Elizabeth Price20, Annie Cooper21, Frances Hall22, Theodoros Dimitroulas23, Gavin Clunie24, Saravanan Vadivelu25, Ian Giles26, Bhaskar Dasgupta27, Steve Young-Min28, Dennis Lendrem29,30 and Wan-Fai Ng2,31, 1Institute of Cellular Medicine, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 2Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 3Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, 4University of Liverpool, Liverpool, UK, Liverpool, United Kingdom, 5Basildon and Thurrock University Hospital, Basildon, UK, Basildon, United Kingdom, 6Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, UK, London, United Kingdom, 7Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, 8Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom, 9NHS Fife, Kirkcaldy, UK, Kirkcaldy, United Kingdom, 10Royal Liverpool University Hospital, Liverpool, UK, Liverpool, United Kingdom, 11Sunderland Royal Hospital, Sunderland, UK, Sunderland, United Kingdom, 12Torbay Hospital, Torquay, UK, Torquay, United Kingdom, 13Macclesfield General Hospital, Macclesfield, UK, macclesfield, United Kingdom, 14Gartnavel General Hospital, Glasgow, UK, Glasgow, United Kingdom, 15Royal Derby Hospital, Derby, UK, Derby, United Kingdom, 16Harrogate District Hospital, Harrogate, UK, Harrogate, United Kingdom, 17Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, 18Nottingham University Hospitals NHS Trust, Nottingham, UK, Nottingham, United Kingdom, 19Royal Hallamshire Hospital, Sheffield, UK, Sheffield, United Kingdom, 20Great Western Hospital, Swindon, UK, Swindon, United Kingdom, 21Royal Hampshire County Hospital, Winchester, UK, Winchester, United Kingdom, 22Addenbrooke’s Hospital, Cambridge, UK, Cambridge, United Kingdom, 23Dudley Group of Hospitals NHS Foundation Trust, Dudley, UK, Dudley, United Kingdom, 24Ipswich Hospital NHS Trust, Ipswich, UK, Ipswich, United Kingdom, 25Queen Elizabeth Hospital, Gateshead, UK, Gateshead, United Kingdom, 26Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, UK, London, United Kingdom, 27Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Westcliff-on-Sea, United Kingdom, 28Queen Alexander Hospital, Portsmouth, UK, Portsmouth, United Kingdom, 29Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle, United Kingdom, 30Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, 31Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune rheumatic disease causing various symptoms including dryness, fatigue and pain. Previous work by our group has…
  • Abstract Number: 566 • 2017 ACR/ARHP Annual Meeting

    Immune Response to Seasonal Flu Vaccination in Patients with Primary Sjogren’s Syndrome

    Albin Björk1, Marika Kvarnström2, Gudny Ella Thorlacius2 and Marie Wahren-Herlenius2, 1Department of Medicine, Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Vaccination of rheumatic patients has been reported to induce lower antibody titers than in healthy individuals. However, studies have primarily included patients treated with…
  • Abstract Number: 567 • 2017 ACR/ARHP Annual Meeting

    Minor Salivary Gland Histopathology, Major Salivary Gland Ultrasonography, and Secretory Function in Smoking Patients with Primary Sjögren’s Syndrome

    Daniel S. Hammenfors1, Haris Causevic2, Johan G. Brun3, Roland Jonsson1 and Malin V. Jonsson4, 1Department of Rheumatology, Haukeland University Hospital, University of Bergen, Bergen, Norway, 2Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 3Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, 4Department of Clinical Dentistry, Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway

    Background/Purpose: Several studies have reported a protective effect of smoking with regard to risk for primary Sjögren’s syndrome (pSS) and minor salivary gland inflammation. To…
  • Abstract Number: 568 • 2017 ACR/ARHP Annual Meeting

    Complement Consumption As a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational Study

    Alisson Pugliesi1, RACHEL ZERBINI MARIANO2, Raquel Baldini Campos3, Simone Appenzeller4, Manoel Bertolo5 and ZORAIDA SACHETTO1, 1INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 2Radiology and Diagnostic Imaging, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 3Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 4Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, 5INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil

    Complement Consumption as a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational StudyBackground/Purpose: Primary Sjögren’s syndrome (pSS) may…
  • Abstract Number: 569 • 2017 ACR/ARHP Annual Meeting

    Is the Oral Microbiome Involved in the Pathogenesis of Sjogren’s Syndrome?

    Taco A van der Meulen1, Frans G.M. Kroese2, S.C. Liefers2, Arnau Vich Vila3, Hermie J.M. Harmsen4, Hendrika Bootsma2, Fred K.L. Spijkervet1 and Arjan Vissink5, 1Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Gastroenterology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Environmental factors involved in the pathogenesis of primary Sjögren’s syndrome (pSS) are still largely unknown. The oral cavity is the microbial habitat closest to…
  • Abstract Number: 570 • 2017 ACR/ARHP Annual Meeting

    Signalling Pathways Identified in Salivary Glands from Primary Sjögren’s Syndrome Patients Reveal Enhanced Adipose Tissue Development, As Demonstrated By Microarray Analysis, Real-Time PCR and Immunohistochemistry

    Lara A Aqrawi1, Janicke C Liaaen Jensen1, Gunnvor Øijordsbakken2, Ann-Kristin Ruus3, Ståle Nygård4,5, Marit Holden6, Roland Jonsson7,8, Hilde Kanli Galtung9 and Kathrine Skarstein10,11, 1Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway, 2Department of Clinical Medicine, University of Bergen, Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, 3Department of Oral Biology, University of Oslo, Oslo, Norway, 4Department of Informatics, University of Oslo, Oslo, Norway, 5Bioinformatics core facility, Institute for Cancer research, Oslo University Hospital, Oslo, Norway, 6Norwegian Computing Center, Oslo, Oslo, Norway, 7Broegelmann Research laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 8Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, 9Department of Oral Biology, University of Oslo, Oslo, Pakistan, 10Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, 11Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway

    Background/Purpose: : A characteristic feature of Sjögren’s syndrome (SS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also…
  • Abstract Number: 571 • 2017 ACR/ARHP Annual Meeting

    Anti-Modified Protein Antibody Response Pattern in Primary Sjögren’s Syndrome: Clinical and Prognostic Implications

    Alessia Alunno1, Francesco Carubbi2,3, Holger Bang4, Onelia Bistoni1, Paul Studenic5, Günter Steiner5, Elena Bartoloni6, Josef S. Smolen5,7 and Roberto Gerli1, 1Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 2ASL1 Avezzano L'Aquila Sulmona, L'Aquila, Italy, 3Rheumatology Unit, University of L'Aquila, L'Aquila, Italy, 4Orgentec Diagnostika GmbH, Mainz, Germany, 5Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 6Rheumatology Unit, University of Perugia, Perugia, Italy, 7Hietzing Hospital, Department of Internal Medicine, Vienna, Austria

    Background/Purpose: Over the last decades, several post translationally modified proteins have been identified as auto-antigens in rheumatoid arthritis (RA). No data regarding Abs against acetylated…
  • Abstract Number: 572 • 2017 ACR/ARHP Annual Meeting

    Biopsy Accuracy in Sjögren’s Syndrome: Analysis of  803 Patients Presenting with Sicca Syndrome Referred to Labial Salivary Gland Biopsy

    Diego Baenas1, Soledad Retamozo2, Juan Pablo Pirola3, Nadia Benzaquén4, María Flavia Ceballos5, Soledad Fiorentino3, Maria Jezabel Haye Salinas4, Nadia Riscanevo6, Janet Flores7, Ana C. Alvarez4, Verónica Saurit8, Alejandro Alvarellos8 and Francisco Caeiro9, 1Reumatologia, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, 2Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 3Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 4Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, 5Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba., Cordoba, Argentina, 6Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, 7Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, 8Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 9Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina

    Background/Purpose: Labial salivary gland biopsy (LSGB) is a minimally invasive procedure used in the diagnostic of Sjögren's Syndrome (SS). Objectives: to describe demographic, clinical and…
  • Abstract Number: 573 • 2017 ACR/ARHP Annual Meeting

    Subepithelial Infiltrate of the Vagina in Primary Sjogren’s Syndrome: The Cause of Vaginal Dryness?

    Jolien F. van Nimwegen1, Karin van der Tuuk2, Ellen R. Klinkert2, Erlin A. Haacke3, Frans G.M. Kroese1, Harry Hollema3, Marian J. Mourits2 and Hendrika Bootsma1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Women with primary Sjögren’s syndrome (pSS) often experience vaginal dryness. The cause of this symptom is unknown. This study compared the vaginal and cervical…
  • Abstract Number: 574 • 2017 ACR/ARHP Annual Meeting

    Is Elastography a New Tool to Differentiate Sjögren Syndrome to Sicca Syndrome?: Results of the Elsa (elastography of salivary glands) Study

    Sandrine Jousse-Joulin1, luc Bressollette2, thibault depinoy3, guillermo carvajal Alegria3, Divi Cornec4, Thierry Marhadour5, Dewi Guellec6, Valérie Devauchelle-Pensec7 and Alain Saraux8, 1Rheumatology, CHu La cavle Blanche, Brest, France, 2Doppler unit, Cavale Blanche hospital, brest, France, 3rheumatology department, cavale blanche hospital, brest, France, 4CHU Brest, Brest, France, 5Rheumatology, CHU La Cavale Blanche, Brest, France, 6Rheumatology, CHU Brest, Brest, France, 7Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, 8Rheumatology, Brest University Medical School Hospital, Brest, France

    Background/Purpose: Ultrasonography (US) has been developed in salivary glands (SG) and particularly in primary Sjögren syndrome (pSS) for 10 years. However, the training curve is…
  • Abstract Number: 575 • 2017 ACR/ARHP Annual Meeting

    Distinct Clinical and Immunological Features of Anti-Centromere Antibody Positive Primary Sjögren’s Syndrome: A Single Center Cross-Sectional Cohort Study

    Masako Tsukamoto1,2, Katsuya Suzuki1, Noriyuki Seta2 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Internal Medicine, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan

    Background/Purpose: Anti-centromere antibody (ACA) positive Sjögren’s syndrome (SS) is considered as a subtype in SS. Recent international collaborative large scale cohort study highlighted several clinical…
  • Abstract Number: 576 • 2017 ACR/ARHP Annual Meeting

    Immunosignature-Based Diagnosis and Prediction of Therapeutic Response Enables Retrospective Patient Stratification in a Phase IIa Clinical Trial for VAY736 in Primary Sjögren’s Syndrome

    Robert Gerwien1, Theodore M. Tarasow2, Jonathan Melnick2, Anna Lei3, Arvind Kinhikar4, Julie Doucet5, Remi Kazma5, Paul Maguire4, Irina Koroleva6, Giulio Macchiarella4, Alexandre Avrameas5, Marie-Anne Valentin5, Stephen Oliver5 and Alessandra Vitaliti5, 1HealthTell, Inc, san ramon, CA, 2HealthTell, Inc., San Ramon, CA, 3Health Tell, San Ramon, CA, 4Novartis, Cambridge, MA, 5Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, 6Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA

    Background/Purpose: Although patient stratification can improve the success rate of clinical trials, efforts to apply this strategy to autoimmune studies such as Sjögren’s syndrome are…
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