Abstracts Archive - Page 1231 of 2607 - ACR Meeting Abstracts

Abstract Number: 670 • 2018 ACR/ARHP Annual Meeting
Low Rate of Spinal Radiographic Progression over 2 Years in Ankylosing Spondylitis Patients Treated with Secukinumab: A Historical Cohort Comparison
Jürgen Braun¹, Hildrun Haibel², Manouk de Hooge³, Robert B.M. Landewé⁴, Martin Rudwaleit⁵, Todd Fox⁶, Aimee Readie⁷, Hanno Richards⁶, Brian Porter⁸, Ruvie Martin⁷, Denis Poddubnyy⁹, Joachim Sieper¹⁰ and Désirée van der Heijde¹¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Charité Universitätmedizin Berlin, Berlin, Germany, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Maastricht Univ Medical Center, Maastricht, Netherlands, ⁵Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ, ⁹Charité Universitätsmedizin Berlin, Berlin, Germany, ¹⁰Charité Universitätsmeidzin Berlin, Berlin, Germany, ¹¹Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Secukinumab, a fully human monoclonal antibody that neutralizes IL-17A, improved signs and symptoms of ankylosing spondylitis (AS) in patients (pts) in the MEASURE 1…
Abstract Number: 671 • 2018 ACR/ARHP Annual Meeting
Validation of the Rexspa (Reductive X-Ray Score for Psoriatic Arthritis) in an Argentinean Cohort of Patients with Psoriatic Arthritis
Carolina Ayelen Isnardi¹, Emilce E Schneeberger², Fernando Dal Pra³, E. Scheines^1,4, Andrea Lujan Coronel Ale⁵, Marina Natalia Fornaro⁶, Osvaldo Luis Cerda⁵ and Gustavo Citera⁵, ¹Reumatology, Instituto de Rehabilitación Psicofísica, CABA, Argentina, ²Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Rheumatology, Hospital Manuel Rocca, Buenos Aires, Argentina, ⁵Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, ⁶Section of Rheumatology, Instituto de Rehabilitación Psicofísica, buenos aires, Argentina
Background/Purpose: There are many scores available to measure radiographic joint damage in patients with PsA, but most of them were developed for RA and then…
Abstract Number: 672 • 2018 ACR/ARHP Annual Meeting
Activation of NLRP3 Inflammasomes in Peripheral Blood Mononuclear Cells of Patients with Ankylosing Spondylitis
Seong-Kyu Kim¹ and Jung-Yoon Choe², ¹Rheumatology, Daegu Catholic University School of Medicine, Daegu, Korea, Republic of (South), ²Department of Internal Medicine, Catholic university of Daegu School of Medicine, Daegu, Korea, Republic of (South)
Background/Purpose: NLRP3 inflammasome is a molecular platform triggering activation of inflammatory cytokines including interleukin-1b (IL-1b). This study aimed to assess the expression of NLRP3 inflammasome…
Abstract Number: 673 • 2018 ACR/ARHP Annual Meeting
Chronic Back Pain (CBP) in First Degree Relatives (FDRs) of Patient with Ankylosing Spondylitis (AS): Comparison with the US Population, HLA-B27 Frequency and Persistence of Symptoms over Time
John D. Reveille¹, MinJae Lee², Laura A. Diekman³, Michael Ward⁴, Lianne S. Gensler⁵, Amirali Tahanan², Mohammad H. Rahbar⁶ and Michael Weisman⁷, ¹McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ²Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ³Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁴National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁵University of California San Francisco, San Francisco, CA, ⁶Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁷Harbor UCLA Medical Center, Los Angeles, CA
Background/Purpose: We examined first degree relatives (FDRs) of patients with ankylosing spondylitis (AS) patients with chronic inflammatory back pain (CIBP), non-inflammatory CBP (NICBP) and no…
Abstract Number: 674 • 2018 ACR/ARHP Annual Meeting
Defining the Therapeutic Target in Psoriatic Arthritis: MDA Versus Dapsa
Andrea Lujan Coronel Ale¹, Osvaldo Luis Cerda¹, Marina Natalia Fornaro², Carolina Ayelen Isnardi³, Emilce E Schneeberger⁴ and Gustavo Citera¹, ¹Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, ²Section of Rheumatology, Instituto de Rehabilitación Psicofísica, buenos aires, Argentina, ³Reumatology, Instituto de Rehabilitación Psicofísica, CABA, Argentina, ⁴Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose: T2T guidelines for psoriatic arthritis (PsA) propose using DAPSA or MDA to define the therapeutic target, but with differences in preference among experts. Objective:…
Abstract Number: 675 • 2018 ACR/ARHP Annual Meeting
Quantitative Ultrasound of the Calcaneus Has a Role to Play in Detecting Low Bone Mineral Density in Axial Spondyloarthropathy Patients
Gillian Fitzgerald^1,2, Tochukwu Anachebe³, Ronan Mullan⁴, David Kane⁵, Kevin McCarroll⁶ and Finbar O' Shea², ¹School of Medicine, Trinity College Dublin, Dublin 2, Ireland, ²Rheumatology, St. James's Hospital, Dublin 8, Ireland, ³Department of Rheumatology, St. James's Hospital, Dublin 8, Ireland, ⁴Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, ⁵Department of Rheumatology, Tallaght Hospital, Dublin 24, Ireland, ⁶Department of Medicine for the Elderly, St. James's Hospital, Dublin 8, Ireland
Background/Purpose: Axial spondyloarthropathy (axSpA) patients have an increased risk of developing osteoporosis compared to matched controls. Dual energy x-ray absorptiometry (DXA) is the technique of…
Abstract Number: 676 • 2018 ACR/ARHP Annual Meeting
A Novel Role for the Psoriatic Arthritis Impact of Disease Questionnaire
Kishor Johnson¹, Justine Y. Ye², Vinod Chandran² and Dafna D Gladman², ¹Western University, London, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis that occurs in about 30% of patients with Psoriasis (Ps). Recently, a new Patient Reported Outcome Measure…
Abstract Number: 677 • 2018 ACR/ARHP Annual Meeting
Structural Damage Characteristics of Patients with Ankylosing Spondylitis in China
Weiping Kong¹, Caroline Jefferies², Thomas Learch³, Jinrui Cui⁴, Xiaowei Gan¹, Nan Zhang¹, Yingze Zhang¹, Jianming Wang¹, Qingwen Tao¹, Xiaoping Yan¹, Michael Weisman⁵ and Mariko Ishimori⁶, ¹China-Japan Friendship Hospital, Beijing, China, ²Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Radiology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Harbor UCLA Medical Center, Los Angeles, CA, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Structural damage is a major cause of poor outcomes in patients with ankylosing spondylitis (AS). In China, structural damage characteristics of AS are rarely…
Abstract Number: 678 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of Achilles Tendon in Early Axial Spondyloarthropathy: Is There Any Difference between Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthropathy?
Shahla Vahidfar¹, Ismihan Sunar², Sebnem Ataman³, Gürkan Yılmaz⁴, Javid M. AZARABADI⁵ and Ayşe Bölükbaşı¹, ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Department of Physical Medicine and Rehabilitation, Division of Rheumatology,, Ankara University, Faculty of Medicine, Ankara, Turkey, ³Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey, ⁴Physical Medicine and Rehabilitation, Rheumatology Division, Ankara University Faculty of Medicine, Ankara, Turkey, ⁵ORTHOPEDICS AND TRAUMATOLOGY, Başkent University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Along with emergence of the term of ‘non-radiographic axial SpA’ (nr-AxSpA), studies comparing AS and nr-AxSpA in terms of genetic, epidemiologic, and clinical issues…
Abstract Number: 679 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Research of the Relationship between Nail Disorders and Peripheral Arthritis or Enthesitis in Patients with Psoriasis and Psoriatic Arthritis
Tadashi Okano¹, Kentaro Inui², Koji Mandai³, Yutaro Yamada⁴, Tatsuya Koike⁵ and Hiroaki Nakamura², ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ³Orthopaedic surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Orthopedic surgery, Yodogawa Christian Hospital, Osaka, Japan, ⁵Center for Senile Degenerative Disorders, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Although skin lesion is the most typical findings in patients with psoriasis (PsO), nail psoriasis is also one of the important clinical manifestation. Moreover,…
Abstract Number: 680 • 2018 ACR/ARHP Annual Meeting
Unmet Needs in the Treatment of Ankylosing Spondylitis. a Long-Term Observational Study from a Single University Center
Eleftherios Pelechas¹, Evripidis Kaltsonoudis², Paraskevi V. Voulgari³ and Alexandros Drosos⁴, ¹Rheumatology Clinic, Department οf Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, Fellow in Rheumatology, Ioannina, Greece, ²Rheumatology Clinic, Department of Internal Medicine, Rheumatologist, Ioannina, Greece, ³Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Professor of Rheumatology, Ioannina, Greece, ⁴Rheumatology Clinic, Department of Internal Medicine, Medical School University of Ioannina, Ioannina, Greece, Professor of Medicine/Rheumatology, Ioannina, Greece
Background/Purpose: Despite the progress in the treatment of ankylosing spondylitis (AS), a significant number of patients does not achieve low disease activity (LDA). The aim…
Abstract Number: 681 • 2018 ACR/ARHP Annual Meeting
Identification of Treatment Naïve Patients with Psoriatic Arthritis Who Will Require a TNF Inhibitor
Dan Gromer¹, Laura C. Coates², Oliver FitzGerald³, Blanca Himes⁴, Philip Helliwell⁵ and Alexis Ogdie⁶, ¹University of Pennsylvania, Medical Student, Philadelphia, PA, ²University of Oxford, Oxford, United Kingdom, ³Department of Rheumatology, St Vincent's University Hospital and Conway Institute, University College Dublin, Ireland, Dublin, Ireland, ⁴Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ⁵LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁶Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease that affects the skin, joints, and soft tissues. No metrics exist to indicate whether an…
Abstract Number: 682 • 2018 ACR/ARHP Annual Meeting
Nonsteroidal Anti-Inflammatory Drug Use and Hypertension in Ankylosing Spondylitis
Jean Liew¹, John D. Reveille², Michael Ward³, MinJae Lee⁴, Matthew Brown⁵, Mohammad H. Rahbar⁶, Michael Weisman⁷ and Lianne S. Gensler⁸, ¹Internal Medicine; Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ³National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁴Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁵Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁶Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, USA, Los Angeles, CA, ⁸University of California San Francisco, San Francisco, CA
Background/Purpose: Cardiovascular morbidity and mortality are increased in Ankylosing Spondylitis (AS). Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first line pharmacological therapy in AS; however, their…
Abstract Number: 683 • 2018 ACR/ARHP Annual Meeting
Spanish Validation of the Gepard Questionnaire for the Detection of Psoriatic Arthritis in Argentinean Patients with Psoriasis
María Victoria Martire¹, María Paula Girard Bosch¹, Santiago Scarafia², Vanesa Laura Cosentino³, María Janina Tapia⁴, Eduardo Kerzberg³, Natalia Estrella⁵, Cristian Troitiño⁶, Josefina Marin⁷, Fernando Andres Sommerfleck⁸, Hernán Maldonado Ficco⁹, Erika Catay¹⁰, Mariana Benegas¹¹ and Enrique R Soriano¹², ¹Rheumatology, Instituto Médico Platense, La Plata, Argentina, ²Rheumatology, Instituto de Asistencia Reumatológica Integral, Buenos Aires, Argentina, ³Ramos Mejía Hospital, Buenos Aires, Argentina, ⁴Reumatology, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, ⁵Consultorio Privado, Buenos Aires, Argentina, ⁶Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ⁷Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁹section of Rheumatology, Clinica Regional Del Sud, Rio Cuarto, Argentina, ¹⁰Consultorios Moreno, Formosa, Argentina, ¹¹Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, ¹²Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina
Background/Purpose: Psoriatic Arthritis (PSA) is preceded by the presence of cutaneous psoriasis (PS) in approximately 80% of the cases. We consider relevant to have tools…
Abstract Number: 684 • 2018 ACR/ARHP Annual Meeting
Efficacy of Ixekizumab in Different Phenotypes of Patients with Active Psoriatic Arthritis (PsA): Results from the Spirit Trials
Frank Behrens¹, Peter Nash², Laure Gossec³, Soyi Liu Leage⁴, Inmaculada de la Torre⁵, Christophe Sapin⁴, Monika Kurzawa⁶, Gerd R. Burmester⁷ and Josef S. Smolen⁸, ¹Division of Rheumatology, Goethe University and Fraunhofer IME-TMP, Frankfurt, Germany, ²University of Queensland, Brisbane, Australia, ³Sorbonne Universités, Paris, France, ⁴Lilly France, Neuilly sur Seine Cedex, France, Neuilly sur Seine Cedex, France, ⁵Eli Lilly and Company, Madrid, Spain, ⁶Eli Lilly and Company, Bad Homburg, Germany, ⁷Department of Rheumatology and Clinical Immunolgy, Charité University Hospital, Berlin, Germany, ⁸Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria
Background/Purpose: PsA is a highly heterogeneous chronic inflammatory disease combining a range of musculoskeletal and extra-articular manifestations. Ixekizumab (IXE) is approved for the treatment of…

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