ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 672

Activation of NLRP3 Inflammasomes in Peripheral Blood Mononuclear Cells of Patients with Ankylosing Spondylitis

Seong-Kyu Kim1 and Jung-Yoon Choe2, 1Rheumatology, Daegu Catholic University School of Medicine, Daegu, Korea, Republic of (South), 2Department of Internal Medicine, Catholic university of Daegu School of Medicine, Daegu, Korea, Republic of (South)

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), inflammasome activation and interleukins (IL)

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, October 21, 2018

Session Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster I: Imaging, Clinical Studies, and Treatment

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: NLRP3 inflammasome is a molecular platform triggering activation of inflammatory cytokines including interleukin-1b (IL-1b). This study aimed to assess the expression of NLRP3 inflammasome complex and pro-inflammatory cytokines in patients with ankylosing spondylitis (AS).

Methods: Peripheral blood mononuclear cells (PBMCs) and serum from 23 male patients and gender-matched 30 healthy controls were consecutively collected. The mRNA expression for target genes including NLRP3, caspase-1, IL-1b, IL-17A, and IL-23 from PBMCs were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Clinical information related with AS patients were collected including Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), peripheral arthritis, enthesitis, and extraarticular manifestations. Statistical analyses were performed using Spearman’s correlation coefficient and Mann-Whitney t test.

Results:

Higher mRNA expression of NLRP3, caspase-1, IL-1b, IL-17A, and IL-23 in AS was noted than those in controls (p = 0.010, p = 0.029, p = 0.005, p = 0.046, and p = 0.002, respectively). Patients treated with biological diseases modifying antirheumatic drugs (bDMARDs) showed significantly lower caspase-1, IL-1b, and IL-17A m RNA levels than those without bDMARDs, but not in IL-23 and NLRP3. NLRP3 mRNA levels were significantly associated with IL-23, IL-17A, caspase-1, and IL-1b (p < 0.05 of all). Increased NLRP3, caspase-1, IL-1b, IL-17A, and IL-23 mRNA expression in PBMC cultured with LPS was marked attenuated by antioxidants.

Conclusion: This study suggests that inflammatory response by activation of NLRP3 inflammasome might be involved in the pathogenesis of AS.


Disclosure: S. K. Kim, None; J. Y. Choe, None.

To cite this abstract in AMA style:

Kim SK, Choe JY. Activation of NLRP3 Inflammasomes in Peripheral Blood Mononuclear Cells of Patients with Ankylosing Spondylitis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/activation-of-nlrp3-inflammasomes-in-peripheral-blood-mononuclear-cells-of-patients-with-ankylosing-spondylitis/. Accessed May 17, 2022.
  • Tweet
  • Email
  • Print

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/activation-of-nlrp3-inflammasomes-in-peripheral-blood-mononuclear-cells-of-patients-with-ankylosing-spondylitis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.