ACR Meeting Abstracts

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  • Abstract Number: 2858 • 2018 ACR/ARHP Annual Meeting

    Gaps in Patient Safety Performance before Treatment with Biologic Disease-Modifying Antirheumatic Drugs or Tofacitinib in a Large Academic Healthcare System

    Sarah L. Patterson1, Michael Evans2, Ishita Aggarwal3, Zara Izadi4, Milena Gianfrancesco5, Gabriela Schmajuk6 and Jinoos Yazdany7, 1Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2University of California - San Francisco, San Francisco, CA, 3Medicine, Santa Clara Valley Medical Center, San Jose, CA, 4Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 5Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 6San Francisco VA Medical Center, San Francisco, CA, 7University of California, San Francisco, San Francisco, CA

    Background/Purpose: Treatment with biologic disease-modifying antirheumatic drugs (DMARDs) and tofacitinib confer increased risk of life-threatening infections, including reactivation of latent tuberculosis infection (LTBI), hepatitis B…
  • Abstract Number: 2859 • 2018 ACR/ARHP Annual Meeting

    Do Preventive Cardiology Consults Versus Usual Care Improve Cardiovascular Risk Factor Assessment and Management in Patients with Rheumatoid Arthritis?

    Ellen Romich1, Haitham Ahmed2, Amy Nowacki3 and M. Elaine Husni4, 1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 4Rheumatology, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Rheumatoid arthritis (RA) patients have around 50% increased risk of cardiovascular disease (CVD). Both traditional and RA-specific cardiovascular (CV) risk factors contribute to the…
  • Abstract Number: 2860 • 2018 ACR/ARHP Annual Meeting

    Disease Activity and Its Measurement in Patients with RA across the U.S.: Data from the Rheumatology Informatics System for Effectiveness (RISE) Registry

    Gabriela Schmajuk1,2, Michael Evans3, Julia Kay1, Lisa Gale Suter4, Megan E. B. Clowse5, Esi Morgan6, Andreas Reimold7, Alex Limmani8, Tracy Johansson9, Lindsay Lewis9 and Jinoos Yazdany10, 1Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, 2San Francisco VA Medical Center, San Francisco, CA, 3University of California - San Francisco, San Francisco, CA, 4Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, 5Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 6University of Cincinnati, Cincinnati, OH, 7Rheumatology, Dallas VA and Univ of TX Southwestern Med Ct, Dallas, TX, 8Arthritis Centers of Texas, Dallas, TX, 9Practice, Advocacy & Quality, American College of Rheumatology, Atlanta, GA, 10University of California, San Francisco, San Francisco, CA

    Background/Purpose: Although national quality measures promote the measurement of disease activity (DA) in RA, the burden of DA in a population-based sample of RA patients…
  • Abstract Number: 2861 • 2018 ACR/ARHP Annual Meeting

    Clinical Laboratory Telephone Communication Outreach to Rheumatology Patients Improves Guideline-Concordant Timeliness of Monitoring of Conventional and Biologic Disease-Modifying Anti-Rheumatic Drugs (DMARDs)

    Tyson Hagen1, Bharati Bhardwaja2, David Silverman3, Susan Shetterly4 and Marsha Raebel5, 1Rheumatology, Kaiser Permanente Colorado, Lafayette, CO, 2Pharmacy, Kaiser Permanente Colorado, Lafayette, CO, 3Kaiser Permanente Colorado, La Fayette, CO, 4Institute for health Research, Kaiser Permanente Colorado, Aurora, CO, 5Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO

    Background/Purpose: The American College of Rheumatology has published guidelines for laboratory monitoring of conventional DMARDs (cDMARDs). At Kaiser Permanente Colorado (KPCO), although most patients eventually…
  • Abstract Number: 2862 • 2018 ACR/ARHP Annual Meeting

    Magnitude of Response to TNF Inhibitors in Children with Spondyloarthritis and Sacroiliitis

    Rosemary Peterson1, Rui Xiao2, Timothy G. Brandon3, David M. Biko4, Michael Francavilla4, Nancy A. Chauvin5 and Pamela F. Weiss6, 1Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 2Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 5Radiology, Penn State Hershey Medical Center, Hershey, PA, 6Pediatrics, Children's Hospital Philadelphia, Philadelphia, PA

    Background/Purpose: We aimed to quantify the magnitude of biologic effect on sacroiliitis in juvenile SpA by comparing the change in the Spondyloarthritis Research Consortium of…
  • Abstract Number: 2863 • 2018 ACR/ARHP Annual Meeting

    Long-Term Efficacy and Safety of Canakinumab in Patients with Colchicine-Resistant FMF (crFMF), Hids/Mkd and TRAPS: Results from the Pivotal Phase 3 Cluster Trial

    Fabrizio De Benedetti1, Joost Frenkel2, Anna Simon3, Jordi Anton4, Helen J. Lachmann5, Marco Gattorno6, Seza Ozen7, Isabelle Koné-Paut8, Eldad Ben-Chetrit9, Magdalena Wozniak10, Xiaoling Wei11 and Eleni Vritzali12, 1IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 2University Medical Center,Utrecht, Utrecht, Netherlands, 3General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, Netherlands, 4Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, 5UCL Division of Medicine, UK National Amyloidosis Centre, London, United Kingdom, 6Pediatric Division, G Gaslini Institute, Genoa, Italy, 7Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 8APHP, CHU de Bicêtre, University of Paris SUD, Paris, France, 9Rheumatology Unit, Hadassah—Hebrew University Medical Center, Jerusalem, Israel, 10Novartis Ireland Ltd, Dublin, Ireland, 11China Novartis Institutes for Biomedical Research Co., Ltd, Beijing, China, 12Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Canakinumab (CAN), a selective, human anti-interleukin (IL)-1β  has demonstrated efficacy and safety in patients (pts) with colchicine-resistant familial Mediterranean fever (crFMF), hyper-IgD syndrome (HIDS)/mevalonate…
  • Abstract Number: 2864 • 2018 ACR/ARHP Annual Meeting

    Identification of Optimal Subcutaneous Doses of Tocilizumab in Children with Systemic Juvenile Idiopathic Arthritis

    Hermine I. Brunner1, Nicola Ruperto2, Daniel J Lovell1, Gerd Horneff3, María Luz Gámir-Gámir4, Markus Hufnagel5, Joy Hsu6, Min Bao6, Wendy Douglass7, Navita L. Mallalieu6, Chris Wells7, Christopher M. Mela8 and Fabrizio De Benedetti9, 1Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Pediatric Rheumatology International Trial Organization (PRINTO), Istituto Giannina Gaslini Pediatria II-Reumatologia, Genoa, Italy, 3Asklepios Clinic Sankt Augustin, and University Hospital of Cologne, Cologne, Germany, 4Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain, 5Department of Pediatrics and Adolescent Medicine, University Medical Center, Medical Faculty, University of Freiburg, Freiburg, Germany, 6Roche Innovation Center, New York, NY, 7Roche Products Ltd., Welwyn Garden City, United Kingdom, 8Roche Products Ltd, Welwyn Garden City, United Kingdom, 9IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy

    Background/Purpose: Efficacy and safety of intravenous (IV) tocilizumab (TCZ) were shown in patients (pts) with systemic JIA (sJIA) in the phase 3 TENDER study.1 This…
  • Abstract Number: 2865 • 2018 ACR/ARHP Annual Meeting

    Canakinumab, on a Reduced Dose or a Prolonged Dose Interval without Concomitant Corticosteroids and Methotrexate, Maintains Efficacy in Systemic Juvenile Idiopathic Arthritis Patients in Clinical Remission

    Pierre Quartier1, Ekaterina Alexeeva2, Carine Wouters3, Inmaculada Calvo4, Tilmann Kallinich5, Bo Magnusson6, Nico Wulffraat7, Xiaoling Wei8, Alan Slade9, Ken Abrams9 and Alberto Martini10, 1AP-HP, Institut des Maladies Génétiques (IMAGINE), and Université Paris-Descartes, Necker-Enfants Malades Hospital, Paris, France, 2National Medical Research Center of Children's Health and Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, 3Gasthuisberg University Hospital, Leuven, Belgium, 4Hospital Universitario La Fe, Valencia, Spain, 5Charité Berlin Campus Virchow, Berlin, Germany, 6Karolinska University Hospital, Stockholm, Sweden, 7University Medical Center Utrecht, Utrecht, Netherlands, 8China Novartis Institutes for Biomedical Research Co., Ltd, Beijing, China, 9Novartis Pharmaceuticals Corporation, East Hanover, NJ, 10Universita di Genova Pediatria II, Genova, Italy

    Background/Purpose: Treatment with canakinumab (CAN), a selective, human anti-IL-1β monoclonal antibody, has shown sustained therapeutic effect along with corticosteroid dose reduction/discontinuation in patients with systemic…
  • Abstract Number: 2866 • 2018 ACR/ARHP Annual Meeting

    Biologic Refractory Disease in a Cohort Study of Children and Young People with Juvenile Idiopathic Arthritis from the United Kingdom

    Eleanor Heaf1, Lianne Kearsley-Fleet1, Rebecca Davies1, Diederik De Cock2, Eileen Baildam3, Michael W. Beresford3,4, Helen E. Foster5, Taunton R. Southwood6, Wendy Thomson7,8 and Kimme L. Hyrich2,8, 1Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 3Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, 4Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, 5Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, 6Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, 7Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 8National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Biologics are a main treatment option for children and young people with juvenile idiopathic arthritis (JIA) who do not respond or are intolerant to…
  • Abstract Number: 2867 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety of Intravenous Belimumab in Children with Systemic Lupus Erythematosus

    Hermine I. Brunner1, Carlos Abud-Mendoza2, Diego I. Viola3, Inmaculada Calvo4, Deborah M. Levy5, Julia Calderon Gallegos6, Manuel Ferrandiz7, Vyacheslav Chasnyk8, Vladmir Keltsev9, Jordi Anton10, Maria Paz11, Michael Shishov12, Alina Lucica Boteanu13, Michael Henrickson14, Damon Bass15, Kenneth Clark16, Anne Hammer15, Beulah Ji16, David Roth15, Herbert Struemper17, Mei-Lun Wang18, Alberto Martini19, Daniel J Lovell20 and Nicola Ruperto19, 1Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosy, Mexico, 3CAICI Institute, Rosario City, Santa Fe State, Argentina, 4Hospital Universitario La Fe, Valencia, Spain, 5Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, 6Instituto de Ginecologia y Reproduccion, Santiago De Surco, Peru, 7Instituto Nacional de Salud del Nino, Lima, Peru, 8St Petersburg State Pediatric Medical Academy, St Petersburg, Russian Federation, 9City Clinical Hospital No.5, Tolyatti, Russian Federation, 10SJD Barcelona Children’s Hospital, Barcelona, Spain, 11Clinica Anglo Americana, Lima, Peru, 12Phoenix Children's Hospital, Phoenix, AZ, 13University Hospital Ramón y Cajal, Madrid, Spain, 14Cincinnati Children’s Medical Center, Cincinnati, OH, 15GlaxoSmithKline, Philadelphia, PA, 16GlaxoSmithKline, Stevenage, United Kingdom, 17GlaxoSmithKline, Research Triangle Park, NC, 18GlaxoSmithKline, Collegeville, PA, 19Universita di Genova Pediatria II, Genova, Italy, 20Cincinnati Children's Medical Center, Cincinnati, OH

    Background/Purpose: Belimumab (BEL) is approved in adults with active systemic lupus erythematosus (SLE). There are no approved biologic therapies for pediatric patients with childhood-onset SLE…
  • Abstract Number: 2868 • 2018 ACR/ARHP Annual Meeting

    Tender Joint Count May Not Reflect Inflammatory Activity in Established Rheumatoid Arthritis Patients; Results from a Longitudinal Study of Tocilizumab

    Hilde B Hammer1, Inger Marie Jensen Hansen2, Pentti Järvinen3, Marjatta Leirisalo-Repo4, Michael Ziegelasch5, Birte Agular6 and Lene Terslev7, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Svendborg Hospital, Svendborg, Denmark, 3Rheumatology, Kiljava Medical Research, Kiljavan, Finland, 4Rheumatology, University of Helsinki, Helsinki, Finland, 5Rheumatology, University Hospital, Linköping, Linköping, Sweden, 6Roche, Copenhagen, Denmark, 7Rheumatology, Rigshospitalet Glostrup, Copenhagen, Denmark

    Background/Purpose: Tender joints may be caused by non-inflammatory pathologies but are still included in composite scores like CDAI. The present objective was to explore the…
  • Abstract Number: 2869 • 2018 ACR/ARHP Annual Meeting

    Incorporation of Patient Reported Outcomes Data in the Care of US Veterans with Rheumatoid Arthritis: A Randomized, Controlled Trial

    Michael R Bubb1, Reuben Judd1 and Ann D Chauffe2, 1Medicine, Malcom Randall VAMC, Gainesville, FL, 2Rheumatology Clinic of Opelousas, Opelousas, LA

    Background/Purpose: Quantitative disease activity measures are required to implement a treat-to-target algorithm for the treatment of rheumatoid arthritis (RA). Available measures based on patient-derived data…
  • Abstract Number: 2870 • 2018 ACR/ARHP Annual Meeting

    Thresholds for Disease Activity Measures DAS28, CDAI, and RAPID3 Do Not Align with Clinical Practice Patterns of Rheumatoid Arthritis (RA) Disease Management Decisions

    Brian C. Sauer1, Chia-Chen Teng, MS1, Neil A. Accortt2, David H. Collier2, Tzu-Chieh Lin2 and Grant W. Cannon1, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Amgen Inc., Thousand Oaks, CA

    Background/Purpose:   Treatment guidelines recommend using disease activity measures (DAMs) to guide RA therapy, but DAM use in real-world treatment decisions is not defined.  We…
  • Abstract Number: 2871 • 2018 ACR/ARHP Annual Meeting

    Comprehensive Provider Judgement Is a Significant Determinant of Major Therapeutic Change in Patients with Moderate to Severe Rheumatoid Arthritis

    Jacob R. Stever1, Brian C. Sauer1 and Grant W. Cannon2, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT

    Background/Purpose:   We have previously reported an evaluation of 941 US Veterans in the Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry that 559 (59%)…
  • Abstract Number: 2872 • 2018 ACR/ARHP Annual Meeting

    Variation in Predictors of Patient and Physician Defined Flares in Rheumatoid Arthritis

    Anna O'Connor1, Joshua Baker2, Bryant R. England3, Brian C. Sauer4, Grant W. Cannon5 and J. Steuart Richards6, 1Department of Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA, 3Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 4Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 5Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 6Pittsburgh VA Medical Center and University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The identification of risk factors associated with flares in RA is challenging because of the use of different composite disease activity scores and a…
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