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  • Abstract Number: 479 • 2019 ACR/ARP Annual Meeting

    Impact of Achieving Early-sustained Remission on Preventing Long-term Functional Loss in Patients with Early Rheumatoid Arthritis

    Evelyn Chow1, Isaac T. Cheng 1, Lai-Shan Tam 1 and CRYSTAL Study Team Hong Kong 2, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2The Chinese University of Hong Kong, Hong Kong

    Background/Purpose: Preventing functional loss is crucial to early RA (ERA) patients in order to maintain usual activities of daily living. However, whether achieving early and…
  • Abstract Number: 480 • 2019 ACR/ARP Annual Meeting

    Not Achieving Clinical Remission Predicts a Poor Health-Related Quality of Life in Rheumatoid Arthritis Patients: Results of a Latin American Real World Database

    Rocío-V. Gamboa-Cárdenas1, Manuel Ugarte-Gil 2, Cristina Reátegui-S 3, Victor Pimentel-Quiroz 4, Mariela Medina 1, Zoila Rodríguez-Bellido 1, Samira Garcia-H 5, Paola Zeña-Huancas 1, Luciana Gil 1, Erika Noriega 1, Francisco Zevallos-M 1, José Alfaro-Lozano 1, Risto Perich-Campos 1, César-A Pastor-A 6 and Graciela Alarcón 7, 1Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Lima, Peru, 2Universidad Científica del Sur, Lima, Lima, Peru, 3Hospital Nacional Guillermo Almenara Irigoyen, Lima, Lima, Peru, 4Hospital Nacional Guillermo Almenara Irigoyen - EsSalud, Lima, Lima, Peru, 5Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Lima, Peru, 6Universidad Nacional Mayor de San Marcos, Lima, Lima, Peru, 7University of Alabama at Birmingham, Birmingham

    Background/Purpose: Uncontrolled Rheumatoid Arthritis (RA) leads to disability, damage, and poor health-related quality of life (HRQoL). Current treatment recommendations emphasize the importance of achieving remission…
  • Abstract Number: 481 • 2019 ACR/ARP Annual Meeting

    Production of IL17A in Synovial Tissue Correlates with MRI RAMRIS Scores in ACPA Positive Early Rheumatoid Arthritis

    Thomas Kirchgesner1, Christine Galant 2, Bernard Lauwerys 3, Bruno Vande Berg 1, Tatiana Sokolova 4, Laurent Meric de Bellefon 5, Adrien Nzeusseu 5 and Patrick Durez 6, 1Musculoskeletal Imaging Unit, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Bruxelles, Belgium, 2Histopathology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Bruxelles, Belgium, 3Rheumatology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Brussels, Belgium, 4Rheumatology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Bruxelles, Belgium, 5Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique, Bruxelles, Belgium, 6Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, UCL Saint-Luc, Brussels, Belgium

    Background/Purpose: We previously studied evolution of MRI RAMRIS scores in a group of 28 early rheumatoid (RA) patients treated with first-line infliximab (IFX) versus placebo.…
  • Abstract Number: 482 • 2019 ACR/ARP Annual Meeting

    Antibody Repertoire Sequencing, Antigen Array Analysis, and Cytokine Profiling of Blood from Individuals at High-risk for RA Reveals Candidate Immunoglobulin V Genes, ACPA, and Cytokines That May Promote the Transition to Arthritis

    Radhika Iyer1, Amin Zia 1, Michelle Bloom 1, Sunil Nagpal 2, Navin Rao 2, Frédéric Baribaud 3, George Vratsanos 4, Wei Wang 5, Gary Firestein 6, David Boyle 5, Jane Buckner 7, V. Michael Holers 8, Kevin Deane 9 and William Robinson 10, 1Stanford University, Stanford, 2Janssen R&D, Spring House, PA, 3Janssen Research & Development, LLC, Spring House, PA, 4JNJ, Raritan, NJ, 5University of California, San Diego, San Diego, CA, 6University of California, San Diego, San Diego, 7Benaroya Research Institute, Seattle, WA, 8University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 9University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 10Stanford University, Stanford, CA

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated…
  • Abstract Number: 483 • 2019 ACR/ARP Annual Meeting

    Can a Single Question on Functional Impairments Facilitate the Diagnosis of Early Inflammatory Arthritis? A Cross-Sectional Derivation and Validation Study in Two Early Arthritis Recognition Clinics

    Bastiaan van Dijk1, Hanna van Steenbergen 1, Ellis Niemantsverdriet 1 and Annette van der Helm-van Mil 2, 1Leiden University Medical Center, Leiden, Netherlands, 2LUMC, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: Early treatment initiation in RA is associated with improved outcomes but requires early identification of synovitis. Joint swelling in early inflammatory arthritis (IA) may…
  • Abstract Number: 484 • 2019 ACR/ARP Annual Meeting

    Effectiveness of Platelet-derived Microparticles for the Diagnosis and Clinical Evaluation of Rheumatoid Arthritis

    Hideyuki Horikoshi1, Ko Takamatsu 1, Rika Suzuki 1, Yasuyoshi Kusanagi 1, Fumihiko Kimura 1 and Kenji Itoh 1, 1National Defense Medical College Division of Hematology and Rheumatology, Department of Internal Medicine, Tokorozawa, Saitama, Japan

    Background/Purpose: Platelet-derived microparticles (PDMP) are membrane vesicles released from activated platelets and contain various inflammatory or angiogenetic factors; therefore, PDMP may be a new biomarker…
  • Abstract Number: 485 • 2019 ACR/ARP Annual Meeting

    Comparison of Clinical Features, Synovial Histology and Immunohistochemistry in Seropositive Arthralgia, Rheumatoid Arthritis, and Osteoarthritis

    Candice Low1, Richard Conway 2, Francis Young 1, Eamonn Molloy 3, Anne Barbara Mongey 3, Gerry Wilson 3, Ursula Fearon 4 and Douglas Veale 5, 1Saint Vincent's University Hospital, Dublin, Ireland, 2Blackrock Clinic, Dublin, Ireland, 3St Vincent's University Hospital, Dublin, Ireland, 4Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland, 5EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland

    Background/Purpose: Seropositive arthralgia is defined as joint pain in patients positive for rheumatoid factor (RF) or anti-citrullinated protein antibodies (ACPA). It is a precursor to…
  • Abstract Number: 486 • 2019 ACR/ARP Annual Meeting

    Evolution of Seropositive Arthralgia over Time: Predictors of Evolution to Rheumatoid Arthritis

    Candice Low1, Richard Conway 2, Francis Young 1, Eamonn Molloy 3, Anne Barbara Mongey 3, Gerry Wilson 3, Ursula Fearon 4 and Douglas Veale 5, 1Saint Vincent's University Hospital, Dublin, Ireland, 2Blackrock Clinic, Dublin, Ireland, 3St Vincent's University Hospital, Dublin, Ireland, 4Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland, 5EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland

    Background/Purpose: Seropositive arthralgia is defined as joint pain in patients positive for rheumatoid factor (RF) or anti-citrullinated protein antibodies (ACPA). In some individuals it is…
  • Abstract Number: 487 • 2019 ACR/ARP Annual Meeting

    Third Generation Anti-cyclic Citrullinated Peptide Antibodies Improve Prediction of Clinical Arthritis in Second Generation Anti-cyclic Citrullinated Peptide Positive Subjects at Risk of Rheumatoid Arthritis

    Andrea Di Matteo1, Kulveer Mankia 1, Laurence Duquenne 2, Leticia Garcia-Montoya 1, Diane Corscadden 3, Katie Mbara 3, Jacqueline Nam 1, Michael Mahler 4 and Paul Emery 1, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, England, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, 4Inova Diagnostics, San Diego, CA

    Background/Purpose: ACPA positive individuals with musculoskeletal symptoms are at increased risk of developing RA. In such individuals, ACPA are conventionally identified on the basis of…
  • Abstract Number: 488 • 2019 ACR/ARP Annual Meeting

    Citrullinated Antigens with Multiple Citruline Similar Motif Could Be Used for RA Diagnosis

    zhiwei ru 1, Xuedong Chen 2, Xiaoyan huang 1, Jianrong Lou 1, YongZheng peng 3 and Xiang Yang1, 1Leide bioscience Inc, guang zhou, Guangdong, China (People's Republic), 2Southern Medicine University, guang zhou, Guangdong, China (People's Republic), 3Southern Medicine University, guang dong, Guangdong, China (People's Republic)

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation that ultimately leads to joint destruction. Diagnosis of RA is important…
  • Abstract Number: 489 • 2019 ACR/ARP Annual Meeting

    S100A11 (calgizzarin) Is Released During Neutrophil Extracellular Traps (NETs) Formation in Rheumatoid Arthritis (RA)

    Adéla Navrátilová1, Jiří Baloun 2, Hana Hulejová 2, Karel Pavelka 3, Jiří Vencovský 3, Ladislav Senolt 3 and Lucie Andrés Cerezo 1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic

    Background/Purpose: S100A11 protein, a member of S100 family, has been associated with several autoimmune inflammatory conditions such as rheumatoid arthritis (RA). Moreover, its pro-inflammatory effect…
  • Abstract Number: 490 • 2019 ACR/ARP Annual Meeting

    Validation of Risk Scores for Predicting Progression in Individuals “At Risk of Rheumatoid Arthritis”

    Laurence Duquenne1, Jacqueline Nam 2, Kulveer Mankia 2, Andrea Di Matteo 2, Leticia Garcia-Montoya 2 and Paul Emery 2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, England, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom

    Background/Purpose: Risk scores for progression have been described in 2015 in a cohort of 100 anti-cyclic citrullinated peptide (anti-CCP) positive individuals at risk of developing…
  • Abstract Number: 491 • 2019 ACR/ARP Annual Meeting

    Diagnostic Performance of Anti-cyclic Citrullinated Peptide (CCP) 2 and CCP3.1 Assays in Early Rheumatoid Arthritis

    Daniela Sieghart1, Christian Konrad 2, Sascha Swiniarski 2, Helmuth Haslacher 3, Daniel Aletaha 4 and Günter Steiner 1, 1Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria, Vienna, Austria, 2Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, 3Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 4Medical University of Vienna, Vienna, Austria

    Background/Purpose: Anti-cyclic citrullinated peptide (CCP) antibodies are the most specific markers for rheumatoid arthritis (RA). Different generations of assays (CCP1-CCP3) have been developed which show…
  • Abstract Number: 492 • 2019 ACR/ARP Annual Meeting

    ‘It Felt Like I Was Walking on Rocks” Patients Share First Symptoms of RA

    Pamela Sinicrope1, Dana Symons 2, Ahmad P. Tafti 1, Christi Patten 1, Martha Bock 1, Jon Tilburt 1, Cynthia Crowson 1, Elena Myasoedova 1, John Davis 1 and Kelly O'Neill 3, 1Mayo Clinic, Rochester, MN, 2Rheumatoid Patient Foundation, Inc., Rockford, MI, 3Rheumatoid Patient Foundation, Inc., Winter Springs, FL

    Background/Purpose: Background: Although early diagnosis and treatment are pivotal for successful outcomes in rheumatoid arthritis (RA), a gap remains in our understanding of its earliest…
  • Abstract Number: 493 • 2019 ACR/ARP Annual Meeting

    Diversity Analysis of Intestinal Flora in Patients with Rheumatoid Arthritis

    Xu-fang Yin 1, Sheng-xiao Zhang1, Ming-xing Zhang 2, Min-jing Chang 1, Xiao-juan Mao 2, Jia Wang 2, Jia-qian Zhang 2, Meng-ting Qiu 2, Chong Gao 3 and Xiao-feng Li 2, 1The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), 2The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), 3Brigham and Women’s Hospital, Harvard Medical School, Boston

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation of the synovial joints. The gut microbe with RA has been reported recently,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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