Abstracts Archive - Page 1156 of 2425 - ACR Meeting Abstracts

Abstract Number: 2272 • 2018 ACR/ARHP Annual Meeting
Missed Opportunity? Evaluation for Systemic Autoimmune Diseases in Patients with Uveitis May Not be Optimal: 5-Year Analysis of Patients Being Seen in a Tertiary Medical Center
Nancy Harrison¹, Swetha Boddeda², Shweta Kishore² and Vikas Majithia³, ¹Rheumatolody, University of Mississippi Medical Center, Jackson, MS, ²Rheumatology, University of Mississippi Medical Center, Jackson, MS, ³Division of Rheumatology, University of Mississippi Medical Center, Jackson, MS
Background/Purpose: Uveitis is the most common inflammatory eye disease and is frequently associated with secondary systemic autoimmune diseases (SSAID) excluding infection in 40-55% of cases.…
Abstract Number: 2273 • 2018 ACR/ARHP Annual Meeting
High Dose Intravenous Methylorednisolone Induces Rapid Improvement in Severe Non-Infectious Uveitis. a Multicenter Study of 120 Patients
Nuria Vegas-Revenga¹, Vanesa Calvo-Río¹, Íñigo González-Mazón², Lara Sánchez-Bilbao², Emma Beltrán³, Alejandro Fonollosa⁴, Olga Maiz-Alonso⁵, Ana Blanco⁶, Miguel Cordero-Coma⁷, Norberto Ortego Centeno⁸, Ignacio Torre-Salaberri⁹, Félix Francisco¹⁰, Santiago Muñoz-Fernández¹¹, Maria del Mar Esteban Ortega¹², Manuel Díaz-Llopis¹³, Mario Agudo², Joaquin Cañal¹, Juan Antonio Ventosa¹, Rosalía Demetrio-Pablo¹, Lucia C. Domínguez-Casas¹, Miguel Angel González-Gay¹⁴ and Ricardo Blanco², ¹Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ³Rheumatology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, ⁴Ophthalmology, Hospital de Cruces. Bilbao. Spain, Bilbao, Spain, ⁵Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, ⁶Ophtamology, Hospital Universitario Donostia. San Sebastian. Spain, San Sebastian, Spain, ⁷Ophthalmology, Hospital de León. Spain, León, Spain, ⁸Medicine Department, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, ⁹Rheumatology, Hospital Universitario de Basurto. Bilbao. Spain, Bilbao, Spain, ¹⁰Rheumatology, Hospital Doctor Negrín. Las Palmas de Gran Canaria. Spain, Las Palmas de Gran Canaria, Spain, ¹¹Hospital Universitario Infanta Sofia. Madrid. Spain, Mardid, Spain, ¹²Hospital Universitario Infanta Sofia. Madrid. Spain, Madrid, Spain, ¹³Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, ¹⁴Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: In uveitis rapid and effective remission-inducing therapy is mandatory to avoid irreversible structural and functional damage.Our aim was to evaluate the efficacy and safety…
Abstract Number: 2274 • 2018 ACR/ARHP Annual Meeting
Refractory and Severe Uveitic Cystoid Macular Edema Improves with Tocilizumab in Different Immune Mediated Diseases
Nuria Vegas-Revenga¹, Vanesa Calvo-Río¹, Marina Mesquida², Alfredo Adan², M. Victoria Hernández², Emma Beltrán³, Elia Valls Pascual⁴, David Diaz-Valle⁵, Gisela Díaz-Cordovés⁶, Marisa Hernandez Grafella⁷, Lucía Martínez-Costa⁸, Inmaculada Calvo⁹, Antonio Atanes¹⁰, Luis Francisco Linares¹¹, Consuelo Modesto¹², Elena Aurrecoechea¹³, Miguel Cordero-Coma¹⁴, Rosalía Demetrio-Pablo¹, Lucia C. Domínguez-Casas¹⁵, José Luis Hernández¹, Miguel Angel González-Gay¹ and Ricardo Blanco¹⁵, ¹Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ³Rheumatology, Hospital del Mar. Barcelona. Spain, Barcelona, Spain, ⁴Hospital Universitario de Valencia. Spain, Valencia, Spain, ⁵Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, ⁶Rheumatology, Hospital Regional Universitario de Málaga. Spain, Málaga, Spain, ⁷Hospital Doctor Peset. Valencia. Spain, Valencia, Spain, ⁸Hospital Doctor Peset. Valencia. Spain, Valencia., Spain, ⁹Hospital Universitario La Fe, Valencia, Spain, ¹⁰Complejo Hospitalario Universitario A Coruña. Spain, A Coruna, Spain, ¹¹Rheumatology, Hospital Virgen de la Arrixaca. Murcia. Spain, Murcia, Spain, ¹²Hospital Universitari Vall d'Hebron. Barcelona. Spain, Barcenola, Spain, ¹³Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, ¹⁴Ophthalmology, Hospital de León. Spain, León, Spain, ¹⁵Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Cystoid macular edema (CME) represents the leading cause of blindness in uveitis of different immune mediated diseases (IMD). Our aim was to evaluate the…
Abstract Number: 2275 • 2018 ACR/ARHP Annual Meeting
Autoimmune Encephalitis with Concomitant Systemic Rheumatologic Auto-Antibodies
Nicole Droz¹, Alexander Rae-Grant² and Rula A Hajj-Ali³, ¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ²Neurology, Cleveland Clinic Foundation, Cleveland, OH, ³Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Autoimmune encephalitis (AE) is a rapidly progressive encephalopathy presenting with neurologic and psychiatric manifestations and is often associated with antibodies targeting neuronal cell-surface or…
Abstract Number: 2276 • 2018 ACR/ARHP Annual Meeting
Risk of Hemorrhagic Strokes in Patients with Adenosine Deaminase 2 Deficiency
Patrycja M. Hoffmann¹, Amanda Ombrello¹, Deborah L. Stone², Dean Follmann³, Karyl Barron⁴, Anne Jones⁵, Tina Romeo¹, Camilo Toro⁶, Ariane Soldatos⁷, Arielle Hay⁸, Qing Zhou⁹, Ivona Aksentijevich¹⁰ and Daniel L. Kastner⁵, ¹NHGRI, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD, ³NIAID, Bethesda, MD, ⁴National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ⁵Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁶NIH Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁷NINDS, National Institutes of Health, Bethesda, MD, ⁸Nicklaus Children’s Hospital, Miami, FL, ⁹China, ¹⁰Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive condition characterized by recurrent fevers, early-onset ischemic strokes, livedo racemosa, polyarteritis nodosa, portal hypertension,…
Abstract Number: 2277 • 2018 ACR/ARHP Annual Meeting
Colchicine: An Effective Treatment Option for Unclassified Autoinflammatory Diseases in Children
Jasmin B. Kuemmerle-Deschner¹, Anna Lena Schock², Sandra Hansmann³ and Susanne Benseler⁴, ¹Department of Pediatrics, Division of Rheumatology, University Hospital Tuebingen, Germany, Tuebingen, Germany, ²Department of Pediatrics, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, Tuebingen, Germany, ³Department of Pediatrics, Division of Pediatric Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, Tuebingen, Germany, ⁴Rheumatology, Department of Paediatrics, Alberta Children's Hospital, University of Calgary, Alberta, Canada, Calgary, AB, Canada
Background/Purpose: Interleukin-1 (IL-1) inhibition was found to be an effective, yet very expensive treatment option for children with clinically and genetically defined autoinflammatory diseases (AID).…
Abstract Number: 2278 • 2018 ACR/ARHP Annual Meeting
Cryopyrinopathy across Generations: Longterm Disease Outcome
Sarka Fingerhutova¹, Jana Franova², Eva Hlavackova³, Eva Jancova⁴, Leona Prochazkova⁵, Marketa Tesarova⁶ and Pavla Dolezalová⁷, ¹Paediatric Rheumatology Unit, General University Hospital in Prague and 1st Faculty of Medicine, Charles University, General University Hospital in Prague and 1st Faculty of Medicine, Prague, Czech Republic, ²Department of Paediatric Rheumatology, University Hospital Brno, Brno, Czech Republic, Brno, Czech Republic, ³Department of Allergology and Immunology, St Ann´s Hospital Brno, University Hospital, Brno, Czech Republic, Brno, Czech Republic, ⁴Department of Nephrology, General University Hospital in Prague and 1st Faculty of Medicine, Prague, Czech Republic, ⁵Department of Rheumatology, St Ann´s Hospital Brno, University Hospital, Brno, Czech Republic, Brno, Czech Republic, ⁶Laboratory for study of Mitochondrial Disorders, Department of Paediatrics and Adolescent Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁷Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic
Background/Purpose: Cryopyrinopathies are autoinflammatory disorders (AID) caused by mutations of NLRP3 gene that lead to interleukin-1 (IL-1) overproduction with the clinical picture of periodic fever.…
Abstract Number: 2279 • 2018 ACR/ARHP Annual Meeting
Therapeutic Value of Canakinumab in Patients with Yao Syndrome
Qingping Yao, Rheumatology, Allergy and Immunology, Stony Brook University Hospital, Stony Brook, NY; Rheumatology, Allergy, and Immunology, Stony Brook University School of Medicine, Stony Brook, NY
Background/Purpose: Yao syndrome (YAOS, OMIM 617321), formerly termed nucleotide-binding, oligomerization domain 2(NOD2)-associated autoinflammatory disease, is characterized by periodic fever, dermatitis, arthritis, and swelling of the…
Abstract Number: 2280 • 2018 ACR/ARHP Annual Meeting
Transcriptomic Analysis of Hidradenitis Suppurativa Skin Demonstrates Dysregulation of Antimicrobial Proteins and Inflammatory Pathways
Victoria Shanmugam¹, Derek Jones², Matthew Bendall³ and Keith Crandall⁴, ¹Rheumatology, The George Washington University, Washington, DC, ²The George Washington University, Washington, DC, ³Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, ⁴Department of Biology, The George Washington University, Washington, DC
Background/Purpose: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of the apocrine sweat glands. The purpose of the current study was to identify transcripts…
Abstract Number: 2281 • 2018 ACR/ARHP Annual Meeting
Treatment Choices and Response Rates of SAPHO Syndrome: Single Center Case Series
Abdulsamet Erden¹, Mustafa Ekici², Alper Sari³, Berkan Armagan³, Levent Kilic³, Sule Apras Bilgen¹, Ali Akdogan¹, Omer Karadag¹, Sedat Kiraz³ and Ihsan Ertenli¹, ¹Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey, ²Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Background/Purpose: SAPHO Syndrome is a chronic disease with bone, joint and skin involvement characterized by synovitis, acne, pustulosis, hyperostosis, osteitis. Treatment decisions of SAPHO syndrome…
Abstract Number: 2282 • 2018 ACR/ARHP Annual Meeting
Measurement of the Pro-Coagulant Activity of Microparticles in Patients with Inflammatory Rheumatic Diseases: Prospective Study
Christine Mekhail¹, Xavier Guillot², Clément Prati³, Philippe Saas⁴, Guillaume Mourey⁵ and Daniel Wendling⁶, ¹Rheumatology, CHRU, Besançon, France, ²PEPITE EA 4267, Bourgogne-Franche-Comté university, Besançon, France, ³Rheumatology, University Hospital - Bourgogne Franche Comté University, Besancon, France, ⁴INSERM UMR1098, Besançon university hospital, Besançon, France, ⁵EFS, Besançon, France, ⁶Rheumatology, University Hospital - Bourgogne Franche Comté University, Besançon, France
Background/Purpose: Microparticles (MPs) are small membrane-bound vesicles that arise from activated and dying cells. Although the majority of MPs in the blood originate from platelets,…
Abstract Number: 2283 • 2018 ACR/ARHP Annual Meeting
Incidental Steroid Use May Worsen Outcomes in Patients with Heparin Induced Thrombocytopenia in the ICU Setting
Roy Souaid¹ and Connie Lu², ¹Internal medicine, Brown University, Providence, RI, ²Medical school, Brown university, Providence, RI
Background/Purpose: Heparin induced thrombocytopenia (HIT) is the destruction of platelets in patients exposed to heparin products. While there are two types of HIT, the term…
Abstract Number: 2284 • 2018 ACR/ARHP Annual Meeting
Safety and Efficacy of Lenabasum in Refractory Skin-Predominant Dermatomyositis Subjects Treated on an Open-Label Extension of Trial JBT101-DM-001
Victoria P. Werth^1,2, David Pearson^1,2, Joyce Okawa^1,2, Rui Feng³, Josef Concha^1,2, Basil Patel^1,2, Emily Hejazi^1,2, Caitlin Cornwall⁴, Scott Constantine⁴ and Barbara White⁴, ¹University of Pennsylvania, Philadelphia, PA, ²Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, ³University of Pennsylvania, Philadelphia', PA, ⁴Corbus Pharmaceuticals, Inc., Norwood, MA
Background/Purpose: Lenabasum is a synthetic, non-immunosuppressive, selective cannabinoid receptor type 2 agonist that activates resolution of innate immune responses. Lenabasum had acceptable safety and tolerability…
Abstract Number: 2285 • 2018 ACR/ARHP Annual Meeting
Factors Associated with Corticosteroid Discontinuation, Complete Clinical Response and Remission in Patients with Juvenile Dermatomyositis
Takayuki Kishi^1,2, William Warren-Hicks³, Nastaran Bayat¹, Ira Targoff⁴, Terri H Finkel⁵, Ellen Goldmuntz⁶, Michael Henrickson⁷, Bianca Lang⁸, Andrew Mammen⁹, Lauren M. Pachman¹⁰, Murray Passo¹¹, Terrance P. O'Hanlon¹, Frederick W. Miller¹, Michael Ward⁹ and Lisa G. Rider¹, ¹Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ²Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan, ³EcoStat, Inc., Mebane, NC, ⁴VA Medical Center, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Department of Pediatrics, Nemours Children's Health System/ Nemours Children's Hospital, Orlando, FL, ⁶NIAID, NIH, Bethesda, MD, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, NS, Canada, ⁹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁰Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ¹¹Division of Rheumatology PTD, Medical University of South Carolina, Charleston, SC
Background/Purpose: We examined patients in a large juvenile dermatomyositis (JDM) registry for frequency of and factors associated with final corticosteroid discontinuation (Steroid DC), complete clinical…
Abstract Number: 2286 • 2018 ACR/ARHP Annual Meeting
Myositis and Fasciitis By Magnetic Resonance Imaging in Recent-Onset Polymyalgia Rheumatica and Effect of Tocilizumab Therapy
Jean Patrick Laporte¹, Florent Garrigues², Anais Huwart², Sandrine Jousse-Joulin³, Thierry Marhadour¹, Dewi Guellec³, Divi Cornec⁴, Valérie Devauchelle-Pensec³ and Alain Saraux³, ¹CHU Brest, Brest, France, ²Radiology, CHU Brest, Brest, France, ³Rheumatology, CHU Brest, Brest, France, ⁴Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France
Background/Purpose: To assess the prevalence of myofascial inflammatory lesions visible by magnetic resonance imaging (MRI) and their changes after tocilizumab therapy in active polymyalgia rheumatica…

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