Abstract Number: 29 • 2019 ACR/ARP Annual Meeting
Therapeutic Anti-TNF Biologic Agents Exhibit Functional Differences in Blocking TNF-induced Effects on Human Monocytes In Vitro
Background/Purpose: Therapeutic anti-TNF biologic agents can be distinct in their structure and/or in their binding to TNF. Whether these differences affect the functional properties of…Abstract Number: 30 • 2019 ACR/ARP Annual Meeting
Aberrant M1 Polarization of Macrophages in Behcet’s Disease
Background/Purpose: Behcet’s disease (BD) is systemic inflammatory vasculitis with unknown etiology. As a critical compartment in innate immunity, macrophages may play a role in BD.…Abstract Number: 31 • 2019 ACR/ARP Annual Meeting
Regulation of Neutrophil Extracellular Traps by Apremilast (phosphodiesterase 4 Inhibition)
Background/Purpose: Increased propensity for neutrophil extracellular trap generation has been described in autoimmune diseases such as rheumatoid arthritis. Neutrophil extracellular traps are thought to contribute…Abstract Number: 32 • 2019 ACR/ARP Annual Meeting
Aberration of Histone Lysine Methylation in Adult-Onset Still’s Disease Are Novel Biomarker Candidates Associated with the Disease Activity
Background/Purpose: Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder characterized by spiking fever, transient rash, arthritis and leukocytosis. Macrophage and neutrophil activation is a…Abstract Number: 33 • 2019 ACR/ARP Annual Meeting
GS-4875, a First-in-Class TPL2 Inhibitor Suppresses MEK-ERK Inflammatory Signaling and Proinflammatory Cytokine Production in Primary Human Monocytes
Background/Purpose: Tumor progression locus 2 (TPL2, also known as MAP3K8) is a mitogen-activated protein kinase kinase kinase and the primary regulator of ERK-mediated gene transcription…Abstract Number: 34 • 2019 ACR/ARP Annual Meeting
The Role of NFAT5-p65 Complex Enhanceosome in the Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via TLR4 Signaling
Background/Purpose: Transcription factors belonging to the family of nuclear factors of activated T cells (NFAT) play an essential role in diverse biological processes, such as…Abstract Number: 35 • 2019 ACR/ARP Annual Meeting
Mass Cytometry Identifies Enhanced Histone H3 Citrullination and TNFα Production by CD14 Monocytes in Subjects At-Risk for Future Development of Rheumatoid Arthritis
Background/Purpose: Our group previously demonstrated that sputum neutrophils from subjects At-Risk for future rheumatoid arthritis (RA) spontaneously form neutrophil extracellular traps with elevated histone H3…Abstract Number: 36 • 2019 ACR/ARP Annual Meeting
Discovery, Verification and Validation of Rheumatoid Arthritis Activity Monitoring Biomarkers
Background/Purpose: Rheumatoid arthritis (RA) is a long-lasting inflammatory autoimmune disorder that ultimately leads to the destruction of joint architecture. The activity of this disease is…Abstract Number: 37 • 2019 ACR/ARP Annual Meeting
Intestinal Microbiota Dynamics in the Progression of Rheumatoid Arthritis
Background/Purpose: Intestinal microbial dysbiosis in patients with rheumatoid arthritis (RA) has raised the interest in studying the role of intestinal microbes in the pathogenesis of…Abstract Number: 38 • 2019 ACR/ARP Annual Meeting
Autophagy Receptor Optineurin in Synovial Fibroblasts Plays a Protective Role Against Joint Destruction in Rheumatoid Arthritis
Background/Purpose: Joint destructions progress throughout the course of rheumatoid arthritis (RA) without complete remission. Optineurin (OPTN) is an autophagy receptor with multiple functions related to…Abstract Number: 39 • 2019 ACR/ARP Annual Meeting
Role of Sialic Acid in the Aggressive Phenotype of RA FLS
Background/Purpose: A comprehensive epigenomic characterization of rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) has recently been described and can help to identify new critical pathways for…Abstract Number: 40 • 2019 ACR/ARP Annual Meeting
Inflammation and Neuronal Growth Factors in Rheumatoid Arthritis
Background/Purpose: Depression and cognitive impairment are frequently reported in rheumatoid arthritis (RA). We have recently presented that reduced hippocampus volume may be linked to functional…Abstract Number: 41 • 2019 ACR/ARP Annual Meeting
Liver Dysfunction Associated with Rheumatoid Arthritis: Impact of Obesity and Effects of DMARDs in Hepatic Alterations
Background/Purpose: 1) To analyze the impact of rheumatoid arthritis (RA) in the liver function, 2) To evaluate the impact of obesity and the effect of…Abstract Number: 42 • 2019 ACR/ARP Annual Meeting
Subclinical Oral Inflammation Is Common Across the Spectrum of Oral Findings in Rheumatoid Arthritis Patients, Whereas Porphyromonas Gingivalis Antibodies Are Primarily a Marker for Clinical Periodontitis
Background/Purpose: Periodontitis and immune responses to periodontal pathogens such as Porphyromonas gingivalis (Pg) are associated with rheumatoid arthritis (RA) but the mechanisms underlying these connections…Abstract Number: 43 • 2019 ACR/ARP Annual Meeting
The Impact of Air Pollution on Extracellular Vesicles as a Potential Pro-inflammatory Stimulus in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an heterogeneous chronic autoimmune disorder potentially leading to a progressive joint damage with great impact on quality of life. RA…
ACR Meeting Abstracts