Abstract Number: 2001 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Stimulation Regulates Autophagy in Chondrocytes
Background/Purpose: Osteoarthritis (OA) is a debilitating condition characterized by chondrocyte dysfunction and loss of cartilage. Autophagy, a homeostatic process that occurs in times of cellular…Abstract Number: 2002 • 2018 ACR/ARHP Annual Meeting
Dynamic Compression of Articular Cartilage Explants Increases Formation and Decreases Degradation of Type II Collagen
Background/Purpose: Mechanical loading is recognized as a major factor in initiation and progression of osteoarthritis (OA). Conversely loading is believed to play an essential role…Abstract Number: 2003 • 2018 ACR/ARHP Annual Meeting
Chondrocyte Size in Articular Cartilage As a Marker of Osteoarthritis Severity
Background/Purpose: Terminal differentiating growth plate chondrocytes are mainly characterized by an increase of their cell size and by the expression of hypertrophic markers such as…Abstract Number: 2004 • 2018 ACR/ARHP Annual Meeting
Effective Inhibition of Metalloproteases By a Viscosupplement Based on a Hyaluronic Acid Amide (HYADD®4)
Background/Purpose: Osteoarthritis (OA) is a disease which results in the degeneration of articular cartilage. The progression of OA involves inflammation in the early stage of…Abstract Number: 2005 • 2018 ACR/ARHP Annual Meeting
Identification of a Human Cartilage Microbial DNA Signature and Characterization of Distinct Microbiome Profiles Associated with Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is both the most common form of arthritis and a leading cause of chronic disability. Bacterial products, including lipopolysaccharide (LPS), have been…Abstract Number: 2006 • 2018 ACR/ARHP Annual Meeting
Murine Ear Wound Cartilage Superhealer Trait Is Associated with Gut Microbiota Changes and Is Transferable to Non-Healer Mice By Gut Microbiome Transplant
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. Previous studies…Abstract Number: 2007 • 2018 ACR/ARHP Annual Meeting
Generation of Human Induced Pluripotent Stem Cell Lines from Patients with Hand Osteoarthritis
Background/Purpose: Although hand osteoarthritis (OA) is a worldwide burden, there is no treatment able to cure it. Induced pluripotent stem cells (iPSCs) are considered ideal…Abstract Number: 2008 • 2018 ACR/ARHP Annual Meeting
Vascular Adhesion Protein-1 (VAP-1) As Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis
Background/Purpose: To investigate the expression of vascular adhesion protein -1 (VAP-1) in joint tissues and serum in knee osteoarthritis (OA) patients and examine whether VAP-1…Abstract Number: 2009 • 2018 ACR/ARHP Annual Meeting
A Novel Role of ZCCHC6 in the Regulation of MMP13 in Experimental Osteoarthritis in Mice
Background/Purpose: Zinc Finger CCHC Domain Containing Protein 6 (ZCCHC6) or Terminal Uridylyltransferase 7 (TUT7) is a member of terminal uridylyltransferase family that mediate terminal uridylation…Abstract Number: 2010 • 2018 ACR/ARHP Annual Meeting
Anti-Endothelial Cell Antibodies in Pediatric Rheumatic Diseases
Background/Purpose: Anti-endothelial cell antibodies (AECA) are antibodies detected in multiple autoimmune and inflammatory diseases. Increased levels of such antibodies may be involved in disease activity…Abstract Number: 2011 • 2018 ACR/ARHP Annual Meeting
Juvenile Arthritis-Associated Single Nucleotide Polymorphisms Identified on Whole Genome Sequencing Show Enrichment within H3K9me3-Marked Regions
Background/Purpose: We have found extensive alterations in chromatin accessibility when the CD4+ T cells of children with active polyarticular juvenile idiopathic arthritis (JIA) are compared…Abstract Number: 2012 • 2018 ACR/ARHP Annual Meeting
The Novel G58V Mutation in the TNFRSF1A Gene Identified in a Family with Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) Decreases the Cell Surface Expression of TNFR1
Background/Purpose: TNF Receptor- Associated Periodic Syndrome (TRAPS) is one of the autoinflammatory diseases characterized by recurrent inflammatory episodes. TRAPS is caused by an autosomal dominant…Abstract Number: 2014 • 2018 ACR/ARHP Annual Meeting
Next Generation Sequencing Analysis of Familial Haemophagocytic Lymphohistiocytosis (HLH) Related Genes in Macrophage Activation Syndrome (MAS) and Secondary HLH (sHLH)
Background/Purpose: Macrophage activation syndrome (MAS), a severe complication of pediatric rheumatic disease, is currently classified among the secondary forms of HLH (sHLH). Primary HLH (pHLH)…Abstract Number: 2015 • 2018 ACR/ARHP Annual Meeting
Association of Anti-Ro52 Autoantibodies with Interstitial Lung Disease and More Severe Disease Manifestations in Juvenile Idiopathic Inflammatory Myopathies
Background/Purpose: Myositis specific autoantibodies (MSA) and myositis associated autoantibodies (MAA) found in adult and juvenile idiopathic inflammatory myopathies (JIIM) often confer a specific disease phenotype.…Abstract Number: 2016 • 2018 ACR/ARHP Annual Meeting
The Chromatin Landscape Around the Juvenile Arthritis-Associated CXCR4 Locus Suggests Regulatory Functions and Genetic Roles in Both Innate and Adaptive Immunity
Background/Purpose: CXCR4 is a recently identified susceptibility locus for juvenile idiopathic arthritis (JIA). The index single nucleotide polymorphism (SNP) used to identify this locus, rs95338,…
ACR Meeting Abstracts