Abstracts Archive - Page 1089 of 2425 - ACR Meeting Abstracts

Abstract Number: 1266 • 2018 ACR/ARHP Annual Meeting
ABCG2 rs2231142 Q141K and Oxypurinol Concentration in People with Gout Receiving Allopurinol
Lisa K. Stamp¹, Mary Wallace², Rebecca Roberts³, Christopher Frampton¹, Jeffrey Miner⁴, Tony R. Merriman³ and Nicola Dalbeth⁵, ¹University of Otago, Christchurch, New Zealand, ²Surgical Sciences, University of Otago, Dunedin, New Zealand, ³University of Otago, Dunedin, New Zealand, ⁴Viscentio Bio, San Diego, CA, ⁵University of Auckland, Auckland, New Zealand
Background/Purpose: Association of ABCG2 Q141K (p.141Lys) with poor urate-lowering response to allopurinol has been reported although the mechanism is unclear. ABCG2 has been reported to…
Abstract Number: 1267 • 2018 ACR/ARHP Annual Meeting
The Association between Clinically Suspect Arthralgia and Adipokines in Obese Patients
Taskin Senturk¹, Reyhan Kose¹, Gokhan Sargin¹, Songul Cildag², Mustafa Unubol³, Burçin İrem Abas⁴ and Cigdem Yenisey⁴, ¹Rheumatology, Adnan Menderes University Medical School, Aydin, Turkey, ²Allergy and Immunology, Adnan Menderes University Medical School, Aydin, Turkey, ³Endocrinology and Metabolism, Adnan Menderes University Medical School, Aydin, Turkey, ⁴Biochemistry, Adnan Menderes University Medical School, Aydin, Turkey
Background/Purpose: Obesity is a moderate low-grade chronic inflammatory condition. Also, it has been reported to be a risk factor for inflammatory rheumatic diseases, seronegative inflammatory…
Abstract Number: 1268 • 2018 ACR/ARHP Annual Meeting
Assessment of the Persistence of Crystals Under Polarised Light Microscopy in Stored Synovial Fluid Samples
Sonia Pastor¹, Rocio Caño², Silvia Gomez-Sabater² and Mariano Andrés^1,3, ¹Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ²Seccion de Reumatologia, Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Lacking an immediate access to a polarized light microscope is sometimes used to justify the clinical diagnosis of crystal-related arthritis. Some studies have assessed…
Abstract Number: 1269 • 2018 ACR/ARHP Annual Meeting
Influence of Diuretic-Response Sodium Transporter Genes on Renal Uric Acid Handling in Response to Frusemide
Faseeh Zaidi¹, Jordyn Allan¹, Gregory Gamble², Amanda Phipps-Green³, Tanya J. Major³, Borislav Mihov¹, Anne Horne², Robert Doughty¹, Lisa K. Stamp⁴, Tony R. Merriman³ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Otago, Dunedin, New Zealand, ⁴University of Otago, Christchurch, New Zealand
Background/Purpose: Elevated serum urate and reduced fractional excretion of uric acid (FEUA) are common in people on diuretics. Changes in FEUA in response to frusemide…
Abstract Number: 1270 • 2018 ACR/ARHP Annual Meeting
Lack of Association of Comorbidities with Ultrasonographic Urate Deposition in Asymptomatic Hyperuricemia
Sharon Dowell¹, Gail S. Kerr², Alvin F. Wells³, Richard Haddad⁴, Paul DeMarco⁵, Joyce Joseph⁶, Mercedes Quinones⁷, Shelby Hochberg⁸, Jennifer Ude⁹, Jim Huang¹⁰ and David Nashel⁶, ¹Division of Rheumatology, Howard University, Washington, DC, ²Rheumatology, Washington DC VAMC and Georgetown and Howard University, Washington, DC, ³Rheumatology and Immunotherapy Center, Franklin, WI, ⁴The Hospital for Special Surgery, New York, New York, NY, ⁵Georgetown University School of Medicine, Washington, DC, ⁶Internal Medicine, Division of Rheumatology, Washington DC VA Medical Center, Washington, DC, ⁷Internal Medicine, Division of Rheumatology, Washington DC VA Medical Center and Howard University, Washington, DC, ⁸Washington DC VA Medical Center and Howard University, Washinton, DC, ⁹Washington DC VA Medical Center and Howard University, Washington, DC, ¹⁰Medstar Health Research Institute, Hyattsville, MD
Background/Purpose: Hyperuricemia is common, and along with other comorbidities (CM), is increasing in prevalence. Though often asymptomatic, it is associated with subclinical urate deposition detectable…
Abstract Number: 1271 • 2018 ACR/ARHP Annual Meeting
Predictive Factors of Increased Vascular Stiffness in Patient with Gout and Hyperuricemia
WooSeong Jeong¹, Jinseok Kim², Joon Hyouk Choi³ and Byeongzu Ghang¹, ¹Division of Rheumatology, Department of Internal Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), ²Department of Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), ³Division of Cardiology, Department of Internal Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South)
Background/Purpose: Background: Gout is the most common form of inflammatory arthritis and its prevalence is increasing in more affluent countries in recent decades. Many studies…
Abstract Number: 1272 • 2018 ACR/ARHP Annual Meeting
Quality of Gout Management in a Rheumatology Clinic Using a Provider-Pharmacist Team-Based Approach
Jessica Michaud¹ and Jenna Beatty², ¹Pharmacy, Froedtert & the Medical College of Wisconsin, Milwaukee, WI, ²University of Kansas, kansas city, MO
Background/Purpose: Gout is the most common form of inflammatory arthritis.1 The cornerstone of treatment for gout is urate-lowering therapy (ULT), which in the U.S. includes…
Abstract Number: 1273 • 2018 ACR/ARHP Annual Meeting
What Did Patients from the US Think about Their Gout in 2017?
Puja P. Khanna¹, Douglas C.A. Taylor², An-Chen Fu² and Robert Morlock³, ¹University of Michigan, Ann Arbor, MI, ²Ironwood Pharmaceuticals, Inc., Cambridge, MA, ³YourCareChoice, Ann Arbor, MI
Background/Purpose: The impact of chronic gout and acute flares on daily activities is severely limiting. Yet only 40% of gout patients receive urate-lowering therapy (ULT),…
Abstract Number: 1274 • 2018 ACR/ARHP Annual Meeting
Atmospheric Temperature and the Incidence of Gout Flare: Data from the Korea Meteorological Association and National Health Insurance Service
Rina So¹, Min Jung Kim², Sang Hee Kim², Sung Hyouk Choi¹, Hyung-Jin Yoon¹ and Kichul Shin³, ¹Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South), ³Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South)
Background/Purpose: Gout management is mainly focused on life style modification and proper medications. Of note, seasonal variation of gout flare was also implemented to be…
Abstract Number: 1275 • 2018 ACR/ARHP Annual Meeting
Dual-Energy CT for the Diagnosis of Gout: A Prospective Study in Patients with No Prior History of Gout
Mihaela Gamala¹, Johannes W. G. Jacobs², Suzanne Linn-Rasker³, Maarten Nix⁴, Ben Heggelman⁴, Pieternel Pasker⁵, Jacob van Laar⁶ and Ruth Klaasen³, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatolgy & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology, Meander Medical Center Amersfoort, Amersfoort, Netherlands, ⁴Radiology, Meander Medical Center Amersfoort, Amersfoort, Netherlands, ⁵Meander Academy, Meander Medical Center Amersfoort, Amersfoort, Netherlands, ⁶Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands
Background/Purpose: Gout is associated with joint damage, and increased cardiovascular morbidity, so to diagnose and treat gout early is important. However, joint aspiration and microscopy…
Abstract Number: 1276 • 2018 ACR/ARHP Annual Meeting
Effect of Colchicine on Diabetes Incidence Among Gout Patients in a Veterans’ Affairs Population
Anastasia Slobodnick¹, Virginia Pike², Michael Toprover¹ and Michael Pillinger¹, ¹Medicine/Rheumatology, NYU School of Medicine, New York, NY, ²Medicine/Rheumatology, New York Harbor VA Healthcare System, New York, NY
Background/Purpose: Previous studies suggest that patients with gout are at increased risk for developing diabetes.1 One possible explanation for this increased risk is the activation…
Abstract Number: 1277 • 2018 ACR/ARHP Annual Meeting
A Prospective Study Examining the Prevalence of CT Erosions in the Feet and Ankles of Patients with Gout Treated with Allopurinol
Chio Yokose¹, Yuqing Zhang², Nicola Dalbeth³, Jie Wei¹, Savvas Nicolaou⁴, Scott Baumgartner⁵, Jia Hu⁶, Maple Fung⁵ and Hyon K. Choi¹, ¹Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ²Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ³University of Auckland, Auckland, New Zealand, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Formerly Ardea Biosciences, San Diego, CA, ⁶Heron Therapeutics, San Diego, CA
Background/Purpose: Gout is characterized by episodes of acute arthritis that are self-limiting. However, patients with gout can also develop tophi, bone erosions, joint deformity and…
Abstract Number: 1278 • 2018 ACR/ARHP Annual Meeting
Evaluating a Causal Role of Mitochondrial Variation in the Development of Gout
Amara Shaukat¹, Anna Gosling¹, Matthew Bixley¹, Amanda Phipps-Green¹, Tanya J. Major¹, Murray Cadzow¹, Nicola Dalbeth², Lisa K. Stamp³, Elizabeth Matisoo-Smith¹, Jennie Harre Hindmarsh⁴, Leo .A.B. Joosten⁵, Tim Jansen⁶, Matthijs Janssen⁶, Anne-Kathrin Tausche⁷, Philip Riches⁸, Alexander So⁹, Mariano Andres¹⁰, Geraldine M. McCarthy¹¹, Fernando Perez-Ruiz¹², Michael Doherty¹³, Rosa Torres¹⁴, Tom W.J. Huizinga¹⁵, Rachel Knevel¹⁶, Fina Kurreeman¹⁷ and Tony R. Merriman¹, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, ⁵Radboud University Medical Center, Nijmegen, Netherlands, ⁶VieCuri Medical Center, Venlo, Netherlands, ⁷Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ⁸University of Edinburgh, Edinburgh, United Kingdom, ⁹University of Lausanne, Lausanne, Switzerland, ¹⁰Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ¹¹Mater Misericordiae University Hospital, Dublin, Ireland, ¹²BioCruces Health Research Institute, Barakaldo, Spain, ¹³The University of Nottingham, Nottingham, United Kingdom, ¹⁴La Paz University Hospital, Madrid, Spain, ¹⁵Department of Rheumatology, LUMC, Leiden, Netherlands, ¹⁶Brigham and Women's Hospital, Boston, MA, ¹⁷Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Mitochondria execute roles in diverse cellular pathways. As a danger signal, damaged mitochondria can induce inflammation in response to stress through NLRP3 inflammasome activation,…
Abstract Number: 1279 • 2018 ACR/ARHP Annual Meeting
Relative Insufficiency of Renal Uric Acid Excretion in Gout Patients with Obesity Leads to High Serum and Glomerular Filtration Load of Uric Acid
Jin-Jian Liang, Qian-Hua Li, Ying-Qian Mo, Xiu-Ning Wei, Dong-Hui Zheng and Lie Dai, Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: Gout is usually accompanied by metabolic diseases including obesity, hypertension, diabetes, and dyslipidemia. Obesity has been confirmed as a risk factor for gout. This study aims to explore…
Abstract Number: 1280 • 2018 ACR/ARHP Annual Meeting
Higher Body Fat Percentage in Non-Obese Late-Onset Gout Patients
Qian-Hua Li, Kui-Min Yang, Yan-Hui Xu, Xin-Yun Du, Jin-Jian Liang, Jian-Zi Lin, Ying-Qian Mo and Lie Dai, Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: There is a trend of younger gout onset related to higher obesity prevalence. BMI is limited to discriminate between fat and lean mass. Body…

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