Abstracts Archive - Page 1061 of 2425 - ACR Meeting Abstracts

Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting
CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^2,3, Ryan Smalley², Nisha Sambamurthy^1,2, George R. Dodge^2,4 and Carla Scanzello^1,2, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
Abstract Number: 847 • 2018 ACR/ARHP Annual Meeting
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase 2
Jing Rong¹, Bregina Pool², Mark Zhu³, Jacob Munro⁴, Geraldine M. McCarthy⁵, Jillian Cornish², Nicola Dalbeth¹ and Raewyn Poulsen³, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Medicine, University of Auckland, Auckland, New Zealand, ⁴Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁵Mater Misericordiae University Hospital, Dublin, Ireland
Background/Purpose: Basic calcium phosphate crystals (BCP) are frequently found in osteoarthritic joints. Whether BCP crystal deposition is a cause or consequence of osteoarthritis (OA) pathology…
Abstract Number: 848 • 2018 ACR/ARHP Annual Meeting
A2A Adenosine Receptor Stimulation Switches TGF-β Signaling to Promote Chondrocyte Proliferation and Cartilage Regeneration
Carmen Corciulo¹, Cristina Castro², Samson Jacob³, David Fenyo³, Oran Kennedy⁴ and Bruce N. Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Institute for Systems Genetics, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We previously found that intra-articular injections of liposomal preparations of adenosine completely prevent progression and reverse cartilage loss in post-traumatic OA. TGF-β signaling plays…
Abstract Number: 849 • 2018 ACR/ARHP Annual Meeting
Constructing a Macrophage Infiltration Timeline in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^1,3, Nisha Sambamurthy^1,2, Michael Dodge^1,4 and Carla Scanzello^1,2, ¹Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ²Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Macrophage infiltration in synovium (SM) and intraarticular fat pads (FP) is common in Osteoarthritis (OA), and can contribute to catabolic cytokine and protease production…
Abstract Number: 850 • 2018 ACR/ARHP Annual Meeting
Long Term Efficacy of Cartilage Repair Induced By scSOX9 in Situ with Bone Marrow-Derived Mesenchymal Stem Cells
Xiaowei Zhang^1,2, Shili Wu³, Yong Zhu³ and Cong-Qiu Chu^4,5, ¹Oregon Health & Science University, Portland, OR, ²VA Portland Health Care System, Portland, OR, ³VivoScript, Inc, Costa Mesa, CA, ⁴Rheumatology, Oregon Health & Science University, Portland, OR, ⁵Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Microfracture induces fibrocartilage or fibro-hyaline cartilage both are biomechanically inferior to hyaline cartilage. We reported previously that a super positively charged SOX9 (scSOX9) improved…
Abstract Number: 851 • 2018 ACR/ARHP Annual Meeting
Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome
Gautam Sule¹, William J. Kelley¹, Srilakshmi Yalavarthi¹, Alison Banka¹, Andrew Vreede², Omolola Eniola-Adefeso¹ and Jason S. Knight³, ¹University of Michigan, Ann Arbor, MI, ²Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ³., University of Michigan, Ann Arbor, MI
Background/Purpose: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of…
Abstract Number: 852 • 2018 ACR/ARHP Annual Meeting
Antigenic Property of Prothrombin/HLA-DR Complex on Procoagulant Cells in Patients with Antiphospholipid Syndrome
Naoki Ohnishi¹, Yuichiro Fujieda¹, Ryo Hisada¹, Hiroyuki Nakamura¹, Masaru Kato¹, Kenji Oku¹, Toshiyuki Bohgaki¹, Olga Amengual¹, Shinsuke Yasuda¹, Hisashi Arase² and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Immunochemistry, Research Institute for Microbial Disease, Osaka University, Suita, Japan
Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL). Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) recognize the phosphatidylserine/prothrombin…
Abstract Number: 853 • 2018 ACR/ARHP Annual Meeting
Enhanced Type I Interferon Gene Signature in Primary Antiphospholipid Syndrome: Association with Earlier Disease Onset and Preeclampsia
Michelle Lopes¹, Giovana Torrezan², Ana Paula Gandara¹, Eloisa Olivieri³, Iana Nascimento¹, Erica Okazaki⁴, Eloisa Bonfa⁵, Dirce Carraro⁶ and Danieli Andrade¹, ¹Rheumatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²Genomics and Molecular Biology Laboratory, AC Camargo Cancer Center, São Paulo, Brazil, ³Macromolecules Laboratory, AC Camargo Cancer Center, São Paulo, Brazil, ⁴Hemathology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁶Division of Genomic Diagnostics, AC Camargo Cancer Center, São Paulo, Brazil
Background/Purpose: Primary antiphospholipid syndrome (PAPS) is an autoimmune vasculopathy mediated by autoantibodies with thrombosis as its main clinical manifestation. The presence of antiphospholipid antibodies, while…
Abstract Number: 854 • 2018 ACR/ARHP Annual Meeting
First and Recurrent Thrombosis Risk after 1897 Patient-Years of Follow-up: Prospective Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository (“Registry”)
Ecem Sevim¹, Ozan Unlu², Danieli Andrade³, Alessandra Banzato⁴, Maria Tektonidou⁵, Amaia Ugarte⁶, Maria Gerosa⁷, Hannah Cohen⁸, David Branch⁹, Guilherme Ramires de Jesus¹⁰, Angela Tincani¹¹, Paul R. Fortin¹², Michelle Petri¹³, Ignasi Rodriguez¹⁴, Jason S Knight¹⁵, Tatsuya Atsumi¹⁶, Rohan Willis¹⁷, Robert Roubey¹⁸ and Doruk Erkan¹⁹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., New York, NY, ³Rheumatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Department of Cardiac Thoracic and Vascular Sciences, Clinical Cardiology, Thrombosis Centre, University of Padova, Padova, Italy, ⁵Rheumatology Unit, 1st Dept. of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Athens University Medical School, Athens, Greece, ⁶Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Biscay, Spain, ⁷Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, ⁸Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom, ⁹Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹⁰Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ¹¹University and Spedali Civili of Brescia, Brescia, Italy, ¹²Medicine, CHU de Québec - University of Laval, Quebec, QC, Canada, ¹³Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁴Rheumatology, Hospital Clinica, Barcelona, Spain, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ¹⁷301 University Blvd, Antiphospholipid Standardization Laboratory, University of Texas Medical Branch, Galveston, TX, USA, Galveston, TX, ¹⁸Rheumatology, Allergy, and Immunology, Department of Medicine and Thurston Arthritis Research Center, Division of Rheumatology, Allergy and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, ¹⁹Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY
Background/Purpose: APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients with/without other systemic…
Abstract Number: 855 • 2018 ACR/ARHP Annual Meeting
IgG Antiphospholipid Antibodies, -a Common but Neglected Finding in Patients with Myocardial Infarction
Giorgia Grosso¹, Natalie Sippl², Barbro Kjellström³, Khaled Amara², Ulf de Faire⁴, Kerstin Elvin⁵, Bertil Lindahl⁶, Per Näsman⁷, Lars Ryden⁸, Anna Norrhammar^9,10 and Elisabet Svenungsson¹¹, ¹Unit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ³Karolinska Institutet, Karolinska University Hospital, Cardiology Unit, Department of Medicine Solna, Stockholm, Sweden, ⁴Division of Cardiovascular Epidemiology IMM, Karolinska Institutet, Stockholm, Sweden, ⁵Dept. of Clinical Immunology and Transfusion Medicine, Unit of Clinical Immunology, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁶Department Medical Sciences, Uppsala University, Uppsala, Sweden, ⁷Center for Safety Research, KTH Royal Institute of Technology, Stockholm, Sweden, ⁸Cardiology Unit, Department of Medicine Solna,, Karolinska Institutet, Stockholm, Sweden, ⁹Cardiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ¹⁰Capio S:t Görans hospital, Stockholm, Sweden, ¹¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: The antiphospholipid syndrome (APS) is present when arterial, venous or microvascular thrombosis or obstetric morbidity concur with confirmed positive tests for antiphospholipid antibodies (aPL).…
Abstract Number: 856 • 2018 ACR/ARHP Annual Meeting
Integrated mRNA and microRNA Transcriptomes of Monocytes from Antiphospholipid Syndrome Patients Identifies Molecular Networks Related to Their Atherothrombotic Status. Modulatory Effects of In Vivo Ubiquinol Supplementation
Carlos Perez-Sanchez¹, Laura Pérez Sánchez², Alejandra Maria Patiño-Trives³, María Luque Tevar³, Luca Scudeler⁴, Alejandro Ibáñez-Costa³, Patricia Ruiz-Limon⁵, Yolanda Jiménez-Gómez¹, Ivan Arias de la Rosa⁶, Maria Carmen Abalos-Aguilera⁶, Pedro Segui⁷, Nuria Barbarroja¹, Jose Manuel Villalba⁸, Eduardo Collantes Estevez³, Maria Jose Cuadrado⁹, Maria Ángeles Aguirre Zamorano¹ and Chary Lopez-Pedrera³, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Università degli Studi di Torino, Turin, Italy, ⁵Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁶Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁷Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁸Departamento de Biologia Celular, Fisiologia e Inmunología, University of Córdoba, Cordoba, Spain, ⁹Clinica Universidad de Navarra, Madrid, Spain
Background/Purpose: 1. To characterize the mRNAs and microRNAs transcriptomes of monocytes, key immune cells in the atherothrombotic pathology of Antiphospholipid Syndrome patients (APS). 2. To…
Abstract Number: 857 • 2018 ACR/ARHP Annual Meeting
An Interactive Rheumatology Curriculum for Interprofessional Teams Using a Novel Mobile App
Jennifer Mandal¹, Maria Dall'Era², Sebastian Andreatta² and Leslie Floren³, ¹Rheumatology, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³School of Pharmacy, University of California, San Francisco, San Francisco, CA
Background/Purpose: The demand for rheumatologic care far exceeds the current supply of rheumatology providers, and this gap is expected to increase. Early exposure to rheumatology…
Abstract Number: 858 • 2018 ACR/ARHP Annual Meeting
Measuring Cognitive Load during Arthrocentesis Training: Our Initial Experience
Erica Jaffe¹, Andrea Barker² and Michael J. Battistone³, ¹Internal Medicine, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Salt Lake City VAMC and University of Utah, North Salt Lake, UT, ³Division of Rheumatology, University of Utah Medical Center, Salt Lake City, UT
Background/Purpose: Cognitive load theory is increasingly recognized as a meaningful construct in medical education and considers learning to be limited by availability of working memory.…
Abstract Number: 859 • 2018 ACR/ARHP Annual Meeting
Using Online Simulation of Pediatric Musculoskeletal Cases to Evaluate How Knowledge of Costs Affects Diagnostic Workup
Allison Yip¹, Simrat Morris², Marc Buchner³ and Angela Robinson⁴, ¹School of Medicine, Case Western Reserve University, Cleveland, OH, ²Rainbow Babies & Children's Hospital / Cleveland Medical Center, Cleveland, OH, ³School of Engineering, Case Western Reserve University, Cleveland, OH, ⁴Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: With rapid rise in healthcare costs, there is increased emphasis to teach cost-conscious care in graduate medical education. Our objective was to develop online…
Abstract Number: 860 • 2018 ACR/ARHP Annual Meeting
Efficacy of a Web-Based Module to Educate Internal Medicine Housestaff on Gout
Allan C. Gelber¹, Olive Tang¹, Uzma Haque², Amanda Bertram³ and Stephen Sisson³, ¹Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins School of Medicine, Lutherville, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Gout is a leading form of inflammatory arthritis. There is a paucity of data that examines the efficacy of teaching internal medicine (IM) residency…

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