Abstracts Archive - Page 1033 of 2425 - ACR Meeting Abstracts

Abstract Number: 425 • 2018 ACR/ARHP Annual Meeting
Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients with Moderate-to-Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study
Naoki Ishiguro¹, Shusuke Oyama², Ryunosuke Higashi³ and Kunio Yanagida⁴, ¹Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Data Science, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ³Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ⁴Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd, Osaka, Japan
Background/Purpose: ONO-4474 is an orally available, peripheral-specific, pan-tropomyosin receptor kinase (pan-Trk) inhibitor currently under development for treatment of musculoskeletal pain in OA patients. This study…
Abstract Number: 426 • 2018 ACR/ARHP Annual Meeting
The Association of Dietary Patterns with Knee Symptoms and MRI Detected Structures in Patients with Knee Osteoarthritis (OA)
Shuang Zheng¹, Feitong Wu¹, Flavia Cicuttini², Anita E Wluka², Dawn Aitken¹, Tania Winzeberg^1,3, Leigh Blizzard¹, Graeme Jones⁴ and Changhai Ding^1,5, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ³Faculty of Health, University of Tasmania, Hobart, Australia, ⁴Menzies Institute for Medical Research, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁵Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China
The association of dietary patterns with knee symptoms and MRI detected structures in patients with knee osteoarthritis (OA)Abstract Background/Purpose: This study aimed to examine the…
Abstract Number: 427 • 2018 ACR/ARHP Annual Meeting
One Year Efficacy and Safety of One or Three Injections of Hylan G-F 20 for Knee Osteoarthritis: A Systematic Literature Review and Meta-Analysis
Orazio De Lucia¹, Georgios Filippou², Joerg Jerosch³, Sophie Yoon⁴, Jean-Francois Bitsch⁴, Tobias Sayre⁴ and Wilson Ngai⁵, ¹Division of Clinical Rheumatology, G. Pini Hospital, Milan, Italy, ²Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, ³Department of Orthopedic Surgery, Johanna-Etienne Krankenhaus, Neuss, Germany, ⁴Doctor Evidence, Santa Monica, CA, ⁵Global Medical Affairs, General Medicines and Emerging Markets, Sanofi, Bridgewater, NJ
Background/Purpose: Hylan G-F 20 is indicated for the treatment of pain in knee osteoarthritis (OA) in patients who failed to respond adequately to conservative nonpharmacologic…
Abstract Number: 428 • 2018 ACR/ARHP Annual Meeting
Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Controlled Phase III Trial of Treatment Effectiveness
Sarah R. Kingsbury¹, Puvan Tharmanathan², Ada Keding², Belen Corbacho², Fiona E Watt³, David L Scott⁴, Edward Roddy⁵, Fraser Birrell⁶, Nigel K Arden⁷, Catherine Arundel², Sarah Ronaldson², Lema Vernon⁸, Catherine Hewitt², Michael Doherty⁹, David Torgerson² and Philip G. Conaghan¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²York Trials Unit, University of York, York, United Kingdom, ³Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁴Department of Rheumatology, King's College London, London, United Kingdom, ⁵Staffordshire and Stoke on Trent Partnership NHS Foundation Trust, Newcastle Under Lyme, United Kingdom, ⁶Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, ⁷Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, University of Oxford, Oxford, United Kingdom, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹The University of Nottingham, Nottingham, United Kingdom
Background/Purpose: Current treatments for osteoarthritis (OA) are severely limited. Synovitis is prevalent in OA and is associated with pain. The slow-acting anti-rheumatic drug methotrexate (MTX)…
Abstract Number: 429 • 2018 ACR/ARHP Annual Meeting
The Potential Clinical Relevance of Imaging Biomarker Data from Short-Term Interventional Trials in Osteoarthritis: A Comparison of the Cathepsin K Inhibitor Miv-711 Phase 2a MRI Knee Joint Data and KL-Matched 5577 Knee Control Data from the Osteoarthritis Initiative
Philip G. Conaghan¹, Michael A Bowes², Sarah R. Kingsbury¹, Alan Brett², Gwenael Guillard², Åsa Jansson³, Cecilia Wadell³, Richard Bethell³ and John Öhd³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³Medivir AB, Huddinge, Sweden
Background/Purpose: New imaging biomarkers using supervised machine learning offer opportunities to demonstrate effects of potential DMOADs on joint structure in short, small trials based on…
Abstract Number: 430 • 2018 ACR/ARHP Annual Meeting
Prevalence of Intra-Articular Mineralization on Knee CT in Persons with or at Risk of Knee Osteoarthritis
Tuhina Neogi¹, John A. Lynch², Mohamed Jarraya³, Margaret M. Clancy¹, David T. Felson¹, Michael C. Nevitt⁴, Cora E. Lewis⁵, James Torner⁶ and Ali Guermazi⁷, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²University of California, San Francisco, San Francisco, CA, ³Musculoskeletal Radiology, Boston University School of Medicine, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: While intra-articular (i.a.) mineralization can be visualized on knee radiographs, the sensitivity of its identification is low with this modality, hampering efforts to understand…
Abstract Number: 431 • 2018 ACR/ARHP Annual Meeting
Early Pre-Radiographic Structural Pathology Precedes the Onset of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Matthew Harkey¹, Julie Davis², Bing Lu³, Lori Lyn Price^4,5, Robert J. Ward⁶, James MacKay⁷, Charles B. Eaton⁸, Grace H. Lo⁹, Mary Barbe¹⁰, Ming Zhang¹¹, Jincheng Pang¹², Alina Stout¹, Timothy E. McAlindon¹³ and Jeffrey B. Driban¹⁴, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, BOSTON, MA, ³Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Temple University School of Medicine, Philadelphia, PA, ¹¹Tufts Medical Center, Boston, MA, ¹²Electrical Engineering, Tufts University, Medford, MA, ¹³Division of Rheumatology, Tufts Medical Center, Boston, MA, ¹⁴Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Individuals that develop accelerated knee osteoarthritis (AKOA) have more frequent knee pain, decreased physical function, and are more likely to receive a knee replacement…
Abstract Number: 432 • 2018 ACR/ARHP Annual Meeting
Relation of Patellofemoral Joint Alignment, Morphology, and Radiographic Osteoarthritis to Frequent Anterior Knee Pain
Erin Macri¹, Tuhina Neogi², Irina Tolstykh³, Cora E. Lewis⁴, James Torner⁵, Michael C. Nevitt⁶ and Joshua J. Stefanik⁷, ¹Physical Therapy, University of Delaware, Newark, DE, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Radiographic patellofemoral osteoarthritis (OA) is prevalent in approximately 25% of population-based samples and 39% of individuals with knee pain. Discordance between knee OA features…
Abstract Number: 433 • 2018 ACR/ARHP Annual Meeting
Impact of Bariatric Surgery on Rheumatic Diseases: A Systematic Review and Meta-Analysis
Marie Moly¹, Bernard Combe¹, Thomas Barnetche², Claire Daien¹, Jacques Morel³, Cédric Lukas¹, Cécile Gaujoux-Viala⁴ and Charlotte Hua⁴, ¹Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ²Rheumatology, University Hospital Pellegrin, Bordeaux, Bordeaux, France, ³Department of Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ⁴Rheumatology, University Hospital Carémeau , Nimes, Nimes, France
Background/Purpose: Obesity increase the incidence of rheumatic diseases (1-3). Bariatric surgery (BS) improve obesity-related comorbidities (4). The aim of our study was to assess currently…
Abstract Number: 434 • 2018 ACR/ARHP Annual Meeting
Trends in Procedure Type, Patient Characteristics, and Outcomes Among Persons with Knee Osteoarthritis Undergoing Bariatric Surgery, 2005-2014
Yusi Gong¹, Faith Selzer², Bhushan Deshpande^1,3 and Elena Losina^1,4,5, ¹Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ²Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴Orthopaedic Surgery, Harvard Medical School, Boston, MA, ⁵BU School of Public Health, Boston, MA
Background/Purpose: Bariatric surgery, the most effective treatment for losing weight and maintaining weight loss among morbidly obese persons, has been evolving as a treatment for…
Abstract Number: 435 • 2018 ACR/ARHP Annual Meeting
Is Frailty Associated with Worse Outcomes after Total Joint Replacements?
Lisa A. Mandl^1,2, Charles N. Cornell^3,4, Michael B. Cross^3,4, Alejandro Gonzalez Della Valle^3,4, Mark P. Figgie^3,4, Seth A. Jerabek^3,4, Justin Do⁵, Mayu Sasaki⁵, Nathaniel Hupert⁶, Jackie Szymonifka¹ and Steven K. Magid^7,8, ¹Hospital for Special Surgery, New York, NY, ²Medicine - Rheumatology, Weill Cornell Medicine, New York, NY, ³Surgery, Weill Cornell Medicine, New York, NY, ⁴Surgery, Hospital for Special Surgery, New York, NY, ⁵Quality Research Center, Hospital for Special Surgery, New York, NY, ⁶Medicine, Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, ⁷Medicine - Rhuematology, Hospital for Special Surgery, New York, NY, ⁸Medicine, Weill Cornell Medicine, New York, NY
Background/Purpose: To determine whether frailty is associated with clinical outcomes 1-year after total hip or total knee replacement, (TKR and THR). Methods: Community-dwelling patients ≥65yo…
Abstract Number: 436 • 2018 ACR/ARHP Annual Meeting
Structural Effects of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: A Post-Hoc Analysis of Cartilage Morphology over the 2-Year Treatment-Period of a 5-Year Randomized, Placebo-Controlled, Phase II Study
Ali Guermazi¹, Jeffrey Kraines², Aida Aydemir², Stephen Wax³, Michel Crema⁴, Marc C. Hochberg⁵ and Frank Roemer^1,6, ¹Radiology, Boston University School of Medicine, Boston, MA, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Sprifermin, a recombinant human fibroblast growth factor 18, is currently being investigated as a potential disease-modifying OA drug. Sprifermin treatment leads to a dose-dependent…
Abstract Number: 437 • 2018 ACR/ARHP Annual Meeting
Does Reduction in Mechanical Knee Joint Loading Explain the Beneficial Effects of Weight Loss in Overweight or Obese Patients with Knee Osteoarthritis?
Dennis Ang¹, Daniel Beavers² and Stephen P. Messier³, ¹Wake Forest University School of Medicine, Winston-Salem, NC, ²Biostatistical Science, Wake Forest School of Medicine, WINSTON SALEM, NC, ³Department of Health and Exerc, Wake Forest University, Winston-Salem, NC
Background/Purpose: Knee osteoarthritis (KOA) is traditionally considered a local joint pathology. The effect of obesity on the pathogenesis of KOA is predominantly attributed to increase…
Abstract Number: 438 • 2018 ACR/ARHP Annual Meeting
What Characterizes Osteoarthritis: Ultrasound-Detected Inflammation but Not Osteophytes Is More Common in Hand Osteoarthritis Than in Painless Bony Enlargements
Nina Gasperi¹, Antonella Adinolfi², Arnd Kleyer³, Melanie Hagen³, Christiane Gasperi⁴, Martin Weger⁵, Stefan Kiechl⁶, Johann Willeit⁶, Georg Schett³, Annamaria Iagnocco⁷, Arno Gasperi⁸, Agnes Mayr⁹ and Christian Dejaco^10,11, ¹Medical University of Graz, Graz, Austria, Graz, Austria, ²Department of Medicine, surgery and Neurosciences, University of Siena, Siena, Italy, Siena, Italy, ³Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen–Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, ⁴Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany, Munich, Germany, ⁵Department of Internal Medicine, Bruneck Hospital, Bruneck, Italy, Bruneck, Italy, ⁶Department of Neurology, Medical University of Innsbruck, Austria, Innsbruck, Austria, ⁷Academic Rhematology Center, University of Torino, Turin, Italy, Turin, Italy, ⁸Department of Neurology, Bruneck Hospital, Bruneck, Italy, Bruneck, Italy, ⁹Department of Laboratory Medicine, Bruneck Hospital, Italy, Bruneck, Italy, ¹⁰Rheumatology Service, South tyrolean Health trust, Hospital of Bruneck, Bruneck, Italy, Bruneck, Italy, ¹¹Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria, Graz, Austria
Background/Purpose: To study structural and inflammatory ultrasound lesions in elderly subjects with hand osteoarthritis (HOA) as well as in pain-free subjects with bony enlargements of…
Abstract Number: 439 • 2018 ACR/ARHP Annual Meeting
Articular Cartilage from Osteoarthritis Patients Shows Extracellular Matrix Remodeling over the Course of Treatment with Sprifermin (Recombinant human fibroblast growth factor 18)
Ditte Reker¹, Christian S. Thudium², Anne Sofie Siebuhr³, Thorbjørn Gantzel⁴, Christoph Ladel⁵, Martin Michaelis⁵, Morten A. Karsdal², Anne Gigout⁵ and Anne C. Bay-Jensen², ¹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁴cOrthopedic Surgery Unit, Gentofte Hospital, Hellerup, Denmark, ⁵Merck KGaA, Darmstadt, Germany
Background/Purpose: Sprifermin, a truncated form of human fibroblast growth factor 18 (FGF18), is being investigated as a potential cartilage and disease-modifying OA drug. In vitro,…

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