Abstracts Archive - Page 1001 of 2425 - ACR Meeting Abstracts

Abstract Number: 700 • 2019 ACR/ARP Annual Meeting
Sleep Quality Among Patients with Systemic Lupus Erythematosus
Alexandra Schwab¹ and Diane Kamen ², ¹Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Poor sleep quality is a frequent concern among patients with systemic lupus erythematosus (SLE) and contributes to fatigue and other comorbidities. This study investigates…
Abstract Number: 701 • 2019 ACR/ARP Annual Meeting
Association of Cumulative Urinary Podocyte Number and Urinary Podocalyxin with Long-term Renal Prognosis in Lupus Nephritis
Hiroshi Kajiyama¹, Hidekazu Ikeuchi ², Junya Suwa ², Daisuke Ikuma ³, Hiroyuki Kurosawa ⁴, Yoshiaki Hirayama ⁴, Masanori Hara ⁵, Yoshihisa Nojima ⁶, Keiju Hiromura ² and Toshihide Mimura ⁷, ¹Department of Rheumatology and Applied Immunology, Saitama Medical University, Nerima, Tokyo, Japan, ²Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gumma, Japan, ³Department of Rheumatology, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan, ⁴Department of reagent research and development, Denka Seiken Co. Ltd., Gosen, Niigata, Japan, ⁵Iwamuro health promotion center, Iwamuro-onsen, Niigata, Japan, ⁶Gunma Rheumatology Clinic, Takasaki, Gumma, Japan, ⁷Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Podocytes, glomerular visceral epithelial cells, function as molecular sieve not to filter high molecular weight proteins such as albumin and globulins. Various immunological insults…
Abstract Number: 702 • 2019 ACR/ARP Annual Meeting
Seasonality of Cutaneous and Systemic Flares in Adults and Children in the Einstein Lupus Cohort
Tamara Tanner¹, Dawn Wahezi ², Ilir Agalliu ³, Chaim Putterman ⁴, Anna Broder ⁵, Nicole Jordan ⁴, Dalynah Maldonado Andujar ⁴ and Tamar Rubinstein ⁶, ¹Children's Hospital at Montefiore, Bronx, NY, ²Children’s Hospital at Montefiore, New York, ³Albert Einstein College of medicine, Bronx, ⁴Montefiore Medical Center, Bronx, ⁵Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, ⁶Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Ultra violet light (UV) exposure has been implicated as a major contributor to pathogenesis and flares in lupus. While some studies have looked at…
Abstract Number: 703 • 2019 ACR/ARP Annual Meeting
Prior Knowledge Feature Reduction Improves Performance in a Machine Learning Model of Systemic Lupus Erythematosus Flare Status Using Serum Proteomics
Nimisha Schneider¹ and Andrew Thompson ¹, ¹PatientsLikeMe, Cambridge
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic auto-immune condition characterized by systemic inflammation that can exacerbate (flare) unpredictably, causing widespread organ damage. Identification of…
Abstract Number: 704 • 2019 ACR/ARP Annual Meeting
Improving Patient-Centered Care by Utilizing Lupus Wellness Program
Jacinta Renaldi¹, Fotios Koumpouras ¹, Lenore Buckley ¹ and Mei Xue Dong ¹, ¹Yale University, New Haven
Background/Purpose: Although the mortality rate of lupus has decreased with improvement of treatment options, it remains high compared to non-SLE mortality. The factors that contribute…
Abstract Number: 705 • 2019 ACR/ARP Annual Meeting
A Tale of Three Cohorts: SLE Criteria in Developed vs Developing Countries
Ashira Blazer¹, Allison Guttmann ¹, Ida Dzifa Dey ², Olusola Ayanlowo ³, Uyi Ima-Edomwonyi ³, Hakeem Olasebikan ³, Margaret Reynolds ³, Festus Ankrah ², Jill Buyon ⁴ and Olufemi Adelowo ⁵, ¹NYU School of Medicine, New York, NY, ²Korle bu Teaching Hospital, Accra, Ghana, ³Lagos University Teaching Hospital, Lagos, Nigeria, ⁴NYU School of Medicine, New York, ⁵Lagos State University Teaching Hospital, Lagos, Nigeria
Background/Purpose: SLE diagnostic criteria are important for reliable epidemiologic data. The prevalence of SLE in West Africa is falsely low due to barriers including limited…
Abstract Number: 706 • 2019 ACR/ARP Annual Meeting
Neuronal BC RNAs: Systemic Lupus Erythematosus Autoantibodies Cause Dendritic Transport Impairments
ILHAM MUSLIMOV¹, ANNA IACOANGELI ², TAESUN EOM ³, ANNE RUIZ ³, MADISEN LEE ³, STACY STEPHENSON ³ and Ellen M Ginzler ⁴, ¹SUNY DOWNSTATE MEDICAL CENTER Center, BROOKLYN, NY, ²Tisch MS Research Center of New York, NEW YORK, NY, ³SUNY DOWNSTATE MEDICAL CENTER, BROOKLYN, NY, ⁴State University of New York Downstate Medical Center, Brooklyn, NY
Background/Purpose: In systemic lupus erythematosus (SLE), autoantibodies are often directed against nucleic acids or their binding proteins. Regulatory Brain-specific Cytoplasmic (BC) RNAs operate as translational…
Abstract Number: 707 • 2019 ACR/ARP Annual Meeting
Severity and Evolution over Time of Gastro-Intestinal Involvement in Patients with Systemic Sclerosis in Two Large and Independent Cohorts
Nina van Leeuwen¹, Håvard Fretheim ², Øyvind Molberg ², Thomas Huizinga ¹, Jeska de Vries-Bouwstra ¹ and Anna Maria Hoffmann-Vold ³, ¹Leiden University Medical Center, Leiden, Netherlands, ²University Hospital Oslo, Oslo, Norway, ³Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: In systemic sclerosis (SSc), the gastro-intestinal tract (GIT) is reported to be the most affected organ after the skin. GIT involvement is associated with…
Abstract Number: 708 • 2019 ACR/ARP Annual Meeting
Improvement and Stabilization of Lung Function in Patients with SSc-ILD Treated with Nintedanib vs Placebo in a Randomized, Placebo-Controlled Phase III Trial: Proportions of Patients with FVC Changes Using Cutoffs Previously Proposed to Define Minimally Clinically Important Differences
Yannick Allanore¹, Dinesh Khanna ², Elizabeth Volkmann ³, Christian Stock ⁴, Martina Gahlemann ⁵, Nils Schoof ⁶, Oliver Distler ⁷ and Toby Maher ⁸, ¹Dept. of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, Paris, France, ²Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ³University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ⁴Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, ⁵Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, ⁶Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, ⁷Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁸National Heart and Lung Institute, Imperial College London, UK and National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK, London, United Kingdom
Background/Purpose: Mean change in forced vital capacity percent predicted (FVC %pred) is a common endpoint in the assessment of treatment-related outcomes in patients with interstitial…
Abstract Number: 709 • 2019 ACR/ARP Annual Meeting
Structural Abnormalities of the Optic Nerve Head and Retinal Nerve Fiber Layer Using Optical Coherence Tomography in Patients with Systemic Sclerosis
Cecilia Agapito Tito¹, Izabela Almeida ², Elise Taniguchi ², Juliana Silvatti ², Tiago Prata ², Augusto Paranhos ² and CRISTIANE KAYSER ¹, ¹Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ²Universidade Federal de Sao Paulo, sao paulo, Brazil
Background/Purpose: Vascular dysfunction, characterized by vasospasm and endothelial activation, represents a central and early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve…
Abstract Number: 710 • 2019 ACR/ARP Annual Meeting
Relationship Between High-Resolution Computer Tomography and FVC% Predicted for Classification of Pulmonary Hypertension in Systemic Sclerosis
Sara Jaafar¹, Paul Cronin ², Dharshan Vummidi ¹, Scott Visovatti ¹, Amber Young ³, Suiyuan Huang ¹, Vallerie McLaughlin ⁴ and Dinesh Khanna ⁵, ¹University of Michigan, Ann Arbor, MI, ²Unviersity of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbot, ⁴Univeristy of Michigan, Ann Arbor, MI, ⁵Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor
Background/Purpose: Pulmonary arterial hypertension (PAH) is one of the leading causes of mortality in scleroderma-spectrum disorders (SSc). FVC% has been used to differentiate Group 1…
Abstract Number: 711 • 2019 ACR/ARP Annual Meeting
Ultrasound Evaluation of the Hands in Patients with Systemic Sclerosis: Osteophytosis Is a Major Contributor to Tender Joints
Robert Fairchild¹, Melody Chung ¹, Laurel Sharpless ¹, Shufeng Li ², Jison Hong ¹, Khushboo Sheth ¹ and Lorinda Chung ¹, ¹Stanford University, Palo Alto, CA, ²Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA
Background/Purpose: Systemic Sclerosis (SSc) is a progressive fibrotic and vascular disease with peripheral manifestations including arthritis, tendinopathy, sclerodactyly, contractures, calcinosis, acroosteolysis, and vascular disease which…
Abstract Number: 712 • 2019 ACR/ARP Annual Meeting
Safety and Tolerability of Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease in the SENSCIS Trial: Subgroup Analysis Based on Demographic Characteristics
Oliver Distler¹, Kristin Highland ², Maureen Mayes ³, Masataka Kuwana ⁴, Lesley Saketkoo ⁵, Madelon Vonk ⁶, Michael Kreuter ⁷, Laura Hummers ⁸, Ute von Wangenheim ⁹, Martina Gahlemann ¹⁰, Veronika Kohlbrenner ¹¹, Margarida Alves ¹², Emmanuelle Clerisme-Beaty ¹² and Arata Azuma ¹³, ¹Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ²Cleveland Clinic, Cleveland, Ohio, USA, Cleveland, OH, ³Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, ⁴Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan, ⁵New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans; Tulane University School of Medicine, University Medical Center – Comprehensive Pulmonary Hypertension Center, USA, New Orleans, ⁶Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen, Gelderland, Netherlands, ⁷Center for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Member of the German Center for Lung Research, Germany, Germany, Germany, ⁸Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, USA, Baltimore, MD, ⁹Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Biberach an der Riss, ¹⁰Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, ¹¹Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA, Ridgefield, ¹²Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, ¹³Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, Tokyo, Japan
Background/Purpose: In the SENSCIS trial in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD), the adverse events associated with nintedanib were manageable for most patients…
Abstract Number: 713 • 2019 ACR/ARP Annual Meeting
NEMO Score in Nailfold Videocapillaroscopy Is a Good Tool to Assess Both Steady State Levels and Overtime Changes of Disease Activity in Patients with Systemic Sclerosis: A Comparison with Both the Composite EScSG and EUSTAR Indices for This Disease Status Entity
Francesca Pignataro ¹, Antonina Minniti ¹, Wanda Maglione ¹, Francesco Campanaro ¹, Domenico Sambataro ², Gianluca Sambataro ², Claudio Vitali ³ and Nicoletta Del Papa¹, ¹UOC Day Hospital Reumatologia, ASST Gaetano Pini, Milan, Italy, ²Istituto ArtroReuma, Catania, Italy, ³Sezione di Reumatologia, Istituto San Giuseppe, Como, Italy
Background/Purpose: We previously demonstrated that NEMO score, i.e., the cumulative number of microhaemorrhages (MHEs) and microthrombosis (MTs) observed in nailfold videocapillaroscopy (NVC), was a good…
Abstract Number: 714 • 2019 ACR/ARP Annual Meeting
Characteristics of Patients with Systemic Sclerosis in the Rheumatology Informatics System for Effectiveness (RISE) Registry
Ankoor Shah¹, Jeffrey Curtis ², Yvonne Lee ³, Fenglong Xie ⁴, Lang Chen ² and Huifeng Yun ², ¹Duke University, Durham, NC, ²University of Alabama at Birmingham, Birmingham, AL, ³Northwestern University Feinberg School of Medicine, Chicago, ⁴University of Alabama at Birmingham, Birmingham
Background/Purpose: Systemic sclerosis (SS), is characterized by fibrosis of the skin and internal organs and vasculopathy with relatively high morbidity and mortality. Given the rarity…

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