ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 069

Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios of Patients with Juvenile Systemic Lupus Erythematosus

Rogerio do Prado1, Fabiola I Suano-Souza1, Wellington D. R. Rodrigues2, Lucila Pereira1, Maria Teresa Terreri3 and Roseli O. S. Sarni4, 1FMABC, São Paulo, Brazil, 2Unicid, São Paulo, Brazil, 3UNIFESP, São Paulo, Brazil, 4Centro Universitário Faculdade de Medicina do ABC (FMABC), Brazil

Meeting: 2023 Pediatric Rheumatology Symposium

Keywords: , ,

Session Information

Date: Thursday, March 30, 2023

Title: Posters: Clinical and Therapeutic I

Session Type: Poster Session A

Session Time: 6:00PM-7:00PM

Background/Purpose: The Neutrophil-Lymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) are markers of systemic inflammation easily available from the blood count. Previous studies have revealed that elevated NLR and PLR are independently associated with cardiovascular mortality. Patients with Systemic Lupus Erythematosus (SLE) have elevated NLR and PLR values in association with disease activity and renal impairment. Studies in juvenile SLE (jSLE) are scarce and show that both NLR and PLR are correlated with serological indicators and can predict tissue involvement, mainly cutaneous, articular, serositis and hematological involvement. Our aim was to compare the NLR and PLR ratios of patients with jSLE with healthy controls. In the jSLE group we also aimed to verify association of NLR and PLR with SLEDAI-2K, ultrasensitive C-reactive protein (usCRP), ESR, plasma selenium and erythrocyte glutathione peroxidase activity (GPx).

Methods: This was an observational, cross-sectional study of 31 female adolescents with jSLE and 31 healthy females as a control group. Demographic and anthropometric data were obtained from both groups, and clinical data (disease activity measured by SLEDAI-2K and corticosteroid – CTC use) from jSLE group; laboratory data including ESR, plasma selenium, GPx, usCRP and complete blood count (NLR, PLR).

Results: Mean age at diagnosis and mean of disease duration of jSLE group was 15.9±1.7 years and 3.6±2.6 years, respectively. The median NLR was significantly higher in the jSLE group [2.37 (0.43;15.55)] compared to the control [1.62 (0.70;5.80)] (p=0.025). The median PLR was also higher in the jSLE group [221.36 (18.36;1,007.7)] compared to the control [127.8 (51.0;202.1)] (p< 0.001). The NLR did not show a significant correlation with any other variables. There was a significant Correlation between PLR and ESR (rho=0.360; p=0.046), dosis of CTC (mg/kg/day) (rho=0.617; p=0.008) and with GPx (rho=0.360; p=0.047). No association was observed between both NLR and PLR and SLEDAI-2K.

Conclusion: Patients with jSLE have higher values of NLR and PLR. In the jSLE group, only PLR was associated with inflammation and CTC use; however no association was found with SLEDAI-2K.

Disclosures: R. do Prado: None; F. I Suano-Souza: None; W. D. R. Rodrigues: None; L. Pereira: None; M. Terreri: None; R. O. S. Sarni: None.

To cite this abstract in AMA style:

do Prado R, I Suano-Souza F, D. R. Rodrigues W, Pereira L, Terreri M, O. S. Sarni R. Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios of Patients with Juvenile Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 4). https://acrabstracts.org/abstract/neutrophil-lymphocyte-and-platelet-lymphocyte-ratios-of-patients-with-juvenile-systemic-lupus-erythematosus/. Accessed .

« Back to 2023 Pediatric Rheumatology Symposium

ACR Meeting Abstracts - https://acrabstracts.org/abstract/neutrophil-lymphocyte-and-platelet-lymphocyte-ratios-of-patients-with-juvenile-systemic-lupus-erythematosus/