Date: Monday, October 22, 2018
Session Type: ACR Concurrent Abstract Session
Session Time: 2:30PM-4:00PM
Background/Purpose: Data regarding long term outcome of patients with thromboangiitis obliterans (TAO) are lacking and most series come from India and Japan. We assess long-term outcome and prognostic factors in a large cohort of TAO.
Methods: Retrospective multicenter study of characteristics and outcomes of 224 TAO patients fulfilling Papa’s and/or 5 Shinoya’s criterias were analyzed. Factors associated with vascular events and amputations were identified.
Results: The median age at diagnosis was 38.5 [32-46] years, 51 (23.8 %) patients were female and 81.7% were Caucasians. After a mean follow up of 5.7 years, vascular events were observed in 58.9%, amputations in 21.4% and death in 1.4%. The 5-, 10- and 15-year vascular event free survival and amputation free survival were 41% and 85%, 23% and 74% and 19% and 66%, respectively. Ethnic group (non-Caucasian) (HR 2.35 [1.30-4.27] p=0.005) and limb infection at diagnosis (3.29 [1.02-10.6] p=0.045) were independent factors of vascular events. Factor associated with amputation was limb infection (HR=12.1[3.5-42.1], p<0.001). Patient who stopped their tobacco consumption had lower risk of amputation (p=0.001) than those who continued.
Conclusion: This nationwide study shows that 34% of TAO patients will experience an amputation within 15 years from diagnosis. We identified specific characteristics that identified those at highest risk for subsequent vascular complications and amputations.
To cite this abstract in AMA style:LE JONCOUR A, Soudet S, Dupont A, Espitia O, Koskas F, Cluzel P, Hatron PY, Emmerich J, Cacoub P, Resche-Rigon M, Lambert M, Saadoun D. Long-Term Outcome and Prognostic Factors of Complications in Thromboangiitis Obliterans (Buerger’s disease): A Multicenter Study of 224 Patients [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/long-term-outcome-and-prognostic-factors-of-complications-in-thromboangiitis-obliterans-buergers-disease-a-multicenter-study-of-224-patients/. Accessed January 20, 2019.
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