Session Information
Session Title: Rheumatoid Arthritis - Clinical Aspects: Novel Biomarkers and Other Measurements of Disease Activity
Session Type: Abstract Submissions (ACR)
Background/Purpose
Excess mortality attributed to cardiovascular causes has been described among patients with rheumatoid arthritis (RA). Atherosclerotic lipid profile has been reported in patients with drug naïve RA without comorbidities. In a European study on inflammatory and atherogenic lipoprotein markers, patients with RA had significantly higher levels of small, dense LDL and lower levels of large, light LDL than controls. The size of LDL particles was smaller in RA patients compared to controls. We have investigated lipid concentrations and particle sizes among patients with newly diagnosed RA in a population based cohort.
Methods
Concentrations and sizes of lipoprotein subclass particles were analyzed by proton nuclear magnetic resonance spectroscopy of native serum samples from patients with RA participating in Northern Savo 2010 Study.
Results
Sixty-three patients, 34 female and 29 male patients with RA satisfying the ACR/Eular 2010 classification criteria were divided into tertiles according to the disease activity measured by DAS28 (<3.9, 3.9-4.7, >4.7). Small LDL concentrations were lowest in the tertile with the highest disease activity, p= 0.031, and the particle size in LDL also increased with increasing disease activity, p<0.001. In HDL, the total, medium and small particle concentrations showed a linear decrease along with the disease activity, p=0.0012, 0.0079 and <0.001, respectively.
Conclusion
Marked changes in lipid concentrations and particle sizes occurred in drug naïve patients with RA and they were associated with disease activity.
References
van Doornum S, McColl G, Wicks IP. Accelerated Atherosclerosis: An extra-articular feature of rheumatoid arthritis? Arthritis Rheum 2002;46:862–873.
Georgiadis AN, Papavasiliou EC, Lourida ES, Alamanos A, Kostara C, Tselepis AD, DrososAA. Atherogenic lipid profile is a feature of patients with early rheumatoid arthritis: effect of early treatment–a prospective, controlled study. Arthritis Res Ther 2006;8:R82.
Hurt-Camejo E, Paredes S, Masana L, Camejo G, Sartipy P, Rosengren B, et al. Elevated levels of small, low-density lipoprotein with high affinity for arterial matrix components in patients with rheumatoid arthritis: Possible contribution of phospholipase A2 to this atherogenic profile. Arthritis Rheum 2001;44:2761-7.
Disclosure:
A. Kononoff,
None;
H. Kautiainen,
Abbvie inc, Pfizer inc,
5;
P. Soininen,
None;
A. Kangas,
None;
L. Laasonen,
None;
L. Arstila,
None;
P. Elfving,
None;
E. Savolainen,
None;
H. Niinisalo,
None;
M. Ala-Korpela,
None;
O. Kaipiainen-Seppanen,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/lipid-concentrations-and-particle-sizes-in-drug-naive-patients-with-rheumatoid-arthritis/