Abstracts tagged "Cholesterol and rheumatoid arthritis (RA)"

Abstract Number: 86 • ACR/ARHP Annual Meeting 2018
Age Dependent Effects of Cholesterol and Smoking on the Risk of Rheumatoid Arthritis in Women – Results from a Nested Case Control Study
Carl Turesson^1,2, Ulf Bergström¹, Jan-Åke Nilsson^1,2 and Lennart Jacobsson³, ¹Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, ³Dept of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Smoking is an established risk factor for rheumatoid arthritis (RA). A positive association between body mass index (BMI) and the risk of RA in…
Abstract Number: 2354 • ACR/ARHP Annual Meeting 2018
Perspectives of Patients with Inflammatory Arthritis Regarding Cardiovascular Risk: A Qualitative Study
Iris Navarro-Millán^1,2, Sarah Young³, Sally Shurbaji⁴, Chastity McDavid⁴, Anna Cornelius-Schecter², Bernadette Johnson⁴, Andrea Cherrington⁴, Liana Fraenkel⁵, Jeffrey R. Curtis⁴ and Monika M. Safford², ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Binghamton University, Binghamton, NY, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Yale University, New Haven, CT
Background/Purpose: Cardiovascular disease (CVD) is the most common cause of death among patients with inflammatory arthritis (IA) such as rheumatoid arthritis (RA), psoriatic arthritis (PsA)…
Abstract Number: 1460 • ACR/ARHP Annual Meeting 2016
Suppression of Cholesterol Levels and Impairment in Cholesterol Efflux By HDL in K/BxN Mice Is Associated with a Specific Cytokine/Chemokine Profile
Christina Charles-Schoeman¹, Ani Shahbazian², Yuen Yin Lee³, Buzand Oganesian⁴, Victor Grijalva⁵, Anabel Garcia Heredia¹ and Srinivasa T. Reddy⁵, ¹University of California, Los Angeles, Los Angeles, CA, ²Medicine-Rheumatology, University of California, Los Angeles, Los Angeles, CA, ³Medicine- Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁴Medicine-Rheumatology, University of California, Los Angeles, Los ANgeles, CA, ⁵Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Better understanding of lipid metabolism in active rheumatoid arthritis (RA) is needed to understand the cholesterol changes associated with active disease, as well as…
Abstract Number: 1558 • ACR/ARHP Annual Meeting 2015
Serum Cathepsin S and Cystatin C Relation with Carotid Subclinical Atheromatosis in Rheumatoid Arthritis Patients
Beatriz Tejera Segura¹, De Vera-González AM², Raquel López-Mejías³, Miguel A. Gonzalez-Gay⁴ and Ivan Ferraz-Amaro¹, ¹Division of Rheumatology, University Hospital of Canary Islands, Tenerife, Spain, ²Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ³Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁴Reumatologia, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular risks. Cathepsin S, a cysteine protease implicated in intracellular and extracellular proteolysis,…
Abstract Number: 1681 • ACR/ARHP Annual Meeting 2015
4-Week Treatment of Rheumatoid Arthritis Patients with the JAK1-Selective Inhibitor Filgotinib (GLPG0634) Changes Lipid Profile with a Preferential Increase in HDL
René Galien¹, Pille Harrison², Reginald Brys², Annegret Van der Aa², Gerben van 't Klooster² and Chantal Tasset², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium
Background/Purpose: Patients with active rheumatoid arthritis (RA) present low levels of lipids - total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c) and…
Abstract Number: 334 • ACR/ARHP Annual Meeting 2014
Inflammatory Arthritis in K/BxN Mice Is Associated with Abnormal HDL Function
C. Charles-Schoeman¹, Ani Shahbazian¹, Yuen Yin Lee¹ and Srinivasa T. Reddy², ¹Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality. Abnormal function of high density lipoprotein (HDL) has been implicated as…
Abstract Number: 1437 • ACR/ARHP Annual Meeting 2014
Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis
Michelle J. Ormseth¹, Patricia Yancey², Suguru Yamamoto², Annette M. Oeser¹, Tebeb Gebretsadik³, Ayumi Shintani¹, MacRae F. Linton¹, Sergio Fazio¹, Sean Davies¹, L Jackson Roberts II¹, Kasey C. Vickers¹, Paolo Raggi⁴, Valentina Kon¹ and C Michael Stein¹, ¹Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Biostatistics, Vanderbilt University, Nashville, TN, ⁴Emory University, Atlanta, GA
Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
Abstract Number: 399 • ACR/ARHP Annual Meeting 2014
Lipid Concentrations and Particle Sizes in Drug Naive Patients with Rheumatoid Arthritis
Aulikki Kononoff¹, Hannu Kautiainen², Pasi Soininen^3,4, Antti Kangas^3,4, Leena Laasonen⁵, Leena Arstila^1,6, Pia Elfving¹, Elina Savolainen⁷, Helena Niinisalo^8,9, Mika Ala-Korpela^3,4,10,11 and Oili Kaipiainen-Seppanen¹, ¹Department of Medicine, Kuopio University Hospital, Kuopio, Finland, ²Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland, ³Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, ⁴NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, ⁵Helsinki Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland, ⁶Iisalmi Hospital, Iisalmi, Finland, ⁷Kuopio Municipal Hospital, Kuopio, Finland, ⁸Varkaus Hospital, Varkaus, Finland, ⁹Suonenjoki Health Center, Suonenjoki, Finland, ¹⁰Oulu University Hospital, Oulu, Finland, ¹¹Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
Background/Purpose Excess mortality attributed to cardiovascular causes has been described among patients with rheumatoid arthritis (RA). Atherosclerotic lipid profile has been reported in patients with…
Abstract Number: 1256 • ACR/ARHP Annual Meeting 2012
High Inflammation May Condition the Antiatherogenic Function of Small, Dense HDL in Patients with Active Rheumatoid Arthritis
Carla Saucedo¹, Leonardo gomez Rosso², Tomas Meroño², Fernando Brites², Anatol Kontush³, Luis J. Catoggio⁴, Enrique Soriano⁴, Laurent Camont⁵, Marie Lhomme⁵, Veronica Malah⁶, Patricia Sorroche⁷, Sandrine Chantepie⁵, Paul Robillard⁸ and John Chapman⁵, ¹Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²University of Buenos Aires, Laboratory of Lipids and Lipoproteins, School of Pharmacy and Biochemistry, Buenos Aires, Argentina, ³Université Pierre et Marie Curie-Paris, Paris, France, ⁴Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Université Pierre et Marie Curie, Paris, France, ⁶Rheumatology section, Hospital de Clínicas “José de San Martín”, Buenos Aires, Argentina, ⁷Central Laboratory , Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Université Pierre et Marie Curie, Paris, Argentina
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality, mainly due to cardiovascular disease. High grade inflammation might drive to premature atherosclerosis. High-density lipoprotein (HDL)…
Abstract Number: 1252 • ACR/ARHP Annual Meeting 2012
Association of Paraoxonase 1 Gene Polymorphisms and Enzyme Activity with Carotid Plaque in Rheumatoid Arthritis
Christina Charles-Schoeman¹, Yuen Yin Lee¹, Veena K. Ranganath¹, John FitzGerald¹, Mihaela B. Taylor², Maureen A. McMahon¹, David Elashoff³ and Srinivasa T. Reddy⁴, ¹University of California, Los Angeles, CA, ²University of California, Los Angeles, Los Angeles, CA, ³Medicine- Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, ⁴Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme, which promotes the anti-oxidant and anti-inflammatory properties of HDL. PON1 polymorphisms and enzyme…