Session Type: Poster Session (Tuesday)
Session Time: 9:00AM-11:00AM
Background/Purpose: Patients with rheumatoid arthritis (RA) have a significantly higher risk of cardiovascular disease (CVD) than general population. The Heart Disease Fact Questionnaire (HDFQ-RA 1 and 2) is a self-reported questionnaire that assesses the knowledge of general CVD risk and more specifically the related with RA and its treatment. The aim of this study was to validate the Spanish version of this questionnaire; and to assess the level of knowledge regarding CVD risk in a cohort of patients with RA.
Methods: Multicenter, observational, cross-sectional study. Translation and cross-cultural adaptation of the HDFQ-RA was performed according to the Beaton et al. guidelines. Consecutive patients ≥ 18 years old with RA (ACR/EULAR 2010) were included. Socio-demographic data, RA characteristics and traditional cardiovascular risk factors were recorded. All patients answered the questionnaire; a subgroup of them attended previously an informative meeting about CVD. A subgroup of patients completed the questionnaire again 10-15 days later. Statistical analysis: Demographic and disease characteristics were described. Internal consistency was assessed with Cronbach’s alpha coefficient and inter-item correlation. Correlation of disease characteristics and questionnaire scores was evaluated with Student’s T test, Chi2 test and Fisher’s exact test or Spearman correlation. Test-retest reliability was determined.
Results: A total of 787 patients from 25 centers across the country were included: 87.7% women, mean age 45 years (±12.7). Cronbach’s alpha test was 0.83 and 0.93 for HDFQ-RA1 and HDFQ-RA2, respectively. There were no redundant questions. Test-retest reliability were 0.48 for HDFQ-RA1 and 0.42 for HDFQ-RA2. Median proportion for correct answers were 53.8% in HDFQ-RA1 and 62.7% in HDFQ-RA2; for incorrect answers 13.8% in HDFQ-RA1 and 0% in HDFQ-RA2; and for unknown responses 21.1% in HDFQ-RA1 and 22.1% in HDFQ-RA2. Sixty-six percent of patients did not know that RA increases the CVD risk, and a high percentage were unaware that NSAIDs and glucocorticoids magnify this risk even more. A higher level of instruction was associated with a higher number of correct answers (p < 0.0001). The subgroup of patients who attended the informative meeting about CVD had higher scores in both questionnaires (p < 0.001 for HDFQ-RA1 and p = 0.001 for HDFQ-RA2). Patients with a history of CVD had higher scores (p = 0.01195 for HDFQ-R1 and p = 0.0114 for HDFQ-RA2) as well as those suffering from hypertension and those who were physically active. Conclusion:
HDFQ-RA1 and HDFQ-RA2 showed good internal consistency. Patients with a history of CVD and those who received previous instruction on CVD had higher scores, proving the construct validity of the questionnaire. This study demonstrates that a high percentage of RA patients neither know the higher risk of CVD caused by the disease nor the negative impact of NSAIDs and glucocorticoids on this risk. We consider that the use of these types of questionnaires would allow the implementation of targeted CVD prevention strategies as well as the ongoing assessment of their effectiveness over time.
To cite this abstract in AMA style:Bande J, Medina M, Sosa J, Kohan M, Papasidero S, Caracciolo J, Klajn D, Wacker J, Alvarez A, Lim R, Kerzberg E, Alvarez D, Trampuz A, Citera G, Correa M, Dellepiane A, Perez Davila A, Bohr A, Pereira D, Giordano F, Sacnun M, Hartvig, C, Bersano M, Díaz M, Cruzat V, Raiti L, Demarchi J, Remolina Rincón I, Segura Escobar C, Benegas M, Saturansky E, Civit E, Garignani F, Casado G, Smichowski A, Callahuara Goiburu N, Arguello J, Girard Bosch M, Quintana R, Pons-Estel B, Gobbi C, Scublinsky D, Salcedo M, de la Vega M, Blanco E, Maldonado Ficco H, Degioanni L, Perez N, Martinez Muñoz A, Rodriguez S, Kirmayr K, Petruzzelli S. Knowledge of Cardiovascular Disease Risk Among Patients with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/knowledge-of-cardiovascular-disease-risk-among-patients-with-rheumatoid-arthritis/. Accessed January 27, 2022.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/knowledge-of-cardiovascular-disease-risk-among-patients-with-rheumatoid-arthritis/