ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2320

Knowledge of Cardiovascular Disease Risk Among Patients with Rheumatoid Arthritis

Juan Bande1, María Medina 1, Julia Sosa 1, María Kohan 1, Silvia Papasidero 1, José Caracciolo 1, Diana Klajn 1, Julio Wacker 1, Analía Alvarez 2, Romina Lim 2, Eduardo Kerzberg 3, Damaris Alvarez 3, Alejandra Trampuz 3, Gustavo Citera 4, Maria Correa 5, Analia Dellepiane 6, Adriana Perez Davila 7, Analía Verónica Bohr 7, Dora Pereira 8, Federico Giordano 8, Mónica Sacnun 9, Claudia Hartvig, 9, Maria Noelia Bersano 9, Mónica Díaz 10, Vanesa Cecilia Cruzat 11, Laura Raiti 12, Julia Demarchi 13, Iván Dario Remolina Rincón 13, Carolina Segura Escobar 13, Mariana Benegas 14, Etel Saturansky 14, Emma Civit 15, Federica Garignani 15, Gustavo Casado 16, Andrea M. Smichowski 16, Noel Agustin Callahuara Goiburu 17, Juan Arguello 17, Maria Paula Girard Bosch 18, Rosana Quintana 19, Bernardo A. Pons-Estel 19, Carla Gobbi 20, Darío Scublinsky 21, Mariana Salcedo 22, Maria de la Vega 23, Eliana Blanco 24, Hernán Maldonado Ficco 25, Lucía Degioanni 25, Nicolás Perez 26, Alejandro Martinez Muñoz 27 Silvina Mariana Rodriguez 28, Karin Kirmayr 29 and Sandra Petruzzelli30, 1Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 2Hospital General de Agudos José M. Penna, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 3Hospital Ramos Mejía, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 4Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 5Consultorios Reumatológicos Pampa, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 6CEMEC, Casilda, Santa Fe, Argentina, 7Hospital de Rehabilitación M. Rocca, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 8Hospital Zonal de Agudos Dr. Ricardo Gutiérrez, La Plata, Buenos Aires, Argentina, 9Hospital Provincial de Rosario, Rosario, Santa Fe, Argentina, 10Centro Traumatológico Bariloche, San Carlos de Bariloche, Rio Negro, Argentina, 11Clínica Bessone, Buenos Aires, Argentina, 12Clinica Bessone, Buenos Aires, Argentina, 13Hospital Británico, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 14Sanatorio Mendez, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 15OSEP. Universidad de Mendoza. F.C. Médicas, Ciudad de Mendoza, Argentina, 16Hospital Militar Central, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 17Hospital General de Agudos B. Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 18Instituto Médico Platense, La Plata, Argentina, 19Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Grupo Oroño, Rosario, Argentina, 20CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Argentina, 21Centros Médicos Ambulatorios SMG, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 22Instituto de Cardiología, San Nicolás, Santa Fe, Argentina, 23CEIM Investigaciones Medicas, Buenos Aires, Argentina, 24Hospital General de Agudos Dr. Cosme Argerich, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 25Hospital San Antonio de Padua, Río Cuarto, Cordoba, Argentina, 26Instituto de Investigaciones Médicas Alfredo Lanari, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 27Hospital Municipal Dr. R. Larcade, San Miguel, Buenos Aires, Argentina, 28Hospital Municipal de Trauma y Emergencias Dr. Federico Abete, Malvinas Argentinas, Buenos Aires, Argentina, 29Hospital Zonal Bariloche, Bariloche, Argentina, 30Casa Hospital San Juan de Dios, La Plata, Buenos Aires, Argentina

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: ,

Session Information

Date: Tuesday, November 12, 2019

Title: RA – Diagnosis, Manifestations, & Outcomes Poster III: Comorbidities

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Patients with rheumatoid arthritis (RA) have a significantly higher risk of cardiovascular disease (CVD) than general population. The Heart Disease Fact Questionnaire (HDFQ-RA 1 and 2) is a self-reported questionnaire that assesses the knowledge of general CVD risk and more specifically the related with RA and its treatment. The aim of this study was to validate the Spanish version of this questionnaire; and to assess the level of knowledge regarding CVD risk in a cohort of patients with RA.

Methods: Multicenter, observational, cross-sectional study. Translation and cross-cultural adaptation of the HDFQ-RA was performed according to the Beaton et al. guidelines. Consecutive patients ≥ 18 years old with RA (ACR/EULAR 2010) were included. Socio-demographic data, RA characteristics and traditional cardiovascular risk factors were recorded. All patients answered the questionnaire; a subgroup of them attended previously an informative meeting about CVD. A subgroup of patients completed the questionnaire again 10-15 days later. Statistical analysis: Demographic and disease characteristics were described. Internal consistency was assessed with Cronbach’s alpha coefficient and inter-item correlation. Correlation of disease characteristics and questionnaire scores was evaluated with Student’s T test, Chi2 test and Fisher’s exact test or Spearman correlation. Test-retest reliability was determined.

Results: A total of 787 patients from 25 centers across the country were included:  87.7% women, mean age 45 years (±12.7). Cronbach’s alpha test was 0.83 and 0.93 for HDFQ-RA1 and HDFQ-RA2, respectively. There were no redundant questions.  Test-retest reliability  were 0.48 for HDFQ-RA1 and 0.42 for HDFQ-RA2. Median proportion for correct answers were 53.8% in HDFQ-RA1 and 62.7% in HDFQ-RA2; for incorrect answers 13.8% in HDFQ-RA1 and 0% in HDFQ-RA2; and for unknown responses 21.1% in HDFQ-RA1 and 22.1% in HDFQ-RA2. Sixty-six percent of patients did not know that RA increases the CVD risk, and a high percentage were unaware that NSAIDs and glucocorticoids magnify this risk even more. A higher level of instruction was associated with a higher number of correct answers (p < 0.0001). The subgroup of patients who attended the informative meeting about CVD had higher scores in both questionnaires (p < 0.001 for HDFQ-RA1 and p = 0.001 for HDFQ-RA2). Patients with a history of CVD had higher scores (p = 0.01195 for HDFQ-R1 and p = 0.0114 for HDFQ-RA2) as well as those suffering from hypertension and those who were physically active. Conclusion:

HDFQ-RA1 and HDFQ-RA2 showed good internal consistency. Patients with a history of CVD and those who received previous instruction on CVD had higher scores, proving the construct validity of the questionnaire. This study demonstrates that a high percentage of RA patients neither know the higher risk of CVD caused by the disease  nor the negative impact of NSAIDs and glucocorticoids on this risk. We consider that the use of these types of questionnaires would allow the implementation of targeted CVD prevention strategies as well as the ongoing assessment of their effectiveness over time.

Disclosure: J. Bande, None; M. Medina, None; J. Sosa, None; M. Kohan, None; S. Papasidero, None; J. Caracciolo, None; D. Klajn, None; J. Wacker, None; A. Alvarez, None; R. Lim, None; E. Kerzberg, None; D. Alvarez, None; A. Trampuz, None; G. Citera, AbbVie, 5, 8, Abbvie, 2, 5, 8, BMS, 5, BRISTOL MYERS SQUIBB ARGENTINA, 8, Bristol-Myers Squibb, 5, 8, Eli Lilly, 5, Gema Biotech, 2, 5, 8, Genzyme, 5, Janssen, 5, 8, Novartis, 5, 8, Pfizer, 5, 8, Roche, 5, 8, Sanofi Genzyme, 5, 8; M. Correa, None; A. Dellepiane, None; A. Perez Davila, None; A. Bohr, None; D. Pereira, None; F. Giordano, None; M. Sacnun, None; C. Hartvig,, None; M. Bersano, None; M. Díaz, None; V. Cruzat, None; L. Raiti, None; J. Demarchi, None; I. Remolina Rincón, None; C. Segura Escobar, None; M. Benegas, None; E. Saturansky, None; E. Civit, None; F. Garignani, None; G. Casado, None; A. Smichowski, None; N. Callahuara Goiburu, None; J. Arguello, None; M. Girard Bosch, None; R. Quintana, None; B. Pons-Estel, None; C. Gobbi, None; D. Scublinsky, None; M. Salcedo, None; M. de la Vega, AbbVie, 8, BMS, 8, Janssen, 8, Lilly, 8, Pfizer, 5, 8, Raffo, 5, 8, Roche, 9, Sanofi, 5, 8; E. Blanco, None; H. Maldonado Ficco, None; L. Degioanni, None; N. Perez, None; A. Martinez Muñoz, None; S. Rodriguez, None; K. Kirmayr, None; S. Petruzzelli, None.

To cite this abstract in AMA style:

Bande J, Medina M, Sosa J, Kohan M, Papasidero S, Caracciolo J, Klajn D, Wacker J, Alvarez A, Lim R, Kerzberg E, Alvarez D, Trampuz A, Citera G, Correa M, Dellepiane A, Perez Davila A, Bohr A, Pereira D, Giordano F, Sacnun M, Hartvig, C, Bersano M, Díaz M, Cruzat V, Raiti L, Demarchi J, Remolina Rincón I, Segura Escobar C, Benegas M, Saturansky E, Civit E, Garignani F, Casado G, Smichowski A, Callahuara Goiburu N, Arguello J, Girard Bosch M, Quintana R, Pons-Estel B, Gobbi C, Scublinsky D, Salcedo M, de la Vega M, Blanco E, Maldonado Ficco H, Degioanni L, Perez N, Martinez Muñoz A, Rodriguez S, Kirmayr K, Petruzzelli S. Knowledge of Cardiovascular Disease Risk Among Patients with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/knowledge-of-cardiovascular-disease-risk-among-patients-with-rheumatoid-arthritis/. Accessed .

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