Session Information
Session Type: Poster Session B
Session Time: 10:30AM-12:30PM
Background/Purpose: During the COVID-19 pandemic there were reports of an increased association between COVID 19 and various autoimmune diseases (AID) in adults. This study aims to investigate the incidence of AIDs in children before and during the pandemic and explores potential links to SARS-CoV-2 vaccination.
Methods: We analyzed 493,705 anonymized medical records from Maccabi Healthcare Services, Israel’s second-largest healthcare provider, to study AID incidence during 2014-2022. The study period was divided into three phases: two pre-pandemic phases of equal duration (A and B) and a pandemic phase (C).
Results: Of 4,596 (0.9%) patients diagnosed with an AID in the cohort, incidence rates were 0.9% for Group A (2014-2016), 1.0% for Group B (2017-2019), and 0.9% for Group C (2020-2022) (p = 0.13). Logistic regression showed no significant differences in overall autoimmune disease incidence between the pre-COVID and COVID periods. Notably, specific conditions like celiac disease showed reduced incidence in Group A (OR 0.8309, p = 0.0071) while arthritis was significantly more common in Groups A and B. Additionally, COVID-19 diagnosis was not significantly associated with increased autoimmune disease risk (HR 1.092, p = 0.491); however, receiving at least one COVID vaccine was linked to higher risk (HR 1.2323, p = 0.0033).
Conclusion: Our findings suggest that the overall incidence of new-onset autoimmune diseases in children remained relatively stable during the COVID-19 pandemic. The study indicates a potential association between COVID-19 vaccination and an increased risk of developing autoimmune diseases, necessitating further research to elucidate long-term effects in the pediatric population
Figure 1.A and B. Multivariable logistic regression analysis comparing the incidence of autoimmune diseases between Group C (pandemic period) and Groups A and B (pre-pandemic periods
To cite this abstract in AMA style:
Butbul Aviel Y, Dotan A, Arnheim D, Freiberg C. Investigating the Association Between SARS-CoV-2 Infection, COVID-19 Vaccination, and Autoimmune Diseases in a Pediatric Population: A comprehensive analysis [abstract]. Arthritis Rheumatol. 2025; 77 (suppl 9). https://acrabstracts.org/abstract/investigating-the-association-between-sars-cov-2-infection-covid-19-vaccination-and-autoimmune-diseases-in-a-pediatric-population-a-comprehensive-analysis/. Accessed .« Back to ACR Convergence 2025
ACR Meeting Abstracts - https://acrabstracts.org/abstract/investigating-the-association-between-sars-cov-2-infection-covid-19-vaccination-and-autoimmune-diseases-in-a-pediatric-population-a-comprehensive-analysis/